Can 4-aminopyridine be used to reverse anaesthesia and muscle relaxation?

Abstract:

:4-aminopyridine has earlier been shown to antagonize neuromuscular block and to release transmitters in CNS. In a study in man the drug was given intravenously at the end of anaesthesia in order to counteract muscle relaxation and possibly also anaesthesia. The effects were followed by clinical observations, intraarterial blood pressure recording, ECG, repetitive muscle nerve stimulation and EEG. It was shown that the drug could reverse the neuromuscular block in lightly curarized patients, but was not as efficient as synstigmine methylsulphate (Neostigmine). In two cases the drug produced a slowing of EEG activity, which was normalized by naloxone. No toxic effects of the drug were observed.

authors

Carlsson C,Rosén I,Nilsson E

doi

10.1111/j.1399-6576.1983.tb01911.x

subject

Has Abstract

pub_date

1983-02-01 00:00:00

pages

87-90

issue

1

eissn

0001-5172

issn

1399-6576

journal_volume

27

pub_type

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