Phototherapy for neonatal jaundice: in vitro comparison of light sources.

Abstract:

:Phototherapy results in the conversion of bilirubin to more water-soluble isomers. Six clinically used phototherapy lamps which differ in their emission spectra have been compared in their ability to produce configurational and structural isomers of bilirubin in vitro. For all of the lamps, the initial rate of configurational isomerization was highly correlated (r = 0.969) with the intensity of irradiation falling within the bilirubin absorption band. The percentage of the total bilirubin converted to the configurational isomer at equilibrium was dependent upon the spectral distribution of the lamp, and was greatest (26.2 +/- 1.3%) with the special blue lamp, which has a narrow spectral output centered at 445 nm. The rate of formation of the structural isomer, lumirubin, was generally dependent upon the intensity of irradiation within the bilirubin absorption band.

journal_name

Pediatr Res

journal_title

Pediatric research

authors

Ennever JF,Sobel M,McDonagh AF,Speck WT

doi

10.1203/00006450-198407000-00021

subject

Has Abstract

pub_date

1984-07-01 00:00:00

pages

667-70

issue

7

eissn

0031-3998

issn

1530-0447

journal_volume

18

pub_type

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