Postganglionic sympathetic discharge in neonatal swine.

Abstract:

:We hypothesized that cardiac and respiratory modulation of postganglionic peroneal activity appeared in an age-related manner. In anesthetized, paralyzed and artificially ventilated piglets, simultaneous recordings of efferent phrenic and peroneal discharges were obtained during hyperoxia (fraction of inspired oxygen, FiO2 = 1.0) and hypoxia (FiO2 = 0.1). Spectral analyses of peroneal and aortic blood pressure signals revealed peaks at the cardiac frequency (3.25-5.0 Hz). Coherence analysis showed that these two signals were highly correlated at those frequencies, providing evidence for baroreceptor entrainment. Statistically significant (p < 0.05) increases of coherence values were observed during hypoxic stimulation. Such results were observed in most animals despite age, and provided evidence of a potent mechanism for insuring vasomotor tone even in newborn animals. In contrast, spontaneous respiration-related peroneal discharges were observed only in animals > or = 20 d old. In animals < 20 d old, hypoxic stimulation elicited respiration-related discharges in peroneal activity. In many cases, peroneal hypoxic discharges exhibited an immature biphasic response pattern despite the presence of a mature response pattern of phrenic activity. Such findings suggest a developmental lag in the linkages of respiratory and sympathetic controlling networks.

journal_name

Pediatr Res

journal_title

Pediatric research

authors

Sica AL,Hundley BW,Gootman PM

doi

10.1203/00006450-199601000-00012

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

85-9

issue

1

eissn

0031-3998

issn

1530-0447

journal_volume

39

pub_type

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