Abstract:
BACKGROUND:Infant adiposity is linked to both high maternal fat mass (FM) and excessive gestational FM gain, whereas the association with maternal adipokines is less clear. The aim was to determine how levels of maternal leptin, the soluble leptin receptor (sOB-R), adiponectin, and FM during pregnancy were linked to infant FM in normal-weight (NW) women and women with obesity (OB). METHODS:Body composition and serum levels of leptin, adiponectin, and sOB-R were determined three times during pregnancy in 80 NW and 46 OB women. For infants, body composition was measured at 1 and 12 weeks of age. RESULTS:Maternal leptin and sOB-R levels increased during pregnancy. For NW women, infant FM at 1 week was inversely associated with changes in maternal leptin and at 12 weeks inversely associated with absolute maternal sOB-R levels throughout pregnancy, as well as changes in sOB-R levels in early pregnancy. For OB women, infant FM at both 1 and 12 weeks were best explained by maternal FM. CONCLUSIONS:Leptin and sOB-R, thought to regulate leptin bioavailability, are associated with fat accumulation in infants born to NW women. In OB women, maternal FM in early pregnancy is more important than leptin in determining infant fat accumulation. IMPACT:In normal-weight women, the regulation of maternal leptin bioavailability during pregnancy has a role in infant fat mass accumulation. In women with obesity, however, pre-pregnancy maternal fat mass seems more important for infant fat mass. This is the first study of maternal adipokines and fat mass including longitudinal measurements in both mothers and their children. Understanding the relationship between maternal factors and infant fat mass is of great importance as obesity is programmed over the generations, and it is important to learn what regulates this programming.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Andersson-Hall UK,Pivodic A,de Maré HK,Pernilla Svedin J,Carina Mallard E,Albertsson-Wikland KG,Holmäng ABdoi
10.1038/s41390-020-01115-9subject
Has Abstractpub_date
2020-09-14 00:00:00eissn
0031-3998issn
1530-0447pii
10.1038/s41390-020-01115-9pub_type
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/PDR.0b013e3180a03232
更新日期:2007-08-01 00:00:00
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journal_title:Pediatric research
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journal_title:Pediatric research
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-197908000-00007
更新日期:1979-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1203/PDR.0b013e3181dbac3d
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journal_title:Pediatric research
pub_type: 杂志文章
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journal_title:Pediatric research
pub_type: 临床试验,杂志文章
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199107000-00008
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journal_title:Pediatric research
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pub_type: 已发布勘误
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journal_title:Pediatric research
pub_type: 杂志文章
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更新日期:2006-01-01 00:00:00
abstract::Respiratory parameters of skeletal muscle were determined in permeabilized muscle fibers by adapting a technique described by Veksler et al. for cardiac fibers (Biochim Biophys Acta, 892:191-196, 1987). This method consists of the permeabilization of muscle fibers by saponin by allowing respiratory substrates and inhi...
journal_title:Pediatric research
pub_type: 杂志文章
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journal_title:Pediatric research
pub_type: 杂志文章
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更新日期:1983-11-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2012-10-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-197809000-00009
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198802000-00009
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199105010-00019
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journal_title:Pediatric research
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journal_title:Pediatric research
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更新日期:1975-03-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
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更新日期:1983-07-01 00:00:00
abstract::In muscle, sepsis reduces protein synthesis (MPS) by restraining translation in neonates and adults. Even though protein accretion decreases with development as neonatal MPS rapidly declines by maturation, the changes imposed by development on the sepsis-associated decrease in MPS have not been described. Pigs at 7 an...
journal_title:Pediatric research
pub_type: 杂志文章
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更新日期:2011-06-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
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更新日期:2008-03-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章,评审
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更新日期:2019-11-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
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更新日期:1985-04-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1038/s41390-019-0535-0
更新日期:2020-01-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
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更新日期:2004-07-01 00:00:00