Initial fluid resuscitation of patients with septic shock in the intensive care unit.


BACKGROUND:Fluid is the mainstay of resuscitation of patients with septic shock, but the optimal composition and volume are unknown. Our aim was to evaluate the current initial fluid resuscitation practice in patients with septic shock in the intensive care unit (ICU) and patient characteristics and outcome associated with fluid volume. METHODS:This was a prospective, cohort study of all patients with septic shock (n=132) admitted in six ICUs during a 3-month period. Patients were divided into two groups according to the overall median volume of resuscitation fluid administered during the first 24 h after the diagnosis. Baseline characteristics, other treatments, monitoring and outcome were compared between the groups. RESULTS:The mean volume of resuscitation fluid was 4.9 l (median 4.0 l and SD 3.5). Patients in the higher volume group received more crystalloids (3.7 vs. 1.2 l, P<0.0001), colloids (1.8 vs. 0.9 l, P<0.0001), blood products (1.8 vs. 0.6 l, P=0.0004), a higher maximum vasopressor dose (0.37 vs. 0.21 μg/kg/min, P<0.0001) and had a higher initial plasma concentration of lactate (4.0 vs. 3.0 mM, P=0.009) compared with the lower volume group. Simplified acute physiology score II in the lower and higher dose group were 52 and 58 (P=0.07). There were no differences in 30-, 90- or 365-day mortality between the two fluid volume groups. CONCLUSION:In the ICU, patients with septic shock were resuscitated with a combination of crystalloids, colloids and blood products. Although the more severely shocked patients received higher volumes of crystalloids, colloids and blood products, mortality did not differ between the groups.


Carlsen S,Perner A,East Danish Septic Shock Cohort Investigators.




Has Abstract


2011-04-01 00:00:00












  • High-frequency oscillatory ventilation combined with intermittent mandatory ventilation in critically ill neonates and infants.

    abstract::We have evaluated the high-frequency oscillatory ventilation (HFOV) combined with intermittent mandatory ventilation (IMV) in critically ill neonates and infants using the Babylog 8000 SW 4.0. We used HFOV combined with IMV as a rescue mode in 10 neonates and infants aged 1 day to 17 months, who were receiving maximal...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Murthy BV,Petros AJ

    更新日期:1996-07-01 00:00:00

  • Thoracic epidural analgesia via the lumbar approach using nerve stimulation in a pediatric patient with Down syndrome.

    abstract::This case illustrates the threading of an epidural catheter with electrical stimulation guidance from the lumbar epidural space to the thoracic space in a pediatric patient. A 17-year-old boy with Down syndrome, weighing 48 kg, was scheduled to undergo a laparotomy for duodenal obstruction and gastrostomy tube inserti...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Tsui BC,Entwistle L

    更新日期:2005-05-01 00:00:00

  • Non-transport emergency medical service missions - a retrospective study based on medical charts.

    abstract:BACKGROUND:In Finland, approximately 40% of emergency medical service (EMS) missions do not result in transport of the patient to a hospital by ambulance, and there is wide variability in the reasons underlying non-transport decisions. The aim of this study was to describe the context of these EMS non-transport mission...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Pekanoja S,Hoikka M,Kyngäs H,Elo S

    更新日期:2018-05-01 00:00:00

  • Blood circulation in the kidney of the cat under methoxyflurane (penthrane) anaesthesia.

    abstract::In order to establish whether methoxyflurane causes any change in renal vascular resistance, the renal venous flow was measured by means of a drop recording technique in six cats under methoxyflurane anaesthesia. Arterial pressure was recorded simultaneously, and the renal vascular resistance was calculated. Methoxyfl...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Irestedt L,Westermark L,Wåhlin A

    更新日期:1975-01-01 00:00:00

  • Light-guided intubation via the intubating laryngeal mask using a prototype illuminated flexible catheter. Clinical experience in 400 patients.

    abstract:BACKGROUND:The transillumination of the soft tissues of the neck using lighted stylets has been used as an aid for tracheal intubation. We evaluated the efficacy and safety of a prototype illuminated flexible catheter to facilitate light-guided intubation through the intubating laryngeal mask. METHODS:The illuminated ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章


    authors: Dimitriou V,Voyagis GS

    更新日期:2000-09-01 00:00:00

  • Pharmacological evacuation of the stomach with metoclopramide.

    abstract::Children admitted for emergency operations because of trauma run a high risk of chemical aspiration pneumonitis syndrome. Fifty-eight children admitted for closed reduction of fractures and suturing of wounds were studied in a double-blind manner in order to see if metoclopramide could be of value in decreasing the ri...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章


    authors: Olsson GL,Hallén B

    更新日期:1982-10-01 00:00:00

  • Intravenous sedation for retrobulbar injection and eye surgery: diazepam and/or propofol?

    abstract::Principle goals of sedation for eye surgery are to provide patient comfort and to allow the patient to stay calm during both retrobulbar injection and surgery. Insufficient sedation may not prevent the patient from moving during retrobulbar injection, whereas very deep sedation may result in respiratory complications ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hampl KF,Marsch SC,Erb T,Drewe J,Schneider MC

    更新日期:1996-01-01 00:00:00

  • Vancomycin levels are frequently subtherapeutic in critically ill patients: a prospective observational study.

    abstract:BACKGROUND:Appropriate utilization of vancomycin is important to attain therapeutic targets while avoiding clinical failure and the development of antimicrobial resistance. Our aim was to observe the use of vancomycin in an intensive care population, with the main focus on achievement of therapeutic serum concentration...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Bakke V,Sporsem H,Von der Lippe E,Nordøy I,Lao Y,Nyrerød HC,Sandvik L,Hårvig KR,Bugge JF,Helset E

    更新日期:2017-07-01 00:00:00

  • The adequate rocuronium dose required for complete block of the adductor muscles of the thigh.

    abstract:BACKGROUND:Rocuronium can prevent the obturator jerk during transurethral resection of bladder tumors. We investigated the adequate rocuronium dose required for complete block of the thigh adductor muscles, and its correlation with individual responses of the adductor pollicis muscle to rocuronium. METHODS:Eleven pati...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Fujimoto M,Kawano K,Yamamoto T

    更新日期:2018-03-01 00:00:00

  • Intermittent pneumatic foot compression can activate blood fibrinolysis without changes in blood coagulability and platelet activation.

    abstract:BACKGROUND:Intermittent pneumatic foot compression (IPC) is a useful technique for prophylaxis of peri-operative venous thromboembolism. The aim of this study was to determine the effect of IPC on blood coagulation/fibrinolysis and platelet function using a blood viscometer (Sonoclot) and a platelet aggregation monitor...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章


    authors: Kohro S,Yamakage M,Sato K,Sato JI,Namiki A

    更新日期:2005-05-01 00:00:00

  • Serum cholinesterase activity in burned patients. II: anaesthesia, suxamethonium and hyperkalaemia.

    abstract::The importance of serum cholinesterase activity in burned patients was evaluated in relation to anaesthesia. Anaesthesia included a repeated administration of suxamethonium. Thirty-two patients with an estimated area of burn between 3 and 72% were studied during 39 anaesthetic procedures. A statistically significant i...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Viby-Mogensen J,Hanel HK,Hansen E,Graae J

    更新日期:1975-01-01 00:00:00

  • Influence of the type of anaesthesia on post-operative subjective physical well-being and mental function in elderly patients.

    abstract::Standardized behavioural observations were used to establish the influence of the type of anaesthesia on the mental function and the subjective physical well-being in 60 patients, all men, following urological surgery. The patients were randomized to two groups, receiving spinal or general anaesthesia. For evaluation ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Crul BJ,Hulstijn W,Burger IC

    更新日期:1992-10-01 00:00:00

  • Treatment of elevated intracranial pressure with indomethacin: friend or foe?

    abstract::Indomethacin has been suggested as a therapeutic tool to manage elevated intracranial pressure in patients with severe head injury and patients undergoing craniotomy for brain tumors. Indomethacin is a non-selective cyclooxygenase inhibitor. Compared to other cyclooxygenase inhibitors indomethacin has unique effects o...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,评审


    authors: Rasmussen M

    更新日期:2005-03-01 00:00:00

  • Circulatory monitoring of children during anaesthesia in low-field magnetic resonance imaging.

    abstract::Anaesthesia for patients in a Magnetic Resonance Imaging (MRI) scanner provides some problems for the design of both the anaesthetic and the monitoring equipment. This report presents a technique for continuously displaying the heart rate during anaesthesia for children in an MRI scanner. The monitoring system used li...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Selldén H,de Chateau P,Ekman G,Linder B,Sääf J,Wahlund LO

    更新日期:1990-01-01 00:00:00

  • Intraperitoneal lidocaine for postoperative pain after laparoscopy.

    abstract:BACKGROUND:A controversy exists over the effectiveness and clinical value of intraperitoneal local anaesthetics for treating pain after laparoscopic cholecystectomy. The use of intraperitoneal lidocaine was evaluated in this study. METHODS:At the end of surgery, 200 ml saline containing 200 mg lidocaine, or the same v...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Elhakim M,Elkott M,Ali NM,Tahoun HM

    更新日期:2000-03-01 00:00:00

  • Effects of prolonged anesthesia with enflurane or halothane on renal function in dogs.

    abstract::Elevated serum inorganic fluoride levels (60-300 mumol/l), maintained over 6 h, influenced renal function in beagle dogs. Changes in water reabsorption were seen with an increased urine flow and free water clearance and decreased urinary concentration capacity. Possible nephrotoxicity as an effect of inorganic fluorid...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Wickström I,Stefansson T

    更新日期:1981-06-01 00:00:00

  • Plasma vasopressin response to extracorporeal circulation in children.

    abstract::Plasma vasopressin levels were measured during open-heart surgery in nine children. The control value of vasopressin was 5.5 +/- 1.5 (s.e.mean) microU/ml. During extracorporeal circulation, a maximum 7.3-fold increase of plasma vasopressin level was demonstrated. This high level of vasopressin was considered to have c...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Yamashita M,Ishihara H,Kudo M,Matsuki A,Oyama T

    更新日期:1984-06-01 00:00:00

  • The effect of continuous intravenous indomethacin infusion on bleeding time and postoperative pain in patients undergoing emergency surgery of the lower extremities.

    abstract::Fifty-four orthopaedic patients were given either indomethacin (25-50 mg bolus plus infusion, 5-7.5 mg h-1) or only lactated Ringer solution intravenously over 20 h in a randomized and double-blind fashion. The study was started at the casualty department as soon as possible after the decision to operate was made. The...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Taivainen T,Hiller A,Rosenberg PH,Neuvonen P

    更新日期:1989-01-01 00:00:00

  • Blockade of endogenous nitric oxide production results in moderate hypertension, reducing sympathetic activity and shortening bleeding time in healthy volunteers.

    abstract:BACKGROUND:Short-term infusion of NG-monomethyl-L-arginine (L-NMMA) reversibly inhibits endogenous nitric oxide (NO) production in humans. We studied responses to more long-lasting (60 min) infusions, at doses high enough to cause effective inhibition of endogenous NO. METHODS:Eight healthy volunteers had catheters (p...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Albert J,Schedin U,Lindqvist M,Melcher A,Hjemdahl P,Frostell C

    更新日期:1997-10-01 00:00:00

  • Effect of different general anaesthetics on ventricular repolarisation in robot-assisted laparoscopic prostatectomy.

    abstract:BACKGROUND:Ventricular repolarisation is affected differently by the types of anaesthetics used. This study aimed to compare the effect of different types of anaesthetics on ventricular repolarisation during robot-assisted laparoscopic radical prostatectomy (RALP). METHODS:Sixty-nine patients were randomly assigned in...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Park JH,Lee KY,Choi YD,Lee J,Shin HJ,Han DW,Baek J,Kim SY

    更新日期:2020-10-01 00:00:00

  • Age-dependent decrease in desflurane concentration for maintaining bispectral index below 50.

    abstract:BACKGROUND:We examined the hypothesis that the minimum alveolar concentration of desflurane for maintaining bispectral index (BIS) below 50 (MACBIS 50 ) decreases with advance of age. METHODS:Sixty young (20-30 year), middle-aged (31-65 year) and elderly (66-80 year) patients were included (n = 20, each group). Five m...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Kanazawa S,Oda Y,Maeda C,Okutani R

    更新日期:2016-02-01 00:00:00

  • Circulation stabilizing therapy and pulmonary high-resolution computed tomography in a porcine brain-dead model.

    abstract:BACKGROUND:Currently 80% of donor lungs are not accepted for transplantation, often due to fluid overload. Our aim was to investigate if forced fluid infusion may be replaced by a new pharmacological therapy to stabilize circulation after brain death in an animal model, and to assess therapy effects on lung function an...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Bozovic G,Steen S,Sjöberg T,Schaefer-Prokop C,Verschakelen J,Liao Q,Höglund P,Siemund R,Björkman-Burtscher IM

    更新日期:2016-01-01 00:00:00

  • Long-term outcome after neurosurgically treated spinal epidural abscess following epidural analgesia.

    abstract:BACKGROUND:A recent investigation demonstrated a high incidence of epidural abscess secondary to epidural catheterization and a 50% frequency of neurologic deficits. We studied short- and long-term neurologic outcome in patients operated for spinal epidural abscess after epidural analgesia. METHODS:Nineteen patients w...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章


    authors: Wang LP,Hauerberg J,Schmidt JF

    更新日期:2001-02-01 00:00:00

  • Preoperative anaesthesia triage with a patient-centred system-A prospective clinical study.

    abstract:BACKGROUND:Increase in day surgery has challenged preoperative anaesthesia with need to identify a few high-risk patients requiring detailed preoperative intervention. We aimed to assess if a nurse-administered Preoperative Patient-centred Anaesthesia System (Pre-PAS) could identify high-risk patients, defined as ASA s...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Molin C,Rovsing ML,Meyhoff CS

    更新日期:2020-11-01 00:00:00

  • Effects of olprinone, a new phosphodiesterase inhibitor, on gastric intramucosal acidosis and systemic inflammatory responses following hypothermic cardiopulmonary bypass.

    abstract:BACKGROUND:Phosphodiesterase (PDE) III inhibitors have both an inotropic and a peripheral vasodilatory effect, and also inhibit the activation of macrophages. Thus a newly developed PDE III inhibitor, olprinone, could modify gastric intramucosal pH (pHi), systemic oxygen consumption, and systemic inflammatory responses...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Yamaura K,Akiyoshi K,Irita K,Taniyama T,Takahashi S

    更新日期:2001-04-01 00:00:00

  • Neuroleptic malignant syndrome with severe liver failure.

    abstract::A schizophrenic patient on long-time neuroleptic medication was admitted with ileus. Secondarily, a high fever, rigidity, mental confusion, tachycardia and hypotension developed. After bromocriptine was given, the temperature dropped by 2 degrees C and the patient improved markedly. A diagnosis of neuroleptic malignan...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Urving SH,Nielsen EW

    更新日期:2003-09-01 00:00:00

  • The conformity of an anatomically shaped endotracheal tube to the shape of the airway.

    abstract::The conformity of a pre-shaped endotracheal tube to the shape of the airway during endotracheal intubation was studied from lateral radiographs in patients lying supine on the operating table, with the neck in the normal, extended and flexed positions. A computer programme calculated the anterior contour of the pre-sh...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Alexopoulos C,Larsson SG,Lindholm CE

    更新日期:1983-08-01 00:00:00

  • Patient fear of anesthesia complications according to surgical type: potential impact on informed consent for anesthesia.

    abstract:BACKGROUND:Past research has explored patients' expectations about the informed consent process. However, it is currently unknown if the complexity of the surgical procedure influences the type of anesthesia-related risks that patients wish disclosed. This study explored fears of anesthesia-related complications and wh...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Burkle CM,Mann CE,Steege JR,Stokke JS,Jacob AK,Pasternak JJ

    更新日期:2014-11-01 00:00:00

  • Continuous spinal anesthesia/analgesia vs. single-shot spinal anesthesia with patient-controlled analgesia for elective hip arthroplasty.

    abstract:BACKGROUND:In total hip replacement surgery several anesthesiological techniques can be used. In this study we compared continuous spinal anesthesia (CSA) and postoperative analgesia vs. single-shot spinal anesthesia (SPA) and postoperative patient-controlled intravenous analgesia with morphine (SPA). METHODS:In a pro...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Maurer K,Bonvini JM,Ekatodramis G,Serena S,Borgeat A

    更新日期:2003-08-01 00:00:00

  • Incidence of transient hypoxia during pre-hospital rapid sequence intubation by anaesthesiologists.

    abstract:BACKGROUND:Pre-hospital tracheal intubation (TI) is an important but difficult procedure with the potential to produce hypoxaemia. The aim of this study was to determine the incidence of desaturation episodes during out-of-hospital rapid sequence induction (RSI) and TI by the medical team of a German Helicopter Emergen...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Helm M,Kremers G,Lampl L,Hossfeld B

    更新日期:2013-02-01 00:00:00