Retrograde cerebral perfusion of oxygenated, compacted red blood cells attenuates brain damage after hypothermia circulation arrest of rat.

Abstract:

BACKGROUND:It was proved that higher haematocrit (Hct) might improve the function of brain after hypothermia circulation arrest (HCA). In the present study we established a new rat HCA model and investigated whether retrograde cerebral perfusion of oxygenated, compacted red blood cells (RBC) could attenuate brain injury after HCA. METHODS:A new rat HCA model was developed and rats were randomly distributed into three groups: HCA group, HCA combined with retrograde cerebral perfusion of oxygenated, compacted red blood cell group (HCArcp group), and sham operation group (sham op. group). Animals both in the HCA group and in the HCArcp group underwent HCA 90 min at 18 degrees C. Brain damage after HCA was evaluated with light microscopy and electron microscopy. Immunohistochemistry and RT-PCR techniques were used to measured the different expressions of the C-Fos, Bcl-2, Bax mRNA and protein among the groups. Additionally we measured the wet/dry ratio of the brain in order to evaluate the oedema degree after HCA. RESULTS:The new HCA model of rat we developed was comparable to the clinical setting not only in terms of the intubation, anaesthesia method and materials employed but also in terms of the priming volume in relation to body weight. The number of injured neurones in the hippocampus CA1 and parietal cortex, but not in the thalamus of the HCA group, was significantly greater than that of the HCArcp group (P<0.05). The mean score of mitochondrion of the hippocampus CA1 in the HCA group was significantly higher than in the HCArcp group (P<0.05). The expression of C-Fos, Bax mRNA and protein in the hippocampus CA1 and/or parietal cortex area was higher in the HCA group than in the HCArcp group (P<0.05). Expression of the mRNA and protein of Bcl-2 was higher in the HCArcp group than in the HCA group (P<0.05). The degree of oedema after HCA between the HCA group and HCArcp group had no significant difference (P>0.05). CONCLUSIONS:We established a new rat model of HCA comparable to the clinical setting. Retrograde cerebral perfusion of oxygenated, compacted RBC is a simple, effective, and safe method to protect the brain during HCA. Adjusting the gene expression in relation to apoptosis might contribute to the neuroprotective effects of a retrograde cerebral infusion of oxygenated, compacted RBC.

authors

Su DS,Wang XR,Zheng YJ,Zhao YH,Zhang TJ

doi

10.1111/j.1399-6576.2005.00747.x

subject

Has Abstract

pub_date

2005-09-01 00:00:00

pages

1172-81

issue

8

eissn

0001-5172

issn

1399-6576

pii

AAS747

journal_volume

49

pub_type

杂志文章
  • Self-administered prophylactic postoperative positive expiratory pressure in thoracic surgery.

    abstract::Application of self-administered postoperative prophylactic positive expiratory pressure (S-PEP) treatment in addition to conventional physiotherapy was investigated in 75 patients undergoing thoracotomy. Twenty-nine patients used a face-mask set supplied with an expiratory resistance (S-PEP group) and 27 patients use...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1986.tb02435.x

    authors: Frølund L,Madsen F

    更新日期:1986-07-01 00:00:00

  • Lung function during anesthesia and respiratory insufficiency in the postoperative period: physiological and clinical implications.

    abstract::This review covers the physiological and clinical implications of lung function during anesthesia and respiratory insufficiency in the postoperative period. We have divided it into 3 main sections: 1) lung function changes induced by anesthesia and surgery, in which the impact on pulmonary mechanics, ventilation/perfu...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-6576.1989.tb02960.x

    authors: Schwieger I,Gamulin Z,Suter PM

    更新日期:1989-10-01 00:00:00

  • High-frequency oscillatory ventilation combined with intermittent mandatory ventilation in critically ill neonates and infants.

    abstract::We have evaluated the high-frequency oscillatory ventilation (HFOV) combined with intermittent mandatory ventilation (IMV) in critically ill neonates and infants using the Babylog 8000 SW 4.0. We used HFOV combined with IMV as a rescue mode in 10 neonates and infants aged 1 day to 17 months, who were receiving maximal...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1996.tb04509.x

    authors: Murthy BV,Petros AJ

    更新日期:1996-07-01 00:00:00

  • Levosimendan improves the initial outcome of cardiopulmonary resuscitation in a swine model of cardiac arrest.

    abstract:BACKGROUND:Cardiac arrest remains the leading cause of death in Western societies. Advanced Life Support guidelines propose epinephrine (adrenaline) for its treatment. The aim of this study was to assess whether a calcium sensitizer agent, such as levosimendan, administered in combination with epinephrine during cardio...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2007.01383.x

    authors: Koudouna E,Xanthos T,Bassiakou E,Goulas S,Lelovas P,Papadimitriou D,Tsirikos N,Papadimitriou L

    更新日期:2007-09-01 00:00:00

  • Repeatability of the acetylene rebreathing method in measuring cardiac output: influence of acetylene concentration.

    abstract::The acetylene rebreathing method is a reliable noninvasive method for estimation of cardiac output. However, the method is not commonly used for clinical purposes. This is due mainly to the fact that acetylene is explosive at concentrations above 2% and that acetylene at concentrations above 0.5% has an unpleasant tas...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1990.tb03102.x

    authors: Wendelboe Nielsen O,Hansen S,Christensen P,Grønlund J

    更新日期:1990-07-01 00:00:00

  • Evaluation of anatomic landmarks for axillary nerve block in the quadrilateral space.

    abstract:BACKGROUND:Axillary nerve block (ANB) was recently introduced along with suprascapular nerve block as an alternative to inter-scalene brachial plexus block for post-operative pain control. However, the methods for performing ANB are variable. We studied the relationship between surface anatomy and the location of the a...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.12294

    authors: Kim YA,Yoon KB,Kwon TD,Kim DH,Yoon DM

    更新日期:2014-05-01 00:00:00

  • Combined spinal and epidural anesthesia for cesarean section in a parturient with moyamoya disease.

    abstract::We present the case of a parturient with moyamoya disease admitted to the hospital for elective cesarean section. Combined spinal and epidural technique was chosen because it allows better analgesia than epidural anesthesia and more hemodynamic stability than either general or spinal anesthesia. Ropivacaine was the lo...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1998.tb05388.x

    authors: Abouleish E,Wiggins M,Ali V

    更新日期:1998-10-01 00:00:00

  • Propofol reduces emesis after sufentanil supplemented anaesthesia in paediatric squint surgery.

    abstract:BACKGROUND:Squint surgery is associated with a high incidence of postoperative emesis. The purpose of this prospective study was to examine the influence of propofol and isoflurane anaesthesia on the incidence of postoperative nausea and vomiting in children. METHODS:Ninety children aged 3-10 years were randomly alloc...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1996.tb04519.x

    authors: Standl T,Wilhelm S,von Knobelsdorff G,Schulte am Esch J

    更新日期:1996-07-01 00:00:00

  • Leptin and perioperative neuroendocrine stress response with two different anaesthetic techniques.

    abstract:BACKGROUND:Stress response to surgery is modulated by several factors, including magnitude of the injury, pain, type of procedure and choice of anaesthesia. Our purpose was to compare intra- and post-operative hormonal changes during total intravenous anaesthesia (TIVA) using propofol and remifentanil vs. sevoflurane a...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2008.01589.x

    authors: Marana E,Scambia G,Colicci S,Maviglia R,Maussier ML,Marana R,Proietti R

    更新日期:2008-04-01 00:00:00

  • Monitoring functional residual capacity (FRC) by quantifying oxygen/carbon dioxide fluxes during a short apnea.

    abstract:BACKGROUND:Clinically applicable methods for measuring FRC are currently lacking. This study presents a new method for FRC monitoring based on quantification of metabolic gas fluxes of O2 and CO2 during a short apnea. METHODS:Base line exchange of oxygen and carbon dioxide was measured with indirect calorimetry. End-t...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1399-6576.2002.460617.x

    authors: Stenqvist O,Olegård C,Søndergaard S,Odenstedt H,Kárason S,Lundin S

    更新日期:2002-07-01 00:00:00

  • Effects of epinephrine and clonidine on plasma concentrations of spinal bupivacaine.

    abstract::ASA II-III patients, scheduled for peripheral vascular surgery, were included in a study designed to assess the effect of spinal epinephrine and clonidine on plasma concentrations of spinally administered 0.5% glucose-free bupivacaine. Patients were allocated randomly to three groups to receive via a spinal catheter 2...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1992.tb03544.x

    authors: Boico O,Bonnet F,Mazoit JX

    更新日期:1992-10-01 00:00:00

  • The effect of promethazine on postoperative pain: a comparison of preoperative, postoperative, and placebo administration in patients following total abdominal hysterectomy.

    abstract:BACKGROUND:Histamine receptors are involved in the development of inflammatory pain and hyperalgesia, and the use of antihistamines is advocated as an alternative for pain therapy and treatment of postoperative nausea and vomiting. We investigated the influence of timing of promethazine administration on postoperative ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2004.00369.x

    authors: Chia YY,Lo Y,Liu K,Tan PH,Chung NC,Ko NH

    更新日期:2004-05-01 00:00:00

  • Blood circulation in the kidney of the cat under methoxyflurane (penthrane) anaesthesia.

    abstract::In order to establish whether methoxyflurane causes any change in renal vascular resistance, the renal venous flow was measured by means of a drop recording technique in six cats under methoxyflurane anaesthesia. Arterial pressure was recorded simultaneously, and the renal vascular resistance was calculated. Methoxyfl...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1975.tb05184.x

    authors: Irestedt L,Westermark L,Wåhlin A

    更新日期:1975-01-01 00:00:00

  • Changes in the T-wave amplitude of ECG during isoflurane anaesthesia.

    abstract::R/T-wave amplitude ratio of electrocardiogram (ECG), heart rate (HR) and systolic arterial pressure (SAP) were recorded in 15 patients awake, at 1 minimal alveolar concentration of isoflurane before and during surgery, and in deep anaesthesia (electroencephalogram burst suppression) during surgery. R/T-wave amplitude ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1993.tb03775.x

    authors: Annila P,Jäntti V,Lindgren L,Yli-Hankala A

    更新日期:1993-08-01 00:00:00

  • Magnesium-induced recurarisation after reversal of rocuronium-induced neuromuscular block with sugammadex.

    abstract::A 61-year-old woman (57 kg, 171 cm) underwent surgery under general anaesthesia with desflurane 5.8-6.1 vol. % end-tidal, remifentanil 0.2-0.4 μg/kg/min and rocuronium 35 mg (0.61 mg/kg). On return of the second twitch in the train-of-four (TOF) stimulation measured by acceleromyography, sugammadex 120 mg (2.1 mg/kg) ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.12461

    authors: Unterbuchner C,Ziegleder R,Graf B,Metterlein T

    更新日期:2015-04-01 00:00:00

  • Fourier analysis of effects of varying pressure waveforms in electrical lung analogs.

    abstract::Six voltage waveforms were devised to simulate pressure curves of varying configuration for use in artificial ventilation. These waveforms were subjected to Fourier analysis and terms of the resulting series applied to a simple two-branch resistive-capacitive circuit intended to represent a lung analog using computer ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1984.tb02036.x

    authors: Bergman NA

    更新日期:1984-04-01 00:00:00

  • Washout of sevoflurane from the GE Avance and Amingo Carestation anesthetic machines.

    abstract:BACKGROUND:Inhalational anesthetics must be removed from anesthetic machines to prevent malignant hyperthermia (MH) in susceptible patients or to treat MH occurring during inhalational general anesthesia. This study examines the sevoflurane washout from the GE Avance and Amingo Carestations™. METHODS:The care stations...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2011.02506.x

    authors: Brünner HW,Pohl S,Grond S

    更新日期:2011-10-01 00:00:00

  • Effect of aminophylline on bispectral index.

    abstract:BACKGROUND:The aim of the present study was to investigate the effects of aminophylline on BIS as well as clinical recovery in patients anesthetized with sevoflurane. METHODS:Sixty patients with status of ASA I-II scheduled for elective surgery were enrolled in this study. Anesthesia was induced by 2 mg kg(-1) of prop...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.0001-5172.2004.00350.x

    authors: Turan A,Memiş D,Karamanlýodthlu B,Pamukçu Z,Süt N

    更新日期:2004-04-01 00:00:00

  • Efficacy and safety of intravenous fentanyl administered by ambulance personnel.

    abstract:BACKGROUND:Management of pain in the pre-hospital setting is often inadequate. In 2011, ambulance personnel were authorized to administer intravenous fentanyl in the Central Denmark Region. The aim of this study was to evaluate the efficacy and safety of intravenous fentanyl administered by ambulance personnel. METHOD...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.12662

    authors: Friesgaard KD,Nikolajsen L,Giebner M,Rasmussen CH,Riddervold IS,Kirkegaard H,Christensen EF

    更新日期:2016-04-01 00:00:00

  • The different responses of the hepatic arterial bed to hypovolaemia and to halothane anaesthesia.

    abstract::Ten dogs were subjected to a period of hypovolaemia (bleeding volume: 2% of body weight) and to a period of halothane anaesthesia (end-tidal halothane concentration: 1%). Mean arterial blood pressure decreased to 79% of control value during hypovolaemia and to 58% of control value during halothane anaesthesia. Mean to...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1977.tb01247.x

    authors: Andreen M,Irestedt L,Zetterström B

    更新日期:1977-01-01 00:00:00

  • Depth of a central venous catheter tip: length of insertion guideline for pediatric patients.

    abstract:BACKGROUND:In pediatric patients, several studies have been undertaken to establish central venous catheter (CVC) tip optimal depth. Assessments of catheter tip position using chest radiographs may be misleading, whereas transesophageal echocardiography (TEE) has been shown to accurately monitor catheter tip placement ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2006.00951.x

    authors: Yoon SZ,Shin TJ,Kim HS,Lee J,Kim CS,Kim SD,Park CD

    更新日期:2006-03-01 00:00:00

  • Pharmacological evacuation of the stomach with metoclopramide.

    abstract::Children admitted for emergency operations because of trauma run a high risk of chemical aspiration pneumonitis syndrome. Fifty-eight children admitted for closed reduction of fractures and suturing of wounds were studied in a double-blind manner in order to see if metoclopramide could be of value in decreasing the ri...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-6576.1982.tb01791.x

    authors: Olsson GL,Hallén B

    更新日期:1982-10-01 00:00:00

  • Changes of endothelin concentration in cerebrospinal fluid and plasma of patients with aneurysmal subarachnoid hemorrhage.

    abstract::To investigate the clinical significance of endothelin (ET), a potent vasoconstrictor peptide, in subarachnoid hemorrhage (SAH) and SAH-related cerebral vasospasm, we measured the ET-like immunoreactivity (ET-LI) in plasma and cerebrospinal fluid (CSF) obtained serially from patients with SAH due to ruptured cerebral ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1994.tb03929.x

    authors: Shirakami G,Magaribuchi T,Shingu K,Kim S,Saito Y,Nakao K,Mori K

    更新日期:1994-07-01 00:00:00

  • Adenosine infusion during isoflurane-nitrous oxide anaesthesia: indications of perioperative analgesic effect.

    abstract::Adenosine, an endogenous compound with a known antinociceptive effect when administered into the CNS, was applied in nine patients (21-65 years) by the peripheral intravenous route (70-130 micrograms.kg-1.min-1) as a replacement for peroperative opioids during inhalation anaesthesia for surgical procedures not requiri...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1992.tb03526.x

    authors: Sollevi A

    更新日期:1992-08-01 00:00:00

  • Post-conditioning with cyclosporine A fails to reduce the infarct size in an in vivo porcine model.

    abstract:BACKGROUND:Cyclosporine A has generated intense interest in the field of cardioprotection due to its ability to protect the mitochondria at reperfusion by blocking the opening of the mitochondrial permeability transition pore. The aim of our study was to examine the cardioprotective effect of Sandimmun, a clinically av...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2010.02241.x

    authors: Lie RH,Stoettrup N,Sloth E,Hasenkam JM,Kroyer R,Nielsen TT

    更新日期:2010-08-01 00:00:00

  • Clinical experience of long-term treatment with epidural and intrathecal opioids--a nationwide survey.

    abstract::Long-term use of spinal opioids to treat chronic severe pain is widely established. However, the indications, shortcomings and complications of the method have not been completely described. Experience with spinal opioids was analysed for the period 1979-1984 in a nationwide Swedish survey. Out of 93 anaesthesia depar...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1988.tb02725.x

    authors: Arnér S,Rawal N,Gustafsson LL

    更新日期:1988-04-01 00:00:00

  • Comparison of three doses of epidural fentanyl followed by bupivacaine and fentanyl for labor analgesia.

    abstract:BACKGROUND:Epidural fentanyl 100 microg after lidocaine-epinephrine test dose has been shown to provide adequate analgesia in early labor. This investigation determines the effect of three different bolus doses of epidural fentanyl on duration and quality of analgesia during early first stage of labor. METHODS:In this...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2008.01765.x

    authors: Siddik-Sayyid SM,Taha SK,Azar MS,Hakki MA,Yaman RA,Baraka AS,Aouad MT

    更新日期:2008-10-01 00:00:00

  • Haemodynamic effects of intravenous procaine as a supplement to general anaesthesia in patients with valvular heart disease.

    abstract::The effect of intravenous procaine, 2 mg/kg/min, on the cardiovascular function of nine patients scheduled for cardiac valve replacement was studied under enflurane-pancuronium anaesthesia. Procaine infusion was started after intubation during steady-state anaesthesia, and continued until start of cardiopulmonary by-p...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1984.tb02005.x

    authors: Waaben J,Sørensen O,Wiberg-Jørgensen F,Flachs H,Skovsted P

    更新日期:1984-02-01 00:00:00

  • Impact of upper respiratory tract infections on perioperative outcomes of children undergoing therapeutic cardiac catheterisation.

    abstract:BACKGROUND:Recent upper respiratory tract infection (URI) is associated with increased incidence of perioperative complications in children undergoing open heart surgery. As a result, surgery is often postponed. However, the effect of recent URI on the incidence of perioperative complications in children undergoing the...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.13113

    authors: Zhang S,Ding S,Cai M,Bai J,Zhang M,Huang Y,Zheng J

    更新日期:2018-08-01 00:00:00

  • PCEA compared to continuous epidural infusion in an ultra-low-dose regimen for labor pain relief: a randomized study.

    abstract:BACKGROUND:Patient-controlled epidural analgesia, PCEA, has been introduced in obstetric analgesia during the past decade. Many studies have shown that the consumption of analgesic is reduced when the parturient requests her own doses. This study investigates whether this is also true when using an ultra-low-dose regim...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1034/j.1399-6576.2003.00207.x

    authors: Ledin Eriksson S,Gentele C,Olofsson CH

    更新日期:2003-10-01 00:00:00