Burden of disease from exposure to secondhand smoke in children in Europe.

Abstract:

BACKGROUND:Secondhand smoke (SHS) exposure at home and fetal SHS exposure during pregnancy are a major cause of disease among children. The aim of this study is quantifying the burden of disease due to SHS exposure in children and in pregnancy in 2006-2017 for the 28 European Union (EU) countries. METHODS:Exposure to SHS was estimated using a multiple imputation procedure based on the Eurobarometer surveys, and SHS exposure burden was estimated with the comparative risk assessment method using meta-analytical relative risks. Data on deaths and disability-adjusted life years (DALYs) were collected from National statistics and from the Global Burden of Disease Study. RESULTS:Exposure to SHS and its attributable burden stalled in 2006-2017; in pregnant women, SHS exposure was 19.8% in 2006, 19.1% in 2010, and 21.0% in 2017; in children it was 10.1% in 2006, 9.6% in 2010, and 12.1% in 2017. In 2017, 35,633 DALYs among children were attributable to SHS exposure in the EU, mainly due to low birth weight. CONCLUSIONS:Comprehensive smoking bans up to 2010 contributed to reduce SHS exposure and its burden in children immediately after their implementation; however, SHS exposure still occurs, and in 2017, its burden in children was still relevant. IMPACT:Exposure to secondhand smoke at home and in pregnancy is a major cause of disease among children. Smoking legislation produced the adoption of voluntary smoking bans in homes; however, secondhand smoke exposure at home still occurs and its burden is substantial. In 2017, the number of deaths and disability-adjusted life years in children attributable to exposure to secondhand smoke in the European Union countries were, respectively, 335 and 35,633. Low birth weight caused by secondhand smoke exposure in pregnancy showed the largest burden. Eastern European Union countries showed the highest burden.

journal_name

Pediatr Res

journal_title

Pediatric research

authors

Carreras G,Lachi A,Cortini B,Gallus S,López MJ,López-Nicolás Á,Lugo A,Pastor MT,Soriano JB,Fernandez E,Gorini G,TackSHS Project Investigators.

doi

10.1038/s41390-020-01223-6

subject

Has Abstract

pub_date

2020-11-04 00:00:00

eissn

0031-3998

issn

1530-0447

pii

10.1038/s41390-020-01223-6

pub_type

杂志文章
  • Gastrointestinal blood flow and O2 uptake in piglets: recovery from hypoxemia.

    abstract::Gastrointestinal (GI) blood flow, O2 transport, and O2 uptake were measured during recovery from severe hypoxemia in newborn piglets. Hypoxemia was induced by lowering the inspired O2 concentration to 0.05 for 15 min. This resulted in an 82% decrease in GI O2 uptake. Recovery measurements were obtained 5 and 65 min af...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198511000-00017

    authors: Nowicki PT,Miller RR,Hansen NB,Hayes JR

    更新日期:1985-11-01 00:00:00

  • Apoptosis of CD4+ and CD8+ T cells isolated immediately ex vivo correlates with disease severity in human immunodeficiency virus type 1 infection.

    abstract::Apoptosis of CD4+ and CD8+ T cells has been shown in peripheral blood mononuclear cells (PBMCs) from HIV-infected adults analyzed after overnight culture. Because cell death may be an artifact of in vitro culture, and because there is little information on apoptosis in pediatric HIV disease, we undertook a cross-secti...

    journal_title:Pediatric research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1203/00006450-199711000-00018

    authors: Cotton MF,Ikle DN,Rapaport EL,Marschner S,Tseng PO,Kurrle R,Finkel TH

    更新日期:1997-11-01 00:00:00

  • Recovery of treatment doses of surfactants from the lungs and vascular compartments of mechanically ventilated premature rabbits.

    abstract::Premature rabbits delivered by cesarean section at 28 d of gestation were each given intratracheally 75 mg/kg of radiolabeled preparation of either natural rabbit surfactant, natural calf surfactant, or surfactant-TA. Each newborn rabbit was ventilated for up to 6 h in a ventilator-plethysmograph with individual adjus...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198904000-00024

    authors: Seidner SR,Jobe AH,Ruffini L,Ikegami M,Pettenazzo A

    更新日期:1989-04-01 00:00:00

  • Tin-protoporphyrin-mediated disruption in vivo of heme oxygenase-2 protein integrity and activity in rat brain.

    abstract::The ability of synthetic metalloporphyrins to suppress heme oxygenase activity and bilirubin formation has recently become of considerable clinical and experimental interest for suppression of jaundice in humans, including neonatal hyperbilirubinemia. The present investigation compares the biochemical effects of Sn- a...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199209000-00016

    authors: Mark JA,Maines MD

    更新日期:1992-09-01 00:00:00

  • A chicken model for DGCR6 as a modifier gene in the DiGeorge critical region.

    abstract::DGCR6 is the most centromeric gene in the human DiGeorge critical region and is the only gene in the region with a second functional copy on a repeat localized more distally on chromosome 22. We isolated the chicken ortholog of DGCR6 and showed an embryonic expression pattern that is initially broad but becomes gradua...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/01.PDR.0000136151.50127.1C

    authors: Hierck BP,Molin DG,Boot MJ,Poelmann RE,Gittenberger-de Groot AC

    更新日期:2004-09-01 00:00:00

  • Arterial blood levels of energy substrates and evidence for renal glucose production in the baboon infant.

    abstract::The age-related changes in fasting arterial levels of energy substrates and insulin were studied at birth and/or 6 wk in eleven baboon infants. In addition, the renal contribution to glucose release in the primate infant was estimated. Arterial blood glucose levels were similar in six fasted newborns and in nine faste...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198008000-00006

    authors: Levitsky LL,Paton JB,Fisher DE,Delannoy CW

    更新日期:1980-08-01 00:00:00

  • Direct evidence for transplacental allergen transfer.

    abstract::Allergies are increasing, and despite deeper insights into the immunologic basis of these diseases, preventive measures are not yet efficient. As the induction of allergic diseases is often triggered in early childhood, perinatal or prenatal preventive strategies would be beneficial. We investigated the transfer of in...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-200009000-00024

    authors: Szépfalusi Z,Loibichler C,Pichler J,Reisenberger K,Ebner C,Urbanek R

    更新日期:2000-09-01 00:00:00

  • "Car. factor" deficiency revisited.

    abstract::Three members of a Virginia family with a bleeding disorder were found to have a serum defect in thromboplastin generation similar to the previously reported "Car. factor" deficiency. Sera from three members of the original Car. family did not correct the defect of affected members of the Virginia family. Partial thro...

    journal_title:Pediatric research

    pub_type: 临床试验,杂志文章

    doi:10.1203/00006450-197504000-00009

    authors: Komp DM

    更新日期:1975-04-01 00:00:00

  • Enhanced iNOS expression in leukocytes and circulating endothelial cells is associated with the progression of coronary artery lesions in acute Kawasaki disease.

    abstract::Nitric oxide (NO) serves many vasoprotective roles, but the massive release of NO causes arterial wall degeneration. We investigated whether enhanced nitric oxide synthase (iNOS) expression in peripheral blood leukocytes and circulating endothelial cells mirrors the progression of coronary arterial lesions in 55 child...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/01.PDR.0000113464.93042.A4

    authors: Yu X,Hirono KI,Ichida F,Uese K,Rui C,Watanabe S,Watanabe K,Hashimoto I,Kumada T,Okada E,Terai M,Suzuki A,Miyawaki T

    更新日期:2004-04-01 00:00:00

  • Autism spectrum disorders in extremely preterm infants and placental pathology findings: a matched case-control study.

    abstract:BACKGROUND:The prevalence of autism spectrum disorders (ASD) is 5-fold higher in preterm (PT) infants born ≤28 weeks gestational age (GA) as compared to the general population. The relationship between placental pathologic lesions and ASD in PT infants has not been studied. OBJECTIVES:The objective of this study was t...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/s41390-020-01160-4

    authors: Mir IN,White SP,Steven Brown L,Heyne R,Rosenfeld CR,Chalak LF

    更新日期:2020-09-19 00:00:00

  • Real-time spectral analysis of the fetal EEG: a new approach to monitoring sleep states and fetal condition during labor.

    abstract::Adverse perinatal events affecting cerebral functions are a major cause of neonatal mortality, morbidity, and long-term neurologic deficit. Intrapartum fetal EEG, which records fetal brain electrical activity, provides a monitoring modality for evaluating the fetal CNS during labor. In this study, we describe a new ap...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-200009000-00013

    authors: Thaler I,Boldes R,Timor-Tritsch I

    更新日期:2000-09-01 00:00:00

  • Stem cells and cell-based therapies for cerebral palsy: a call for rigor.

    abstract::Cell-based therapies hold significant promise for infants at risk for cerebral palsy (CP) from perinatal brain injury (PBI). PBI leading to CP results from multifaceted damage to neural cells. Complex developing neural networks are injured by neural cell damage plus unique perturbations in cell signaling. Given that c...

    journal_title:Pediatric research

    pub_type: 杂志文章,评审

    doi:10.1038/pr.2017.233

    authors: Jantzie LL,Scafidi J,Robinson S

    更新日期:2018-01-01 00:00:00

  • Metabolomic and proteomic analysis of serum from preterm infants with necrotising entercolitis and late-onset sepsis.

    abstract:BACKGROUND:Necrotising enterocolitis (NEC) and late-onset sepsis (LOS) are the leading causes of death among preterm infants in the developed world. This study aimed to explore the serum proteome and metabolome longitudinally in preterm infants with NEC or LOS, matched to controls. METHODS:Nineteen patients (10 cases,...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/pr.2015.235

    authors: Stewart CJ,Nelson A,Treumann A,Skeath T,Cummings SP,Embleton ND,Berrington JE

    更新日期:2016-03-01 00:00:00

  • Parental concerns based general developmental screening tool and autism risk: the Taiwan National Birth cohort study.

    abstract::Early detection of developmental delay and childhood disorders are important for early intervention. This study aimed to describe the distribution of responses in a large population-based survey, identify cutoff points for the parent concern checklist (PCC) suitable for the Chinese language and culture, and explore ho...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/PDR.0b013e3181c8ed3d

    authors: Lung FW,Shu BC,Chiang TL,Lin SJ

    更新日期:2010-02-01 00:00:00

  • Comparison of short- and long-duration oxygen treatment after cerebral asphyxia in newborn piglets.

    abstract::We tested whether reoxygenation with 100% O(2) for 5 min after experimental asphyxia in newborn piglets was as efficient as 100% O(2) for 20 min compared with room air. Forty-one anesthetized piglets, 1-3 d old, were randomized to cerebral hypoxemia-ischemia-hypercapnia (HIH) or control (n = 5). HIH was achieved by ve...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/01.PDR.0000128978.90201.1D

    authors: Solas AB,Munkeby BH,Saugstad OD

    更新日期:2004-07-01 00:00:00

  • Alpha-mannosidosis in the guinea pig: a new animal model for lysosomal storage disorders.

    abstract::Alpha-mannosidosis is a lysosomal storage disorder resulting from deficient activity of lysosomal alpha-mannosidase. It has been described previously in humans, cattle, and cats, and is characterized in all of these species principally by neuronal storage leading to progressive mental deterioration. Two guinea pigs wi...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199911000-00003

    authors: Crawley AC,Jones MZ,Bonning LE,Finnie JW,Hopwood JJ

    更新日期:1999-11-01 00:00:00

  • Type-I but not type-II interferon receptor knockout mice are susceptible to biliary atresia.

    abstract::The etiology of biliary atresia (BA) is not yet understood, but recent studies have shown inflammation with an up-regulated interferon (IFN) activity in the intra- and extrahepatic bile ducts of patients with BA. These findings support an inflammatory/infectious cause of BA as mimicked in our infective murine model. T...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/01.pdr.0000219860.96732.09

    authors: Kuebler JF,Czech-Schmidt G,Leonhardt J,Ure BM,Petersen C

    更新日期:2006-06-01 00:00:00

  • Drosophila, a golden bug, for the dissection of the genetic basis of tolerance and susceptibility to hypoxia.

    abstract::We have previously discovered that the adult Drosophila melanogaster is tolerant to a low O2 environment, withstanding hours of total O2 deprivation without showing any evidence of cell injury. Subsequently, our laboratory embarked on the study of hypoxia tolerance using a mutagenesis and overexpression screens to beg...

    journal_title:Pediatric research

    pub_type: 杂志文章,评审

    doi:10.1203/PDR.0b013e3181b27275

    authors: Zhou D,Visk DW,Haddad GG

    更新日期:2009-09-01 00:00:00

  • aEEG and neurologic exam findings correlate with hypoxic-ischemic brain damage severity in a piglet survival model.

    abstract:BACKGROUND:Newborn pigs offer theoretical advantages for studying newborn hypoxic-ischemic (HI) brain damage because of a development and structure similar to the human brain. However, the correlation between functional features and actual HI brain damage has not been reported. METHODS:Newborn pigs were examined daily...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/s41390-019-0282-2

    authors: Barata L,Cabañas A,Lafuente H,Vargas C,Ceprián M,Campa L,Jiménez-Sánchez L,Pazos MR,Alvarez FJ,Martínez-Orgado J

    更新日期:2019-03-01 00:00:00

  • Metabolomic profiles and development of metabolic risk during the pubertal transition: a prospective study in the ELEMENT Project.

    abstract:OBJECTIVES:(1) Examine associations of a branched-chain amino acid (BCAA) metabolite pattern with metabolic risk across adolescence; (2) use Least Absolute Shrinkage and Selection Operator (LASSO) to identify novel metabolites of metabolic risk. METHODS:We used linear regression to examine associations of a BCAA score...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/s41390-018-0195-5

    authors: Perng W,Tang L,Song PXK,Tellez-Rojo MM,Cantoral A,Peterson KE

    更新日期:2019-02-01 00:00:00

  • Effects of hyperoxia on the arousal response to upper airway obstruction in lambs.

    abstract::Experiments were done to investigate the effects of increased inspired oxygen on the arousal response from sleep to upper airway obstruction in 10 newborn lambs. Each lamb was anesthetized and instrumented for recordings of electrocorticograms, electrooculogram, nuchal and diaphragm electromyograms, and measurements o...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198702000-00002

    authors: Baker SB,Fewell JE

    更新日期:1987-02-01 00:00:00

  • Leptin levels and body fatness in children: effects of gender, ethnicity, and sexual development.

    abstract::Leptin, a hormone secreted by adipocytes, is elevated in blood of obese adults. It is unknown whether the concentration is affected by gender, ethnicity, age, or stage of sexual maturation in children. We measured serum leptin levels in 183 children and 27 young adults using a double-antibody ELISA assay. Body fat mas...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199710000-00010

    authors: Ellis KJ,Nicolson M

    更新日期:1997-10-01 00:00:00

  • Nutrition and the microbiome 2015.

    abstract::Carlo Agostoni, MD, and Kwang Sik Kim, MD, are the Guest Editors for this annual review issue on Nutrition and the Microbiome. Dr Agostoni is a Professor of Pediatrics at the Department of Clinical Sciences and Community Health, University of Milan, within the Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, ...

    journal_title:Pediatric research

    pub_type: 历史文章

    doi:10.1038/pr.2014.195

    authors: Agostoni C,Kim KS

    更新日期:2015-01-01 00:00:00

  • Comparative hemodynamic effects of isoproterenol, dopamine, and dobutamine in the newborn dog.

    abstract::To compare the hemodynamic effects of isoproterenol, dopamine, and dobutamine in the immature animal, each drug was infused into anesthetized open chest puppies and cardiac output was measured, as were systemic arterial blood pressure, heart rate, and renal artery blood flow. Cardiac output was increased by dopamine a...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-197909000-00011

    authors: Driscoll DJ,Gillette PC,Lewis RM,Hartley CJ,Schwartz A

    更新日期:1979-09-01 00:00:00

  • Radiant warmer power and body size as determinants of insensible water loss in the critically ill neonate.

    abstract::Twelve critically ill neonates mechanically ventilated for respiratory failure (mean weight 1.33 kg, mean gestation 31 wk) were studied to quantitate the effects of radiant power from a radiant warming device, body weight, and body surface area on insensible water loss. Radiant power density (Mw/cm2) was measured usin...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198112000-00008

    authors: Baumgart S,Engle WD,Fox WW,Polin RA

    更新日期:1981-12-01 00:00:00

  • Effect of pH and CO2 on in vitro susceptibility of Pseudomonas cepacia to beta-lactams.

    abstract::Inhibition of Pseudomonas cepacia (but not Pseudomonas aeruginosa) by beta-lactams was decreased in 5% CO2 in air compared with air alone. The effect of CO2 and pH (range, 6.0 to 8.0) on beta-lactam susceptibility, beta-lactamase expression, and outer membrane proteins was studied in isolates recovered from the sputum...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199403000-00003

    authors: Corkill JE,Deveney J,Pratt J,Shears P,Smyth A,Heaf D,Hart CA

    更新日期:1994-03-01 00:00:00

  • Gel electrophoretic studies on proteoglycans and collagen of abnormal human growth cartilage: proteoglycan abnormalities in pseudoachondroplasia and in Kniest's disease.

    abstract::The microchemical study of growth cartilage biopsies may improve the classification and the genetic advice of some types of growth disturbances and contribute to the understanding of biochemical defects. Small tibial growth cartilage biopsies were performed during orthopedic surgery in cases with achondroplasia, pseud...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-197510000-00006

    authors: Stanescu V,Maroteaux P

    更新日期:1975-10-01 00:00:00

  • The dietary treatment of children with type I glycogen storage disease with slow release carbohydrate.

    abstract::The effect of ingestion of uncooked cornstarch (2 g/kg body weight) in water, uncooked starch (1 g/kg) added to a meal, and glucose (2 g/kg) in water, was studied in eight patients with type IA glycogen storage disease (GSD) and one patient with type IB GSD. Blood glucose concentrations were determined at 30-min inter...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198409000-00015

    authors: Smit GP,Berger R,Potasnick R,Moses SW,Fernandes J

    更新日期:1984-09-01 00:00:00

  • Short-term (0-48 h) effects of maternal betamethasone administration on fetal heart rate and its variability.

    abstract::The short-term (0-48 h) effects of maternal betamethasone administration on computerized fetal heart rate (FHR) parameters were studied in 36 pregnancies at increased risk for preterm delivery. FHR was recorded for 90 min immediately before the start of betamethasone treatment and again at 6-h intervals during the nex...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/01.PDR.0000155948.83570.EB

    authors: Lunshof MS,Boer K,Wolf H,Koppen S,Velderman JK,Mulder EJ

    更新日期:2005-04-01 00:00:00

  • Functional activity of class-specific antibodies to type III, group B streptococcus.

    abstract::The functional activity of naturally acquired IgG and IgM with specificity for the capsular polysaccharide of type III, group B Streptococcus (III-GBS) was compared. Sera collected during convalescence from 14 infants who had developed specific antibodies following III-GBS infection were employed for separation of IgG...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198801000-00007

    authors: Campbell JR,Baker CJ,Metzger TG,Edwards MS

    更新日期:1988-01-01 00:00:00