Abstract:
BACKGROUND:The aim of this study was to evaluate the efficacy of 1.5 mg/kg bolus of amrinone on low cardiac output (CO) state following emergence from cardiopulmonary bypass (CPB) in cardiac surgical patients. METHODS:Immediately after emergency from CPB, 14 patients with a cardiac index (CI) less than 2.2 l.min-1.m-2 despite administration of inotropes and nitroglycerin, received 1.5 mg/kg amrinone over 3 min without changing catecholamine infusion rates (amrinone group). Hemodynamics and left ventricular short axis views with transesophageal echocardiography were recorded at baseline, 3, 4, and 10 min following amrinone administration. Left ventricular filling volumes were maintained constant by volume reinfusion from the CPB reservoir. We matched the data of the amrinone group with the other 14 patients who did not receive amrinone (non-amrinone group) to evaluate the efficacy of amrinone in low CO state. RESULTS:At baseline, CI (1.8 +/- 0.1 l.min-1.m-2) in the amrinone group was significantly lower than CI (3.0 +/- 0.2) in the non-amrinone group. Following amrinone administration, CI and velocity of circumferential fibershortening corrected for heart rate (Vcfc) significantly increased, and systemic vascular resistance index and pulmonary vascular resistance index significantly decreased from the baseline within 10 min without changes in heart rate, mean arterial blood pressure, or pulmonary artery occlusion pressure, and became equivalent with those of the non-amrinone group. CONCLUSIONS:A 1.5 mg/kg amrinone loading dose to patients in a low CO state, despite catecholamine therapy immediately after emergence from CPB, effectively improves ventricular function when loading conditions are maintained constant.
journal_name
Acta Anaesthesiol Scandjournal_title
Acta anaesthesiologica Scandinavicaauthors
Kikura M,Levy JH,Bailey JM,Shanewise JS,Michelsen LG,Sadel SMdoi
10.1111/j.1399-6576.1998.tb05329.xsubject
Has Abstractpub_date
1998-08-01 00:00:00pages
825-33issue
7eissn
0001-5172issn
1399-6576journal_volume
42pub_type
杂志文章abstract:BACKGROUND:Ephedrine is one of the most commonly used non-catecholamine sympathomimetic agents. It is used in operating rooms and critical care settings worldwide. While it has many side effects, its ability to rapidly raise blood pressure makes it an ideal agent to maintain homeostasis as well as in emergency situatio...
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journal_title:Acta anaesthesiologica Scandinavica
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pub_type: 杂志文章
doi:10.1111/j.1399-6576.2005.00633.x
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journal_title:Acta anaesthesiologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1399-6576.1981.tb01697.x
更新日期:1981-12-01 00:00:00
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journal_title:Acta anaesthesiologica Scandinavica
pub_type: 杂志文章
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journal_title:Acta anaesthesiologica Scandinavica
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doi:10.1034/j.1399-6576.2001.450115.x
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pub_type: 杂志文章,随机对照试验
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journal_title:Acta anaesthesiologica Scandinavica
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pub_type: 杂志文章,随机对照试验
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更新日期:2011-01-01 00:00:00
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journal_title:Acta anaesthesiologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1399-6576.2006.01083.x
更新日期:2006-08-01 00:00:00
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journal_title:Acta anaesthesiologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aas.12281
更新日期:2014-04-01 00:00:00
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journal_title:Acta anaesthesiologica Scandinavica
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pub_type: 杂志文章
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journal_title:Acta anaesthesiologica Scandinavica
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journal_title:Acta anaesthesiologica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Acta anaesthesiologica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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journal_title:Acta anaesthesiologica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-10-01 00:00:00
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journal_title:Acta anaesthesiologica Scandinavica
pub_type: 杂志文章
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更新日期:2013-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1987-04-01 00:00:00
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journal_title:Acta anaesthesiologica Scandinavica
pub_type: 杂志文章,随机对照试验
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更新日期:2011-03-01 00:00:00
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journal_title:Acta anaesthesiologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1399-6576.1994.tb03890.x
更新日期:1994-04-01 00:00:00
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journal_title:Acta anaesthesiologica Scandinavica
pub_type: 杂志文章,评审
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更新日期:2020-08-01 00:00:00
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journal_title:Acta anaesthesiologica Scandinavica
pub_type: 杂志文章
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更新日期:2014-11-01 00:00:00