High-frequency oscillatory ventilation is not associated with increased risk of neuropathology compared with positive pressure ventilation: a preterm primate model.

abstract：:Chloroform:methanol extracts of bovine pulmonary surfactant contain small hydrophobic proteins, designated surfactant-associated apoproteins 6,000 (SAP-6), but do not contain the major surfactant-associated 35,000-dalton glycoprotein, designated SAP-35. Examination of lipid extract surfactant on sodium dodecylsulfate-...

journal_title：Pediatric research

authors： Yu SH,Wallace D,Bhavnani B,Enhorning G,Harding PG,Possmayer F

更新日期：1988-01-01 00:00:00

abstract：:Sparse-fur mice, 28 d of age with the x-chromosomal inherited defect of ornithine carbamoyltransferase, were used to investigate if tryptophan and the serotonin pathway in the brain are affected in this animal model which closely resembles the human inborn error of metabolism. Increased concentrations of tryptophan an...

journal_title：Pediatric research

authors： Bachmann C,Colombo JP

更新日期：1984-04-01 00:00:00

abstract：:We measured body composition, basal metabolic rate (BMR), and total energy expenditure in 28 nonobese and 35 obese adolescents aged 12-18 y using indirect calorimetry and the doubly labeled water method. BMR was highly correlated with fat-free mass in both the nonobese and obese groups (r = 0.77 and 0.84, respectively...

journal_title：Pediatric research

authors： Bandini LG,Schoeller DA,Dietz WH

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:Phytosterols in soybean oil (SO) lipids likely contribute to parenteral nutrition-associated liver disease (PNALD) in infants. No characterization of phytosterol metabolism has been done in infants receiving SO lipids. METHODS:In a prospective cohort study, 45 neonates (36 SO lipid vs. 9 control) underwent ...

journal_title：Pediatric research

authors： Nghiem-Rao TH,Tunc I,Mavis AM,Cao Y,Polzin EM,Firary MF,Wang X,Simpson PM,Patel SB

更新日期：2015-08-01 00:00:00

abstract：:The uterus is unique among smooth muscular organs in that, during pregnancy, it undergoes profound, largely reversible, changes orchestrated by the ovarian hormones. These changes facilitate uterine adaptation to the stretch induced by the growing fetus such that a state of myometrial contractile quiescence can be mai...

journal_title：Pediatric research

authors： Riemer RK,Heymann MA

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:The rate of accrual of muscle mass in neonates has not been assessed. We describe the D3-creatine (D3Cr) dilution method, a noninvasive assessment of muscle mass in neonates. METHODS:A total of 76 neonates >26-week-old corrected gestational age were enrolled and measured at 2-week intervals while admitted t...

journal_title：Pediatric research

authors： Evans WJ,Scottoline B,Imam F,Hellerstein M,Garton K,Czerwieniec G,Nyangau E,Shankaran M

更新日期：2020-09-12 00:00:00

abstract：:Sudden infant death syndrome (SIDS) is multifactorial and may result from the interaction of a number of environmental, genetic, and developmental factors. We studied three major genes causing long QT syndrome in 42 Japanese SIDS victims and found five mutations, KCNQ1-K598R, KCNH2-T895M, SCN5A-F532C, SCN5A-G1084S, an...

journal_title：Pediatric research

authors： Otagiri T,Kijima K,Osawa M,Ishii K,Makita N,Matoba R,Umetsu K,Hayasaka K

更新日期：2008-11-01 00:00:00

abstract：:Premature newborns are highly susceptible to severe bacterial infections. This is partially due to their immature innate immune system, characterized by decreased neutrophil and monocyte activity as well as by reduced concentrations of complement factors. However, additional mechanisms might be important for innate im...

journal_title：Pediatric research

authors： Förster-Waldl E,Sadeghi K,Tamandl D,Gerhold B,Hallwirth U,Rohrmeister K,Hayde M,Prusa AR,Herkner K,Boltz-Nitulescu G,Pollak A,Spittler A

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:The prevalence of autism spectrum disorders (ASD) is 5-fold higher in preterm (PT) infants born ≤28 weeks gestational age (GA) as compared to the general population. The relationship between placental pathologic lesions and ASD in PT infants has not been studied. OBJECTIVES:The objective of this study was t...

journal_title：Pediatric research

authors： Mir IN,White SP,Steven Brown L,Heyne R,Rosenfeld CR,Chalak LF

更新日期：2020-09-19 00:00:00

abstract：:Obese children have a great risk of hypertension and cardiovascular morbidity in adults. The insulin-like growth factor type II (IGF-II) regulates glucose homeostasis, cardiovascular functions, and lipid metabolism. IGF2 gene variants have shown a strong association with weight, body mass index (BMI), and metabolic pr...

journal_title：Pediatric research

authors： Faienza MF,Santoro N,Lauciello R,Calabrò R,Giordani L,Di Salvo G,Ventura A,Delvecchio M,Perrone L,Del Giudice EM,Cavallo L

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:The prevalence of vitamin D (vitD) deficiency presenting as rickets is increasing worldwide. Insufficient sun exposure, vitD administration, and/or calcium intake are the main causes. However, vitD system-related genes may also have a role. METHODS:Prospective study: 109 rachitic children completed a 6-mo s...

journal_title：Pediatric research

authors： El Kholy M,Elsedfy H,Fernández-Cancio M,Hamza RT,Amr NH,Ahmed AY,Toaima NN,Audí L

更新日期：2017-02-01 00:00:00

abstract：:Phototherapy results in the conversion of native bilirubin to more water-soluble configurational and structural isomers. The serum half-life for the configurational isomer, the principal photoproduct in vivo, was determined by high pressure liquid chromatography in six premature infants following cessation of photothe...

journal_title：Pediatric research

authors： Ennever JF,Knox I,Denne SC,Speck WT

更新日期：1985-02-01 00:00:00

abstract：:Children treated for acute lymphoblastic leukemia may develop reduced bone mineral density during treatment, but there is little information on the mechanisms involved. In a prospective, longitudinal study on 15 children with ALL, we undertook serial measurements of markers of bone and collagen turnover, insulin-like ...

journal_title：Pediatric research

authors： Crofton PM,Ahmed SF,Wade JC,Elmlinger MW,Ranke MB,Kelnar CJ,Wallace WH

更新日期：2000-10-01 00:00:00

abstract：:To investigate the role of nutrition in the regulation of IGFs during the perinatal period, 10-d-old rats were infused intravenously with various concentrations of nutrients for 24 h. Breast-fed litter mates served as controls. The effect of caloric intake on concentrations of IGF-I and IGF-II as well as IGF-binding p...

journal_title：Pediatric research

authors： Philipps A,Drakenberg K,Persson B,Sjögren B,Eklöf AC,Hall K,Sara V

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:Exposure to inflammation exacerbates injury in neonatal encephalopathy (NE). We hypothesized that brain biomarker mRNA, cytokine mRNA and microRNA differentiate inflammation (E. coli LPS), hypoxia (Hypoxia), and inflammation-sensitized hypoxia (LPS+Hypoxia) in an NE piglet model. METHODS:Sixteen piglets wer...

journal_title：Pediatric research

authors： Lingam I,Avdic-Belltheus A,Meehan C,Martinello K,Ragab S,Peebles D,Barkhuizen M,Tann CJ,Tachtsidis I,Wolfs TGAM,Hagberg H,Klein N,Fleiss B,Gressens P,Golay X,Kramer BW,Robertson NJ

更新日期：2020-06-10 00:00:00

abstract：INTRODUCTION:Data regarding neonatal arterial ischemic stroke (NAIS) topography are still sparse and inaccurate. Despite the importance of locating NAIS to predict the long-term outcome of neonates, a map of arterial territories is not yet available. Our aim was therefore to generate the first three-dimensional map of ...

journal_title：Pediatric research

authors： Núñez C,Arca G,Agut T,Stephan-Otto C,García-Alix A

更新日期：2020-06-01 00:00:00

abstract：:Normal hemostasis depends in part on the balance achieved between proaggregatory and prothrombotic platelet thromboxane A2, measured as its stable end-product thromboxane B2 (TXB2), and vascular prostacyclin (PGI2), which inhibits platelet aggregation and is antithrombotic. Cystathionine-beta-synthase deficiency is ch...

journal_title：Pediatric research

authors： Graeber JE,Slott JH,Ulane RE,Schulman JD,Stuart MJ

更新日期：1982-06-01 00:00:00

abstract：:Apoptosis of CD4+ and CD8+ T cells has been shown in peripheral blood mononuclear cells (PBMCs) from HIV-infected adults analyzed after overnight culture. Because cell death may be an artifact of in vitro culture, and because there is little information on apoptosis in pediatric HIV disease, we undertook a cross-secti...

journal_title：Pediatric research

authors： Cotton MF,Ikle DN,Rapaport EL,Marschner S,Tseng PO,Kurrle R,Finkel TH

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:Early brain development is closely dictated by distinct neurobiological principles. Here, we aimed to map early trajectories of structural brain wiring in the neonatal brain. METHODS:We investigated structural connectome development in 44 newborns, including 23 preterm infants and 21 full-term neonates scan...

journal_title：Pediatric research

authors： Keunen K,van der Burgh HK,de Reus MA,Moeskops P,Schmidt R,Stolwijk LJ,de Lange SC,Išgum I,de Vries LS,Benders MJ,van den Heuvel MP

更新日期：2018-12-01 00:00:00

abstract：:A recently introduced test measures the concentration of transferrin receptor (TfR) in serum, which increases shortly after the onset of iron deficiency. In adults this increase reflects the degree to which tissue iron availability is impaired. We developed a fluoroimmunoassay to quantify TfR. The purpose of this stud...

journal_title：Pediatric research

authors： Kivivuori SM,Anttila R,Viinikka L,Pesonen K,Siimes MA

更新日期：1993-09-01 00:00:00

abstract：:An assessment of pulsatile secretion of luteinizing hormone (LH), measured by both immunoassay (I-LH) and rat interstitial cell testosterone production bioassay (B-LH), as well as of follicle-stimulating hormone and glycoprotein hormone alpha-subunit was carried out in seven normal prepubertal and six normal premenarc...

journal_title：Pediatric research

authors： Reiter EO,Biggs DE,Veldhuis JD,Beitins IZ

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND:Prolonged hypoglycemia leads to brain injury, despite treatment with 10% dextrose. Whether induction of hyperglycemia or ketonemia achieves better neuroprotection is unknown. Hyperglycemia is neuroprotective in other brain injuries during development; however, it worsens hypoglycemia-induced injury in the ad...

journal_title：Pediatric research

authors： Ennis K,Dotterman H,Stein A,Rao R

更新日期：2015-01-01 00:00:00

abstract：:Long-term EEG monitoring (LTM) with several electrodes could be a useful tool for surveillance of the brain during the first critical days of life. This study aimed to assess the feasibility of multichannel LTM for automated analysis of EEG activity from d 1 to 3 using eight electrodes. Premature infants (GA <31 wk; n...

journal_title：Pediatric research

authors： Schumacher EM,Westvik AS,Larsson PG,Lindemann R,Westvik J,Stiris TA

更新日期：2011-05-01 00:00:00

abstract：:Children with nephropathic cystinosis store 50 to 100 times normal amounts of free cystine in many cells and display negligible lysosomal cystine transport in their leucocytes and cultured fibroblasts. A patient with intermediate (adolescent) cystinosis exhibited a similar deficiency of egress out of fibroblast lysoso...

journal_title：Pediatric research

authors： Gahl WA,Tietze F

更新日期：1987-02-01 00:00:00

abstract：:Heme oxygenase (HO), the rate-limiting enzyme in the formation of bilirubin, is expressed in the lung and may serve as an antioxidant. This enzyme results in the formation of antioxidant bile pigments and the degradation of pro-oxidant heme. We wanted to evaluate the differences in expression of HO-1, the inducible fo...

journal_title：Pediatric research

authors： Dennery PA,Lee CS,Ford BS,Weng YH,Yang G,Rodgers PA

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Early identification of infants at risk for complications from patent ductus arteriosus (PDA) may improve treatment outcomes. The aim of this study was to identify biochemical markers associated with persistence of PDA, and with failure of pharmacological treatment for PDA, in extremely preterm infants. MET...

journal_title：Pediatric research

authors： Olsson KW,Larsson A,Jonzon A,Sindelar R

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF), a well-characterized regulator of angiogenesis, has been mechanistically implicated in retinal neovascularization and in the pathogenesis of retinopathy of prematurity. However, the ontogeny of VEGF expression in the human fetal retina is not well known. Because ret...

journal_title：Pediatric research

authors： Ma IT,McConaghy S,Namachivayam K,Halloran BA,Kurundkar AR,MohanKumar K,Maheshwari A,Ohls RK

更新日期：2015-04-01 00:00:00

abstract：:Leptin, a hormone secreted by adipocytes, is elevated in blood of obese adults. It is unknown whether the concentration is affected by gender, ethnicity, age, or stage of sexual maturation in children. We measured serum leptin levels in 183 children and 27 young adults using a double-antibody ELISA assay. Body fat mas...

journal_title：Pediatric research

authors： Ellis KJ,Nicolson M

更新日期：1997-10-01 00:00:00

abstract：:Neurological injury is the primary lethal mechanism of injury in children, and the primary etiology of long-term disability after trauma. Laboratories and clinical/translational teams have sought to develop stem/progenitor cell therapies to improve recovery in a clinical setting in which there is no significant repara...

journal_title：Pediatric research

authors： Cox CS Jr

更新日期：2018-01-01 00:00:00

abstract：:Small bowel resection decreases brush border membrane (BBM) glucose uptake kinetics. Oral epidermal growth factor (EGF) returns net glucose transport across intact tissue to control levels despite persistence of a defect in BBM glucose uptake. The purpose of this study was to examine the effects of resection and EGF t...

journal_title：Pediatric research

authors： Chung BM,Wallace LE,Winkfein RK,O'Loughlin EV,Hardin JA,Gall DG

更新日期：2004-01-01 00:00:00