Pentoxifylline in regional cerebral ischemia in cats.

Abstract:

:The effect of pentoxifylline on regional cerebral ischemia was evaluated in 22 cats. In one group of 10 cats the middle cerebral artery (MCA) was occluded by a transorbital approach, and the cats were maintained on an intensive care protocol for 48 h. Pentoxifylline 10 mg.kg-1 initiated intravenously 30 min post-occlusion and followed by 6.3 mg.kg-1.h-1 for 48 h failed improve the neurologic outcome or infarct size when compared to controls. In another group of 12 cats with the same ischemic lesion, regional cerebral blood flow in the anterior (ischemic) area and an ipsilateral parieto-occipital region was measured by 133Xe wash-out after intra-arterial injection. MCA occlusion reduced the anterior flow by 50% from a mean control value of 62.7 ml.100 g-1.min-1 to 31.9 ml.100 g-1.min-1. The parieto-occipital flow was reduced by 20-30%, probably due to diaschisis. Pentoxifylline produced only a brief, although approximately 50%, increase in flow detected over both brain regions and failed to improve the cerebral energy stores as measured 150 min following MCA occlusion. From the neurologic, blood flow and metabolic data, it is concluded that pentoxifylline failed to affect cerebral ischemia favorably in cats.

authors

Steen PA,Milde JH,Michenfelder JD

doi

10.1111/j.1399-6576.1982.tb01722.x

subject

Has Abstract

pub_date

1982-02-01 00:00:00

pages

39-43

issue

1

eissn

0001-5172

issn

1399-6576

journal_volume

26

pub_type

杂志文章
  • The redistribution of granulocytes following E. coli endotoxin induced sepsis.

    abstract::Infusion of endotoxin elicits granulocytopenia followed by increased numbers of granulocytes in peripheral blood. The purpose of this study was to investigate the redistribution and sequestration of granulocytes in the tissues following E. coli endotoxin induced sepsis. From 16 rabbits granulocytes were isolated, labe...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1994.tb04017.x

    authors: Toft P,Lillevang ST,Tønnesen E,Nielsen CH,Rasmussen JW

    更新日期:1994-11-01 00:00:00

  • Lactate levels predict mortality and need for peritoneal dialysis in children undergoing congenital heart surgery.

    abstract:BACKGROUND:The purpose of this study was to investigate whether an initial post-operative lactate level is a predictor of mortality, need for peritoneal dialysis (PD), duration of intubation or length of stay (LOS) in the intensive care unit (ICU) in children undergoing cardiac surgery. METHOD:A retrospective, observa...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2011.02588.x

    authors: Maarslet L,Møller MB,Dall R,Hjortholm K,Ravn H

    更新日期:2012-04-01 00:00:00

  • Lumbar versus thoracic epidural buprenorphine for postoperative analgesia following coronary artery bypass graft surgery.

    abstract:BACKGROUND:Thoracic epidural analgesia (TEA) is reported to provide effective analgesia following cardiac surgery. We compared the effect of buprenorphine (BN) through the lumbar and thoracic epidural routes for postoperative analgesia following coronary artery bypass graft surgery (CABG). METHODS:Forty patients with ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1034/j.1399-6576.1999.430404.x

    authors: Mehta Y,Juneja R,Madhok H,Trehan N

    更新日期:1999-04-01 00:00:00

  • Monitoring functional residual capacity (FRC) by quantifying oxygen/carbon dioxide fluxes during a short apnea.

    abstract:BACKGROUND:Clinically applicable methods for measuring FRC are currently lacking. This study presents a new method for FRC monitoring based on quantification of metabolic gas fluxes of O2 and CO2 during a short apnea. METHODS:Base line exchange of oxygen and carbon dioxide was measured with indirect calorimetry. End-t...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1399-6576.2002.460617.x

    authors: Stenqvist O,Olegård C,Søndergaard S,Odenstedt H,Kárason S,Lundin S

    更新日期:2002-07-01 00:00:00

  • Low dose intrathecal morphine effects on post-hysterectomy pain: a randomized placebo-controlled study.

    abstract:BACKGROUND:Spinal anesthesia with different doses of intrathecal morphine has been shown to relieve post-operative pain. We studied in a prospective randomized, double-blind fashion the effects of morphine 0, 100, 200, or 300 μg added to intrathecal bupivacaine on first post-operative 24 h patient-controlled analgesia ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2011.02574.x

    authors: Hein A,Rösblad P,Gillis-Haegerstrand C,Schedvins K,Jakobsson J,Dahlgren G

    更新日期:2012-01-01 00:00:00

  • Is there an association between PONV and chemotherapy-induced nausea and vomiting?

    abstract:BACKGROUND:Drug-induced nausea and vomiting, both post-operatively and following chemotherapy, is often distressing for the patients. Our clinical impression is that certain patients are not prone to but instead protected against both post-operative and chemotherapy-induced nausea and vomiting (CINV). If support for th...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.12053

    authors: Oddby-Muhrbeck E,Öbrink E,Eksborg S,Rotstein S,Lönnqvist PA

    更新日期:2013-07-01 00:00:00

  • Post-void residual volume in labor: a prospective study comparing parturients with and without epidural analgesia.

    abstract:BACKGROUND:This prospective, non-randomized study compared post-void residual volume in laboring and postpartum women with or without epidural analgesia. METHODS:The study was conducted over 1 year with institutional review board approval. Parturients were recruited in early labor and self-selected to either the study...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2006.01122.x

    authors: Weiniger CF,Wand S,Nadjari M,Elchalal U,Mankuta D,Ginosar Y,Matot I

    更新日期:2006-11-01 00:00:00

  • Washout of sevoflurane from the GE Avance and Amingo Carestation anesthetic machines.

    abstract:BACKGROUND:Inhalational anesthetics must be removed from anesthetic machines to prevent malignant hyperthermia (MH) in susceptible patients or to treat MH occurring during inhalational general anesthesia. This study examines the sevoflurane washout from the GE Avance and Amingo Carestations™. METHODS:The care stations...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2011.02506.x

    authors: Brünner HW,Pohl S,Grond S

    更新日期:2011-10-01 00:00:00

  • Implementation of a trauma system in Norway: a national survey.

    abstract:BACKGROUND:Trauma systems have improved outcomes for injured patients, but might be challenging to implement. We assessed the implementation of a trauma system in Norway after recommendations for a national trauma system were published in 2007, with a focus on elements in acute care hospitals. METHODS:All hospitals in...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.12467

    authors: Dehli T,Gaarder T,Christensen BJ,Vinjevoll OP,Wisborg T

    更新日期:2015-03-01 00:00:00

  • Comparison of methohexital and pentobarbital for premedication in children.

    abstract::Thirty children scheduled for elective orchiopexy or herniotomy were consecutively assigned at random to premedication with methohexital 80 mg/ml, 20 mg/kg rectally, 15 min before transportation to the operating room, or pentobarbital 28 mg/ml, 7 mg/kg rectally, 45 min before transportation. The quality of premedicati...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1990.tb03127.x

    authors: Christensen PA,Balslev T,Hasselstrøm L

    更新日期:1990-08-01 00:00:00

  • Clonidine abolishes the adverse effects on apoptosis and behaviour after neonatal ketamine exposure in mice.

    abstract:BACKGROUND:An increasing amount of both experimental and epidemiological data indicates that neonatal anaesthesia causes disruption of normal brain development in rodents and primates, as manifested by acute increased apoptosis and long-lasting altered behaviour and learning. It is necessary to seek strategies that avo...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2012.02722.x

    authors: Pontén E,Viberg H,Gordh T,Eriksson P,Fredriksson A

    更新日期:2012-09-01 00:00:00

  • Successful vasoconstrictor therapy of anaphylactoid reactions during induction of anaesthesia. A report of two cases.

    abstract::Anaphylactoid reactions were evoked during intravenous induction of anaesthesia in two patients on three occasions. In the first patient the reaction occurred during the first anaesthetic on propranolol and hydrochlorthiazide medication due to hypertension. Since the major target organ for the anaphylactoid reaction i...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1985.tb02272.x

    authors: Pontén J,Biber B,Henriksson BA

    更新日期:1985-08-01 00:00:00

  • Ultrasound-guided technique allowed early detection of intravascular injection during an infraclavicular brachial plexus block.

    abstract::The reported incidence of complications after peripheral nerve blocks is generally low and varies from 0% to 5%. The injuries related to brachial plexus block are perhaps more commonly reported, than after peripheral blocks of the lower extremity nerves. Recent reports suggest that expert ultrasound guidance may reduc...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2009.01981.x

    authors: Martínez Navas A,DE LA Tabla González RO

    更新日期:2009-08-01 00:00:00

  • Blockade of endogenous nitric oxide production results in moderate hypertension, reducing sympathetic activity and shortening bleeding time in healthy volunteers.

    abstract:BACKGROUND:Short-term infusion of NG-monomethyl-L-arginine (L-NMMA) reversibly inhibits endogenous nitric oxide (NO) production in humans. We studied responses to more long-lasting (60 min) infusions, at doses high enough to cause effective inhibition of endogenous NO. METHODS:Eight healthy volunteers had catheters (p...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1997.tb04852.x

    authors: Albert J,Schedin U,Lindqvist M,Melcher A,Hjemdahl P,Frostell C

    更新日期:1997-10-01 00:00:00

  • Right ventricular end-systolic pressure-volume relation during propofol infusion.

    abstract::The effects of propofol on right ventricular function were studied in 11 ICU patients who needed sedation for acute respiratory failure or neurological diseases. Right ventricular function was studied using a thermodilution method at patients' bedside. Right ventricular ejection fraction (RVEF), cardiac output (CO), r...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1994.tb03878.x

    authors: Martin C,Perrin G,Saux P,Papazian L,Albanese J,Gouin F

    更新日期:1994-04-01 00:00:00

  • Changes of endothelin concentration in cerebrospinal fluid and plasma of patients with aneurysmal subarachnoid hemorrhage.

    abstract::To investigate the clinical significance of endothelin (ET), a potent vasoconstrictor peptide, in subarachnoid hemorrhage (SAH) and SAH-related cerebral vasospasm, we measured the ET-like immunoreactivity (ET-LI) in plasma and cerebrospinal fluid (CSF) obtained serially from patients with SAH due to ruptured cerebral ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1994.tb03929.x

    authors: Shirakami G,Magaribuchi T,Shingu K,Kim S,Saito Y,Nakao K,Mori K

    更新日期:1994-07-01 00:00:00

  • The effect of isoflurane on cerebrospinal fluid pressure in patients undergoing neurosurgery.

    abstract::Ten patients with intracerebral tumours (TC) and 13 patients with subarachnoid haemorrhage (SAH) from a ruptured cerebral arterial aneurysm were studied before intracranial surgery, and during a 3-h postoperative period. Cerebrospinal fluid pressure (CSFP) determined by an intraventricular (TC group) or intraspinal (S...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1988.tb02696.x

    authors: Gordon E,Lagerkranser M,Rudehill A,von Holst H

    更新日期:1988-02-01 00:00:00

  • Intermittent pneumatic foot compression can activate blood fibrinolysis without changes in blood coagulability and platelet activation.

    abstract:BACKGROUND:Intermittent pneumatic foot compression (IPC) is a useful technique for prophylaxis of peri-operative venous thromboembolism. The aim of this study was to determine the effect of IPC on blood coagulation/fibrinolysis and platelet function using a blood viscometer (Sonoclot) and a platelet aggregation monitor...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-6576.2005.00661.x

    authors: Kohro S,Yamakage M,Sato K,Sato JI,Namiki A

    更新日期:2005-05-01 00:00:00

  • Initial fluid resuscitation of patients with septic shock in the intensive care unit.

    abstract:BACKGROUND:Fluid is the mainstay of resuscitation of patients with septic shock, but the optimal composition and volume are unknown. Our aim was to evaluate the current initial fluid resuscitation practice in patients with septic shock in the intensive care unit (ICU) and patient characteristics and outcome associated ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2011.02399.x

    authors: Carlsen S,Perner A,East Danish Septic Shock Cohort Investigators.

    更新日期:2011-04-01 00:00:00

  • Ropivacaine 1 mg/ml, plus fentanyl 2 microg/ml for epidural analgesia during labour. Is mode of administration important?

    abstract:BACKGROUND:Patient-controlled epidural analgesia (PCEA) with a moderate to high concentration of bupivacaine in obstetrics has been shown to give comparable analgesia and even higher level of satisfaction compared to continuous epidural infusion. We hypothesised that the use of a very low concentration technique (ropiv...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1034/j.1399-6576.2001.045005595.x

    authors: Smedvig JP,Soreide E,Gjessing L

    更新日期:2001-05-01 00:00:00

  • Comparison of fentanyl and halothane as supplement to nitrous-oxide-oxygen anaesthesia for coronary artery surgery.

    abstract::Twenty unselected patients suffering from incapacitating angina, in spite of medication with nitrates, beta-blockers and calcium antagonists, were studied before and during coronary artery bypass surgery. Fentanyl or halothane was randomly used in combination with nitrous oxide for maintenance of anaesthesia in order ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1985.tb02152.x

    authors: Fischerström A,Ohqvist G,Settergren G

    更新日期:1985-01-01 00:00:00

  • Severe ARDS may cause right heart failure with extreme hepatomegaly but without hepatic failure.

    abstract::A young trauma patient developed severe adult respiratory distress syndrome (ARDS), right heart failure, hepatic congestion and an extreme hepatomegaly but no hepatic failure. The patient needed 100% oxygen during ventilatory support for 80 days and was weaned from the ventilator after more than 100 days. The hepatome...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1399-6576.2002.460724.x

    authors: Søreide E,Harboe S,Søndenaa K

    更新日期:2002-08-01 00:00:00

  • Depth of a central venous catheter tip: length of insertion guideline for pediatric patients.

    abstract:BACKGROUND:In pediatric patients, several studies have been undertaken to establish central venous catheter (CVC) tip optimal depth. Assessments of catheter tip position using chest radiographs may be misleading, whereas transesophageal echocardiography (TEE) has been shown to accurately monitor catheter tip placement ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2006.00951.x

    authors: Yoon SZ,Shin TJ,Kim HS,Lee J,Kim CS,Kim SD,Park CD

    更新日期:2006-03-01 00:00:00

  • Stability of an epidural analgesic solution containing adrenaline, bupivacaine and fentanyl.

    abstract:BACKGROUND:A low dose solution of adrenaline 2 microg x ml(-1), fentanyl 2 microg x ml(-1) and bupivacaine 1 mg x ml(-1) has been reported to give superior pain control when used for epidural analgesia after major surgery. The present paper describes the compounding and chemical stability of this triple-component solut...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1399-6576.2000.440713.x

    authors: Kjønniksen I,Brustugun J,Niemi G,Breivik H,Anderssen E,Klem W

    更新日期:2000-08-01 00:00:00

  • Efficacy of simulation-based trauma team training of non-technical skills. A systematic review.

    abstract::Trauma resuscitation is a complex situation, and most organisations have multi-professional trauma teams. Non-technical skills are challenged during trauma resuscitation, and they play an important role in the prevention of critical incidents. Simulation-based training of these is recommended. Our research question wa...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/aas.12336

    authors: Gjeraa K,Møller TP,Østergaard D

    更新日期:2014-08-01 00:00:00

  • Is there a risk of sensitization and allergy to chlorhexidine in health care workers?

    abstract:BACKGROUND:In Denmark, chlorhexidine is the standard disinfectant in most hospitals and health care workers are repeatedly exposed to it. The aim of this study was to establish whether there is a risk of sensitization and allergy to chlorhexidine from this type of exposure. METHODS:Two hundred and forty-eight doctors,...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1034/j.1399-6576.2003.00150.x

    authors: Garvey LH,Roed-Petersen J,Husum B

    更新日期:2003-07-01 00:00:00

  • Relationship between stroke volume, cardiac output and filling of the heart during tilt.

    abstract:BACKGROUND:Cardiac function curves are widely accepted to apply to humans but are not established for the entire range of filling of the heart that can be elicited during head-up (HUT) and head-down tilt (HDT), taken to represent minimal and maximal physiological filling of the heart, respectively. With the supine rest...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2009.02062.x

    authors: Bundgaard-Nielsen M,Sørensen H,Dalsgaard M,Rasmussen P,Secher NH

    更新日期:2009-11-01 00:00:00

  • The effect of thoracic epidural analgesia on respiratory function after cholecystectomy.

    abstract::To assess the effect of thoracic epidural analgesia (TEA) on postoperative respiratory function and pulmonary complications, a prospective randomized trial was conducted in patients undergoing cholecystectomy. One hundred patients were allocated to TEA (n = 30), TEA + general anesthesia (TEA + GA) (n = 30), or general...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1987.tb02637.x

    authors: Hendolin H,Lahtinen J,Länsimies E,Tuppurainen T,Partanen K

    更新日期:1987-10-01 00:00:00

  • Comparison of pituitary-adrenocortical response to hypoglycaemia and surgery.

    abstract::The hypothalamic-pituitary-adrenocortical (HPA) responses to the hypoglycaemic stimulus and to operation (laparotomy) are compared. The studies were carried out in eight patients who were subjected to insulin-induced hypoglycaemia on the day before elective abdominal surgery. Plasma corticotrophin (ACTH) and plasma co...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1979.tb01428.x

    authors: Blichert-Toft M,Christiansen C,Engquist A,Kehlet H,Lindholm J,Hummer L,Dinesen B

    更新日期:1979-02-01 00:00:00

  • Recovery characteristics of sevoflurane or halothane for day-case anaesthesia in children aged 1-3 years.

    abstract:BACKGROUND:Our objective was to compare the recovery characteristics of sevoflurane and halothane for short day-case anaesthesia in a specifically limited age group of children 1-3 yr. METHODS:Eighty unpremedicated children undergoing day-case adenoidectomy were randomly assigned to receive inhalational induction with...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1034/j.1399-6576.2000.440118.x

    authors: Viitanen H,Baer G,Annila P

    更新日期:2000-01-01 00:00:00