Surfactant protein A-producing cells in human fetal lung are good targets for recombinant adenovirus-mediated gene transfer.

abstract：:Spring steel coils have been used to occlude abnormal vessels in patients with a congenital heart malformation. However, long-term adverse effects of steel spring coils remain uncertain, although some long-term results appear to be good. The purpose of this study was to evaluate the angiographic and histologic results...

journal_title：Pediatric research

authors： Ino T,Kishiro M,Yamashiro Y,Tanaka A,Ito H

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:Genotyping tests were developed to attenuate the impact of viral resistance. Information about the efficacy in genotype base antiretroviral therapy in children is rare and even more in low- and middle-income countries. METHODS:Sixteen children with antiretroviral therapy (ART) failure and triple-class drug-...

journal_title：Pediatric research

authors： Huerta-García G,Vazquez-Rosales JG,Mata-Marín JA,Peregrino-Bejarano L,Flores-Ruiz E,Solórzano-Santos F

更新日期：2016-07-01 00:00:00

abstract：:Germinal matrix hemorrhage-intraventricular hemorrhage (GMH-IVH) commonly affects premature neonates. The gravity of the consequences associated with GMH-IVH makes it a major concern in their care. GMH-IVH begins in the germinal matrix tissue and is, most commonly, the result of venous rupture. Arteriole-to-venous pre...

journal_title：Pediatric research

authors： Anstrom JA,Brown WR,Moody DM,Thore CR,Challa VR,Block SM

更新日期：2002-10-01 00:00:00

abstract：:Although the use of antenatal glucocorticoids has resulted in decreased neonatal morbidity/mortality, recent animal studies have raised concerns regarding adverse effects of these medications on postnatal cardiovascular function. We hypothesized that antenatal betamethasone (Beta) exposure alters cerebral vascular rea...

journal_title：Pediatric research

authors： Eckman DM,Kerr BA,Fuloria M,Simandle SA,Watt SE,Rose JC,Figueroa JP

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:The epithelial-mesenchymal transition (EMT) has been implicated as a key mechanism in the pathogenesis of liver fibrosis. The miR-200 family has been shown to inhibit EMT. METHODS:Liver fibrosis levels were assessed with Masson's trichrome staining of liver samples obtained from biliary atresia (BA) patient...

journal_title：Pediatric research

authors： Xiao Y,Zhou Y,Chen Y,Zhou K,Wen J,Wang Y,Wang J,Cai W

更新日期：2015-02-01 00:00:00

abstract：:Prematurity is associated with delayed postnatal activation of mitochondrial oxidative phosphorylation and impaired switch from glycolytic to oxidative metabolism. Fatty acids (FA), which represent a major energy substrate in mature muscle cells, are engaged in the postnatal activation of genes of energy metabolism an...

journal_title：Pediatric research

authors： Brauner P,Kopecký P,Flachs P,Ruffer J,Sebron V,Plavka R,Vítková I,Vorlícek J,Kopecký J

更新日期：2003-04-01 00:00:00

abstract：:The effects of passive respiratory syncytial virus (RSV) immune serum given as preinoculation prophylaxis, postinoculation prophylaxis, and as therapy on d 5 after inoculation were evaluated in an illness model of RSV infection in BALB/c mice. Pre- and postinoculation prophylaxis reduced RSV replication in lung after ...

journal_title：Pediatric research

authors： Graham BS,Davis TH,Tang YW,Gruber WC

更新日期：1993-08-01 00:00:00

abstract：:Wu and colleagues analyzed the placental pathology from a subset of the neonates in the NEATO trial who had reports available and correlated the placental pathology findings with outcomes. This study highlights the importance of placental pathology, and its potential to bring precision medicine to critically-ill neona...

journal_title：Pediatric research

authors： Jantzie LL,Robinson S

更新日期：2020-04-01 00:00:00

abstract：:Hydrocephalus may result in loss of tissue associated with neuronal degeneration, axonal damage, and reactive gliosis. The soluble form of the anti-apoptotic regulator Fas (sFas) and the pro-apoptotic factors soluble FasL (sFasL) and activated caspase 3 were studied in the cerebrospinal fluid of infants with hydroceph...

journal_title：Pediatric research

authors： Felderhoff-Mueser U,Buhrer C,Groneck P,Obladen M,Bartmann P,Heep A

更新日期：2003-11-01 00:00:00

abstract：:Inflammatory phenomena seem to contribute to the occurrence of perinatal cerebral white matter damage and CP. The stimulus that initiates the inflammation remains obscure. One thousand two hundred forty-six infants born before the 28th postmenstrual week had a protocol ultrasound scan of the brain read concordantly by...

journal_title：Pediatric research

authors： Leviton A,Allred EN,Kuban KC,Hecht JL,Onderdonk AB,O'shea TM,Paneth N

更新日期：2010-01-01 00:00:00

abstract：:Hypoxic-ischemic injuries can evolve over several days, and recent studies suggest that further neuronal death may occur 6 to 72 h later. Because cerebral temperature is an important determinant of outcome during the primary injury, we investigated the effect of temperature, on outcome, during the later phases of inju...

journal_title：Pediatric research

authors： Sirimanne ES,Blumberg RM,Bossano D,Gunning M,Edwards AD,Gluckman PD,Williams CE

更新日期：1996-04-01 00:00:00

abstract：:BackgroundExtracellular adenine nucleotides contribute to ischemia-reperfusion injury following infant cardiopulmonary bypass (CPB), whereas conversion to adenosine may be protective. Alkaline phosphatase (AP), a key enzyme responsible for this conversion, decreases after infant CPB. Indirect evidence suggests that so...

journal_title：Pediatric research

authors： Persson JN,Baird CH,Tong S,Urban TT,Klawitter J,Wischmeyer PE,Davidson JA

更新日期：2018-04-01 00:00:00

abstract：:The absolute and the percentage plasma NEFA pattern of healthy children, Cystic Fibrosis (C.F.) patients and their parents have been determined (table I, III, V) and compared with those of age and sex matched control subjects (table II, Iv, V). There is a striking difference in the percentage plasma NEFA pattern of C....

journal_title：Pediatric research

authors： Rogiers V,Dab I,Crokaert R,Vis HL

更新日期：1980-09-01 00:00:00

abstract：BACKGROUND:For the second aim of the Kellogg Foundation grant, this double-blind RCT investigated the impact of plasma vitamin D metabolite 25-hydroxyvitamin D (25(OH)D) on plasma immune-mediators during pregnancy. We hypothesized that higher 25(OH)D concentrations would associate with reduced pro-inflammatory and incr...

journal_title：Pediatric research

authors： Khatiwada A,Wolf BJ,Mulligan JK,Shary JR,Hewison M,Baatz JE,Newton DA,Hawrylowicz C,Hollis BW,Wagner CL

更新日期：2020-04-20 00:00:00

abstract：:Antenatal cocaine administration is associated with increases in catecholamines and glucocorticoids and results in fetal hypoxemia, with the speculated potential for increased free radical formation in the fetus. Because of this, we hypothesized that antenatal cocaine exposure would produce not only accelerated pulmon...

journal_title：Pediatric research

authors： Sosenko IR

更新日期：1993-04-01 00:00:00

abstract：:Previous studies in mature fetal sheep have shown that alcohol depresses cerebral blood flow (CBF), cerebral O2 consumption (CMRO2), and cerebral glucose consumption (CMRglu). This effect earlier in gestation might contribute to the pathogenesis of fetal alcohol syndrome. Physiologic studies of immature fetal sheep ha...

journal_title：Pediatric research

authors： Gleason CA,Hotchkiss KJ

更新日期：1992-06-01 00:00:00

abstract：:Surface active aerosols were produced from aqueous dispersions of mixed lipids (CLL), extracted from bovine lung lavage. Particle size distributions were measured as a function of humidity for two types of aerosol generators: ultrasonic and jet. Lipid dispersions before aerosolization were prepared by sonication in an...

journal_title：Pediatric research

authors： Marks LB,Notter RH,Oberdorster G,McBride JT

更新日期：1983-09-01 00:00:00

abstract：:Hirschsprung's disease, affecting one in 5000 live newborns, is the most common cause of neonatal intestinal obstruction. The obstruction or, later in life, constipation arises from the lack of enteric ganglia in the hindgut, thus resulting in poor coordination of peristalsis. Mutations in Hirschsprung patients have s...

journal_title：Pediatric research

authors： Svensson PJ,Von Tell D,Molander ML,Anvret M,Nordenskjöld A

更新日期：1999-05-01 00:00:00

abstract：:The primary manifestations of Pompe disease are muscle weakness and cardiomyopathy. Although accumulation of glycogen has also been seen in the nervous system in patients, the significance of brain involvement in infantile-onset Pompe disease is not clear. In this study, brain development in five cases of infantile-on...

journal_title：Pediatric research

authors： Chien YH,Lee NC,Peng SF,Hwu WL

更新日期：2006-09-01 00:00:00

abstract：:We studied properties of saliva and of dental plaque which affect the caries process in an effort to understand the low prevalence of caries in patients with chronic renal failure. Plaque pH, before and following carbohydrate exposure, saliva pH, and saliva composition were evaluated in children and adolescents with c...

journal_title：Pediatric research

authors： Peterson S,Woodhead J,Crall J

更新日期：1985-08-01 00:00:00

abstract：:The history of Pediatric Infectious Diseases closely parallels the history of Pediatrics at least until the last century, because historically infections comprised the major causes of childhood morbidity and mortality, as they still do in the developing world. This history reviews developments in the field through the...

journal_title：Pediatric research

authors： Shulman ST

更新日期：2004-01-01 00:00:00

abstract：:Time-corrected measurements of transplacental and transamniotic electrical potentials were made in potassium-deficient rats on the 20th day of gestation. These averaged 6.4 mV and 2.0 mV, respectively, in the deficient group as compared with 14.3 and 18.4, respectively, in the controls. The measured maternal potassium...

journal_title：Pediatric research

authors： Fantel AG

更新日期：1978-10-01 00:00:00

abstract：:Ethylmalonic aciduria is a common biochemical finding in patients with inborn errors of short chain fatty acid beta-oxidation. The urinary excretion of ethylmalonic acid (EMA) may stem from decreased oxidation by short chain acyl-CoA dehydrogenase (SCAD) of butyryl-CoA, which is alternatively metabolized by propionyl-...

journal_title：Pediatric research

authors： Corydon MJ,Gregersen N,Lehnert W,Ribes A,Rinaldo P,Kmoch S,Christensen E,Kristensen TJ,Andresen BS,Bross P,Winter V,Martinez G,Neve S,Jensen TG,Bolund L,Kølvraa S

更新日期：1996-06-01 00:00:00

abstract：:The mitochondria play a major role in the regulation of intracellular calcium. Despite the fact that the enterocytes receive the majority of absorbed calcium, the role of the intestinal mitochondria in calcium transport during maturation is not known. Therefore, the current studies were designed to characterize calciu...

journal_title：Pediatric research

authors： Kikuchi T,Kikuchi K,Arab N,Ghishan FK

更新日期：1989-01-01 00:00:00

abstract：INTRODUCTION:Infection is a risk factor for adverse neurodevelopmental outcome in preterm newborns. Our objective was to characterize the association of postnatal infection with adverse microstructural and metabolic brain development in premature newborns. RESULTS:In 34/117 newborns studied, clinical signs were accomp...

journal_title：Pediatric research

authors： Chau V,Brant R,Poskitt KJ,Tam EW,Synnes A,Miller SP

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Phytosterols in soybean oil (SO) lipids likely contribute to parenteral nutrition-associated liver disease (PNALD) in infants. No characterization of phytosterol metabolism has been done in infants receiving SO lipids. METHODS:In a prospective cohort study, 45 neonates (36 SO lipid vs. 9 control) underwent ...

journal_title：Pediatric research

authors： Nghiem-Rao TH,Tunc I,Mavis AM,Cao Y,Polzin EM,Firary MF,Wang X,Simpson PM,Patel SB

更新日期：2015-08-01 00:00:00

abstract：:Evidence is increasing for a role of polymorphisms in maternal or fetal innate immune response genes in preterm birth. Toll-like receptors (TLRs) are important receptors in the innate immunity. The genotype distribution of two TLR2 single nucleotide polymorphisms (SNPs) and one TLR4 SNP were determined among 524 neona...

journal_title：Pediatric research

authors： Krediet TG,Wiertsema SP,Vossers MJ,Hoeks SB,Fleer A,Ruven HJ,Rijkers GT

更新日期：2007-10-01 00:00:00

abstract：:The purpose of this study was to assess differences in sound spectra of crying of term newborns in relation to different pain levels. Fifty-seven consecutively born neonates were evaluated during heel-prick performed with different analgesic techniques. Crying was recorded and frequency spectrograms analyzed. A pain s...

journal_title：Pediatric research

authors： Bellieni CV,Sisto R,Cordelli DM,Buonocore G

更新日期：2004-01-01 00:00:00

abstract：:It is increasingly recognized that the abnormal physiologic consequences of pulmonary hypertension (PH) may contribute to poor cardiopulmonary health in premature babies. Conflicting literature has led to clinical uncertainty, pathological misinterpretation, and variability in treatment approaches among practitioners....

journal_title：Pediatric research

authors： Giesinger RE,More K,Odame J,Jain A,Jankov RP,McNamara PJ

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Oral propranolol, a nonselective β-blocker, is able to reduce the progression of retinopathy of prematurity in newborns, but it appeared unsafe. This study aimed to find, in rabbits, a propranolol eye drop concentration able to induce lower plasma but higher retinal concentrations than those obtained after o...

journal_title：Pediatric research

authors： Padrini L,Isacchi B,Bilia AR,Pini A,Lanzi C,Masini E,Della Bona ML,Calvani AM,Ceccantini R,la Marca G,Filippi L

更新日期：2014-10-01 00:00:00