T-lymphocyte subpopulations and function during murine cytomegalovirus infection.

Abstract:

:To study the effects of cytomegalovirus infection on T-lymphocyte subpopulations, we determined helper (Lyt 1.2) and suppressor (Lyt 2.2) T-lymphocyte subset numbers using monoclonal antibodies and measured lymphocyte responsiveness to mitogen during sublethal murine cytomegalovirus (MCMV) infection of 3-wk-old Balb/c mice. MCMV-infected mice had reduced Lyt 1.2 to Lyt 2.2 T-lymphocyte ratios on days 1, 3, 5, and 9 of infection. Alterations in T-lymphocyte subsets were accompanied by diminished lymphocyte response to concanavalin A. Lymphocyte responsiveness and Lyt 1.2 to Lyt 2.2 ratios were maximally reduced on day 5 of MCMV infection and correlated strongly with peak virus recovery from spleen, bone marrow, and peripheral blood leukocytes. These results indicate that acute MCMV infection of mice causes abnormalities in T-lymphocyte subset ratios and responsiveness to mitogen similar to the abnormalities observed in human cytomegalovirus infections. MCMV infection of mice is a useful model to study the mechanism by which cytomegalovirus infections induce altered T-lymphocyte subpopulations.

journal_name

Pediatr Res

journal_title

Pediatric research

authors

Sell MS,Bale JF Jr,Giller RH

doi

10.1203/00006450-198506000-00016

subject

Has Abstract

pub_date

1985-06-01 00:00:00

pages

583-7

issue

6

eissn

0031-3998

issn

1530-0447

journal_volume

19

pub_type

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