Antenatal betamethasone alters vascular reactivity in adult female ovine cerebral arteries.

Abstract:

:Although the use of antenatal glucocorticoids has resulted in decreased neonatal morbidity/mortality, recent animal studies have raised concerns regarding adverse effects of these medications on postnatal cardiovascular function. We hypothesized that antenatal betamethasone (Beta) exposure alters cerebral vascular reactivity in adult female sheep. We observed that K-induced constriction was comparable in middle cerebral artery (MCA) from Beta-exposed animals and age-matched controls. Pressure-induced constriction was significantly attenuated in MCA from Beta-exposed compared with control sheep. Inhibition of NOS significantly augmented pressure-induced constriction in MCA from both Beta-exposed and control sheep, whereas cyclooxygenase (COX) inhibition augmented pressure-induced constriction only in MCA from Beta-exposed sheep. Furthermore, NOS and COX inhibition significantly attenuated bradykinin (BK)-induced dilation in MCA from both Beta-exposed and control sheep. However, there seemed to be a greater contribution of both NOS and COX to BK-induced dilation in Beta-exposed compared with control MCA. Our findings demonstrate that fetal exposure to a clinically relevant course of Beta alters cerebral vascular tone and reactivity in adult female sheep.

journal_name

Pediatr Res

journal_title

Pediatric research

authors

Eckman DM,Kerr BA,Fuloria M,Simandle SA,Watt SE,Rose JC,Figueroa JP

doi

10.1203/PDR.0b013e3181edb9fa

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

344-8

issue

4

eissn

0031-3998

issn

1530-0447

journal_volume

68

pub_type

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