Tissue distribution of thiopental and diazepam in rats at 71 atmospheres pressure.

Abstract:

:35S-thiopental 15 mg/kg and 14C-diazepam 5 mg/kg were injected intravenously in separate groups of rats (n = 6) at 1 ATA air and at 71 ATA air-He. Total radioactivity was measured in the brain, liver, kidney, muscle and fat after 1, 3, 5 and 15 min. The thiopental content was significantly reduced at pressure in the brain at 3, 5 and 15 min. The diazepam content of the brain was significantly reduced at pressure at 1, 5 and 15 min. The liver, muscle and kidney tissue generally contained slightly less of either drug at pressure, particularly at the earliest sampling times.

authors

Aanderud L,Thoner J,Bakke OM

doi

10.1111/j.1399-6576.1983.tb01982.x

subject

Has Abstract

pub_date

1983-12-01 00:00:00

pages

433-8

issue

6

eissn

0001-5172

issn

1399-6576

journal_volume

27

pub_type

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