"Car. factor" deficiency revisited.

Abstract:

:Three members of a Virginia family with a bleeding disorder were found to have a serum defect in thromboplastin generation similar to the previously reported "Car. factor" deficiency. Sera from three members of the original Car. family did not correct the defect of affected members of the Virginia family. Partial thromboplastin times of Car. deficient individuals and affected members of the Virginia family were normal. Although correction with normal serum is attained in vitro, the serum defect persisted after infusion of fresh frozen plasma. Platelet function studies of the Virginia family revealed less than 30% aggregation after the addition of exogenous ADP and disaggregation within 2 min. Evaluation of children with Noonan's syndrome, albinism, and "Portsmouth" syndrome showed coexistent platelet aggregation defects and nonspecific serum defects.

journal_name

Pediatr Res

journal_title

Pediatric research

authors

Komp DM

doi

10.1203/00006450-197504000-00009

subject

Has Abstract

pub_date

1975-04-01 00:00:00

pages

184-9

issue

4

eissn

0031-3998

issn

1530-0447

journal_volume

9

pub_type

临床试验,杂志文章
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    journal_title:Pediatric research

    pub_type: 杂志文章,随机对照试验

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    更新日期:1977-02-01 00:00:00

  • Role of caregiver-reported outcomes in identification of children with prenatal alcohol exposure during the first year of life.

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