Cognitive function in patients with chronic pain treated with opioids: characteristics and associated factors.

Abstract:

BACKGROUND:The paucity of studies regarding cognitive function in patients with chronic pain, and growing evidence regarding the cognitive effects of pain and opioids on cognitive function prompted us to assess cognition via neuropsychological measurement in patients with chronic non-cancer pain treated with opioids. METHODS:In this cross-sectional study, 49 patients were assessed by Continuous Reaction Time, Finger Tapping, Digit Span, Trail Making Test-B and Mini-mental State Examination tests. Linear regressions were applied. RESULTS:Patients scored poorly in the Trail Making Test-B (mean = 107.6 s, SD = 61.0, cut-off = 91 s); and adequately on all other tests. Several associations among independent variables and cognitive tests were observed. In the multiple regression analyses, the variables associated with statistically significant poor cognitive performance were female sex, higher age, lower annual income, lower schooling, anxiety, depression, tiredness, lower opioid dose, and more than 5 h of sleep the night before assessment (P < 0.05). CONCLUSIONS:Patients with chronic pain may have cognitive dysfunction related to some reversible factors, which can be optimized by therapeutic interventions.

authors

Kurita GP,de Mattos Pimenta CA,Braga PE,Frich L,Jørgensen MM,Nielsen PR,Højsted J,Sjøgren P

doi

10.1111/j.1399-6576.2012.02760.x

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

1257-66

issue

10

eissn

0001-5172

issn

1399-6576

journal_volume

56

pub_type

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