That sinking feeling, again? The state of National Institutes of Health pediatric research funding, fiscal year 1992-2010.

abstract：:New information is emerging concerning the influence of environmental factors (e.g., viruses, pollutants, nutrients) on fetal lung development and the prenatal modulation of cellular and molecular effectors essential to the control of airway function, which may shed new light into the pathogenesis of chronic obstructi...

journal_title：Pediatric research

authors： Piedimonte G,Harford TJ

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:The aim of this study was to examine in detail levels and patterns of physical activity in preschool children and the effects of gender and BMI on this activity. METHODS:Two hundred and fifty-three children aged 5 y participating in the Copenhagen Prospective Studies on Asthma in Childhood wore an accelerom...

journal_title：Pediatric research

authors： Brasholt M,Chawes B,Kreiner-Møller E,Vahlkvist S,Sinding M,Bisgaard H

更新日期：2013-09-01 00:00:00

abstract：:The effect of hypoxia-ischemia (HI) on IL-1, and IL-6 bioactivity in relation to expression of IL-1 alpha, IL-1 beta, and IL-6 mRNA was studied, and the neuroprotective efficacy of IL-1 receptor antagonist (IL-1ra) was evaluated in neonatal rats. HI was induced in 7-d-old rats by unilateral carotid artery ligation and...

journal_title：Pediatric research

authors： Hagberg H,Gilland E,Bona E,Hanson LA,Hahin-Zoric M,Blennow M,Holst M,McRae A,Söder O

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:Infant adiposity is linked to both high maternal fat mass (FM) and excessive gestational FM gain, whereas the association with maternal adipokines is less clear. The aim was to determine how levels of maternal leptin, the soluble leptin receptor (sOB-R), adiponectin, and FM during pregnancy were linked to in...

journal_title：Pediatric research

authors： Andersson-Hall UK,Pivodic A,de Maré HK,Pernilla Svedin J,Carina Mallard E,Albertsson-Wikland KG,Holmäng AB

更新日期：2020-09-14 00:00:00

abstract：:Newly identified forms of electron transfer flavoprotein (ETF) deficiency in two patients with glutaric aciduria type II (GA II) were described. GA II has been attributed to a defect of either ETF or ETF dehydrogenase, resulting in multiple acyl-CoA dehydrogenation deficiency. ETF is a mitochondrial flavoprotein consi...

journal_title：Pediatric research

authors： Yamaguchi S,Orii T,Suzuki Y,Maeda K,Oshima M,Hashimoto T

更新日期：1991-01-01 00:00:00

abstract：:Phototherapy results in the conversion of native bilirubin to more water-soluble configurational and structural isomers. The serum half-life for the configurational isomer, the principal photoproduct in vivo, was determined by high pressure liquid chromatography in six premature infants following cessation of photothe...

journal_title：Pediatric research

authors： Ennever JF,Knox I,Denne SC,Speck WT

更新日期：1985-02-01 00:00:00

abstract：:Factors, such as insulin, found in human and pig colostrum and mature milk likely influence small intestinal growth and development. Although pharmacologic doses of insulin injected parenterally may accelerate small intestinal development in altricial animals such as the rodent, the effects of oral insulin on intestin...

journal_title：Pediatric research

authors： Shulman RJ

更新日期：1990-08-01 00:00:00

abstract：:Our aim was to compare white matter (WM) microstructure in preterm infants with and without punctate WM lesions on MRI using tract-based spatial statistics (TBSS) and probabilistic tractography. We studied 23 preterm infants with punctate lesions, median GA at birth 30 (25-35) wk, and 23 GA- and sex-matched preterm co...

journal_title：Pediatric research

authors： Bassi L,Chew A,Merchant N,Ball G,Ramenghi L,Boardman J,Allsop JM,Doria V,Arichi T,Mosca F,Edwards AD,Cowan FM,Rutherford MA,Counsell SJ

更新日期：2011-06-01 00:00:00

abstract：:Shigellosis in children can cause growth retardation, worsening of malnutrition, and hypoproteinemia. To assess the effects of ingestion of a protein-rich diet during convalescence, 22 children aged 2 to 4 y with culture-proven shigellosis were randomly assigned after 5 d of antibiotic treatment to 21-d feeding regime...

journal_title：Pediatric research

authors： Kabir I,Butler T,Underwood LE,Rahman MM

更新日期：1992-12-01 00:00:00

abstract：:The growth hormone-releasing hexapeptide (GHRP-6) specifically stimulates growth hormone (GH) secretion in several animal species and humans. The mechanism of action of GHRP-6 is largely unknown, although experimental evidence indicates that it may modulate growth hormone-releasing hormone (GHRH) and somatostatin acti...

journal_title：Pediatric research

authors： Locatelli V,Grilli R,Torsello A,Cella SG,Wehrenberg WB,Müller EE

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:Hirschsprung disease (HSCR) is the third most common congenital disorder of the gastrointestinal tract. This study aims to elucidate changes in protein expression between the normal and aganglionic hindgut in human HSCR. METHODS:The biopsies were obtained from the normal and aganglionic hindgut in human HSC...

journal_title：Pediatric research

authors： Zhang SC,Chen F,Jiang KL,Yuan ZW,Wang WL

更新日期：2014-06-01 00:00:00

abstract：:Pseudohypoaldosteronism is a hereditary salt-wasting syndrome usually seen in infancy with weight loss, dehydration, and failure to thrive. The pathophysiologic origin of pseudohypoaldosteronism is unknown. The defect could be related to the unresponsiveness of target organs to mineralocorticoids resulting in hyponatr...

journal_title：Pediatric research

authors： Bistritzer T,Evans S,Cotariu D,Goldberg M,Aladjem M

更新日期：1994-03-01 00:00:00

abstract：:The effects of ascorbic acid on the excretion of homogentisic acid and its derivative benzoquinone acetic acid were studied in two adults and three infants. The administration of relatively large amounts of ascorbic acid to the adults was followed by a disappearance of benzoquinone acetic acid from the urine, whereas ...

journal_title：Pediatric research

authors： Wolff JA,Barshop B,Nyhan WL,Leslie J,Seegmiller JE,Gruber H,Garst M,Winter S,Michals K,Matalon R

更新日期：1989-08-01 00:00:00

abstract：:BackroundMicrocephaly can either be isolated or it may coexist with other neurological entities and/or multiple congenital anomalies, known as syndromic microcephaly. Although many syndromic cases can be classified based on the characteristic phenotype, some others remain uncertain and require further investigation. T...

journal_title：Pediatric research

authors： Tsoutsou E,Tzetis M,Giannikou K,Braoudaki M,Mitrakos A,Amenta S,Selenti N,Kanavakis E,Zafeiriou D,Kitsiou-Tzeli S,Fryssira H

更新日期：2017-08-01 00:00:00

abstract：:Our goal for this study was to determine whether the maturation of fat absorption in neonatal life is functionally related to an increased ability to hydrolyze dietary fat, to absorb long-chain fatty acids, or to do both. In 16 preterm and in eight term neonates, the intestinal ability to hydrolyze triacylglycerols an...

journal_title：Pediatric research

authors： Rings EH,Minich DM,Vonk RJ,Stellaard F,Fetter WP,Verkade HJ

更新日期：2002-01-01 00:00:00

abstract：:Twenty-two reported cases of neuroblastoma missed by the mass screening programs were reviewed (six cases in Sapporo City where a quantitative measurement for both vanillylmandelic acid (VMA) and homovanillic acid (HVA) is used and 16 cases in the districts of qualitative judgment only for VMA), and some potential fac...

journal_title：Pediatric research

authors： Nishi M,Miyake H,Takeda T,Takasugi N,Sato Y,Hanai J,Kawai T

更新日期：1989-12-01 00:00:00

abstract：INTRODUCTION:Current advances in neonatology have improved survival among preterm and low-birth-weight infants. However, the risk of neonatal death in preterm infants is much greater than in full-term neonates and is frequently associated with infections. METHODS:Little is known about the immune status of preterm neon...

journal_title：Pediatric research

authors： Correa-Rocha R,Pérez A,Lorente R,Ferrando-Martínez S,Leal M,Gurbindo D,Muñoz-Fernández MÁ

更新日期：2012-05-01 00:00:00

abstract：:The mitochondrial DNA (mtDNA) point mutation T8993G has been associated with maternally inherited Leigh syndrome (MILS) when very abundant (> 95%). MILS patients are usually severely affected and die in early infancy. In 1993, a novel T8993C point mutation was described in a juvenile form of Leigh syndrome (LS) charac...

journal_title：Pediatric research

authors： Santorelli FM,Mak SC,Vazquez-Memije ME,Shanske S,Kranz-Eble P,Jain KD,Bluestone DL,De Vivo DC,DiMauro S

更新日期：1996-05-01 00:00:00

abstract：:Acute kidney injury (AKI) is common in premature infants and is associated with poor outcomes. Novel biomarkers can detect AKI promptly. Because premature infants are born with underdeveloped kidneys, baseline biomarker values may differ. We describe baseline values of urinary neutrophil gelatinase-associated lipocali...

journal_title：Pediatric research

authors： Askenazi DJ,Koralkar R,Levitan EB,Goldstein SL,Devarajan P,Khandrika S,Mehta RL,Ambalavanan N

更新日期：2011-09-01 00:00:00

abstract：:Several epithelial ion transporters are developmentally regulated in the preweaning period, at the time when the circulating levels of glucocorticoid and mineralocorticoid hormones increase. The specific role of glucocorticoids and mineralocorticoids in the maturation of epithelial ion transport is still disputed. In ...

journal_title：Pediatric research

authors： Wang ZM,Yasui M,Celsi G

更新日期：1995-08-01 00:00:00

abstract：:The specific activities of four folate enzymes have been measured in livers from preterm infants (Group 1), full-term infants (Group 2), and from control subjects (Group 3). The four enzymes studied were methylene tetrahydrofolate reductase (EC 1.1.1.68), methionine synthetase (EC 2.1.1.13), methylenetetrahydrofolate ...

journal_title：Pediatric research

authors： Kalnitsky A,Rosenblatt D,Zlotkin S

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND:Bilirubin-induced neurologic dysfunction (BIND) is a spectrum of preventable neurological sequelae in jaundiced newborns. Current total plasma bilirubin (BT) concentration thresholds for phototherapy and/or exchange transfusion poorly predict BIND. METHODS:The unbound (free) bilirubin (Bf) measured at these...

journal_title：Pediatric research

authors： Ahlfors CE,Bhutani VK,Wong RJ,Stevenson DK

更新日期：2018-10-01 00:00:00

abstract：:Localized proton magnetic resonance spectra were recorded from human cerebellum in vivo with a 1.5-T magnet. The spectra from healthy adults and preterm and term babies showed resonances from N-acetylaspartate, creatine and phosphocreatine, choline-containing compounds such as phosphocholine and glycerophosphocholine,...

journal_title：Pediatric research

authors： Hüppi PS,Posse S,Lazeyras F,Burri R,Bossi E,Herschkowitz N

更新日期：1991-12-01 00:00:00

abstract：:Neutrophils (PMN) from newborn calves generate significantly less superoxide anion (O2-) than do their adult counterparts after stimulation with direct protein kinase C agonists. To better understand this observation, we compared the activity and kinetics of NADPH oxidase in membrane fractions from phorbol 12-myristat...

journal_title：Pediatric research

authors： Doré M,Slauson DO,Neilsen NR

更新日期：1990-10-01 00:00:00

abstract：:The mucopolysaccharidoses (MPS) are inherited metabolic disorders resulting from the defective catabolism of glycosaminoglycans. In this report, we find that the stimulation of MPS connective tissue cells by the inflammatory cytokines causes enhanced secretion of several matrix-degrading metalloproteinases (MMPs). In ...

journal_title：Pediatric research

authors： Simonaro CM,D'Angelo M,Haskins ME,Schuchman EH

更新日期：2005-05-01 00:00:00

abstract：:Recently a soybean oil emulsion (Intralipid) (IL) has been released in the United States for use as a parenteral nutrient. The study reported here was undertaken to determine the effect of ingestion of IL on the synthesis and secretion of the second (C2) and fourth (C4) components of complement by guinea pig peritonea...

journal_title：Pediatric research

authors： Strunk RC,Kunke K,Nagle RB,Payne CM,Harrison HR

更新日期：1979-03-01 00:00:00

abstract：BACKGROUND:Kawasaki disease (KD) is an acute febrile illness associated with the development of vasculitis. Administration of intravenous immunoglobulin (IVIG) is the standard treatment for KD. However, IVIG treatment is not effective in approximately 15% of children with KD. Some reports have presented evidence of imm...

journal_title：Pediatric research

authors： Wakiguchi H,Hasegawa S,Suzuki Y,Kudo K,Ichiyama T

更新日期：2015-04-01 00:00:00

abstract：:The association between lung injury and thrombocytopenia was investigated by comparing the megakaryocyte and platelet counts, and platelet activation using P-selectin as a marker, between the prepulmonary (right atrial) and postpulmonary (left atrial) blood in adult and neonatal (preterm and term) rats with and withou...

journal_title：Pediatric research

authors： Yang J,Yang M,Xu F,Li K,Lee SK,Ng PC,Tam JS,Yuen PM,Fok TF

更新日期：2003-09-01 00:00:00

abstract：:Nutrition in early life, growth, and subsequent health over a lifetime are significantly interrelated. The aim of this study was to assess body composition changes in exclusively breast-fed infants from birth up to 6 mo of age. An observational, prospective, cohort study was conducted. Fifty-nine full-term, healthy, e...

journal_title：Pediatric research

authors： Roggero P,Giannì ML,Orsi A,Piemontese P,Amato O,Liotto N,Morlacchi L,Taroni F,Fields DA,Catalano PM,Mosca F

更新日期：2010-12-01 00:00:00

abstract：:Thoracoabdominal asynchrony (TAA) and chest wall distortion (CWD) are commonly seen in preterm infants secondary to a highly compliant rib cage and poor compensation of distorting forces by inspiratory rib cage muscles. Continuous positive airway pressure (CPAP) reduces TAA and CWD by stenting the chest wall. We hypot...

journal_title：Pediatric research

authors： Musante G,Schulze A,Gerhardt T,Everett R,Claure N,Schaller P,Bancalari E

更新日期：2001-02-01 00:00:00