Insulin-like growth factor-I (IGF-I) ameliorates and IGF binding protein-1 (IGFBP-1) exacerbates the effects of undernutrition on brain growth during early postnatal life: studies in IGF-I and IGFBP-1 transgenic mice.

Abstract:

:Insulin-like growth factor-I (IGF-I) plays an important role in the stimulation of postnatal brain growth. In transgenic (Tg) mice, IGF-I overexpression stimulates postnatal brain growth, whereas decreased IGF-I availability caused by ectopic brain expression of IGF binding protein-1 [(IGFBP-1), an inhibitor of IGF-I action] retards postnatal brain growth. Because undernutrition during early postnatal development profoundly retards growth and maturation of the brain in rodents, we sought to determine the influence of IGF-I on undernutrition-induced brain growth retardation. Caloric restriction was imposed on IGF-I Tg mice, IGFBP-1 Tg mice, and their non-Tg littermates by separating half of each litter from their dams during the suckling period, postnatal d 1 to 21. Undernutrition reduced the brain growth of each group of mice, but the growth of undernourished IGF-I Tg mice was comparable to that of well-fed control mice (increased 4.13- and 4.22-fold, respectively) and greater than that of undernourished control mice (increased 3.45-fold), whereas undernourished IGFBP-1 Tg mice exhibited less growth (increased 3.15-fold) than undernourished control mice. When the effects of undernutrition were examined in specific brain regions of each group, the same pattern was observed, and IGF-I was found to be more effective in preserving the growth of the regions with the highest transgene expression (cerebral cortex, hippocampus, and diencephalon). Despite undernutrition, IGF-I transgene expression stimulated overgrowth of these regions as well as that of the posterior medial barrel subfield, a somatosensory area of the cerebral cortex in which IGF-I may be especially important in development. These data indicate that IGF-I can ameliorate the brain growth retardation caused by undernutrition imposed during development, although it is unclear whether IGF-I directly opposes the impact of undernutrition or acts independently of nutritional status. Nonetheless, these findings raise the possibility that the relatively high IGF-I expression during early postnatal life may be responsible for sparing the brain from the full impact of undernutrition during this time in development.

journal_name

Pediatr Res

journal_title

Pediatric research

authors

Lee KH,Calikoglu AS,Ye P,D'Ercole AJ

doi

10.1203/00006450-199903000-00007

subject

Has Abstract

pub_date

1999-03-01 00:00:00

pages

331-6

issue

3

eissn

0031-3998

issn

1530-0447

journal_volume

45

pub_type

杂志文章
  • Effects of hyperoxia on the arousal response to upper airway obstruction in lambs.

    abstract::Experiments were done to investigate the effects of increased inspired oxygen on the arousal response from sleep to upper airway obstruction in 10 newborn lambs. Each lamb was anesthetized and instrumented for recordings of electrocorticograms, electrooculogram, nuchal and diaphragm electromyograms, and measurements o...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198702000-00002

    authors: Baker SB,Fewell JE

    更新日期:1987-02-01 00:00:00

  • Severe congenital hypothyroidism due to a homozygous mutation of the betaTSH gene.

    abstract::Isolated TSH deficiency leading to hypothyroidism seems to be a rare condition, escaping the diagnosis by neonatal screening programs, which are based on the primary determination of TSH. This is the first report of a case with an autosomal recessive TSH defect caused by a homozygous mutation of the betaTSH gene that ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199908000-00007

    authors: Biebermann H,Liesenkötter KP,Emeis M,Oblanden M,Grüters A

    更新日期:1999-08-01 00:00:00

  • Cytidine 5'-diphosphocholine ameliorates hyperoxic lung injury in a neonatal rat model.

    abstract:BACKGROUND:Bronchopulmonary dysplasia (BPD) is an important cause of morbidity. The aim of this study was to evaluate the preventive effect of cytidine 5'-diphosphocholine (CDP-choline) treatment on hyperoxic lung injury in a neonatal rat model. METHODS:A total of 30 newborn pups were divided into control, hyperoxia, ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/pr.2013.68

    authors: Cetinkaya M,Cansev M,Kafa IM,Tayman C,Cekmez F,Canpolat FE,Tunc T,Sarici SU

    更新日期:2013-07-01 00:00:00

  • A chicken model for DGCR6 as a modifier gene in the DiGeorge critical region.

    abstract::DGCR6 is the most centromeric gene in the human DiGeorge critical region and is the only gene in the region with a second functional copy on a repeat localized more distally on chromosome 22. We isolated the chicken ortholog of DGCR6 and showed an embryonic expression pattern that is initially broad but becomes gradua...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/01.PDR.0000136151.50127.1C

    authors: Hierck BP,Molin DG,Boot MJ,Poelmann RE,Gittenberger-de Groot AC

    更新日期:2004-09-01 00:00:00

  • Profiling scoliosis in Rett syndrome.

    abstract::To understand scoliosis, related comorbidities, and phenotype-genotype correlations in individuals with Rett syndrome (RTT), the Rare Disease Clinical Research Network database for RTT was probed. Clinical evaluations included a detailed history and physical examination, comprehensive anthropometric measurements, and ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/PDR.0b013e3181d0187f

    authors: Percy AK,Lee HS,Neul JL,Lane JB,Skinner SA,Geerts SP,Annese F,Graham J,McNair L,Motil KJ,Barrish JO,Glaze DG

    更新日期:2010-04-01 00:00:00

  • That sinking feeling, again? The state of National Institutes of Health pediatric research funding, fiscal year 1992-2010.

    abstract::This review article examines the National Institutes of Health's (NIH) overall budget and its pediatric research funding across three time periods: predoubling [fiscal year (FY) 1992-1997]; doubling (FY 1998-2003); and postdoubling (FY 2004-2009). The average annual NIH appropriations increased by 5.4%, 13.4%, and 1.3...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/PDR.0b013e31818912fd

    authors: Gitterman DP,Hay WW Jr

    更新日期:2008-11-01 00:00:00

  • Early-life growth of preterm infants and its impact on neurodevelopment.

    abstract:BACKGROUND:Increasing numbers of preterm-born children survive nowadays, and improving long-term health and neurodevelopment is becoming more important. Early-life growth has been linked to neurodevelopmental outcomes. We aimed to study whether this association has changed with time. METHODS:We studied two cohorts of ...

    journal_title:Pediatric research

    pub_type: 杂志文章,多中心研究

    doi:10.1038/s41390-018-0139-0

    authors: Ruys CA,Hollanders JJ,Bröring T,van Schie PEM,van der Pal SM,van de Lagemaat M,Lafeber HN,Rotteveel J,Finken MJJ

    更新日期:2019-02-01 00:00:00

  • Appraising endocrine pulse signals at low circulating hormone concentrations: use of regional coefficients of variation in the experimental series to analyze pulsatile luteinizing hormone release.

    abstract::We have developed a regional dual-threshold method for detecting endocrine pulses at variably low hormone concentrations such as those that occur in the pediatric age group. This algorithm uses the local intra-series coefficient of variation to test for a significant increase and decrease (peak or pulse) in the experi...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198607000-00011

    authors: Velduis JD,Weiss J,Mauras N,Rogol AD,Evans WS,Johnson ML

    更新日期:1986-07-01 00:00:00

  • Obesity, metabolic syndrome, and cardiovascular disease.

    abstract::Early childhood overweight and obesity have alarmingly increased over the years. Adulthood obesity is a well demonstrated significant independent predictor of cardiovascular risk (CVR) and/or mortality, which predisposes to the major components of metabolic syndrome (MS). Evidence of MS in obese children has been also...

    journal_title:Pediatric research

    pub_type: 杂志文章,评审

    doi:10.1203/pdr.0b013e31805d8a8c

    authors: Aggoun Y

    更新日期:2007-06-01 00:00:00

  • FMRI responses to hyperoxia in congenital central hypoventilation syndrome.

    abstract::Congenital Central Hypoventilation Syndrome (CCHS) patients show partial retention of peripheral chemoreception despite impaired ventilatory responses to CO2 and hypoxia. The condition allows examination of central responses to hyperoxia, which minimizes afferent traffic from peripheral chemoreceptors. We used functio...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/01.PDR.0000155763.93819.46

    authors: Woo MA,Macey PM,Macey KE,Keens TG,Woo MS,Harper RK,Harper RM

    更新日期:2005-04-01 00:00:00

  • Glycogenosis due to liver and muscle phosphorylase kinase deficiency.

    abstract::A four-year-old Israeli Arab boy was found to have glycogen accumulation in both liver and muscle without clinical symptoms. Liver phosphorylase kinase (PK) activity was 20% of normal, resulting in undetectable activity of phosphorylase a. Muscle PK activity was about 25% of normal, resulting in a marked decrease of p...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198104000-00002

    authors: Bashan N,Iancu TC,Lerner A,Fraser D,Potashnik R,Moses SW

    更新日期:1981-04-01 00:00:00

  • Development of Na+-K+-ATPase in neonatal rat brain synaptosomes after perinatal protein malnutrition.

    abstract::Four protein dietary groups of rats were used in this study, namely: 27% casein diet fed throughout gestation and lactation (group C-C); 27% gestation, 10% lactation (group C-D); 10% gestation, 27% lactation (group D-C); 10% throughout gestation and lactation (group D-D). Mean body weight of group D-D at warning was 1...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-197503000-00008

    authors: Kissane JQ,Hawrylewicz EJ

    更新日期:1975-03-01 00:00:00

  • Impaired D-myo-inositol 1,4,5-triphosphate generation from cord blood polymorphonuclear leukocytes.

    abstract::D-myo-Inositol 1,4,5-triphosphate (IP3) is a key second messenger in many cells, including macrophages, T and B cells, and neutrophils, in which it regulates free intracellular calcium ion levels. In human polymorphonuclear leukocytes the rise of intracellular [Ca2+] is the signal that activates a number of functions ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199510000-00015

    authors: Santoro P,Agosti V,Viggiano D,Palumbo A,Sarno T,Ciccimarra F

    更新日期:1995-10-01 00:00:00

  • Perspectives from the Society for Pediatric Research: Decreased Effectiveness of the Live Attenuated Influenza Vaccine.

    abstract::The intranasal live attenuated influenza vaccine (LAIV), FluMist, has been widely appreciated by pediatricians, parents, and children alike for its ease of administration. However, concerns regarding lack of effectiveness in recent influenza seasons led to the CDC Advisory Committee on Immunization Practices (ACIP) re...

    journal_title:Pediatric research

    pub_type: 杂志文章,评审

    doi:10.1038/pr.2017.239

    authors: Gill MA,Schlaudecker EP

    更新日期:2018-01-01 00:00:00

  • Posttranslational activation of endothelial nitric oxide synthase attenuates carbon tetrachloride-induced hepatotoxicity in newborn rats.

    abstract::Nitric Oxide (NO) can be cytotoxic or cytoprotective depending on amount and location of its generation. eNOS is important in modulating blood flow and is allosterically regulated. Inducible NOS (iNOS) tends to produce large quantities of NO leading to cell injury. We studied the role and regulation of NOS in carbon t...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/PDR.0b013e31816d9146

    authors: Liu H,Subramony C,Nowicki M

    更新日期:2008-06-01 00:00:00

  • Effect of a ring-deleted atrial natriuretic factor analogue on ovine fetal renal and cardiovascular function.

    abstract::The proposed actions of atrial natriuretic factor (ANF) are mediated through specific plasma membrane (R1) receptors coupled to guanylate cyclase. A second receptor, R2, has been characterized by its ability to bind to an acyclic, truncated ANF analog (C-ANF4-23). The ANF-R2 receptor has not been identified in the fet...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:

    authors: Castro R,Ervin MG,Leake RD,Ross MG,Fisher DA

    更新日期:1991-04-01 00:00:00

  • Nitric oxide in retinal and choroidal blood flow autoregulation in newborn pigs: interactions with prostaglandins.

    abstract::The role of nitric oxide (NO) as well as its interaction with prostaglandins (PG) in setting the limits of autoregulation of retinal blood flow (RBF) and choroidal blood flow (ChBF) were studied in newborn pigs (1-5 d old). Blood flows were measured by the microsphere technique. Low and high ocular perfusion pressures...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199603000-00017

    authors: Hardy P,Nuyt AM,Abran D,St-Louis J,Varma DR,Chemtob S

    更新日期:1996-03-01 00:00:00

  • Maternofetal transfer of thyrotrophin-releasing hormone: effect of concentration and mode of administration.

    abstract::We studied the effect of maternal concentration and mode of administration on transfer rate of TSH-releasing hormone (TRH) in an in vitro model of dually perfused isolated lobule of human term placenta. Varying concentrations (4-40 microg dL(-1)) of TRH were added either to the open maternal circulation to mimic an in...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199705000-00012

    authors: Bajoria R,Fisk NM

    更新日期:1997-05-01 00:00:00

  • Response of human and rat small intestinal mucosa to oral administration of Saccharomyces boulardii.

    abstract::To evaluate the response of the small intestinal mucosa to Saccharomyces boulardii (S.b.), a yeast widely used in some countries as an adjuvant drug with oral antimicrobial therapy, seven healthy adult volunteers were treated with high doses of lyophilized S.b. (250 mg four times per day) for 2 wk. A peroral jejunal s...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198602000-00020

    authors: Buts JP,Bernasconi P,Van Craynest MP,Maldague P,De Meyer R

    更新日期:1986-02-01 00:00:00

  • Serum insulin-like growth factors I and II concentrations and growth hormone and insulin responses to arginine infusion in children with protein-energy malnutrition before and after nutritional rehabilitation.

    abstract::Serum insulin, growth hormone (GH), insulin-like growth factors (IGFs) I and II, cortisol, and albumin concentrations were measured in 15 children with kwashiorkor, 15 with marasmic-kwashiorkor, and 21 with marasmus, before and in the survivors, after nutritional rehabilitation, as well as in 10 underweight and eight ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198611000-00012

    authors: Soliman AT,Hassan AE,Aref MK,Hintz RL,Rosenfeld RG,Rogol AD

    更新日期:1986-11-01 00:00:00

  • Intracellular calcium handling in cystic fibrosis: normal cytosolic calcium and intracellular calcium stores in neutrophils.

    abstract::We used quin2, a high affinity fluorescent calcium indicator to measure free cytosolic Ca++ in neutrophils isolated from fresh heparinized blood of 13 cystic fibrosis (CF) patients (age range 6-32 yr) and 11 healthy individuals (age range 25-41 yr) as controls. The mean value of free cytosolic Ca++ for CF patients was...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198519040-00006

    authors: Suter S,Lew PD,Ballaman J,Waldvogel FA

    更新日期:1985-04-01 00:00:00

  • Interaction between pulmonary surfactant and vernix: a potential mechanism for induction of amniotic fluid turbidity.

    abstract::The development of amniotic fluid turbidity during the third trimester is a known marker of fetal lung maturity. We hypothesized that this turbidity results from detachment of vernix caseosa from the fetal skin secondary to interaction with pulmonary-derived phospholipids in the amniotic fluid. To test this hypothesis...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-200007000-00021

    authors: Narendran V,Wickett RR,Pickens WL,Hoath SB

    更新日期:2000-07-01 00:00:00

  • The promise of a prophylactic Epstein-Barr virus vaccine.

    abstract::The worldwide burden of disease due to Epstein-Barr virus (EBV) infection is enormous. Diseases include endemic Burkitt lymphoma, infectious mononucleosis, cancers after transplantation, Hodgkin lymphoma, and nasopharyngeal carcinoma. A prophylactic EBV vaccine has the potential to significantly reduce the incidence a...

    journal_title:Pediatric research

    pub_type: 杂志文章,评审

    doi:10.1038/s41390-019-0591-5

    authors: Balfour HH Jr,Schmeling DO,Grimm-Geris JM

    更新日期:2020-01-01 00:00:00

  • A case of transient renal tubular acidosis type 1,4 hybrid RTA: a study of the pathophysiologic characteristics of the acidification defect.

    abstract::The diagnosis of transient renal tubular acidosis was made in a 16 months old boy. Bicarbonate titration studies revealed that the acidification defect consisted of an association of proximal and distal tubular acidosis. The effect of experimentally induced potassium depletion revealed that hyperkalemia contributed to...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-197910000-00020

    authors: Donckerwolcke RA,Valk C,van Wijngaarden-Penterman MJ,van Stekelenburg GJ

    更新日期:1979-10-01 00:00:00

  • Identification of Helicobacter pylori and the evolution of an efficacious childhood vaccine to protect against gastritis and peptic ulcer disease.

    abstract::Establishment of Helicobacter pylori infection as an etiologic agent of peptic ulcer disease and other gastric pathologies marked a revolution in gastroenterology which spurred an enormous interest in gastric physiology and immunology research. The association was soon also demonstrated in children as well. Applicatio...

    journal_title:Pediatric research

    pub_type: 杂志文章,评审

    doi:10.1038/pr.2016.199

    authors: Blanchard TG,Czinn SJ

    更新日期:2017-01-01 00:00:00

  • Uridine diphosphate hexoses in leukocytes and fibroblasts of classic galactosemics and patients with other metabolic diseases.

    abstract::To examine uridine diphosphate hexose (UDPhexose) content of cells that have more complete metabolic patterns than erythrocytes, which have been commonly used in the study of galactosemia, the concentrations of uridine diphosphate galactose (UDPgalactose) and uridine diphosphate glucose (UDPglucose) were determined in...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199411000-00014

    authors: Gibson JB,Reynolds RA,Palmieri MJ,States B,Berry GT,Segal S

    更新日期:1994-11-01 00:00:00

  • Partially restricted antitoxins of tetanus and diphtheria in man.

    abstract::Antibodies of restricted specificity have been identified in the human in response to certain antigens. The present study analyzed tetanus and diphtheria antitoxins isolated from selected human sera and suggested a restricted response in antibody production to each of these antigens. Purified antibodies from eight ser...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-197712000-00009

    authors: Nathenson G,Litwin SD

    更新日期:1977-12-01 00:00:00

  • Short-term (0-48 h) effects of maternal betamethasone administration on fetal heart rate and its variability.

    abstract::The short-term (0-48 h) effects of maternal betamethasone administration on computerized fetal heart rate (FHR) parameters were studied in 36 pregnancies at increased risk for preterm delivery. FHR was recorded for 90 min immediately before the start of betamethasone treatment and again at 6-h intervals during the nex...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/01.PDR.0000155948.83570.EB

    authors: Lunshof MS,Boer K,Wolf H,Koppen S,Velderman JK,Mulder EJ

    更新日期:2005-04-01 00:00:00

  • Effects of acute hypercapnia on maternal and fetal vasopressin and catecholamine release.

    abstract::Although fetal asphyxia, i.e. hypoxemia, acidosis, and hypercapnia, increases plasma arginine vasopressin (AVP) greater than 40-fold, hypoxemia and metabolic acidosis occurring independently cause only 5-fold and 2-fold increases, respectively. To determine the effects of hypercapnia on AVP release, we examined the ef...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199110000-00014

    authors: Faucher DJ,Laptook AR,Porter JC,Rosenfeld CR

    更新日期:1991-10-01 00:00:00

  • Effect of racemic epinephrine on ventilatory function in the neonate postextubation.

    abstract::The use of nebulized racemic epinephrine to improve ventilatory function in the newborn postextubation was studied. Forty-five infants intubated for more than 3 days were randomized to receive racemic epinephrine by nebulization immediately postextubation or to receive only warmed, humidified gas. Measurements of air ...

    journal_title:Pediatric research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1203/00006450-198704000-00012

    authors: Courtney SE,Wachtl JP,Hopson JF,Siervogel RM

    更新日期:1987-04-01 00:00:00