Vancomycin levels are frequently subtherapeutic in critically ill patients: a prospective observational study.

Abstract:

BACKGROUND:Appropriate utilization of vancomycin is important to attain therapeutic targets while avoiding clinical failure and the development of antimicrobial resistance. Our aim was to observe the use of vancomycin in an intensive care population, with the main focus on achievement of therapeutic serum concentrations (15-20 mg/l) and to evaluate how this was influenced by dose regimens, use of guidelines and therapeutic drug monitoring. METHODS:A prospective observational study was carried out in the intensive care units at two tertiary hospitals in Norway. Data were collected from 83 patients who received vancomycin therapy, half of these received continuous renal replacement therapy. Patients were followed for 72 h after initiation of therapy. Blood samples were drawn for analysis of trough serum concentrations. Urine was collected for calculations of creatinine clearance. Information was gathered from medical records and electronic health records. RESULTS:Less than 40% of the patients attained therapeutic trough serum concentrations during the first 3 days of therapy. Patients with augmented renal clearance had lower serum trough concentrations despite receiving higher maintenance doses and more loading doses. When trough serum concentrations were outside of therapeutic range, dose adjustments in accordance to therapeutic drug monitoring were made to less than half. CONCLUSION:The present study reveals significant challenges in the utilization of vancomycin in critically ill patients. There is a need for clearer guidelines regarding dosing and therapeutic drug monitoring of vancomycin for patient subgroups.

authors

Bakke V,Sporsem H,Von der Lippe E,Nordøy I,Lao Y,Nyrerød HC,Sandvik L,Hårvig KR,Bugge JF,Helset E

doi

10.1111/aas.12897

subject

Has Abstract

pub_date

2017-07-01 00:00:00

pages

627-635

issue

6

eissn

0001-5172

issn

1399-6576

journal_volume

61

pub_type

杂志文章
  • Direct myocardial depressant effect of naloxone: mechanical and electrophysiological actions in vitro.

    abstract:BACKGROUND:Naloxone, an opioid antagonist, has a cardiovascular pressor effect and has been used in various types of shock states. The aim was to determine the non-opioid effect on direct cardiac muscle contractility and explore the mechanism using guinea pig right ventricular papillary muscles. METHODS:With instituti...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2004.00267.x

    authors: Kim KJ,Chung NS,Park WK

    更新日期:2004-01-01 00:00:00

  • Anesthetic effect of epidural anesthesia with cephalad or caudad catheterization for ankle surgery or hemorrhoidectomy.

    abstract:BACKGROUND:The larger size of the first sacral nerve root has been reported to be an unfavorable factor leading to sacral sparing in epidural anesthesia. Previous studies have shown that an adequate analgesic effect of the epidural block was achieved with the catheter placement in the caudal direction. In this study, t...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2005.00620.x

    authors: Chou WY,Hsu CJ,Cheng JT,Yang LC,Lin CR,Chia YY,Yu SW,Tan PH

    更新日期:2005-03-01 00:00:00

  • Preferences for shared decision making in chronic pain patients compared with patients during a premedication visit.

    abstract:BACKGROUND:There is some evidence that patients' outcomes improve if they are involved in shared decision making (SDM). A chronic pain clinic or premedication visit could be adequate settings for the implementation of SDM. So far, the patients' preference for involvement in decision making and their desire for informat...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2006.01097.x

    authors: Spies CD,Schulz CM,Weiss-Gerlach E,Neuner B,Neumann T,von Dossow V,Schenk M,Wernecke KD,Elwyn G

    更新日期:2006-09-01 00:00:00

  • Ropivacaine 1 mg/ml, plus fentanyl 2 microg/ml for epidural analgesia during labour. Is mode of administration important?

    abstract:BACKGROUND:Patient-controlled epidural analgesia (PCEA) with a moderate to high concentration of bupivacaine in obstetrics has been shown to give comparable analgesia and even higher level of satisfaction compared to continuous epidural infusion. We hypothesised that the use of a very low concentration technique (ropiv...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1034/j.1399-6576.2001.045005595.x

    authors: Smedvig JP,Soreide E,Gjessing L

    更新日期:2001-05-01 00:00:00

  • Performance of the quick SOFA in very old ICU patients admitted with sepsis.

    abstract:BACKGROUND:The number of very elderly ICU patients (abbreviated to VOPs; ≥80 years) with sepsis increases. Sepsis was redefined in 2016 (sepsis 3.0) using the quick SOFA (qSOFA) score. Since then, multiple studies have validated qSOFA for prognostication in different patient categories, but the prognostic value in VOPs...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.13536

    authors: Haas LEM,Termorshuizen F,de Lange DW,van Dijk D,de Keizer NF

    更新日期:2020-04-01 00:00:00

  • Serum cholinesterase activity in burned patients. II: anaesthesia, suxamethonium and hyperkalaemia.

    abstract::The importance of serum cholinesterase activity in burned patients was evaluated in relation to anaesthesia. Anaesthesia included a repeated administration of suxamethonium. Thirty-two patients with an estimated area of burn between 3 and 72% were studied during 39 anaesthetic procedures. A statistically significant i...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1975.tb05237.x

    authors: Viby-Mogensen J,Hanel HK,Hansen E,Graae J

    更新日期:1975-01-01 00:00:00

  • Pharmacokinetics and clinical effects of intramuscular scopolamine plus morphine. A comparison of two injection sites.

    abstract:BACKGROUND:Intramuscular scopolamine plus morphine premedication is traditionally used when prominent sedative or antisialogogue effect is needed. Knowledge of the pharmacokinetics of scopolamine is limited due to low plasma concentrations found after therapeutic doses. This investigation compares the pharmacokinetics ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1998.tb04924.x

    authors: Kentala E,Scheinin H,Kaila T,Seppälä T,Kanto J

    更新日期:1998-03-01 00:00:00

  • Lumbar versus thoracic epidural buprenorphine for postoperative analgesia following coronary artery bypass graft surgery.

    abstract:BACKGROUND:Thoracic epidural analgesia (TEA) is reported to provide effective analgesia following cardiac surgery. We compared the effect of buprenorphine (BN) through the lumbar and thoracic epidural routes for postoperative analgesia following coronary artery bypass graft surgery (CABG). METHODS:Forty patients with ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1034/j.1399-6576.1999.430404.x

    authors: Mehta Y,Juneja R,Madhok H,Trehan N

    更新日期:1999-04-01 00:00:00

  • Cervical epidural analgesia via a thoracic approach using nerve-stimulation guidance in adult patients undergoing total shoulder replacement surgery.

    abstract:BACKGROUND:Continuous cervical epidural anesthesia can provide excellent peri- and post-operative analgesia, although several factors prevent its widespread use. Advancing catheters from thoracic levels to the cervical region may circumvent these barriers, provided they are accurately positioned. We hypothesize that gu...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2006.1184.x

    authors: Tsui BC,Bury J,Bouliane M,Ganapathy S

    更新日期:2007-02-01 00:00:00

  • Laryngeal papillomatosis with airway obstruction in an infant.

    abstract::Laryngeal papillomatosis in infants and children is a benign condition, but the location and a marked tendency for recurrence makes the disease both dangerous and troublesome. This case report deals with a little girl who had suffered hoarseness and wheezing since she was born. The diagnosis of laryngeal papillomatosi...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1399-6576.2001.045005645.x

    authors: Mikkelsen PG

    更新日期:2001-05-01 00:00:00

  • Per- and postoperative monocyte and lymphocyte functions: effects of combined epidural and general anaesthesia.

    abstract::Monocyte-mediated cytolysis and thymidine uptake in phytohaemagglutinin-stimulated lymphocytes during and after hip replacement performed under combined epidural- and general anaesthesia were studied using in vitro culture techniques. Monocyte-mediated cytolysis was unchanged during operation but was significantly red...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1984.tb02078.x

    authors: Hole A

    更新日期:1984-08-01 00:00:00

  • Hemodynamic effects of tracheal and intravenous adrenaline in infants with congenital heart anomalies.

    abstract:BACKGROUND:If intravenous access cannot be accomplished during cardiopulmonary resuscitation in children, tracheal administration of 100 micrograms/kg of adrenaline (ten times greater than the intravenous dose) is recommended. METHODS:In a randomized crossover study we recoreded the hemodynamic effect of a low dose of...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1996.tb04562.x

    authors: Jonmarker C,Olsson AK,Jögi P,Forsell C

    更新日期:1996-09-01 00:00:00

  • Mechanism of the ropivacaine-induced increase in intracellular Ca2+ concentration in rat aortic smooth muscle.

    abstract:BACKGROUND:Ropivacaine is a long-acting local anesthetic with low cardiac toxicity that induces vasoconstriction in vitro and in vivo. Vascular smooth muscle tone is regulated by changes in both intracellular Ca(2+) concentration ([Ca(2+)](i)) and myofilament Ca(2+) sensitivity. Therefore, the aim of this study was to ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2007.01390.x

    authors: Tokinaga Y,Ogawa K,Yu J,Kuriyama T,Minonishi T,Hatano Y

    更新日期:2007-10-01 00:00:00

  • Diminished interleukin-6 and C-reactive protein responses to laparoscopic versus open cholecystectomy.

    abstract:BACKGROUND:Cytokines and their inhibitors are thought to be involved in many of the pathophysiological changes associated with trauma and infection. The magnitude of the trauma and the degree of tissue damage have an impact on the trauma response. The purpose of the study was to examine cytokine and hormonal responses ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1034/j.1399-6576.1999.430205.x

    authors: Kristiansson M,Saraste L,Soop M,Sundqvist KG,Thörne A

    更新日期:1999-02-01 00:00:00

  • Is there a risk of sensitization and allergy to chlorhexidine in health care workers?

    abstract:BACKGROUND:In Denmark, chlorhexidine is the standard disinfectant in most hospitals and health care workers are repeatedly exposed to it. The aim of this study was to establish whether there is a risk of sensitization and allergy to chlorhexidine from this type of exposure. METHODS:Two hundred and forty-eight doctors,...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1034/j.1399-6576.2003.00150.x

    authors: Garvey LH,Roed-Petersen J,Husum B

    更新日期:2003-07-01 00:00:00

  • Intravenous glucose-insulin-potassium during off-pump coronary artery bypass surgery does not reduce myocardial injury.

    abstract:BACKGROUND:This randomized, double-blind, placebo-controlled study was designed to determine whether an intra-operative, intravenous infusion of glucose-insulin-potassium (GIK) could be helpful in the prevention of myocardial ischemia and in the maintenance of intra-operative cardiac performance in patients undergoing ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2006.01115.x

    authors: Shim YH,Kweon TD,Lee JH,Nam SB,Kwak YL

    更新日期:2006-09-01 00:00:00

  • The association between pre-operative sepsis and 30-day mortality in hip fracture patients-A cohort study.

    abstract:BACKGROUND:Post-operative sepsis considerably increases mortality, but the extent of pre-operative sepsis in hip fracture patients and its consequences are sparsely elucidated. The aim of this study was to assess the association between pre-operative sepsis and 30-day mortality after hip fracture surgery. METHODS:We c...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.13160

    authors: Mørch SS,Tantholdt-Hansen S,Pedersen NE,Duus CL,Petersen JA,Andersen CØ,Jarløv JO,Meyhoff CS

    更新日期:2018-10-01 00:00:00

  • Haemodynamic stability during moderate hypotensive anaesthesia for spinal surgery. A comparison between desflurane and isoflurane.

    abstract:BACKGROUND:The aim of this study was to compare desflurane and isoflurane for spinal procedures requiring moderate levels of controlled arterial hypotension, when these agents were administered via a semi-closed circuit at 1 l x min(-1) fresh gas flow. METHODS:After ethics committee approval and written informed conse...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1034/j.1399-6576.2000.440921.x

    authors: Beaussier M,Paugam C,Deriaz H,Mestari M,Chandon M,Sautet A,Lienhart A

    更新日期:2000-10-01 00:00:00

  • Neuromuscular blockade induced by flunarizine alone and in combination with pancuronium, suxamethonium or neomycin: studies in isolated rat phrenic-hemidiaphragm preparations.

    abstract::The in vitro effects of flunarizine on indirectly- and directly-elicited contractions in rat phrenic-hemidiaphragm preparations were studied. The interactions of flunarizine with non-depolarizing and depolarizing neuromuscular blocking drugs (pancuronium and suxamethonium) and with an aminoglycoside antibiotic (neomyc...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1989.tb02971.x

    authors: del Pozo E,Baeyens JM

    更新日期:1989-10-01 00:00:00

  • The interaction of temperature with thiopental and etomidate on extracellular dopamine and glutamate levels in Wistar-Kyoto rats subjected to forebrain ischemia.

    abstract:BACKGROUND:Many studies demonstrate an association between brain damage and the extracellular release of catecholamines and amino acids during cerebral ischemia. While the clinical value of hypothermia during periods of compromised cerebral blood flow and oxygen delivery is well established, the role of anesthetic agen...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1399-6576.1999.431004.x

    authors: Lesser JB,Koorn R,Vloka JD,Kuroda MM,Thys DM

    更新日期:1999-11-01 00:00:00

  • Early predictability of the need for tracheotomy after admission to ICU: an observational study.

    abstract:BACKGROUND:The goal of this study was to explore the ability of professional judgment to predict the need for tracheotomy early among intensive care unit (ICU) patients. METHODS:Prospective study using daily questionnaires among ICU physicians in a mixed medical-surgical ICU. The prediction of tracheotomy was by a vis...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2010.02290.x

    authors: Veelo DP,Binnekade JM,Buddeke AW,Dongelmans DA,Schultz MJ

    更新日期:2010-10-01 00:00:00

  • Arterial hypotension and hypoxaemia during total hip replacement: the importance of thromboplastic products, fat embolism and acrylic monomers.

    abstract::Thirteen patients submitted to total hip replacement surgery by the Charnley technique were studied. Operations were performed under epidural analgesia with the patients awake and breathing air. During the surgical procedure, the magnitude of tissue-thromboplastic activity, the amount of fat globules, the presence of ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1975.tb05219.x

    authors: Modig J,Busch C,Olerud S,Saldeen T,Waernbaum G

    更新日期:1975-01-01 00:00:00

  • The Magill-Venturi attachment: studies in volunteers and patients.

    abstract::Including a venturi injector in a Magill breathing attachment reduces the requirement of compressed gases to 40% of that normally used: 100-120 ml x kg-1 x min-1. The entrainment of ambient air through the venturi injector enables the supply of an adequate flow of gas mixture to the patient. In 10 awake volunteers and...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1989.tb02937.x

    authors: Jakubaszko J,Christensen P,Jørgensen S

    更新日期:1989-07-01 00:00:00

  • Non-transport emergency medical service missions - a retrospective study based on medical charts.

    abstract:BACKGROUND:In Finland, approximately 40% of emergency medical service (EMS) missions do not result in transport of the patient to a hospital by ambulance, and there is wide variability in the reasons underlying non-transport decisions. The aim of this study was to describe the context of these EMS non-transport mission...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.13071

    authors: Pekanoja S,Hoikka M,Kyngäs H,Elo S

    更新日期:2018-05-01 00:00:00

  • Light-guided intubation via the intubating laryngeal mask using a prototype illuminated flexible catheter. Clinical experience in 400 patients.

    abstract:BACKGROUND:The transillumination of the soft tissues of the neck using lighted stylets has been used as an aid for tracheal intubation. We evaluated the efficacy and safety of a prototype illuminated flexible catheter to facilitate light-guided intubation through the intubating laryngeal mask. METHODS:The illuminated ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1034/j.1399-6576.2000.440818.x

    authors: Dimitriou V,Voyagis GS

    更新日期:2000-09-01 00:00:00

  • alpha 1-adrenoceptor stimulation is able to reverse halothane-induced cardiac depression in isolated rat hearts.

    abstract:BACKGROUND:Stimulation of myocardial alpha 1-adrenoceptors has been shown to exert positive inotropic effects through a cyclic AMP-independent mechanism. The purpose of this study was to examine if alpha 1-adrenoceptor stimulation is able to attenuate myocardial depression produced by exposure to halothane, and to test...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1997.tb04812.x

    authors: Okuyama T,Hoka S,Okamoto H,Kawasaki T,Yamaura K,Takahashi S

    更新日期:1997-08-01 00:00:00

  • Socioeconomic status and risk of intensive care unit admission with sepsis.

    abstract:BACKGROUND:A recent study showed higher risk of bacteremia among individuals with low socioeconomic status (SES). We hypothesized that patients with a low SES have a higher risk of intensive care unit (ICU) admission with sepsis compared to patients with higher SES. METHODS:This was a case-control study on patients wi...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.13114

    authors: Storm L,Schnegelsberg A,Mackenhauer J,Andersen LW,Jessen MK,Kirkegaard H

    更新日期:2018-08-01 00:00:00

  • Left ventricular ejection and the Heather Index measured by non-invasive methods during postural changes in man.

    abstract::Differences have been found, which are usually 1% or less, between the left ventricular ejection time measured from the external carotid pulse tracing, and from the rate of change of thoracic impedance (dZ/dt) waveform, using either the second heart sound or the X-point of the dZ/dt tracing as the end-point. The Heath...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1976.tb05044.x

    authors: Hill DW,Merrifield AJ

    更新日期:1976-01-01 00:00:00

  • Mortality of anesthesiologists, pediatricians, and other specialists in Norway.

    abstract:BACKGROUND:Following sensational media reports, particularly from Sweden, there has been discussion in Scandinavia during the last couple of years about whether anesthesiologists have shorter life spans than other medical specialists. METHODS:Survival analysis (Cox regression) from the master file of the Norwegian Med...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1399-6576.2002.461005.x

    authors: Aasland OG

    更新日期:2002-11-01 00:00:00

  • Decreases in myocardial glucose and increases in pyruvate but not ischaemia are observed during porcine endotoxaemia.

    abstract:BACKGROUND:Myocardial dysfunction occurs commonly in septic shock. It is not known whether this is due to local ischaemia and metabolic disturbances. Our hypothesis was that endotoxaemic myocardial dysfunction may be associated with interstitial ischaemic and metabolic changes, measured using interstitial microdialysis...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2008.01603.x

    authors: Chew MS,Johansson A,Anderson C,Ersson A,Tønnesen E

    更新日期:2008-08-01 00:00:00