Phagocytosis of neonatal pathogens by peripheral blood neutrophils and monocytes from newborn preterm and term infants.

abstract：:Recent data suggest that umbilical venous perfusion of the fetal liver has an important influence on fetal growth and postnatal liver function, and that maternal factors in late pregnancy modify this circulation. In a longitudinal study of 160 low-risk pregnancies, we determined how umbilical and portal venous blood f...

journal_title：Pediatric research

authors： Kessler J,Rasmussen S,Godfrey K,Hanson M,Kiserud T

更新日期：2008-03-01 00:00:00

abstract：:Increased deposition of hyaluronan (HA) is part of the early response to fibrogenic stimulus in the lung exposed to bleomycin injury and has been associated with increased lung water in adult animals. Early respiratory distress syndrome (RDS) in premature infants is characterized by increased lung water, and late sequ...

journal_title：Pediatric research

authors： Juul SE,Kinsella MG,Jackson JC,Truog WE,Standaert TA,Hodson WA

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:Therapeutic hypothermia (TH) has become standard treatment for severe and moderate hypoxic-ischemic neonatal encephalopathy (HIE). Our group has developed an optically based, noninvasive concept of assessing the capacity for oxygen delivery from the microcirculation to the cells of a tissue under investigati...

journal_title：Pediatric research

authors： Fredly S,Fugelseth D,Nygaard CS,Salerud EG,Stiris T,Kvernebo K

更新日期：2016-06-01 00:00:00

abstract：:Accurate interpretation of the results of GH stimulation tests is of pivotal importance not only in the evaluation of the etiology of growth retardation in children but also in the selection of the best candidates for GH therapy. We performed this study to test a novel immunofunctional GH ( IFGH) assay that makes use ...

journal_title：Pediatric research

authors： Mauras N,Walton P,Nicar M,Welch S,Rogol AD

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Prodromal symptoms are frequently reported in the atypical form of Hemolytic uremic syndrome (aHUS) suggesting implication of infectious triggers. Some pathogens may also play a role in the mechanisms of production of autoantibody directed against Factor H (FH), a complement regulator, leading to aHUS. METH...

journal_title：Pediatric research

authors： Togarsimalemath SK,Si-Mohammed A,Puraswani M,Gupta A,Vabret A,Liguori S,Mariani-Kurkdjian P,Bagga A,Dragon-Durey MA

更新日期：2018-07-01 00:00:00

abstract：:This report deals with quantitative and qualitative investigations of alkaline phosphatase in two unrelated infants with the severe infantile form of hypophosphatasia. Both affected infants had no detectable leukocyte alkaline phosphatase activities and both sets of parents and one sibling tended to have low but varia...

journal_title：Pediatric research

authors： Gorodischer R,Davidson RG,Mosovich LL,Yaffe SJ

更新日期：1976-07-01 00:00:00

abstract：BACKGROUND:Intrauterine growth restriction (IUGR) has been linked to heart disease in adulthood. Hence the IUGR heart is likely to be vulnerable to diabetic heart disease. The aim of this study was to examine the effect of induction of type 1 diabetes on myocardial collagen deposition and cardiac function in adult rats...

journal_title：Pediatric research

authors： Lim K,Lombardo P,Schneider-Kolsky M,Black MJ

更新日期：2012-10-01 00:00:00

abstract：:Chenodeoxycholic acid labeled with 2H in the 11 and positions was prepared by catalytic reduction of delta 11-12 unsaturated derivatives of cholic acid. To validate the use of this stable isotope for the determination of bile acid kinetics by isotope dilution, it was administered to seven normal male volunteers simult...

journal_title：Pediatric research

authors： Balistreri WF,Cowen AE,Hofmann AF,Szczepanik PA,Klein PD

更新日期：1975-10-01 00:00:00

abstract：:The effect of various lipids, proteins, and other substances on the adsorption rate of dipalmitoyl phosphatidylcholine (DPC) was investigated. Each substance was added to a sonicated suspension of DPC in saline, and the surface pressure of the adsorbed surface film was measured using a platinum plate suspended from an...

journal_title：Pediatric research

authors： Meban C

更新日期：1981-07-01 00:00:00

abstract：:Dietary n-3 polyunsaturated fatty acids (PUFA) may represent a mode of allergy prevention. Cord blood (CB) CD34+ hemopoietic progenitors are altered in infants at risk of atopy. We therefore studied the effects of dietary n-3 PUFA supplementation during pregnancy on numbers and function of progenitors in neonates at h...

journal_title：Pediatric research

authors： Denburg JA,Hatfield HM,Cyr MM,Hayes L,Holt PG,Sehmi R,Dunstan JA,Prescott SL

更新日期：2005-02-01 00:00:00

abstract：INTRODUCTION:To examine the immune-modulatory effects of probiotics during early infancy, Bifidobacterium breve M-16V (B. breve) was administered to rat pups during the newborn or weaning period, and the expression of inflammatory genes was investigated using a cDNA microarray and real-time PCR. RESULTS:After B. breve...

journal_title：Pediatric research

authors： Ohtsuka Y,Ikegami T,Izumi H,Namura M,Ikeda T,Ikuse T,Baba Y,Kudo T,Suzuki R,Shimizu T

更新日期：2012-01-01 00:00:00

abstract：:Twenty-four samples of breast milk from nine mothers of infants suffering from breast milk jaundice were studied. Eight samples of milk from mothers of nonjaundiced infants, along with five formula milks enriched with polyunsaturated fatty acids, served as controls. Milks from mothers with jaundiced infants had no inh...

journal_title：Pediatric research

authors： Foliot A,Ploussard JP,Housset E,Christoforov

更新日期：1976-06-01 00:00:00

abstract：:Increased concentrations of carcinoembryonic antigen (CEA) have been reported in the sera and sputum of patients with cystic fibrosis. We have found significantly higher concentrations of CEA in both extracted and unextracted saliva of patients with cystic fibrosis compared to age-matched controls and a comparable gro...

journal_title：Pediatric research

authors： MacSween JM,Gillespie CT

更新日期：1980-03-01 00:00:00

abstract：:Previous studies in adults have shown that chronic pulmonary hypertension is associated with decreased endothelial nitric oxide synthase (eNOS) expression in pulmonary arteries. However, the role of decreased eNOS expression in persistent pulmonary hypertension of the newborn (PPHN) is unknown. We investigated the hyp...

journal_title：Pediatric research

authors： Villanueva ME,Zaher FM,Svinarich DM,Konduri GG

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Secondhand smoke (SHS) exposure at home and fetal SHS exposure during pregnancy are a major cause of disease among children. The aim of this study is quantifying the burden of disease due to SHS exposure in children and in pregnancy in 2006-2017 for the 28 European Union (EU) countries. METHODS:Exposure to ...

journal_title：Pediatric research

authors： Carreras G,Lachi A,Cortini B,Gallus S,López MJ,López-Nicolás Á,Lugo A,Pastor MT,Soriano JB,Fernandez E,Gorini G,TackSHS Project Investigators.

更新日期：2020-11-04 00:00:00

abstract：:The present study was performed to investigate simultaneously total lung water, T(1) and T(2) relaxation times, and hyaluronan (HA) in preterm and term rabbits. Attempts were also made to establish the relationship of HA to total lung water and to T(2)-derived motionally distinct water fractions. Experiments were perf...

journal_title：Pediatric research

authors： Sedin G,Bogner P,Berényi E,Repa I,Nyúl Z,Sulyok E

更新日期：2000-10-01 00:00:00

abstract：:It seems quite likely that the normal process of fetal lung biochemical maturation is delayed by maternal diabetes and that abnormalities in the pulmonary surfactant system are involved. The appearance of PG in amniotic fluid and possibly in fetal lung is impaired or at least delayed. The same is possibly true for DSP...

journal_title：Pediatric research

authors： Bourbon JR,Farrell PM

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND:The aim of the study was to describe and contrast the brain development and outcome among very preterm infants that were and were not exposed to surgery requiring general anesthesia prior to term equivalent age (TEA). METHODS:Preterm infants born ≤30 weeks' gestation who did (n = 25) and did not (n = 59) ha...

journal_title：Pediatric research

authors： Walsh BH,Paul RA,Inder TE,Shimony JS,Smyser CD,Rogers CE

更新日期：2020-06-23 00:00:00

abstract：:Essential fatty acid deficiency (EFAD) occurs in infants fed fat-free mixtures of glucose and amino acids. Although infusion of lipid emulsion rapidly reverses clinical symptoms, little is known about effects on tissue fatty acids. To study this question, five groups (n = 4/group) of neonatal pigs were studied. Three ...

journal_title：Pediatric research

authors： Andersen DW,Filer LJ Jr,Stegink LD

更新日期：1984-12-01 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) and Langerhans cell histiocytosis (LCH) are members of a group of rare heterogenous disorders, the histiocytoses, characterized by uncontrolled accumulation of pleomorphic infiltrates of leukocytes. The etiology of these diseases is mainly unknown. CD45 is a hemopoietic cell sp...

journal_title：Pediatric research

authors： Boxall S,McCormick J,Beverley P,Strobel S,De Filippi P,Dawes R,Klersy C,Clementi R,De Juli E,Ferster A,Wallace D,Aricò M,Danesino C,Tchilian E

更新日期：2004-03-01 00:00:00

abstract：:BackgroundSotos syndrome (SoS) is an overgrowth disorder with various congenital anomalies and is usually accompanied by other clinical problems. However, anorectal malformations have not been documented as part of the SoS entity. Our objective is to report on a case of SoS associated with Hirschsprung's disease (HSCR...

journal_title：Pediatric research

authors： Sio CA,Jung K,Kim JH,Cheong HS,Shin E,Jang H,Yoon M,Jang H,Shin HD

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Near-infrared spectroscopy is used in the assessment of regional splanchnic oxygen saturation (rsSO2), but solid reference values are scarce. We aimed to establish reference values of rsSO2 for preterm infants during the first week after birth, both crude and modeled based on predictors. METHODS:We included...

journal_title：Pediatric research

authors： van der Heide M,Dotinga BM,Stewart RE,Kalteren WS,Hulscher JBF,Reijneveld SA,Bos AF,Kooi EMW

更新日期：2021-01-27 00:00:00

abstract：:Hypoxic-ischemic (HI) injury in the preterm neonate incurs numerous functional deficits, however little is known about the neurochemically-defined brain nuclei that may underpin them. Key candidates are the brainstem catecholamine neurons. Using an immature animal model, the postnatal day (P)-3 (P3) rat pup, we invest...

journal_title：Pediatric research

authors： Buller KM,Wixey JA,Pathipati P,Carty M,Colditz PB,Williams CE,Scheepens A

更新日期：2008-04-01 00:00:00

abstract：:Chronic fetal anemia causes polyhydramnios and fetal hydrops and is associated with increased fetal diuresis and natriuresis. To determine the role of atrial natriuretic peptide (ANP) in the renal adaptation to chronic fetal anemia we studied the effects of HS-142-1 (HS), a specific inhibitor of the guanylate cyclase-...

journal_title：Pediatric research

authors： Silberbach M,Woods LL,Hohimer AR,Shiota T,Matsuda Y,Davis LE

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Neonatal seizures can result in chronic epilepsy and long-term behavioral and cognitive deficits. Levetiracetam (LEV), an antiepileptic drug that binds to the synaptic vesicle protein 2A (SV2A), has been increasingly used off-label for the therapy of neonatal seizures. Preclinical data regarding the acute or...

journal_title：Pediatric research

authors： Talos DM,Chang M,Kosaras B,Fitzgerald E,Murphy A,Folkerth RD,Jensen FE

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Necrotizing enterocolitis is characterized by intestinal inflammation and epithelial barrier dysfunction. Mitogen-activated protein kinase (MAPK) phosphatase (MKP)-1 plays a pivotal role in the feedback control of MAPK signaling, which regulates inflammation and apoptosis. We hypothesized that MKP-1 prevents...

journal_title：Pediatric research

authors： Talavera MM,Kralik N,Jin Y,Chen B,Liu Y,Nelin LD

更新日期：2015-08-01 00:00:00

abstract：:Premature infants are at risk for bilirubin-associated brain damage. In cell cultures bilirubin causes neuronal apoptosis and necrosis. Ibuprofen is used to close the ductus arteriosus, and is often given when hyperbilirubinemia is at its maximum. Ibuprofen is known to interfere with bilirubin-albumin binding. We hypo...

journal_title：Pediatric research

authors： Berns M,Toennessen M,Koehne P,Altmann R,Obladen M

更新日期：2009-04-01 00:00:00

abstract：:We tested whether reoxygenation with 100% O(2) for 5 min after experimental asphyxia in newborn piglets was as efficient as 100% O(2) for 20 min compared with room air. Forty-one anesthetized piglets, 1-3 d old, were randomized to cerebral hypoxemia-ischemia-hypercapnia (HIH) or control (n = 5). HIH was achieved by ve...

journal_title：Pediatric research

authors： Solas AB,Munkeby BH,Saugstad OD

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Real-time detection and classification of apneic episodes remain significant challenges. This study explores the applicability of a novel method of monitoring the respiratory effort and dynamics for rapid detection and classification of apneic episodes. METHODS:Obstructive apnea (OA) and hypopnea/central ap...

journal_title：Pediatric research

authors： Waisman D,Lev-Tov L,Levy C,Faingersh A,Colman Klotzman I,Bibi H,Rotschild A,Landesberg A

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Current tools to predict the severity of respiratory syncytial virus (RSV) infection might be improved by including immunological parameters. We hypothesized that a combination of inflammatory markers would differentiate between severe and mild disease in RSV-infected children. METHODS:Blood and nasopharyng...

journal_title：Pediatric research

authors： Brand HK,Ferwerda G,Preijers F,de Groot R,Neeleman C,Staal FJ,Warris A,Hermans PW

更新日期：2013-02-01 00:00:00