Equal effects of gelatin and hydroxyethyl starch (6% HES 130/0.42) on modified thrombelastography in children.

Abstract:

BACKGROUND:Artificial colloids are frequently used to prevent or treat circulatory failure due to hypovolaemia. Whereas gelatin has been shown not to affect coagulation besides its haemodilutional effect, hydroxyethyl starches (HES) have additional negative effects on haemostasis. The third-generation HES solutions have been developed to minimise these effects. We therefore conducted a prospective, randomised study, to verify the hypothesis that a 6% HES 130/0.42/6 : 1 and a 4% gelatin infusion influences modified thrombelastography (TEM) parameters in children in the same manner and to the same extent. METHODS:A total of 50 paediatric patients aged 0-12 years scheduled for surgery were assigned to receive either 10 ml/kg HES 130/0.42 or gelatin. Blood gas analysis, haemodynamic parameters and TEM measurements were performed before and after colloid administration. RESULTS:Patient characteristics, indications/surgical procedures and the main results obtained from blood gas analysis were comparable between the two groups. After administration of either gelatin or HES, all TEM parameters, except for clotting time, indicated impaired coagulation whereas the mean values of all TEM parameters remained within the normal ranges. Comparing the gelatin and HES 130/0.42/6 : 1 groups, none of the measured TEM parameters was found to show between-group differences at baseline or after colloid infusion. CONCLUSION:In conclusion, we could demonstrate that the investigational product, HES 130/0.42/6 : 1 solution, administered at a dosage of 10 ml/kg to children, had comparable effects on coagulation monitored with TEM as a gelatin solution. Perioperative administration of HES 130/0.42/6 : 1 does not alter coagulation to an extent above and beyond the effect of haemodilution.

authors

Osthaus WA,Witt L,Johanning K,Boethig D,Winterhalter M,Huber D,Heimbucher C,Suempelmann R

doi

10.1111/j.1399-6576.2008.01863.x

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

305-10

issue

3

eissn

0001-5172

issn

1399-6576

pii

AAS1863

journal_volume

53

pub_type

杂志文章
  • A comparison between reaction time measurement and critical flicker fusion frequency under rising nitrous oxide inhalation in healthy subjects.

    abstract::Ten subjects volunteered to inhale a test gas containing 0, 10, 20 and 30% nitrous oxide. After equilibration at each nitrous oxide concentration, the reaction time was measured using both the single-hand and the double-hand methods, and then the critical flicker fusion frequency was measured. Using the flicker funsio...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1980.tb01511.x

    authors: Wernberg M,Nielsen SF,Hommelgaard P

    更新日期:1980-04-01 00:00:00

  • Atelectasis and pulmonary shunting during induction of general anaesthesia--can they be avoided?

    abstract:BACKGROUND:Gas exchange is regularly impaired during general anaesthesia with mechanical ventilation. A major cause of this disorder appears to be atelectasis and consequently pulmonary shunt. After re-expansion, atelectasis reappears very slowly if 30% oxygen in nitrogen is used, but much faster if 100% oxygen is used...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1996.tb04483.x

    authors: Rothen HU,Sporre B,Engberg G,Wegenius G,Reber A,Hedenstierna G

    更新日期:1996-05-01 00:00:00

  • Pulmonary function in obese patients scheduled for jejuno-ileostomy.

    abstract::Preoperative pulmonary parameters were evaluated in 37 extremely obese but otherwise healthy patients. They were on average 100.9% overweight. X-ray of the chest, electrocardiograms, and residual volume, vital capacity, total lung capacity, maximum breathing capacity, forced expired volume in 1 second, and related rat...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1977.tb01230.x

    authors: Andersen J,Rasmussen JP,Eriksen J

    更新日期:1977-01-01 00:00:00

  • Sevoflurane vs. propofol in post-operative catheter-related bladder discomfort: a prospective randomized study.

    abstract:BACKGROUND:Post-operative catheter-related bladder discomfort (CRBD) causes increased emergence agitation. Muscarinic receptor activation is a major mechanism in CRBD development. Experimental studies showed that sevoflurane has anti-muscarinic effects whereas propofol does not. Our hypothesis was that sevoflurane anae...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/aas.12922

    authors: Kim HC,Park HP,Lee J,Jeong MH,Lee KH

    更新日期:2017-08-01 00:00:00

  • Selective lumbar epidural block in labour. A clinical analysis.

    abstract::Segmental epidural analgesia (T10-T12) was performed in 418 parturients, using a 4-6 ml dose of 0.5% bupivacaine, with or without adrenaline. Seventy per cent of parturients were primiparas and 30% had histories, or signs, of possible uteroplacental insufficiency. Our aim was to relieve pain during the long passive op...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1977.tb01207.x

    authors: Hollmén A,Jouppila R,Pihlajaniemi R,Karvonen P,Sjöstedt E

    更新日期:1977-01-01 00:00:00

  • Intraoperative methadone for postoperative pain after laparoscopic hysterectomy: Protocol for a randomised, double-blind trial.

    abstract:BACKGROUND:Hysterectomy is often carried out as same-day surgery. Treatment of postoperative pain is, therefore, of utmost importance to ensure timely discharge from hospital. Methadone has several desirable pharmacological features, including a long elimination half-life. Theoretically, a single intraoperative dose co...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/aas.13433

    authors: Friesgaard KD,Brix LD,Kristensen CB,Rian O,Nikolajsen L

    更新日期:2019-10-01 00:00:00

  • The pressor response after laryngeal mask or cuffed oropharyngeal airway insertion.

    abstract:BACKGROUND:Since the cuffed oropharyngeal airway (COPA) has been suggested to cause less pharyngeal trauma than the laryngeal mask airway (LMA), we conducted a prospective, randomised study to compare haemodynamic changes after placing either the COPA or LMA in healthy anaesthetised adults. METHODS:After standard mida...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1034/j.1399-6576.1999.431014.x

    authors: Casati A,Cappelleri G,Fanelli G,Magistris L,Beccaria P,Albertin A,Torri G

    更新日期:1999-11-01 00:00:00

  • Cognitive function in patients with chronic pain treated with opioids: characteristics and associated factors.

    abstract:BACKGROUND:The paucity of studies regarding cognitive function in patients with chronic pain, and growing evidence regarding the cognitive effects of pain and opioids on cognitive function prompted us to assess cognition via neuropsychological measurement in patients with chronic non-cancer pain treated with opioids. ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2012.02760.x

    authors: Kurita GP,de Mattos Pimenta CA,Braga PE,Frich L,Jørgensen MM,Nielsen PR,Højsted J,Sjøgren P

    更新日期:2012-11-01 00:00:00

  • MAC for halothane and isoflurane during normothermia and hypothermia in the newborn piglet.

    abstract:BACKGROUND:Halothane and isoflurane are frequently used in studies of perinatal hypoxia and ischemia. Little information exists on the minimum alveolar concentration (MAC) necessary to prevent movement to a painful stimulus in newborn pigs and no information on the effects of hypothermia on MAC in pigs. Hypothermia is ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1996.tb04468.x

    authors: Satas S,Haaland K,Thoresen M,Steen PA

    更新日期:1996-04-01 00:00:00

  • Inhaled prostacyclin for the prevention of increased pulmonary vascular resistance in cemented hip hemiarthroplasty-A randomised trial.

    abstract:BACKGROUND:Bone cementation may cause pulmonary vasoconstriction and ventilation/perfusion abnormalities in patients undergoing cemented hip hemiarthroplasty. In this randomised trial, we tested the hypothesis that intra-operative inhalation of prostacyclin could attenuate the increase in pulmonary vascular resistance ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/aas.13423

    authors: Hård Af Segerstad M,Olsen F,Houltz E,Nellgård B,Ricksten SE

    更新日期:2019-10-01 00:00:00

  • Effect of nicotine dependence on opioid requirements of patients after thoracic surgery.

    abstract:BACKGROUND:This retrospective study investigated the effect of nicotine dependence on required postoperative opioid administration in patients undergoing thoracic surgery. METHODS:The subjects consisted of 215 male patients (112 nonsmokers, 103 smokers) who underwent thoracic surgery and received postoperative patient...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.12430

    authors: Yu A,Cai X,Zhang Z,Shi H,Liu D,Zhang P,Fu Z

    更新日期:2015-01-01 00:00:00

  • Effect of hemodiafiltration and sepsis on chemotaxis of granulocytes and the release of IL-8 and IL-10.

    abstract:BACKGROUND:Extracorporeal circulation, such as cardiopulmonary bypass and hemodialysis, has been associated with an activation of the immune system. Continuous veno venous hemodiafiltration (CVVHD) is used in critically ill septic patients. During CVVHD, cytokines are excreted in ultrafiltrate. When the membranes, used...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1399-6576.2002.460203.x

    authors: Toft P,Brix-Christensen V,Baech J,Krog J,Jørgensen HS,Tønnesen E,Petersen TK,Dagnaes-Hansen F

    更新日期:2002-02-01 00:00:00

  • Comparison of P6 acupoint injection with 50% glucose in water and intravenous droperidol for prevention of vomiting after gynecological laparoscopy.

    abstract::Postoperative vomiting causes patients distress and delays discharge after outpatient surgery. Although P6 electroacupuncture is recognized as having an antiemetic effect, its inconvenient instrumentation may limit its clinical applicability. The purpose of this study was to explore a simple and effective alternative ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1993.tb03699.x

    authors: Yang LC,Jawan B,Chen CN,Ho RT,Chang KA,Lee JH

    更新日期:1993-02-01 00:00:00

  • Propofol attenuates responses of the auditory cortex to acoustic stimulation in a dose-dependent manner: a FMRI study.

    abstract:BACKGROUND:Functional magnetic resonance imaging (fMRI) using blood-oxygen-level-dependent (BOLD) contrasts is a common method for studying sensory or cognitive brain functions. The aim of the present study was to assess the effect of the intravenous anaesthetic propofol on auditory-induced brain activation using BOLD ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2005.00703.x

    authors: Dueck MH,Petzke F,Gerbershagen HJ,Paul M,Hesselmann V,Girnus R,Krug B,Sorger B,Goebel R,Lehrke R,Sturm V,Boerner U

    更新日期:2005-07-01 00:00:00

  • Effect of alfentanil on intracranial pressure during propofol-fentanyl anesthesia for craniotomy. A randomized prospective dose-response study.

    abstract:BACKGROUND:The effect of alfentanil on intracranial pressure (ICP) in patients with supratentorial cerebral tumors has only been sparsely examined and with somewhat contradictory results. METHODS:Thirty-one patients were anesthetized with propofol and fentanyl. After removal of the bone flap a bolus-dose of alfentanil...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2005.00648.x

    authors: Olsen KS,Juul N,Cold GE

    更新日期:2005-04-01 00:00:00

  • Effects of anticoagulant treatment on intestinal ischaemia and reperfusion injury in rats.

    abstract:BACKGROUND:In recent years it has become increasingly clear that a cross-talk between the inflammatory response and blood coagulation exists, although many of the underlying mechanisms remain unclear. In the present study we investigated the potential anti-inflammatory properties of two different anticoagulant compound...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2005.00633.x

    authors: Olanders K,Börjesson A,Zhao X,Andersson R

    更新日期:2005-04-01 00:00:00

  • The efficacy of intrathecal injection of sufentanil using a microspinal catheter for labor analgesia.

    abstract::Intrathecal sufentanil can provide labor analgesia. We investigated the efficacy of multiple injections and the maternal and neonatal effects of intrathecal sufentanil during labor. Seventeen healthy women in active labor received multiple injections of intrathecal sufentanil of 5 micrograms each through microspinal c...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1996.tb04421.x

    authors: Abboud TK,Zhu J,Sharp R,LaGrange C,Rosa C,Kassells B

    更新日期:1996-02-01 00:00:00

  • Shock treatment in a cohort of Scandinavian intensive care units in 2014.

    abstract:BACKGROUND:Shock is common in intensive care units, and treatment includes fluids, vasopressor and/or inotropic drugs, guided by hemodynamic monitoring. The aim of this study was to identify current practice for treatment of shock in Scandinavian intensive care units. METHODS:Seven-day inception cohort study in 43 int...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 评论,杂志文章

    doi:10.1111/aas.12745

    authors: Kollind M,Wickbom F,Wilkman E,Snäckestrand MS,Holmén A,Oldner A,Perner A,Åneman A,Chew MS,Scandinavian Critical Care Trials Group.

    更新日期:2016-08-01 00:00:00

  • Effects of a leucocyte depleting arterial line filter on perioperative proteolytic enzyme and oxygen free radical release in patients undergoing aortocoronary bypass surgery.

    abstract:BACKGROUND:Proteolytic enzymes and oxygen free radicals released from activated leucocytes contribute significantly to the organ dysfunction associated with cardiopulmonary bypass. Leucocyte depletion during extracorporeal circulation should reduce the release of these toxic compounds and thereby improve postbypass myo...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1034/j.1399-6576.1999.430414.x

    authors: Mair P,Hoermann C,Mair J,Margreiter J,Puschendorf B,Balogh D

    更新日期:1999-04-01 00:00:00

  • Comparison of propofol and the combination of propofol and alfentanil during bronchoscopy: a randomized study.

    abstract:BACKGROUND:propofol is an excellent sedative agent for use in patients undergoing bronchoscopy. The addition of an opioid to propofol can be advantageous because of the antitussive effect of the opioid and the possible improvement in sedation quality. However, it may increase the risk of hypoxaemia. To investigate the ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2010.02336.x

    authors: Yoon HI,Kim JH,Lee JH,Park S,Lee CT,Hwang JY,Nahm SF,Han S

    更新日期:2011-01-01 00:00:00

  • Retrograde cerebral perfusion of oxygenated, compacted red blood cells attenuates brain damage after hypothermia circulation arrest of rat.

    abstract:BACKGROUND:It was proved that higher haematocrit (Hct) might improve the function of brain after hypothermia circulation arrest (HCA). In the present study we established a new rat HCA model and investigated whether retrograde cerebral perfusion of oxygenated, compacted red blood cells (RBC) could attenuate brain injur...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2005.00747.x

    authors: Su DS,Wang XR,Zheng YJ,Zhao YH,Zhang TJ

    更新日期:2005-09-01 00:00:00

  • Neurologic deficits and arachnoiditis following neuroaxial anesthesia.

    abstract::Of late, regional anesthesia has enjoyed unprecedented popularity; this increase in cases has brought a higher frequency of instances of neurological deficit and arachnoiditis that may appear as transient nerve root irritation, cauda equina, and conus medullaris syndromes, and later as radiculitis, clumped nerve roots...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-6576.2003.470102.x

    authors: Aldrete JA

    更新日期:2003-01-01 00:00:00

  • Keeping the spirit high: why trauma team training is (sometimes) implemented.

    abstract:BACKGROUND:Systematic and multiprofessional trauma team training using simulation was introduced in Norway in 1997. The concept was developed out of necessity in two district general hospitals and one university hospital but gradually spread to 45 of Norway's 50 acute-care hospitals over the next decade. Implementation...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1399-6576.2007.01539.x

    authors: Wisborg T,Brattebø G

    更新日期:2008-03-01 00:00:00

  • Bilateral eye hemorrhage after laparoscopic cholecystectomy.

    abstract::A case of bilateral eye hemorrhage after laparoscopic cholecystectomy, probably caused by an increase in venous blood pressure due to carbon dioxide insufflation, is reported. ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1399-6576.2001.450821.x

    authors: Calenda E,Muraine M,Zerzour H,Sambo B,Siahmed K

    更新日期:2001-09-01 00:00:00

  • Life-threatening upper airway obstruction in a child caused by retropharyngeal emphysema.

    abstract::A 2 1/2-year-old boy with acute obstructive lung disease from adenovirus infection developed cough-induced paroxysms of intense dyspnoea leading to respiratory failure. Chest x-ray and fluoroscopy demonstrated retropharyngeal air occluding the airway. The clinical management of this and similar air-leak problems is di...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1399-6576.2001.045003393.x

    authors: Skogvoll E,Grammeltvedt AT,Aadahl P,Mostad U,Slørdahl S

    更新日期:2001-03-01 00:00:00

  • Anesthetic effect of epidural anesthesia with cephalad or caudad catheterization for ankle surgery or hemorrhoidectomy.

    abstract:BACKGROUND:The larger size of the first sacral nerve root has been reported to be an unfavorable factor leading to sacral sparing in epidural anesthesia. Previous studies have shown that an adequate analgesic effect of the epidural block was achieved with the catheter placement in the caudal direction. In this study, t...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2005.00620.x

    authors: Chou WY,Hsu CJ,Cheng JT,Yang LC,Lin CR,Chia YY,Yu SW,Tan PH

    更新日期:2005-03-01 00:00:00

  • Prediction of post-operative pain by an electrical pain stimulus.

    abstract:BACKGROUND:Treatment of post-operative pain is still a significant problem. Recently, interest has focused on pre-operative identification of patients who may experience severe post-operative pain in order to offer a more aggressive analgesic treatment. The nociceptive stimulation methods have included heat injury and ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2007.01271.x

    authors: Nielsen PR,Nørgaard L,Rasmussen LS,Kehlet H

    更新日期:2007-05-01 00:00:00

  • Light-guided intubation via the intubating laryngeal mask using a prototype illuminated flexible catheter. Clinical experience in 400 patients.

    abstract:BACKGROUND:The transillumination of the soft tissues of the neck using lighted stylets has been used as an aid for tracheal intubation. We evaluated the efficacy and safety of a prototype illuminated flexible catheter to facilitate light-guided intubation through the intubating laryngeal mask. METHODS:The illuminated ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1034/j.1399-6576.2000.440818.x

    authors: Dimitriou V,Voyagis GS

    更新日期:2000-09-01 00:00:00

  • Effects of thoracic epidural anesthesia and adrenoceptor blockade on the cardiovascular response to dopamine in the dog.

    abstract::The cardiovascular effects of dopamine are different before and during thoracic epidural anesthesia (TEA). To evaluate underlying adrenoceptor-mediated mechanisms, dopamine effects were investigated in nine chloralose-anesthetized dogs. The circulatory response to dopamine (0-40 micrograms.kg-1.min-1) was studied befo...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1991.tb03306.x

    authors: Lundberg J,Biber B,Henriksson BA,Martner J,Raner C,Werner O,Winsö O

    更新日期:1991-05-01 00:00:00

  • Multi-detector computed tomography in critically ill patients.

    abstract:BACKGROUND:There is a lack of studies showing the overall impact of multi-detector computed tomography (MDCT) on the treatment of critically ill patients in a general intensive care unit (ICU) setting. METHODS:A prospective observational study on the effects of MDCT on the treatment of patients in a 12-bed medical-sur...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2007.01559.x

    authors: Ahvenjärvi LK,Laurila JJ,Jartti A,Ylipalosaari P,Ala-Kokko TI,Syrjälä HP

    更新日期:2008-04-01 00:00:00