Abstract：
:Groups of newborn rats were transthoracically inoculated with 1 X 10(6) type III group B streptococci/g body wt, either alone or in combination with 1.5 microgram/g body wt of type-specific antibody derived from hybridoma cell lines. Ninety-four percent of the animals who received bacteria alone died. In contrast, none of those treated with antibody died (P less than 0.005). Kinetic studies suggested that antibody may have offered protection, In part, by facilitating the neutrophil response. Animals who received only bacteria exhibited a marked neutropenia (20 +/- 18/mm3, mean +/- S.E.M.) whereas infected animals treated with antibody did not (3800 +/- 30/mm3, P less than 0.001). Furthermore, within 2 h of inoculation, antibody-treated animals mobilized and stored neutrophils, whereas significant neutrophil mobilization did not occur in the animals which received bacteria alone until 6 h. In the animals receiving bacteria alone, exhaustion of the neutrophil supply quickly occurred (remaining storage neutrophils at 6 h, 0.2 +/- 0.1 X 10(6) cells). In contrast, animals, which received antibody, maintained an adequate supply of stored neutrophils (7.0 +/- 0.4 X 10(6) P less than 0.001). The migration of neutrophils to the site of inoculation was measured by assaying the lungs' content of myeloperoxidase, a marker enzyme for granulocytes. The right and left lungs of animals not receiving antibody accumulated the same quantity of neutrophils, with peak pulmonary neutrophil accumulation occurring 6 h after the infection. In antibody recipients, however, the inoculated lung accumulated significantly more neutrophils than the opposite lung and peak pulmonary neutrophil accumulation occurred at 2 rather than 6 h.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Christensen RD,Rothstein G,Hill HR,Pincus SHdoi
10.1203/00006450-198310000-00005subject
Has Abstractpub_date
1983-10-01 00:00:00pages
795-9issue
10eissn
0031-3998issn
1530-0447journal_volume
17pub_type
杂志文章abstract：:Spontaneous preterm birth is a serious and common pregnancy complication associated with hormonal dysregulation, infection, inflammation, immunity, rupture of fetal membranes, stress, bleeding, and uterine distention. Heredity is 25-40% and mostly involves the maternal genome, with contribution of the fetal genome. Si...
journal_title：Pediatric research
pub_type： 杂志文章,评审
doi：10.1038/s41390-018-0180-z
更新日期：2019-03-01 00:00:00
abstract：:Our objectives were to establish antecedent factors and patterns of brain injury and their prognostic value in preterm infants with hypoxic-ischemic encephalopathy (HIE). Essential inclusion criteria were gestation (GA) < or =36 wk, Apgar scores <5/<7 at 1/5 min, major resuscitation at birth, and a brain MRI <6 postna...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/PDR.0b013e3181a9ef34
更新日期：2009-08-01 00:00:00
abstract：:Mutations in multidrug resistance 3 gene (MDR3 or ABCB4) underlie progressive familial intrahepatic cholestasis type 3 (PFIC3), a severe pediatric liver disease progressing to cirrhosis. Abcb4-/- mice exhibit slowly developing hepatic lesions that can be accelerated by feeding a cholic acid (CA)-supplemented diet. We ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/pdr.0b013e31802d7780
更新日期：2007-02-01 00:00:00
abstract：:The specific activities of four folate enzymes have been measured in livers from preterm infants (Group 1), full-term infants (Group 2), and from control subjects (Group 3). The four enzymes studied were methylene tetrahydrofolate reductase (EC 1.1.1.68), methionine synthetase (EC 2.1.1.13), methylenetetrahydrofolate ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198208000-00008
更新日期：1982-08-01 00:00:00
abstract：BACKGROUND:The objective was to determine the association between perioperative risk factors and brain imaging abnormalities on neurologic outcome in neonates with hypoplastic left heart syndrome (HLHS) or d-Transposition of the great arteries (d-TGA) who underwent cardiac surgery including cardiopulmonary bypass. MET...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-020-1085-1
更新日期：2020-07-25 00:00:00
abstract：BACKGROUND:Therapeutic hypothermia (TH) has become standard treatment for severe and moderate hypoxic-ischemic neonatal encephalopathy (HIE). Our group has developed an optically based, noninvasive concept of assessing the capacity for oxygen delivery from the microcirculation to the cells of a tissue under investigati...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2016.16
更新日期：2016-06-01 00:00:00
abstract：BACKGROUND:The prevalence of autism spectrum disorders (ASD) is 5-fold higher in preterm (PT) infants born ≤28 weeks gestational age (GA) as compared to the general population. The relationship between placental pathologic lesions and ASD in PT infants has not been studied. OBJECTIVES:The objective of this study was t...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-020-01160-4
更新日期：2020-09-19 00:00:00
abstract：:The metabolism of proteoglycans in normal growth plate and the changes in growth plate morphology induced by diabetes and malnutrition were studied in rats. The proteoglycans had a significantly faster turnover (half-life measured with [35S]sulfate labeling: 25-30 h) than the cells in the growth plate. Morphometric st...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199001000-00014
更新日期：1990-01-01 00:00:00
abstract：:The influence of maternal stress during pregnancy on the postpartum iron status and immune maturation of infants was investigated in a nonhuman primate model. Forty infant rhesus monkeys were generated from two types of disturbed pregnancies, early or late gestation stress, and compared with 24 undisturbed controls. P...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/pdr.0b013e318045be53
更新日期：2007-05-01 00:00:00
abstract：:We have evaluated the effect of galanin (Gal), a newly identified hypothalamic peptide, on growth hormone (GH) secretion in 10 children with normal stature (NS), nine with constitutional growth delay (CGD), and five with isolated GH deficiency (IGHD). Gal was infused intravenously at a rate of 8 or 15 micrograms/kg/h....
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198910000-00006
更新日期：1989-10-01 00:00:00
abstract：:The effects on the conceptus of persistently decreased maternal plasma amino acid concentrations were studied in pregnant rats by the infusion of glucagon (0.21 mg/day) to the mother from day 14 to 20 of gestation with a subcutaneous, osmotically driven minipump. Controls received diluent. The experimental animals eit...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198611000-00002
更新日期：1986-11-01 00:00:00
abstract：:Neonatal PMN (polymorphonuclear neutrophils) exhibit altered inflammatory responsiveness and greater longevity compared with adult PMN; however, the involved mechanisms are incompletely defined. Receptors containing immunoreceptor tyrosine-based inhibitory motif (ITIM) domains promote apoptosis by activating inhibitor...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/PDR.0b013e3181b1bc19
更新日期：2009-09-01 00:00:00
abstract：:Women who are at risk of preterm delivery are treated with antenatal steroids to facilitate fetal lung maturation. During this period, there is a potential for fetal or maternal hypoxemia to occur. Fetal responses to hypoxemia in sheep are well documented. However, less is known regarding maternal responses to hypoxem...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/01.PDR.0000117847.59343.B2
更新日期：2004-05-01 00:00:00
abstract：:It has been shown that glucocorticoids accelerate lung development by limiting alveolar formation resulting from a premature maturation of the alveolar septa. Based on these data, the aim of the present work was to analyze the influence of dexamethasone on cell cycle control mechanisms during postnatal lung developmen...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-200202000-00008
更新日期：2002-02-01 00:00:00
abstract：:The objective of this study was to establish longitudinal normative limits for home memory monitors during early infancy. Eighty-eight healthy infants were monitored overnight at 0.25-19 wk of age using the Healthdyne Smart Monitor. Apnea settings were 14 s for recording and 40 s for alarm; the bradycardia setting was...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199602000-00005
更新日期：1996-02-01 00:00:00
abstract：:To determine the role of pili in mediating adherence of type b and nontypeable Haemophilus influenzae to several respiratory cell types, piliated bacteria, nonpiliated phase variants, and nonpiliated mutants possessing insertionally inactivated pilin genes were tested. Both piliated and nonpiliated strains adhered to ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199602000-00025
更新日期：1996-02-01 00:00:00
abstract：BACKGROUND:Early brain development is closely dictated by distinct neurobiological principles. Here, we aimed to map early trajectories of structural brain wiring in the neonatal brain. METHODS:We investigated structural connectome development in 44 newborns, including 23 preterm infants and 21 full-term neonates scan...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-018-0138-1
更新日期：2018-12-01 00:00:00
abstract：:Premature birth causes significant health risks of the neonate and increases the cost for neonatal care. Urogenital infection, often caused by Gram-negative bacteria, is a known risk factor. Toll-like receptor-4 (TLR4) is the major endotoxin-signaling receptor and as such is crucial for the initiation of the innate im...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-200209000-00011
更新日期：2002-09-01 00:00:00
abstract：:Data are scant regarding the development of cerebrovascular autoregulation in intrauterine growth-restricted (IUGR) newborns. We tested the hypothesis that IUGR improves the ability of neonates to withstand critical periods of gradual hemorrhagic hypotension by optimizing cerebrovascular autoregulation. Studies were c...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/01.PDR.0000139425.94975.77
更新日期：2004-10-01 00:00:00
abstract：:Several neuropathologic findings in infants and children with human immunodeficiency virus type-1 (HIV-1) infection are different from those observed in adults, probably related to the fact that the retroviral infection occurs in the setting of neuro-development. This report describes the interaction and biologic acti...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199511000-00025
更新日期：1995-11-01 00:00:00
abstract：:Our objective was to determine the quantitative changes of individual triacylglycerol (TG) species in liver and carcass during early postnatal growth. Pregnant rats were killed at d 21 of pregnancy, and neonatal rats were killed at d 3 or 9 after birth. Quantitative changes in fatty acids and TG species of fetal/neona...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199201000-00009
更新日期：1992-01-01 00:00:00
abstract：:Branching morphogenesis, defined as growth and branching of epithelial tubules during embryogenesis, is a fundamental feature of renal, lung, mammary gland, submandibular gland, and pancreatic morphogenesis in mammals. Disruption of branching morphogenesis has been demonstrated to result in maldevelopment of some of t...
journal_title：Pediatric research
pub_type： 杂志文章,评审
doi：10.1203/01.PDR.0000085170.44226.DB
更新日期：2003-10-01 00:00:00
abstract：:Necrotizing enterocolitis (NEC) is one of the leading causes of death in neonatal intensive care units. The underlying pathophysiology of NEC is poorly defined, although there is a suggestion that bacterial agents play an important role in the process. In this study, we evaluated bacterial isolates from 17 NEC cases a...
journal_title：Pediatric research
pub_type： 临床试验,杂志文章
doi：10.1203/00006450-199407001-00021
更新日期：1994-07-01 00:00:00
abstract：:Mucolipidosis 4 (ML4) is an autosomal recessive disorder with both lipid and mucopolysaccharide storage. The disease is characterized by severe visual impairment and psychomotor retardation. In our effort to find a phenotypic marker for ML4 fibroblasts, living cells were stained with fluorescent compounds. The stainin...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199506000-00003
更新日期：1995-06-01 00:00:00
abstract：:This work examines the dynamic surface pressure-area behavior of films of unconjugated bilirubin spread from chloroform solution at 22 degrees C on 0.15 M NaCl and buffered phosphate subphases. Film behavior is examined at pH 5.5, 7.4 and 8.0. The interactions of bilirubin in mixed films with dipalmitoyl phosphatidylc...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198202000-00011
更新日期：1982-02-01 00:00:00
abstract：:Tolazoline is used in neonatal intensive care to treat hypoxia secondary to persistent pulmonary hypertension of the newborn. Its use is often complicated by systemic hypotension. We compared the effect of tolazoline-induced hypotension on organ blood flow, regional brain blood flow, and cerebral metabolism in hypoxic...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199008000-00007
更新日期：1990-08-01 00:00:00
abstract：:The present study examined the extent to which abundance of the prolactin receptor (PRLR) and a range of primary mitochondrial proteins are influenced by either maternal nutrition and/or fetal number in adipose tissue. Pregnant sheep were control fed [consuming 100% of total metabolizable energy (ME) requirements (tak...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/01.PDR.0000047653.73271.C4
更新日期：2003-02-01 00:00:00
abstract：:Exposure of neonatal rats to > or = 95% O2 for 2 wk, a widely used model of oxidant/antioxidant interactions in neonatal lung injury, results in arrested lung growth without the dysplastic lesions observed in chronic human neonatal lung injury. To determine whether dysplastic lung cell growth would be seen at lesser O...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199606000-00001
更新日期：1996-06-01 00:00:00
abstract：:Alpha-mannosidosis is a lysosomal storage disorder resulting from deficient activity of lysosomal alpha-mannosidase. It has been described previously in humans, cattle, and cats, and is characterized in all of these species principally by neuronal storage leading to progressive mental deterioration. Two guinea pigs wi...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199911000-00003
更新日期：1999-11-01 00:00:00
abstract：:BackgroundExtracellular adenine nucleotides contribute to ischemia-reperfusion injury following infant cardiopulmonary bypass (CPB), whereas conversion to adenosine may be protective. Alkaline phosphatase (AP), a key enzyme responsible for this conversion, decreases after infant CPB. Indirect evidence suggests that so...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2017.325
更新日期：2018-04-01 00:00:00
