Intravenous diadenosine tetraphosphate in dogs. Cardiovascular effects and influence on blood gases.

Abstract:

:Diadenosine tetraphosphate (AP4A) has a considerable vasodilating effect. Its dose was adjusted to decrease mean arterial pressure (MAP) by 20%, 40%, 50%, 60%, and 80% of the pretreatment value, and the effects on hemodynamics and gas exchange were evaluated. AP4A produced a dose-dependent decrease in MAP within the range of doses which decreased blood pressure by up to 60%. Heart rate remained constant at hypotension levels of 40% or less, but decreased significantly at hypotension levels of 50% or more. Cardiac output increased significantly at hypotension levels of 40% or less. Systemic vascular resistance (SVR) showed a significant decrease at that time. No significant changes were observed in central venous pressure and pulmonary capillary wedge pressure at any level of hypotension. Arterial oxygen tension and calculated pulmonary shunt ratio showed no change. Base excess and pH were decreased significantly with a 60% or 80% fall of blood pressure. In conclusion, AP4A seems to act on the resistance vessels and cause a decrease in SVR.

authors

Kikuta Y,Sekine A,Tezuka S,Okada K,Yamaura T,Nakajima H

doi

10.1111/j.1399-6576.1994.tb03890.x

subject

Has Abstract

pub_date

1994-04-01 00:00:00

pages

284-8

issue

3

eissn

0001-5172

issn

1399-6576

journal_volume

38

pub_type

杂志文章
  • Gas embolism: an exceptional complication of radial arterial catheterization.

    abstract:BACKGROUND:We report a rare complication of radial arterial catheterization in a 74-year-old man who had undergone retroperitoneal surgery for an infra-renal aortic aneurysm. A right subclavian venous catheter and a right radial artery catheter were inserted for hemodynamic monitoring. RESULTS:The patient suddenly wen...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2004.00476.x

    authors: Dube L,Soltner C,Daenen S,Lemarieé J,Asfar P,Alquier P

    更新日期:2004-10-01 00:00:00

  • Comparison of three doses of epidural fentanyl followed by bupivacaine and fentanyl for labor analgesia.

    abstract:BACKGROUND:Epidural fentanyl 100 microg after lidocaine-epinephrine test dose has been shown to provide adequate analgesia in early labor. This investigation determines the effect of three different bolus doses of epidural fentanyl on duration and quality of analgesia during early first stage of labor. METHODS:In this...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2008.01765.x

    authors: Siddik-Sayyid SM,Taha SK,Azar MS,Hakki MA,Yaman RA,Baraka AS,Aouad MT

    更新日期:2008-10-01 00:00:00

  • Intermittent pneumatic foot compression can activate blood fibrinolysis without changes in blood coagulability and platelet activation.

    abstract:BACKGROUND:Intermittent pneumatic foot compression (IPC) is a useful technique for prophylaxis of peri-operative venous thromboembolism. The aim of this study was to determine the effect of IPC on blood coagulation/fibrinolysis and platelet function using a blood viscometer (Sonoclot) and a platelet aggregation monitor...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-6576.2005.00661.x

    authors: Kohro S,Yamakage M,Sato K,Sato JI,Namiki A

    更新日期:2005-05-01 00:00:00

  • Repeated episodes of myocardial ischaemia during combined thoracic epidural-isoflurane anaesthesia.

    abstract::A patient with a history of coronary artery diseases developed new ST segment depressions in the ECG registration during a low dose (0.7%) isoflurane anaesthesia that was combined with a continuous thoracic epidural analgesia. Simultaneously a small decrease in mean arterial blood pressure (MAP) was noted. During the ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1994.tb03941.x

    authors: Sigurdsson GH,Brouwer RP,Thomson D

    更新日期:1994-07-01 00:00:00

  • Mucopolysaccharidoses and anaesthetic risks.

    abstract::The purpose of this review is to asses the current knowledge of mucopolysaccharidosis (MPS), with reference to the serious complications which may arise in connection with anaesthesia and operation. MPS consists of a heterogeneous group of hereditary diseases which are characterized by an abnormal accumulation of muco...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-6576.1987.tb02553.x

    authors: Sjøgren P,Pedersen T,Steinmetz H

    更新日期:1987-04-01 00:00:00

  • Haemodynamic effects of intravenous procaine as a supplement to general anaesthesia in patients with valvular heart disease.

    abstract::The effect of intravenous procaine, 2 mg/kg/min, on the cardiovascular function of nine patients scheduled for cardiac valve replacement was studied under enflurane-pancuronium anaesthesia. Procaine infusion was started after intubation during steady-state anaesthesia, and continued until start of cardiopulmonary by-p...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1984.tb02005.x

    authors: Waaben J,Sørensen O,Wiberg-Jørgensen F,Flachs H,Skovsted P

    更新日期:1984-02-01 00:00:00

  • Effect of aminophylline or physostigmine on recovery from nitrous oxide-enflurane anaesthesia.

    abstract::If facilities for recovery are limited, shortening the recovery time from general anaesthesia is important. A comparative study on the effect of 3 mg.kg-1 aminophylline or 0.04 mg.kg-1 physostigmine on duration and quality of the recovery time from nitrous oxide-enflurane anaesthesia is presented. Three groups of 35 p...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1991.tb03359.x

    authors: Kesecioglu J,Rupreht J,Telci L,Dzoljic M,Erdmann W

    更新日期:1991-10-01 00:00:00

  • Paramedic helicopter emergency service in rural Finland - do benefits justify the cost?

    abstract:BACKGROUND:The benefit of the Helicopter Emergency Medical Service (HEMS) is not well documented. The aim of our study was to investigate the potential health benefits of HEMS, and their relation to cost of the service in a rural area in Finland. We also evaluated whether the patient benefit is due to early Advanced Li...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1399-6576.2002.460704.x

    authors: Kurola J,Wangel M,Uusaro A,Ruokonen E

    更新日期:2002-08-01 00:00:00

  • A study of ECG abnormalities and myocardial specific enzymes in patients with subarachnoid haemorrhage.

    abstract::Twenty-two patients with subarachnoid haemorrhage were investigated for changes in myoglobin, total CK, CK-MB and CK-BB in serum and for the incidence of ECG abnormalities. Serial ECG's showed abnormalities in 20 patients; 15 of these had T wave changes, 15 Q-Tc prolongation, ten had S-T depression and nine U waves an...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1982.tb01779.x

    authors: Rudehill A,Gordon E,Sundqvist K,Sylvén C,Wahlgren NG

    更新日期:1982-08-01 00:00:00

  • Reversal of atracurium-induced neuromuscular block in paediatric patients.

    abstract::We studied the efficacy of neostigmine and edrophonium to reverse an atracurium-induced 90% neuromuscular block in 80 paediatric patients anaesthetized with thiopentone, fentanyl and nitrous oxide. The patients were divided into five age groups: 0-2 months, 3-11 months, 2-5 years, 6-10 years, and 11-15 years. At the e...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1995.tb04196.x

    authors: Kirkegaard-Nielsen H,Meretoja OA,Wirtavuori K

    更新日期:1995-10-01 00:00:00

  • The reduction of pain on injection of propofol: the effect of addition of lignocaine.

    abstract::The effects of addition of 1 ml of lignocaine (10 mg) or isotonic saline to 19 ml of the emulsified preparation of propofol (Diprivan) were studied in a randomised, double-blind trial in 80 patients. The incidence and severity of pain on injection of propofol were significantly reduced by the addition of lignocaine (P...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1988.tb02774.x

    authors: Helbo-Hansen S,Westergaard V,Krogh BL,Svendsen HP

    更新日期:1988-08-01 00:00:00

  • Focus-assessed transthoracic echocardiography in the sitting position: two life-saving cases.

    abstract::Focus-Assessed Transthoracic Echocardiography (FATE) is a point-of-care ultrasound protocol allowing the fast evaluation of the cardio-pulmonary status. It has been well established that patients with an exacerbation of chronic obstructive lung disease and lung oedema benefit from the sitting position. These and other...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2010.02330.x

    authors: Frederiksen CA,Knudsen L,Juhl-Olsen P,Sloth E

    更新日期:2011-01-01 00:00:00

  • Comparison of pituitary-adrenocortical response to hypoglycaemia and surgery.

    abstract::The hypothalamic-pituitary-adrenocortical (HPA) responses to the hypoglycaemic stimulus and to operation (laparotomy) are compared. The studies were carried out in eight patients who were subjected to insulin-induced hypoglycaemia on the day before elective abdominal surgery. Plasma corticotrophin (ACTH) and plasma co...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1979.tb01428.x

    authors: Blichert-Toft M,Christiansen C,Engquist A,Kehlet H,Lindholm J,Hummer L,Dinesen B

    更新日期:1979-02-01 00:00:00

  • Cortisol, glucose, and hemodynamic responses to surgery after naloxone administration.

    abstract::The adrenocortical, hyperglycemic, and hemodynamic responses to cholecystectomy or vagotomy were studied in 16 patients under halothane and N2O/O2 anesthesia. The patients were randomly divided into two groups: eight patients received naloxone in doses used clinically (2.5 microgram/kg i.v.) just before induction of a...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1981.tb01598.x

    authors: Engquist A,Hicquet J,Saurbrey N,Blichert-Toft M

    更新日期:1981-02-01 00:00:00

  • Successful vasoconstrictor therapy of anaphylactoid reactions during induction of anaesthesia. A report of two cases.

    abstract::Anaphylactoid reactions were evoked during intravenous induction of anaesthesia in two patients on three occasions. In the first patient the reaction occurred during the first anaesthetic on propranolol and hydrochlorthiazide medication due to hypertension. Since the major target organ for the anaphylactoid reaction i...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1985.tb02272.x

    authors: Pontén J,Biber B,Henriksson BA

    更新日期:1985-08-01 00:00:00

  • Ropivacaine 1 mg/ml, plus fentanyl 2 microg/ml for epidural analgesia during labour. Is mode of administration important?

    abstract:BACKGROUND:Patient-controlled epidural analgesia (PCEA) with a moderate to high concentration of bupivacaine in obstetrics has been shown to give comparable analgesia and even higher level of satisfaction compared to continuous epidural infusion. We hypothesised that the use of a very low concentration technique (ropiv...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1034/j.1399-6576.2001.045005595.x

    authors: Smedvig JP,Soreide E,Gjessing L

    更新日期:2001-05-01 00:00:00

  • Oxygen and carbon dioxide concentrations in anaesthetic circuits ventilated with an AGA UV 705 in an oxygen consuming model lung.

    abstract::An oxygen consuming an carbon dioxide producing model lung was used for evaluation of anaesthetic circle systems. Two different circles, the AGA metal circle and the AGA Monosorb circle ventilated by an AGA UV-705 were tested with reference to inspired oxygen concentrations and end-tidal CO2 levels. Carbon dioxide is ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1982.tb01731.x

    authors: Sonander H,Stenqvist O

    更新日期:1982-02-01 00:00:00

  • Electrophysiological effects of desflurane in children with Wolff-Parkinson-White syndrome: a randomized crossover study.

    abstract:BACKGROUND:We hypothesized that, compared with propofol, desflurane prolongs the antegrade accessory pathway effective refractory period (APERP) in children undergoing radiofrequency catheter ablation for Wolff-Parkinson-White (WPW) syndrome. METHODS:In this randomized crossover study, children aged 4.1-16.1 years und...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/aas.13023

    authors: Hino H,Oda Y,Yoshida Y,Suzuki T,Shimada M,Nishikawa K

    更新日期:2018-02-01 00:00:00

  • Analgesia for labour: a survey of Norwegian practice - with a focus on parenteral opioids.

    abstract:BACKGROUND:During the last two decades, epidural analgesia has become 'a gold standard' for labour pain in most Western countries. Newer short-acting opioids given systemically represent an alternative for adequate pain relief without using regional techniques. With this survey, we wish to explore how Norwegian hospita...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2009.01988.x

    authors: Tveit TO,Halvorsen A,Rosland JH

    更新日期:2009-07-01 00:00:00

  • Ethical issues in intensive care--a survey among Scandinavian intensivists.

    abstract:BACKGROUND:The general principles of medical ethics are universally accepted. In practice, however, there is variation on how these principles are interpreted by people with different cultural backgrounds. The aim of this study was to document the views of Scandinavian intensive care physicians on intensive care unit (...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2005.00799.x

    authors: Tallgren M,Klepstad P,Petersson J,Skram U,Hynninen M

    更新日期:2005-09-01 00:00:00

  • Anesthetic approach to postdural puncture headache in the peripartum period: An Israeli national survey.

    abstract:BACKGROUND:Accidental dural puncture frequency among pregnant women is about 1.5%, while approximately 60% of these women will suffer from post-dural puncture headache (PDPH) that may be debilitating. METHODS:Following IRB approval, we conducted a national survey of the lead anesthesiologist in 23 labor and delivery r...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.13208

    authors: Ioscovich A,Giladi Y,Fuica RL,Weiniger CF,Orbach-Zinger S,Gozal Y,Shatalin D

    更新日期:2018-11-01 00:00:00

  • Cardiovascular effects of desflurane and isoflurane in patients with coronary artery disease.

    abstract:BACKGROUND:Anaesthesia in patients with ischaemic heart disease may cause adverse haemodynamic reactions. This investigation compares the cardiovascular effects of equipotent concentrations of desflurane and isoflurane in 30 patients (ASA III) with coronary artery disease before surgical stimulation. METHODS:After sta...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1996.tb05571.x

    authors: Grundmann U,Müller M,Kleinschmidt S,Larsen B,Larsen R

    更新日期:1996-10-01 00:00:00

  • Effect of low-dose N-acetyl-cysteine infusion on tourniquet-induced ischaemia-reperfusion injury in arthroscopic knee surgery.

    abstract:BACKGROUND:Temporary occlusion of blood flow is used during arthroscopic knee surgery in order to provide a bloodless surgical field. The resulting ischaemia-reperfusion causes lipid peroxidation, which contributes to tissue injury. The aim of the study was to investigate the effect of low-dose n-acetyl cysteine (NAC) ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2005.00722.x

    authors: Saricaoglu F,Dal D,Salman AE,Atay OA,Doral MN,Salman MA,Kilinç K,Aypar U

    更新日期:2005-07-01 00:00:00

  • Survival after primary breast cancer surgery following propofol or sevoflurane general anesthesia-A retrospective, multicenter, database analysis of 6305 Swedish patients.

    abstract:BACKGROUND:Retrospective studies indicate that the choice of anesthetic can affect long-term cancer survival. Propofol seems to have an advantage over sevoflurane. However, this is questioned for breast cancer. We gathered a large cohort of breast cancer surgery patients from seven Swedish hospitals and hypothesized th...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.13644

    authors: Enlund M,Berglund A,Ahlstrand R,Walldén J,Lundberg J,Wärnberg F,Ekman A,Sjöblom Widfeldt N,Enlund A,Bergkvist L

    更新日期:2020-09-01 00:00:00

  • Comparison of fentanyl and halothane as supplement to nitrous-oxide-oxygen anaesthesia for coronary artery surgery.

    abstract::Twenty unselected patients suffering from incapacitating angina, in spite of medication with nitrates, beta-blockers and calcium antagonists, were studied before and during coronary artery bypass surgery. Fentanyl or halothane was randomly used in combination with nitrous oxide for maintenance of anaesthesia in order ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1985.tb02152.x

    authors: Fischerström A,Ohqvist G,Settergren G

    更新日期:1985-01-01 00:00:00

  • Mucociliary transport with and without the use of a heat and moisture exchanger. An animal study.

    abstract::The importance to mucociliary transport (MCT) and the condition of the mucus of using a heat and moisture exchanger (HME) was investigated. A high tracheotomy was performed on 10 young pigs. The animals were ventilated using a non-breathing system. In five animals an HME was used; the other five were connected directl...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1991.tb03293.x

    authors: Eckerbom B,Lindholm CE,Mannting F

    更新日期:1991-05-01 00:00:00

  • Multi-detector computed tomography in critically ill patients.

    abstract:BACKGROUND:There is a lack of studies showing the overall impact of multi-detector computed tomography (MDCT) on the treatment of critically ill patients in a general intensive care unit (ICU) setting. METHODS:A prospective observational study on the effects of MDCT on the treatment of patients in a 12-bed medical-sur...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2007.01559.x

    authors: Ahvenjärvi LK,Laurila JJ,Jartti A,Ylipalosaari P,Ala-Kokko TI,Syrjälä HP

    更新日期:2008-04-01 00:00:00

  • Anaesthesia and systemic oxygenation.

    abstract:BACKGROUND:Anaesthesia induction and deep anaesthesia may be accompanied by a considerable haemodynamic depression, especially in patients suffering from cardiovascular diseases. A decrease in cardiac index (CI) leads to a concomitant decrease in oxygen transport (DO2I). We examined whether these changes in haemodynami...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1996.tb04552.x

    authors: Bacher A,Mayer N,Mittlboeck M,Zadrobilek E

    更新日期:1996-09-01 00:00:00

  • Transient radicular irritation after spinal anesthesia induced with hyperbaric solutions of cerebrospinal fluid-diluted lidocaine 50 mg/ml or mepivacaine 40 mg/ml or bupivacaine 5 mg/ml.

    abstract:BACKGROUND:Transient radicular irritation (TRI) is common after spinal anesthesia induced with hyperbaric lidocaine 50 mg/ml. The purpose of this study was to determine the incidence of TRI after spinal anesthesia with hyperbaric lidocaine 50 mg/ml diluted with cerebrospinal fluid (CSF) 1:1 and hyperbaric mepivacaine 4...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1998.tb05319.x

    authors: Salmela L,Aromaa U

    更新日期:1998-08-01 00:00:00

  • Equal effects of gelatin and hydroxyethyl starch (6% HES 130/0.42) on modified thrombelastography in children.

    abstract:BACKGROUND:Artificial colloids are frequently used to prevent or treat circulatory failure due to hypovolaemia. Whereas gelatin has been shown not to affect coagulation besides its haemodilutional effect, hydroxyethyl starches (HES) have additional negative effects on haemostasis. The third-generation HES solutions hav...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2008.01863.x

    authors: Osthaus WA,Witt L,Johanning K,Boethig D,Winterhalter M,Huber D,Heimbucher C,Suempelmann R

    更新日期:2009-03-01 00:00:00