Transfusion has no effect on recurrence in hepatitis C after liver transplantation.

Abstract:

BACKGROUND:The literature suggests that blood product transfusions have a negative impact on the survival of liver transplant patients. We investigated the impact of intraoperative blood product usage on the survival of liver transplantation patients being transplanted for hepatitis C-related end-stage liver disease. In addition, we analyzed a potentially more sensitive metric, namely disease recurrence and fibrosis progression, obtained from follow-up liver biopsies. METHODS:We retrospectively studied 194 consecutive patients with hepatitis C virus (HCV) undergoing liver transplantation. To investigate the effect of red blood cell (RBC) or platelet transfusions on post-transplant HCV recurrence, hepatic biopsy data from 4 months and 1 year after transplantation were studied. In addition, survival data were analyzed. RESULTS:There was no effect of intraoperative RBC or platelet transfusion on either 1- or 5-year patient survival following liver transplantation. There was no difference in HCV disease recurrence or progression of hepatic fibrosis at 4 months or 1 year attributable either to RBC or to platelet transfusion. CONCLUSION:This study was not able to confirm an effect on the survival of HCV-infected liver transplant patients related to intraoperative transfusion of RBCs or platelets. In addition, these transfusions had no effect on HCV recurrence or fibrosis progression. This is not to condone a liberal transfusion practice, but rather to reassure that when clinically indicated, transfusion does not have a significant impact on patient survival or disease recurrence in HCV-infected liver transplant patients.

authors

Rice MJ,Wendling A,Firpi RJ,Hemming AW,Nelson DR,Schwab WK,Gravenstein N,Morey TE

doi

10.1111/j.1399-6576.2010.02313.x

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

1224-32

issue

10

eissn

0001-5172

issn

1399-6576

journal_volume

54

pub_type

杂志文章
  • Alveolar integrity and ultrastructure in pigs remain undamaged after exposure to sevoflurane.

    abstract::Previous studies have shown that both halothane and isoflurane have adverse but reversible effects on alveolar physiology. The present study was designed to test the hypothesis that also sevoflurane may affect alveolar integrity. Fifteen pigs were randomly selected to receive either thiopentone infusion (control group...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1399-6576.2002.460913.x

    authors: Takala RS,Soukka HR,Kirvelä OA,Kujari HP,Pelliniemi LJ,Kääpä PO,Aantaa RE

    更新日期:2002-10-01 00:00:00

  • Reversal of multiorgan system dysfunction in sickle cell disease with plasma exchange.

    abstract::A 23-year-old man with sickle cell anemia and multiorgan system dysfunction was treated with plasma exchange during a sickle cell crisis. The patient failed to respond to conventional treatment including hydration, blood transfusions, broad spectrum antibiotics, supplemental oxygen, and analgesics. The clinical pictur...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1997.tb04759.x

    authors: Geigel EJ,Francis CW

    更新日期:1997-05-01 00:00:00

  • Stimulating or conventional perineural catheters after hallux valgus repair: a double-blind, pharmaco-economic evaluation.

    abstract:BACKGROUND:We prospectively evaluated direct analgesia-related costs of continuous sciatic nerve block using either a stimulating or conventional catheter after hallux valgus repair. METHODS:The perineural catheter was inserted through a stimulating introducer either blindly (group Conventional, n= 38) or while stimul...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2006.01101.x

    authors: Casati A,Fanelli G,Danelli G,Baciarello M,Ghisi D,Nobili F,Chelly JE

    更新日期:2006-11-01 00:00:00

  • Caudal block for post-operative pain relief in children after genital operations. A comparison between bupivacaine and morphine.

    abstract::Twenty-two children formed the basis for a controlled study of the effect and duration of the postoperatively applied caudal block on postoperative pain after genital operations. The purpose of the study was to compare the effect and duration of bupivacaine and morphine. Ten children (Group I, outpatients) underwent c...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1981.tb01668.x

    authors: Jensen BH

    更新日期:1981-10-01 00:00:00

  • Left ventricular ejection and the Heather Index measured by non-invasive methods during postural changes in man.

    abstract::Differences have been found, which are usually 1% or less, between the left ventricular ejection time measured from the external carotid pulse tracing, and from the rate of change of thoracic impedance (dZ/dt) waveform, using either the second heart sound or the X-point of the dZ/dt tracing as the end-point. The Heath...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1976.tb05044.x

    authors: Hill DW,Merrifield AJ

    更新日期:1976-01-01 00:00:00

  • Recovery from sevoflurane and isoflurane anaesthesia after outpatient gynaecological laparoscopy.

    abstract::As the low blood solubility (blood gas partition coefficient 0.69) of sevoflurane suggests a rapid emergence from anaesthesia, recovery from sevoflurane anaesthesia was compared to isoflurane in outpatient gynaecological laparoscopy. Fifty ASA I or II, consenting women participated in a randomised, controlled and sing...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1995.tb04081.x

    authors: Eriksson H,Haasio J,Korttila K

    更新日期:1995-04-01 00:00:00

  • Plasma concentrations following repeated rectal or intravenous administration of paracetamol after heart surgery.

    abstract:BACKGROUND:Paracetamol is commonly used for post-operative pain management in combination with more potent analgesics. The best route of paracetamol administration after major surgery, when oral intake may not be optimal, is not known. Our primary purpose was to study plasma concentrations after the 1st and 4th dose of...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2006.01043.x

    authors: Holmér Pettersson P,Jakobsson J,Owall A

    更新日期:2006-07-01 00:00:00

  • Epinephrine as an adjuvant to amino-amide local anesthetics does not prolong their duration of action in infraorbital nerve block in the rat.

    abstract::The effects of epinephrine as an adjuvant to local anesthetics were studied in the rat infraorbital nerve block (IONB) model, using solutions of 0.5% prilocaine, 0.5% mepivacaine, 0.125% bupivacaine or 0.125% ropivacaine in 50 mmol/l tris-hydroxymethylaminomethane (THAM) tested both without and with epinephrine (EPI) ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1992.tb03486.x

    authors: Renck H,Hassan HG

    更新日期:1992-07-01 00:00:00

  • Neostigmine 50 microg kg(-1) with glycopyrrolate increases postoperative nausea in women after laparoscopic gynaecological surgery.

    abstract:BACKGROUND:Neostigmine, used for reversal of neuromuscular block, has been implicated in the development of postoperative nausea and vomiting (PONV). The use of mivacurium, which does not require neostigmine reversal due to its metabolism by plasma cholinesterase, has made it possible to study the effect of neostigmine...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1034/j.1399-6576.2001.045004495.x

    authors: Løvstad RZ,Thagaard KS,Berner NS,Raeder JC

    更新日期:2001-04-01 00:00:00

  • Adenosine in the inhibition of diazepam sedation by aminophylline.

    abstract::Aminophylline in a low dose has been shown to reverse diazepam sedation. The present investigation was performed as a double-blind study to compare the effects of aminophylline and enprofylline on deep diazepam sedation after surgery. Enprofylline is a xanthine derivative with anti-asthmatic effect but, in contrast to...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1986.tb02462.x

    authors: Niemand D,Martinell S,Arvidsson S,Ekström-Jodal B,Svedmyr N

    更新日期:1986-10-01 00:00:00

  • Extreme metabolic acidosis. Case report.

    abstract::A 42-year-old male patient, who suffered from insulin-dependent diabetes mellitus (IDDM) and intolerance of lactose, presented with extreme metabolic acidosis (lactic acidosis). On arrival, an arterial blood sample showed: pH 6.79, PO2 18.8 kPa, PCO2 0.9 kPa, base excess-33 mmol l-1, blood glucose 38 mmol l-1 and oeso...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1987.tb02620.x

    authors: Sjøgren P,Andersen LW

    更新日期:1987-08-01 00:00:00

  • Two cases of fatal air embolism in children undergoing scoliosis surgery.

    abstract::Venous air embolism during surgery is a rare but important complication and can be rapidly fatal. We present two cases of fatal air embolism in the prone position occurring in small children undergoing surgery for progressive scoliosis. Venous air embolism is a rare complication in the prone position. This is thought ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1997.tb04839.x

    authors: Sutherland RW,Winter RJ

    更新日期:1997-09-01 00:00:00

  • Treatment of elevated intracranial pressure with indomethacin: friend or foe?

    abstract::Indomethacin has been suggested as a therapeutic tool to manage elevated intracranial pressure in patients with severe head injury and patients undergoing craniotomy for brain tumors. Indomethacin is a non-selective cyclooxygenase inhibitor. Compared to other cyclooxygenase inhibitors indomethacin has unique effects o...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-6576.2005.00647.x

    authors: Rasmussen M

    更新日期:2005-03-01 00:00:00

  • Hyperoxia and antioxidants during major non-cardiac surgery and risk of cardiovascular events: Protocol for a 2 × 2 factorial randomised clinical trial.

    abstract:BACKGROUND:Myocardial injury after non-cardiac surgery occurs in a high number of patients, resulting in increased mortality in the post-operative period. The use of high inspiratory oxygen concentrations may cause hyperoxia, which is associated with impairment of coronary blood flow. Furthermore, the surgical stress r...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.13518

    authors: Petersen C,Loft FC,Aasvang EK,Vester-Andersen M,Rasmussen LS,Wetterslev J,Jorgensen LN,Christensen R,Meyhoff CS

    更新日期:2020-03-01 00:00:00

  • The influence of naloxone infusion on the action of intrathecal diamorphine: low-dose naloxone and neuroendocrine responses.

    abstract::The influence of an intravenous infusion of naloxone 1 microgram kg-1 h-1, in combination with intrathecal diamorphine, on analgesia and hormonal stress responses after laminectomy was assessed in a blinded, randomized, placebo-controlled study. Twenty-seven patients undergoing laminectomy with postoperative analgesia...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1992.tb03455.x

    authors: Wright PM,O'Toole DP,Barron DW

    更新日期:1992-04-01 00:00:00

  • A randomised double-blind evaluation of adenosine as adjunct to sufentanil in spinal labour analgesia.

    abstract:BACKGROUND:Intrathecal injection of sufentanil offers labour pain relief of short duration. This double-blind randomised study evaluates if the combination of adenosine to sufentanil could give relevant prolongation (40%) of the duration of sufentanil spinal analgesia. METHODS:Twenty-five healthy parturients requestin...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1034/j.1399-6576.2003.00110.x

    authors: Rane K,Sollevi A,Segerdahl M

    更新日期:2003-05-01 00:00:00

  • Referral and treatment patterns for complex regional pain syndrome in the Netherlands.

    abstract:BACKGROUND:Patients with complex regional pain syndrome (CRPS) are seen and treated by a variety of physicians. The present study aims to describe referral and treatment patterns for CRPS patients in the Netherlands. METHODS:Patients, who were selected (1996-2005) from an electronic general practice (GP) database (Int...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2009.01927.x

    authors: DE Mos M,Huygen FJ,VAN DER Hoeven-Borgman M,Dieleman JP,Stricker BH,Sturkenboom MC

    更新日期:2009-07-01 00:00:00

  • Thrombosis following percutaneous radial artery cannulation.

    abstract::A prospective study of the arterial supply of the hand was carried out in 100 ICU patients after cannulation of the radial artery. Patency of the radial artery was checked using a reversed Allen's test and Doppler ultrasonic technique. Furthermore, radial artery angiography was carried out in 15 patients with suspect ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1986.tb02402.x

    authors: Cederholm I,Sørensen J,Carlsson C

    更新日期:1986-04-01 00:00:00

  • The different responses of the hepatic arterial bed to hypovolaemia and to halothane anaesthesia.

    abstract::Ten dogs were subjected to a period of hypovolaemia (bleeding volume: 2% of body weight) and to a period of halothane anaesthesia (end-tidal halothane concentration: 1%). Mean arterial blood pressure decreased to 79% of control value during hypovolaemia and to 58% of control value during halothane anaesthesia. Mean to...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1977.tb01247.x

    authors: Andreen M,Irestedt L,Zetterström B

    更新日期:1977-01-01 00:00:00

  • Perineural meperidine blocks nerve conduction in a dose-related manner: a randomized double-blind study.

    abstract:BACKGROUND:Meperidine has been shown to exhibit a sensory block in peripheral nerves. However, its motor blockade ability is controversial. The aim of this study was to investigate, electroneurographically, the ability of meperidine to inhibit conduction in both sensory and motor fibres in the ulnar nerve. MATERIALS A...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2009.01953.x

    authors: Oztürk E,Beyazova M,Kaya K,Meray J,Zinnuroglu M,Tarhan B

    更新日期:2009-07-01 00:00:00

  • Transcutaneous oxygen measurement in adult intensive care.

    abstract::Transcutaneous oxygen measurement (PtcO2-measurement) gives by a non-invasive technique continuous information about central PO2. The method has as yet been tested mainly on newborns, and systematic studies of the applicability of the method on adults are still few. The current systematic study reports on consecutive ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1979.tb01484.x

    authors: Löfgren O

    更新日期:1979-12-01 00:00:00

  • Keeping the spirit high: why trauma team training is (sometimes) implemented.

    abstract:BACKGROUND:Systematic and multiprofessional trauma team training using simulation was introduced in Norway in 1997. The concept was developed out of necessity in two district general hospitals and one university hospital but gradually spread to 45 of Norway's 50 acute-care hospitals over the next decade. Implementation...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1399-6576.2007.01539.x

    authors: Wisborg T,Brattebø G

    更新日期:2008-03-01 00:00:00

  • The effect of perineural dexamethasone on duration of sciatic nerve blockade: a randomized, double-blind study.

    abstract:BACKGROUND:Major hindfoot and ankle surgery is associated with severe postoperative pain, which is effectively alleviated by combined sciatic and saphenous nerve blockade. Local anaesthetics with added dexamethasone consistently prolongs the duration of pain relief compared to local anaesthetics alone. However, whether...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/aas.13054

    authors: Hauritz RW,Hannig KE,Henriksen CW,Børglum J,Bjørn S,Bendtsen TF

    更新日期:2018-04-01 00:00:00

  • Reducing the risk of systemic embolization during gynecologic laparoscopy--effect of volume preload.

    abstract:BACKGROUND:About 27% of the population is known to have a patent foramen ovale. It can be opened if the left atrial pressure is less than the right atrial pressure. This pressure reversal has been reported during gynecologic laparoscopic surgery. The present paper describes with help of transesophageal echocardiography...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:

    authors: Tuppurainen T,Mäkinen J,Salonen M

    更新日期:2002-01-01 00:00:00

  • Psychological changes in children after anaesthesia: a comparison between halothane and ketamine.

    abstract::The psychological reactions to hospitalization, anaesthesia, and operation in a group of 107 children from 1 to 12 years old, anaesthetized with ketamine or halothane after randomization were investigated through questionnaires, which the parents answered 1 month postoperatively. The percentage of replies was 96.3%. F...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1977.tb01258.x

    authors: Modvig KM,Nielsen SF

    更新日期:1977-01-01 00:00:00

  • Effects of propranolol pretreatment on cerebral blood flow, oxygen uptake and catecholamines during metabolic acidosis following E. coli endotoxin in dogs.

    abstract::After an intravenous injection of E. coli endotoxin in dogs a decrease in cerebral blood flow (CBF) and an increase in cerebral metabolic rate of oxygen (CMRo2) have been shown to occur. In metabolic acidosis following endotoxin CMRo2 increased with decreasing pH. A possible explanation for the increased CMRo2 after e...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1995.tb04101.x

    authors: Westerlind A,Larsson LE,Häggendal J,Ekström-Jodal B

    更新日期:1995-05-01 00:00:00

  • Oxygen and carbon dioxide concentrations in anaesthetic circuits ventilated with an AGA UV 705 in an oxygen consuming model lung.

    abstract::An oxygen consuming an carbon dioxide producing model lung was used for evaluation of anaesthetic circle systems. Two different circles, the AGA metal circle and the AGA Monosorb circle ventilated by an AGA UV-705 were tested with reference to inspired oxygen concentrations and end-tidal CO2 levels. Carbon dioxide is ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1982.tb01731.x

    authors: Sonander H,Stenqvist O

    更新日期:1982-02-01 00:00:00

  • Spondylitis without epidural abscess formation following short-term use of an epidural catheter.

    abstract::A 42-year-old patient had undergone total hip replacement for aseptic femoral head necrosis 9 years previously. He now presented with loosening of the prosthesis and pseudoarthrosis sustained following a femoral shaft fracture 7 months earlier. A total hip replacement was carried out in general anaesthesia combined wi...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1990.tb03064.x

    authors: Lynch J,Zech D

    更新日期:1990-02-01 00:00:00

  • Lumbar versus thoracic epidural buprenorphine for postoperative analgesia following coronary artery bypass graft surgery.

    abstract:BACKGROUND:Thoracic epidural analgesia (TEA) is reported to provide effective analgesia following cardiac surgery. We compared the effect of buprenorphine (BN) through the lumbar and thoracic epidural routes for postoperative analgesia following coronary artery bypass graft surgery (CABG). METHODS:Forty patients with ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1034/j.1399-6576.1999.430404.x

    authors: Mehta Y,Juneja R,Madhok H,Trehan N

    更新日期:1999-04-01 00:00:00

  • Low dose intrathecal morphine effects on post-hysterectomy pain: a randomized placebo-controlled study.

    abstract:BACKGROUND:Spinal anesthesia with different doses of intrathecal morphine has been shown to relieve post-operative pain. We studied in a prospective randomized, double-blind fashion the effects of morphine 0, 100, 200, or 300 μg added to intrathecal bupivacaine on first post-operative 24 h patient-controlled analgesia ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2011.02574.x

    authors: Hein A,Rösblad P,Gillis-Haegerstrand C,Schedvins K,Jakobsson J,Dahlgren G

    更新日期:2012-01-01 00:00:00