Alveolar integrity and ultrastructure in pigs remain undamaged after exposure to sevoflurane.

Abstract:

:Previous studies have shown that both halothane and isoflurane have adverse but reversible effects on alveolar physiology. The present study was designed to test the hypothesis that also sevoflurane may affect alveolar integrity. Fifteen pigs were randomly selected to receive either thiopentone infusion (control group, n=8) or sevoflurane (n=7) at 4.0% inspiratory concentration (1.5 MAC) in air for 6 h. Tissue samples from the lungs were obtained at the end of the experiment. Both histopathological light microscopy and electron microscopy were used to assess the structural integrity of the alveoli. Pulmonary hemodynamics were comparable in both groups. Light microscopy showed no difference between the groups in the amount of alveolar macrophages, red blood cells or edema. Electron microscopy showed minor changes such as moderate local swelling of alveolar epithelium in both study groups. Alveolar type II cells were ultrastructurally unaltered in both study groups. We conclude that long-term, high concentration exposure to sevoflurane has no detrimental effect on the alveolar integrity in pigs.

authors

Takala RS,Soukka HR,Kirvelä OA,Kujari HP,Pelliniemi LJ,Kääpä PO,Aantaa RE

doi

10.1034/j.1399-6576.2002.460913.x

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

1137-43

issue

9

eissn

0001-5172

issn

1399-6576

pii

aas460913

journal_volume

46

pub_type

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