Placental phenotypes of intrauterine growth.

Abstract:

:The placenta is essential to nutrition before birth. Recent work has shown that a range of clearly defined alterations can be found in the placentas of infants with intrauterine growth restriction (IUGR). In the mouse, a placental specific knockout of a single imprinted gene, encoding IGF-2, results in one pattern of alterations in placenta structure and function which leads to IUGR. We speculate that the alterations in the human placenta can also be grouped into patterns, or phenotypes, that are associated with specific patterns of fetal growth. Identifying the placental phenotypes of different fetal growth patterns will improve the ability of clinicians to recognize high-risk patients, of laboratory scientists to disentangle the complexities of IUGR, and of public health teams to target interventions aimed at ameliorating the long-term adverse effects of inadequate intrauterine growth.

journal_name

Pediatr Res

journal_title

Pediatric research

authors

Sibley CP,Turner MA,Cetin I,Ayuk P,Boyd CA,D'Souza SW,Glazier JD,Greenwood SL,Jansson T,Powell T

doi

10.1203/01.PDR.0000181381.82856.23

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

827-32

issue

5

eissn

0031-3998

issn

1530-0447

pii

01.PDR.0000181381.82856.23

journal_volume

58

pub_type

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