Ibuprofen augments bilirubin toxicity in rat cortical neuronal culture.

abstract：:Fetal dermal wounds heal scarlessly and with a minimal inflammatory response. When a robust inflammatory response is induced at the site of fetal dermal wounds by the application of cytokines, healing results in fibrosis. To test the hypothesis that the reduced inflammatory response in fetal wounds is due to impaired ...

journal_title：Pediatric research

authors： Olutoye OO,Zhu X,Cass DL,Smith CW

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Therapeutic hypothermia (TH) has become standard treatment for severe and moderate hypoxic-ischemic neonatal encephalopathy (HIE). Our group has developed an optically based, noninvasive concept of assessing the capacity for oxygen delivery from the microcirculation to the cells of a tissue under investigati...

journal_title：Pediatric research

authors： Fredly S,Fugelseth D,Nygaard CS,Salerud EG,Stiris T,Kvernebo K

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Recent studies suggest that infantile hypertrophic pyloric stenosis (IHPS) and congenital heart defects (CHDs) may share some genetic risk factors, but little is known about the co-occurrence of the two conditions in patients. METHODS:Our study cohort included 2,212,756 persons born in Denmark 1977-2013. We...

journal_title：Pediatric research

authors： Feenstra B,Gørtz S,Lund M,Ranthe MF,Geller F,Melbye M

更新日期：2019-06-01 00:00:00

abstract：:Thrombocytopenia in the first days of life, in association with evidence of reduced megakaryocytopoiesis and platelet production at birth, is common in sick preterm babies. Thrombopoietin (Tpo) is the major regulator of platelet production in adults. However, these babies have low Tpo levels at birth, suggesting that ...

journal_title：Pediatric research

authors： Watts TL,Murray NA,Roberts IA

更新日期：1999-07-01 00:00:00

abstract：:The mitochondria play a major role in the regulation of intracellular calcium. Despite the fact that the enterocytes receive the majority of absorbed calcium, the role of the intestinal mitochondria in calcium transport during maturation is not known. Therefore, the current studies were designed to characterize calciu...

journal_title：Pediatric research

authors： Kikuchi T,Kikuchi K,Arab N,Ghishan FK

更新日期：1989-01-01 00:00:00

abstract：:We studied healthy and saline lavaged rabbits during high frequency oscillatory ventilation to determine what combination of frequency (f), tidal volume (Vt), and mean airway pressure (Paw) produced the lowest peak-to-peak alveolar pressure amplitude (Palv) and physiologic blood gas tensions. Sinusoidal volume changes...

journal_title：Pediatric research

authors： Kamitsuka MD,Boynton BR,Villanueva D,Vreeland PN,Frantz ID 3rd

更新日期：1990-01-01 00:00:00

abstract：:Pulmonary surfactant is inactivated in meconium aspiration syndrome and neonatal pneumonia. Development of an exogenous surfactant less sensitive to inactivation might be useful for treating these diseases. We investigated in vitro whether addition of the cationic cyclic membrane cross-linking peptide polymyxin B (PxB...

journal_title：Pediatric research

authors： Stichtenoth G,Jung P,Walter G,Johansson J,Robertson B,Curstedt T,Herting E

更新日期：2006-03-01 00:00:00

abstract：:Guinea pig gallbladder smooth muscle contractility undergoes a period of postnatal maturation. Because tissues from adult animals contract more forcefully than tissues from newborn animals when stimulated with agonists that activate the contractile process through different mechanisms (receptor activation, membrane de...

journal_title：Pediatric research

authors： Lambert R,Ryan JP

更新日期：1990-10-01 00:00:00

abstract：:Depression is one of the most debilitating chronic disorders in the United States, affecting 15 million children in homes with depressed mothers, many of whom endure household chaos, inconsistent nurturing, inadequate safety practices, and harsh discipline. Depressed mothers are under diagnosed and undertreated, yet t...

journal_title：Pediatric research

authors： Weiss-Laxer NS,Platt R,Osborne LM,Kimmel M,Solomon BS,Mendelson T,Webb L,Riley AW

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Despite substantial heritability in pubertal development, children differ in maturational tempo. HYPOTHESES:(i) puberty and its duration are influenced by early changes in height and adiposity. (ii) Adiposity rebound (AR) is a marker for pubertal tempo. METHODS:We utilized published prospective data from 6...

journal_title：Pediatric research

authors： German A,Shmoish M,Hochberg Z

更新日期：2015-10-01 00:00:00

abstract：:The aim of the present study was to determine the proportion of gamma/delta T-lymphocytes and CD16/CD56 (CD3- and CD3+) cells in the peripheral blood of children and adolescents with Graves' disease (GD; n = 27; mean age, 15.5 +/- 5.1 y) and nontoxic nodular goiter (NTNG; n = 25; mean age, 15.2 +/- 5.7 y), in comparis...

journal_title：Pediatric research

authors： Bossowski A,Urban M,Stasiak-Barmuta A

更新日期：2003-09-01 00:00:00

abstract：:Completely penetrant mutations in the surfactant protein B gene (SFTPB) and >75% reduction of SFTPB expression disrupt pulmonary surfactant function and cause neonatal respiratory distress syndrome. To inform studies of genetic regulation of SFTPB expression, we created a catalogue of SFTPB variants by comprehensive r...

journal_title：Pediatric research

authors： Hamvas A,Wegner DJ,Carlson CS,Bergmann KR,Trusgnich MA,Fulton L,Kasai Y,An P,Mardis ER,Wilson RK,Cole FS

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Continuous and intermittent bolus orogastric feedings are strategies used in infants unable to tolerate normal feeds. METHODS:To determine the effects of feeding modality on protein synthesis in different tissues, neonatal pigs received a balanced formula by orogastric tube as an intermittent bolus feed eve...

journal_title：Pediatric research

authors： El-Kadi SW,Gazzaneo MC,Suryawan A,Orellana RA,Torrazza RM,Srivastava N,Kimball SR,Nguyen HV,Fiorotto ML,Davis TA

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Cardiovascular (CV) complications are the most significant cause of mortality in adults with Cushing disease (CD); little is known about CV risk factors in children with CD. Measurement of lipoprotein particles by nuclear magnetic resonance (NMR) spectroscopy is a novel technology to assess CV risk. The obje...

journal_title：Pediatric research

authors： Makri A,Cheung A,Sinaii N,Remaley AT,Sampson M,Keil M,Belyavskaya E,Lyssikatos C,De La Luz Sierra M,Stratakis CA,Lodish M

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Childhood body mass index (BMI) trajectory classes are rarely linked to early puberty risk, particularly among Chinese children. We estimated early puberty risk across BMI trajectory classes, investigated factors contributing to pubertal development, and examined differences in final adult height between chi...

journal_title：Pediatric research

authors： Fan HY,Lee YL,Hsieh RH,Yang C,Chen YC

更新日期：2020-07-01 00:00:00

abstract：:Studies were designed to develop an animal model for the syndrome of hypochloremic, hypokalemic metabolic alkalosis (HMA), and failure to thrive in infants due to intake of chloride-deficient formula. Littermate canine puppies, 2 wk old, were fed soy formula containing normal chloride, 20 mEq/liter (NC, n = 5), or low...

journal_title：Pediatric research

authors： Felder CC,Robillard JE,Roy S 3rd,Jose PA

更新日期：1987-05-01 00:00:00

abstract：:Cerebellar injury has been increasingly recognized as a complication of preterm birth, with decreased cerebellar volumes seen on follow-up neuroimaging. A cohort of 38 preterm newborns, including 14 with two scans, was studied with MRI, including single-shot fast spin-echo diffusion tensor imaging (DTI) sequence speci...

journal_title：Pediatric research

authors： Tam EW,Ferriero DM,Xu D,Berman JI,Vigneron DB,Barkovich AJ,Miller SP

更新日期：2009-07-01 00:00:00

abstract：:The cerebral metabolic effects of hypoglycemia due to intrauterine growth retardation were studied in newborn dogs. Intrauterine growth retardation was induced in newborn dogs after 3 days of maternal nutritional deprivation (birth weight 251 +/- 7 versus 227 +/- 7 g, p less than 0.01). After birth, growth retarded pu...

journal_title：Pediatric research

authors： Kliegman RM

更新日期：1988-11-01 00:00:00

abstract：:We used quin2, a high affinity fluorescent calcium indicator to measure free cytosolic Ca++ in neutrophils isolated from fresh heparinized blood of 13 cystic fibrosis (CF) patients (age range 6-32 yr) and 11 healthy individuals (age range 25-41 yr) as controls. The mean value of free cytosolic Ca++ for CF patients was...

journal_title：Pediatric research

authors： Suter S,Lew PD,Ballaman J,Waldvogel FA

更新日期：1985-04-01 00:00:00

abstract：:After an initial postnatal diuresis, neonates are in positive sodium balance. Because atrial natriuretic peptide (ANP) contributes to sodium homeostasis, this study was designed to evaluate the maturational effects of increased dietary sodium intake on cardiac ANP production. Preweaned Sprague-Dawley rat pups were art...

journal_title：Pediatric research

authors： Muchant DG,Belmonte DC,Garmey MJ,Baertschi AJ,Pence RA,Chevalier RL

更新日期：1995-03-01 00:00:00

abstract：:BackgroundBeing aware of the impact of low birth weight on late-onset hypertension, our aim was to describe systolic blood pressure (sBP) and renal function in 3-5-year-old preterm-born children and to determine which perinatal factors or childhood factors were associated with an altered renal function at 5 years in t...

journal_title：Pediatric research

authors： Vieux R,Gerard M,Roussel A,Sow A,Gatin A,Guillemin F,Hascoet JM

更新日期：2017-12-01 00:00:00

abstract：:Skin reflectance in red, green, and blue light was measured at the sternum of 99 Caucasian infants ranging in gestational age from 26 to 44 weeks. Skin reflectance was consistently higher in female infants, but this difference was not statistically significant. Highly significant (P less than 0.001) increases in refle...

journal_title：Pediatric research

authors： Krauss AN,Post PW,Waldman S,Auld PA

更新日期：1976-09-01 00:00:00

abstract：:Premature rabbits delivered by cesarean section at 28 d of gestation were each given intratracheally 75 mg/kg of radiolabeled preparation of either natural rabbit surfactant, natural calf surfactant, or surfactant-TA. Each newborn rabbit was ventilated for up to 6 h in a ventilator-plethysmograph with individual adjus...

journal_title：Pediatric research

authors： Seidner SR,Jobe AH,Ruffini L,Ikegami M,Pettenazzo A

更新日期：1989-04-01 00:00:00

abstract：:The metabolism of proteoglycans in normal growth plate and the changes in growth plate morphology induced by diabetes and malnutrition were studied in rats. The proteoglycans had a significantly faster turnover (half-life measured with [35S]sulfate labeling: 25-30 h) than the cells in the growth plate. Morphometric st...

journal_title：Pediatric research

authors： Axelsson I,Pita JC,Howell DS,Lorentzon R,Berman I,Boquist L

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Biliary atresia (BA) is an infantile disorder characterized by progressive sclerosing cholangiopathy leading to biliary obstruction. First-line treatment of BA is hepatoportoenterostomy, the prognosis of which is related to age at surgery and to histological variables such as extent of fibrosis and ductular ...

journal_title：Pediatric research

authors： de Souza AF,Meurer L,da Silveira TR,Gregório C,Reus N,Uribe C,Matte U,dos Santos JL

更新日期：2014-01-01 00:00:00

abstract：:Phagocytosis of apoptotic cells, e.g., neutrophils, by monocytes is essential for resolution of inflammation. Delayed removal leads to secondary necrosis, perpetuating inflammation, and tissue destruction. Common histologic features in neonatal chronic inflammatory disorders are an accumulation of apoptotic cells in i...

journal_title：Pediatric research

authors： Gille C,Steffen F,Lauber K,Keppeler H,Leiber A,Spring B,Poets CF,Orlikowsky TW

更新日期：2009-11-01 00:00:00

abstract：:The precise mechanism by which the most common cause of bacterial enterocolitis in humans, Campylobacter jejuni, perturbs the intestinal mucosa remains elusive. To define effects of C. jejuni infection on mucosal permeability, Madin-Darby canine kidney (MDCK)-I and T84 cell monolayers were infected with C. jejuni for ...

journal_title：Pediatric research

authors： Wine E,Chan VL,Sherman PM

更新日期：2008-12-01 00:00:00

abstract：:We have developed a method for measuring oxygen consumption (Vo2) in preterm infants in their normal incubator environment over prolonged periods. The results of measurements made over 24 h in 18 infants are presented. In normally grown infants, the mean Vo2 was 9.66 +/- 1.25 liters/kg X 24 h (SD) (6.71 +/- 0.87 ml/kg...

journal_title：Pediatric research

authors： Abdulrazzaq YM,Brooke OG

更新日期：1984-10-01 00:00:00

abstract：:Tonsillectomy and adenoidectomy (T&A) is a frequent surgical procedure in children with obstructive sleep apnea (OSA). Many symptomatic children who do not fulfill the currently recommended criteria for T&A may benefit from topical intranasal steroid therapy. However, the expression of glucocorticoid receptor (GCR) ex...

journal_title：Pediatric research

authors： Goldbart AD,Veling MC,Goldman JL,Li RC,Brittian KR,Gozal D

更新日期：2005-02-01 00:00:00

abstract：:Critically ill infants are treated with dexamethasone (Dx) and other glucocorticoids to reduce inflammation and to promote lung and cardiac function. The neonatal immune system is immature, so neonatal dendritic cells (DCs) might be especially sensitive to glucocorticoid-mediated immunosuppression. To test this, we co...

journal_title：Pediatric research

authors： Mainali ES,Kikuchi T,Tew JG

更新日期：2005-07-01 00:00:00