Proteomic biomarkers of intra-amniotic inflammation: relationship with funisitis and early-onset sepsis in the premature neonate.

abstract：:A sensitive and rapid high-performance liquid chromatography method for determining lecithin/sphingomyelin (L/S) ratios in small volume tracheal aspirates has been evaluated in 115 infants sampled within 3 h of delivery. Respiratory distress syndrome was present in 41 infants and all had L/S ratios of less than or equ...

journal_title：Pediatric research

authors： D'Costa M,Dassin R,Bryan H

更新日期：1987-08-01 00:00:00

abstract：:11-Beta hydroxysteroid dehydrogenase type 2 (HSD2) oxidizes the biologically active glucocorticoid (GC), cortisol, to inactive cortisone. We characterized HSD2 gene expression and activity in human adult and fetal lung tissues and in cultured fetal lung explants, and examined the potential regulation of HSD2 in the fe...

journal_title：Pediatric research

authors： Garbrecht MR,Klein JM,McCarthy TA,Schmidt TJ,Krozowski ZS,Snyder JM

更新日期：2007-07-01 00:00:00

abstract：:Five patients with Bartter's syndrome were investigated. Sodium restriction (less than 10 mEq/day for at least 5 days) showed a renal sodium wastage in only two patients (I and II) in spite of increased aldosterone secretion rate (from 151-427 to 680-842 mug/day). The effect of angiotensin II (A II) 80ng/kg/min for 30...

journal_title：Pediatric research

authors： Sann L,David M,Richard P,Floret D,Sassard J,Bizollon CA,Francois R

更新日期：1976-12-01 00:00:00

abstract：:This work examines the dynamic surface pressure-area behavior of films of unconjugated bilirubin spread from chloroform solution at 22 degrees C on 0.15 M NaCl and buffered phosphate subphases. Film behavior is examined at pH 5.5, 7.4 and 8.0. The interactions of bilirubin in mixed films with dipalmitoyl phosphatidylc...

journal_title：Pediatric research

authors： Notter RH,Shapiro DL,Taubold R,Chen J

更新日期：1982-02-01 00:00:00

abstract：BACKGROUND:Macrosomia and child obesity are growing health-care issues worldwide. The purpose of the study was to evaluate how extremely high or low birth weight affects metabolic markers evaluated in newborn screening. METHODS:The study was register-based and included full-term singletons born in Iceland from 2009 to...

journal_title：Pediatric research

authors： Vidarsdottir H,Thorkelsson T,Halldorsson TI,Bjarnason R,Geirsson RT,Rinaldo P,Franzson L

更新日期：2020-06-29 00:00:00

abstract：:We have previously demonstrated that enterally administered heparin-binding EGF-like growth factor (HB-EGF) produced in Escherichia coli decreases the incidence and severity of intestinal injury in a neonatal rat model of necrotizing enterocolitis (NEC). In preparation for upcoming human clinical trials, large-scale p...

journal_title：Pediatric research

authors： Radulescu A,Zorko NA,Yu X,Besner GE

更新日期：2009-04-01 00:00:00

abstract：:Active compression-decompression (ACD) cardiopulmonary resuscitation (CPR) with the inspiratory threshold valve (ITV) has been recently recommended by the American Heart Association for treatment of adults in cardiac arrest (class IIb: alternative, useful intervention), but this new technique has never been used in a ...

journal_title：Pediatric research

authors： Voelckel WG,Lurie KG,Sweeney M,McKnite S,Zielinski T,Lindstrom P,Peterson C,Wenzel V,Lindner KH

更新日期：2002-04-01 00:00:00

abstract：:Human GH is encoded by the GH-1 gene which belongs to the GH gene cluster encompassing a distance of about 65 kb on the long arm of chromosome 17. Familial isolated growth hormone deficiency (IGHD) is associated with at least four Mendelian disorders. These include two forms that have autosomal recessive inheritance (...

journal_title：Pediatric research

authors： Wagner JK,Eblé A,Hindmarsh PC,Mullis PE

更新日期：1998-01-01 00:00:00

abstract：:We investigated early postnatal changes of the mesenteric circulation and its relationship to the systemic circulation in two groups of newborn infants. Group I (n = 10) was studied before the first feeding at 1 h and preprandially at 6 and 24 h. Group II (n = 10) was studied before the first feeding at 2 h of age and...

journal_title：Pediatric research

authors： Martinussen M,Brubakk AM,Linker DT,Vik T,Yao AC

更新日期：1994-09-01 00:00:00

abstract：:Chitosan is a natural, cationic polysaccharide derived from fully or partially deacetylated chitin. Chitosan is capable of inducing large phospholipid aggregates, closely resembling the function of nonionic polymers tested previously as additives to therapeutic lung surfactants. The effects of chitosan on improving th...

journal_title：Pediatric research

authors： Zuo YY,Alolabi H,Shafiei A,Kang N,Policova Z,Cox PN,Acosta E,Hair ML,Neumann AW

更新日期：2006-08-01 00:00:00

abstract：:Disorders affecting fetal growth are commonly associated with premature birth. IGFs and their binding proteins (IGFBPs) are potent regulators of fetal growth. In vitro evidence suggests that they regulate collagen turnover. Collagen turnover can be monitored by serum markers of type I collagen synthesis (PINP) and deg...

journal_title：Pediatric research

authors： Kajantie E,Hytinantti T,Koistinen R,Risteli J,Rutanen EM,Seppälä M,Andersson S

更新日期：2001-04-01 00:00:00

abstract：:Television viewing (TVV) is considered a contributing factor to the development of childhood obesity yet it is unclear whether obesity results, in part, from increased energy intake during TVV. The objective of this study was to determine the effect of TVV on food intake (FI) of boys at a meal and its effect on calori...

journal_title：Pediatric research

authors： Bellissimo N,Pencharz PB,Thomas SG,Anderson GH

更新日期：2007-06-01 00:00:00

abstract：:The use of tissue engineering to develop new urinary bladder could have direct impact on children suffering from congenital bladder dysfunction. Current bladder tissue engineering protocols rely on scaffolds to support the ingrowth of new cells and the subsequent development of new tissues. The interaction between cel...

journal_title：Pediatric research

authors： Roth CC

更新日期：2010-05-01 00:00:00

abstract：:BackgroundSpecific HLA-DQ genes have been recognized as necessary - but not sufficient - factors for the occurrence of Celiac Disease (CD). Through a meta-analysis, evaluating the distribution of CD-related HLA genotypes in children, we aimed at providing insights for a potential widened screening strategy.MethodsAfte...

journal_title：Pediatric research

authors： De Silvestri A,Capittini C,Poddighe D,Valsecchi C,Marseglia G,Tagliacarne SC,Scotti V,Rebuffi C,Pasi A,Martinetti M,Tinelli C

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Clinicians could modify dietary interventions during early infancy by monitoring fat and fat-free mass accretion in very preterm infants. METHODS:Preterm infants were randomly assigned to either having reports on infant body composition available to the clinicians caring for them (intervention group) or not...

journal_title：Pediatric research

authors： Salas AA,Jerome ML,Chandler-Laney P,Ambalavanan N,Carlo WA

更新日期：2020-11-01 00:00:00

abstract：:Neutrophils contribute to ischemic brain injury in adult animals. The role of neutrophils in perinatal hypoxic-ischemic (HI) brain injury is unknown. Allopurinol reduces neutrophil accumulation after tissue ischemia and is protective against HI brain injury. This study was designed to investigate how neutrophils contr...

journal_title：Pediatric research

authors： Hudome S,Palmer C,Roberts RL,Mauger D,Housman C,Towfighi J

更新日期：1997-05-01 00:00:00

abstract：:In the original article, the legend within Fig. 3 incorrectly read as '*p < 0.10, **p < 0.05, ***p > 0.01'. This has now been changed to '*p < 0.10, **p < 0.05, ***p < 0.01'. This has been corrected in both the PDF and HTML versions of the Article. The authors would like to apologise for this error. ...

journal_title：Pediatric research

authors： Benavides A,Metzger A,Tereshchenko A,Conrad A,Bell EF,Spencer J,Ross-Sheehy S,Georgieff M,Magnotta V,Nopoulos P

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Neonatal seizures can result in chronic epilepsy and long-term behavioral and cognitive deficits. Levetiracetam (LEV), an antiepileptic drug that binds to the synaptic vesicle protein 2A (SV2A), has been increasingly used off-label for the therapy of neonatal seizures. Preclinical data regarding the acute or...

journal_title：Pediatric research

authors： Talos DM,Chang M,Kosaras B,Fitzgerald E,Murphy A,Folkerth RD,Jensen FE

更新日期：2013-01-01 00:00:00

abstract：:The odds risk of vertical transmission of human immunodeficiency virus (HIV) to preterm infants is almost four times that of term infants and may relate to maternal and neonatal factors. We characterized the competence of early nonspecific cellular immunity, namely natural killer cytotoxicity (NKC) and antibody-depend...

journal_title：Pediatric research

authors： Merrill JD,Sigaroudinia M,Kohl S

更新日期：1996-09-01 00:00:00

abstract：:Monocyte chemoattractant protein-1 (MCP-1), acting through its C-C chemokine receptor 2 (CCR-2), has important roles in inflammation, angiogenesis, and wound repair. The individual and combined effects of inhaled nitric oxide (NO) and hyperoxia on lung MCP-1 and CCR-2 in relation to lung leukocyte dynamics are unknown...

journal_title：Pediatric research

authors： Ekekezie II,Thibeault DW,Garola RE,Truog WE

更新日期：2001-11-01 00:00:00

abstract：:The fibroblast of the fetal and neonatal lung is intimately involved with lung development and function. Additionally, the perinatal rat lung fibroblast is a significant source of prostaglandins (PG) I2 and E2, which in turn affect lung development and function. Their effects may be mediated by cAMP. We, therefore, te...

journal_title：Pediatric research

authors： Teixeira FJ,Bevan ML,Olson DM

更新日期：1992-04-01 00:00:00

abstract：:Hereditary surfactant protein B (SP-B) deficiency has been lethal in the first year of life without lung transplantation. We tested the hypothesis that SP-B gene mutations may result in milder phenotypes by investigating the mechanisms for lung disease in two children with less severe symptoms than have been previousl...

journal_title：Pediatric research

authors： Dunbar AE 3rd,Wert SE,Ikegami M,Whitsett JA,Hamvas A,White FV,Piedboeuf B,Jobin C,Guttentag S,Nogee LM

更新日期：2000-09-01 00:00:00

abstract：:The objective of the present study is to compare the emergence of a circadian respiratory pattern in subsequent siblings of SIDS and controls infants to see whether the unique time and age of SIDS is correlated with altered circadian manifestations. During the first three months of life, a pattern in respiratory rates...

journal_title：Pediatric research

authors： Hoppenbrouwers T,Jensen DK,Hodgman JE,Harper RM,Sterman MB

更新日期：1980-04-01 00:00:00

abstract：BACKGROUND:Previous studies indicate an increased risk for neuropsychological difficulties in young children prenatally exposed to opioids and polysubstances, but longitudinal information is scarce. The present longitudinal study investigated whether these waned, persisted, or increased over time. METHODS:The cognitiv...

journal_title：Pediatric research

authors： Nygaard E,Moe V,Slinning K,Walhovd KB

更新日期：2015-09-01 00:00:00

abstract：:Meconium aspiration syndrome (MAS) is a serious condition in newborns, associated with a poorly characterized inflammatory reaction. The aim of this study was to investigate a possible role for complement in pulmonary pathophysiology and systemic inflammation in experimental MAS. MAS was induced by instillation of mec...

journal_title：Pediatric research

authors： Lindenskov PH,Castellheim A,Aamodt G,Saugstad OD,Mollnes TE

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:The aim of this study was to determine whether small-for-gestational-age (SGA) infants born very prematurely had increased respiratory morbidity in the neonatal period and at follow-up. METHODS:Data were examined from infants recruited into the United Kingdom Oscillation Study (UKOS). Of the 797 infants who...

journal_title：Pediatric research

authors： Peacock JL,Lo JW,D'Costa W,Calvert S,Marlow N,Greenough A

更新日期：2013-04-01 00:00:00

abstract：:The present study aimed to test whether an acute period of asphyxia during birth in the rat results in long-term alterations in CNS function. Morphologic studies have indicated that the hippocampus is particularly vulnerable to perinatal anoxia. Thus, the present study tested adult rats, which had undergone acute birt...

journal_title：Pediatric research

authors： Boksa P,Krishnamurthy A,Brooks W

更新日期：1995-04-01 00:00:00

abstract：:The head sizes of 38 patients, growth hormone (GH) deficient following craniospinal (n = 26) or cranial irradiation (n = 12), have been assessed before (n = 38) and on completion of GH therapy (n = 15) or at the end of a similar period of observation without GH (n = 7). These results were compared to the change in hea...

journal_title：Pediatric research

authors： Clayton PE,Shalet SM,Price DA,Surtees RA,Pearson D

更新日期：1987-10-01 00:00:00

abstract：:Compliant immature airways sustain significant deformation following positive pressure ventilation. To evaluate the structural changes induced by in vivo positive pressure ventilation, tracheae of preterm lambs (107-116 d gestational age) were studied histologically. Nonventilated (group I: n = 7) and ventilated (grou...

journal_title：Pediatric research

authors： Deoras KS,Wolfson MR,Bhutani VK,Shaffer TH

更新日期：1989-11-01 00:00:00

abstract：:Neonatal hypoxic-ischemic encephalopathy (HIE) is a clinically defined neurological condition after lack of oxygen and often associated with cardiac dysfunction in term infants. Therapeutic hypothermia (HT) after birth is neuroprotective in infants with HIE. However, it is not known whether HT is also cardioprotective...

journal_title：Pediatric research

authors： Liu X,Tooley J,Løberg EM,Suleiman MS,Thoresen M

更新日期：2011-10-01 00:00:00