Dose-response relationship for mivacurium in patients with phenotypically abnormal plasma cholinesterase activity.

Abstract:

:During thiopentone-fentanyl-nitrous oxide anaesthesia and using a cumulative design, we studied the dose-response relationship of mivacurium in 8 patients: 7 patients phenotypically homozygous for the atypical plasma cholinesterase gene and 1 patient homozygous for the silent gene. The estimated mean ED50 and ED95 were 15 and 20 micrograms.kg.bw-1 in patients homozygous for the atypical gene, and 13 and 16 micrograms.kg.bw-1 in the patient homozygous for the silent gene, respectively. The results indicate that mivacurium is 4-5 times more potent in patients homozygous for the atypical or the silent gene than in patients with normal plasma cholinesterase activity and phenotype.

authors

Ostergaard D,Jensen FS,Skovgaard LT,Viby-Mogensen J

doi

10.1111/j.1399-6576.1995.tb04220.x

subject

Has Abstract

pub_date

1995-11-01 00:00:00

pages

1016-8

issue

8

eissn

0001-5172

issn

1399-6576

journal_volume

39

pub_type

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