Atracurium and vecuronium block nicotine-induced carotid body chemoreceptor responses.

Abstract:

BACKGROUND:Vecuronium depresses carotid body chemosensitivity during hypoxia. We hypothesized that this is caused by inhibition of cholinergic transmission of the carotid body. METHODS:The carotid body with its sinus nerve was removed en bloc from thiopentone-anaesthetized adult male New Zealand rabbits and perfused in vitro with modified Tyrodes buffer solution at constant perfusion pressure, temperature, a buffer pH of 7.4 and normocapnia. Chemoreceptor discharge and spike frequencies (fx) were recorded from the whole sinus nerve after administration of 500 microg nicotine, given as duplicated controls and thereafter following 30 min perfusion of equipotent concentrations of atracurium (28.1 microM) or vecuronium(10 microM), after 30 min of neostigmine perfusion (9.2 microM) and finally after 30 min wash-out with buffer solution only. A short-lasting hypoxic test was performed before and at the end of the experimental period to confirm the responsiveness and validity of the preparation. RESULTS:Atracurium (n = 7) and vecuronium (n = 6) reduced chemoreceptor responses to nicotine by 70 +/- 30% and 66 +/- 19% (SEM) (P<0.05). Chemoreceptor discharges showed full recovery after neostigmine in the atracurium group and partial recovery in the vecuronium group (P<0.05). Finally, after wash-out the chemoreceptor responses to nicotine had fully recovered in both groups. CONCLUSION:Atracurium and vecuronium in equipotent concentrations block nicotine-induced chemoreceptor responses of the carotid body.

authors

Jonsson M,Kim C,Yamamoto Y,Runold M,Lindahl SG,Eriksson LI

doi

10.1034/j.1399-6576.2002.460503.x

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

488-94

issue

5

eissn

0001-5172

issn

1399-6576

pii

aas460503

journal_volume

46

pub_type

杂志文章
  • Effect of low-dose N-acetyl-cysteine infusion on tourniquet-induced ischaemia-reperfusion injury in arthroscopic knee surgery.

    abstract:BACKGROUND:Temporary occlusion of blood flow is used during arthroscopic knee surgery in order to provide a bloodless surgical field. The resulting ischaemia-reperfusion causes lipid peroxidation, which contributes to tissue injury. The aim of the study was to investigate the effect of low-dose n-acetyl cysteine (NAC) ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2005.00722.x

    authors: Saricaoglu F,Dal D,Salman AE,Atay OA,Doral MN,Salman MA,Kilinç K,Aypar U

    更新日期:2005-07-01 00:00:00

  • Intermittent high frequency ventilation: a new mode to measure changes in lung volume and alveolar gas concentration, enhance CO2 elimination and reduce intrapulmonary pressures.

    abstract::A new method of artificial ventilation, intermittent high frequency ventilation (IHFV), is described in which high frequency ventilation (HFV) is intermittently interrupted so that short periods of ventilation and pauses in ventilation occur in sequence several times a minute. During the pauses in ventilation the incr...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1988.tb02732.x

    authors: Chakrabarti MK,Swenzen GO,Whitwam JG

    更新日期:1988-05-01 00:00:00

  • Colloid osmotic pressure and extravasation of plasma proteins following infusion of Ringer's acetate and hydroxyethyl starch 130/0.4.

    abstract:BACKGROUND:During fluid infusion therapy, plasma proteins are diluted and leak from the intravascular space, which alters the colloid osmotic pressure (COP) and potentially affects coagulation. We hypothesised that acetated Ringer's and starch solution, alone or in combination, influence these mechanisms differently. ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.12558

    authors: Zdolsek JH,Bergek C,Lindahl TL,Hahn RG

    更新日期:2015-11-01 00:00:00

  • Complement partially mediates acid aspiration-induced remote organ injury in the rat.

    abstract:BACKGROUND:Acid aspiration into one lung is known to cause both a local as well as remote organ injury characterized by neutrophil sequestration and subsequent edema. This study investigated investigated the role of the complement cascade in the development of acid aspiration-induced local lung and remote organ injurie...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1997.tb04771.x

    authors: Yamada H,Kudoh I,Nishizawa H,Kaneko K,Miyazaki H,Ohara M,Okumura F

    更新日期:1997-06-01 00:00:00

  • Preoperative anaesthesia triage with a patient-centred system-A prospective clinical study.

    abstract:BACKGROUND:Increase in day surgery has challenged preoperative anaesthesia with need to identify a few high-risk patients requiring detailed preoperative intervention. We aimed to assess if a nurse-administered Preoperative Patient-centred Anaesthesia System (Pre-PAS) could identify high-risk patients, defined as ASA s...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.13678

    authors: Molin C,Rovsing ML,Meyhoff CS

    更新日期:2020-11-01 00:00:00

  • Verification of endotracheal intubation in obese patients - temporal comparison of ultrasound vs. auscultation and capnography.

    abstract:BACKGROUND:Ultrasound (US) may have an emerging role as an adjunct in verification of endotracheal intubation. Obtaining optimal US images in obese patients is generally regarded more difficult than for other patients. This study compared the time consumption of bilateral lung US with auscultation and capnography for v...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2011.02630.x

    authors: Pfeiffer P,Bache S,Isbye DL,Rudolph SS,Rovsing L,Børglum J

    更新日期:2012-05-01 00:00:00

  • Decisions not to resuscitate in a Swedish university hospital.

    abstract:BACKGROUND:Cardiopulmonary resuscitation (CPR) has the potential to save many lives. Used indiscriminately though, it may be harmful and not in the best interest of the patient. An advance directive to refrain from resuscitation in selected patients is probably not uncommon in Sweden, but guidelines ruling this are sti...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1997.tb04642.x

    authors: Friberg H,Adolfsson A,Lundberg D

    更新日期:1997-11-01 00:00:00

  • Effect of the menstrual cycle phase on post-operative pain perception and analgesic requirements.

    abstract:BACKGROUND:Research has shown that menstrual cycle phase may affect pain sensitivity. There is a lack of studies evaluating this effect on post-operative pain and analgesic needs. METHODS:In this prospective cohort study, we determined the effect of menstrual cycle phase on pain perception and analgesic requirements f...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2012.02661.x

    authors: Ahmed A,Khan F,Ali M,Haqnawaz F,Hussain A,Azam SI

    更新日期:2012-05-01 00:00:00

  • The pressor response after laryngeal mask or cuffed oropharyngeal airway insertion.

    abstract:BACKGROUND:Since the cuffed oropharyngeal airway (COPA) has been suggested to cause less pharyngeal trauma than the laryngeal mask airway (LMA), we conducted a prospective, randomised study to compare haemodynamic changes after placing either the COPA or LMA in healthy anaesthetised adults. METHODS:After standard mida...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1034/j.1399-6576.1999.431014.x

    authors: Casati A,Cappelleri G,Fanelli G,Magistris L,Beccaria P,Albertin A,Torri G

    更新日期:1999-11-01 00:00:00

  • Scandinavian glutamine trial: a pragmatic multi-centre randomised clinical trial of intensive care unit patients.

    abstract:BACKGROUND:Low plasma glutamine concentration is an independent prognostic factor for an unfavourable outcome in the intensive care unit (ICU). Intravenous (i.v.) supplementation with glutamine is reported to improve outcome. In a multi-centric, double-blinded, controlled, randomised, pragmatic clinical trial of i.v. g...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1399-6576.2011.02453.x

    authors: Wernerman J,Kirketeig T,Andersson B,Berthelson H,Ersson A,Friberg H,Guttormsen AB,Hendrikx S,Pettilä V,Rossi P,Sjöberg F,Winsö O,Scandinavian Critical Care Trials Group.

    更新日期:2011-08-01 00:00:00

  • DEX-2-TKA-DEXamethasone twice for pain treatment after Total Knee Arthroplasty: A protocol for a randomized, blinded, three-group multicentre clinical trial.

    abstract:BACKGROUND:Multimodal analgesia is considered the leading principle for post-operative pain treatment, but no gold standard after total knee arthroplasty (TKA) exists. AIM:To investigate the beneficial and harmful effects of one or two doses of 24 mg intravenous dexamethasone (DXM) as part of a multimodal analgesic re...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.13481

    authors: Gasbjerg KS,Hägi-Pedersen D,Lunn TH,Jakobsen JC,Overgaard S,Pedersen NA,Bagger J,Lindholm P,Brorson S,Schrøder HM,Thybo KH,Mathiesen O

    更新日期:2020-02-01 00:00:00

  • Cervical epidural steroid injection for cervicobrachialgia.

    abstract::Fifty patients with chronic resistant cervicobrachialgia were randomly divided into two groups. Twenty-five patients (group A) were treated with cervical epidural steroid/lidocaine injections and 17 patients (group B) were treated with steroid/lidocaine injections into the posterior neck muscles. Another eight patient...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1993.tb03765.x

    authors: Stav A,Ovadia L,Sternberg A,Kaadan M,Weksler N

    更新日期:1993-08-01 00:00:00

  • Thrombosis following percutaneous radial artery cannulation.

    abstract::A prospective study of the arterial supply of the hand was carried out in 100 ICU patients after cannulation of the radial artery. Patency of the radial artery was checked using a reversed Allen's test and Doppler ultrasonic technique. Furthermore, radial artery angiography was carried out in 15 patients with suspect ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1986.tb02402.x

    authors: Cederholm I,Sørensen J,Carlsson C

    更新日期:1986-04-01 00:00:00

  • Functional intravascular volume deficit in patients before surgery.

    abstract:BACKGROUND:Stroke volume (SV) maximization with a colloid infusion, referred to as individualized goal-directed therapy, improves outcome in high-risk surgery. The fraction of patients who need intravascular volume to establish a maximal SV has, however, not been evaluated, and there are only limited data on the volume...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2009.02175.x

    authors: Bundgaard-Nielsen M,Jørgensen CC,Secher NH,Kehlet H

    更新日期:2010-04-01 00:00:00

  • MAC for halothane and isoflurane during normothermia and hypothermia in the newborn piglet.

    abstract:BACKGROUND:Halothane and isoflurane are frequently used in studies of perinatal hypoxia and ischemia. Little information exists on the minimum alveolar concentration (MAC) necessary to prevent movement to a painful stimulus in newborn pigs and no information on the effects of hypothermia on MAC in pigs. Hypothermia is ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1996.tb04468.x

    authors: Satas S,Haaland K,Thoresen M,Steen PA

    更新日期:1996-04-01 00:00:00

  • Fatal lipoid pneumonia due to bronco-aspiration of isoparaffin after ingestion of an organophosphate insecticide.

    abstract::A 66-year-old-male patient with a history of depression voluntarily ingested around 400 ml of an insecticide composed of 5% methylparathion, 75% isoparaffin, 8% etoxylated oleic acid, 4% 1,2,4-trimethylbenzene, 6% naphtha, 1% 1,3,5- trimethylbenzene, 0.4% propylbenzene and 0.3% xylene. The patient was conscious and al...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1399-6576.2003.00122.x

    authors: Nogué S,Sanz P,Borondo JC,Picón M,de la Red G,Mestre G

    更新日期:2003-07-01 00:00:00

  • Recovery from sufentanil anaesthesia for outpatient arthroscopy: a comparison with isoflurane.

    abstract::This study compares the recovery from sufentanil and isoflurane anaesthesia in patients undergoing outpatient arthroscopy of the knee under general anaesthesia. In 40 unpremedicated patients, divided at random into two groups, anaesthesia was induced with methohexitone and vecuronium bromide and, after intubation, mai...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1987.tb02539.x

    authors: Zuurmond WW,van Leeuwen L

    更新日期:1987-02-01 00:00:00

  • Effect of hemodiafiltration and sepsis on chemotaxis of granulocytes and the release of IL-8 and IL-10.

    abstract:BACKGROUND:Extracorporeal circulation, such as cardiopulmonary bypass and hemodialysis, has been associated with an activation of the immune system. Continuous veno venous hemodiafiltration (CVVHD) is used in critically ill septic patients. During CVVHD, cytokines are excreted in ultrafiltrate. When the membranes, used...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1399-6576.2002.460203.x

    authors: Toft P,Brix-Christensen V,Baech J,Krog J,Jørgensen HS,Tønnesen E,Petersen TK,Dagnaes-Hansen F

    更新日期:2002-02-01 00:00:00

  • Effects of olprinone, a new phosphodiesterase inhibitor, on gastric intramucosal acidosis and systemic inflammatory responses following hypothermic cardiopulmonary bypass.

    abstract:BACKGROUND:Phosphodiesterase (PDE) III inhibitors have both an inotropic and a peripheral vasodilatory effect, and also inhibit the activation of macrophages. Thus a newly developed PDE III inhibitor, olprinone, could modify gastric intramucosal pH (pHi), systemic oxygen consumption, and systemic inflammatory responses...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1034/j.1399-6576.2001.045004427.x

    authors: Yamaura K,Akiyoshi K,Irita K,Taniyama T,Takahashi S

    更新日期:2001-04-01 00:00:00

  • In vitro diagnosis of susceptibility to malignant hyperthermia: comparison between dynamic and static halothane and caffeine tests.

    abstract::In vitro tests for the diagnosis of malignant hyperthermia susceptibility were performed in 105 patients and 20 normal controls according to the protocol of the European MH Group. Results of dynamic halothane and caffeine tests (in which muscle bundle length is cyclically changed) were compared to those of static test...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1987.tb02603.x

    authors: Ording H,Skovgaard LT

    更新日期:1987-07-01 00:00:00

  • Who is responsible for operating room management and how do we measure how well we do it?

    abstract:BACKGROUND:Managing the surgical process in the operating suite - often the most expensive unit in the hospital - is vital, yet challenging. While sensible management can improve efficiency, unclear managerial structures can hinder the optimal use of resources. Despite that, no previous data exists as to how the operat...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2007.01368.x

    authors: Marjamaa RA,Kirvelä OA

    更新日期:2007-08-01 00:00:00

  • Effects of thoracic epidural block and the beta-1-adrenoreceptor agonist prenalterol on the cardiovascular response to infrarenal aortic cross-clamping in man.

    abstract::Sixteen patients scheduled for abdominal aortic resection and grafting were randomly assigned to two groups to study the cardiovascular effects of infrarenal aortic cross-clamping. The patients in the first group had received a thoracic epidural block followed by intravenous administration of the selective beta-1-adre...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1979.tb01466.x

    authors: Reiz S,Nath S,Pontén E,Friedman A,Bäcklund U,Olsson B,Rais O

    更新日期:1979-10-01 00:00:00

  • The association between pre-operative sepsis and 30-day mortality in hip fracture patients-A cohort study.

    abstract:BACKGROUND:Post-operative sepsis considerably increases mortality, but the extent of pre-operative sepsis in hip fracture patients and its consequences are sparsely elucidated. The aim of this study was to assess the association between pre-operative sepsis and 30-day mortality after hip fracture surgery. METHODS:We c...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.13160

    authors: Mørch SS,Tantholdt-Hansen S,Pedersen NE,Duus CL,Petersen JA,Andersen CØ,Jarløv JO,Meyhoff CS

    更新日期:2018-10-01 00:00:00

  • Catheter-related epidural abscesses -- don't wait for neurological deficits.

    abstract::Epidural abscess is a rare but serious complication of epidural anesthesia for peri- and postoperative analgesia. It is feared because of possible persistent neurological deficits. Epidural abscess presents mostly with a classic triad of symptoms: back pain, fever and variable neurological signs and symptoms. When neu...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1399-6576.2002.460523.x

    authors: Royakkers AA,Willigers H,van der Ven AJ,Wilmink J,Durieux M,van Kleef M

    更新日期:2002-05-01 00:00:00

  • Adjusting positive end-expiratory pressure and tidal volume in acute respiratory distress syndrome according to the pressure-volume curve.

    abstract:BACKGROUND:Management of acute respiratory distress syndrome (ARDS) patients implies the selection of the adequate ventilatory parameters, essentially PEEP and tidal volume (Vt), to prevent ventilator-induced lung injury. These parameters should be reset as the lung injury evolves. Among the different methods proposed ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1034/j.1399-6576.2003.00011.x

    authors: Pestaña D,Hernández-Gancedo C,Royo C,Uña R,Villagrán MJ,Peña N,Criado A

    更新日期:2003-03-01 00:00:00

  • Monitoring functional residual capacity (FRC) by quantifying oxygen/carbon dioxide fluxes during a short apnea.

    abstract:BACKGROUND:Clinically applicable methods for measuring FRC are currently lacking. This study presents a new method for FRC monitoring based on quantification of metabolic gas fluxes of O2 and CO2 during a short apnea. METHODS:Base line exchange of oxygen and carbon dioxide was measured with indirect calorimetry. End-t...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1399-6576.2002.460617.x

    authors: Stenqvist O,Olegård C,Søndergaard S,Odenstedt H,Kárason S,Lundin S

    更新日期:2002-07-01 00:00:00

  • Ketorolac or fentanyl continuous infusion for post-operative analgesia in children undergoing ureteroneocystostomy.

    abstract:BACKGROUND:children undergoing ureteroneocystostomy suffer from post-operative pain due to the surgical incision and bladder spasm. A single-shot caudal block is a common technique for paediatric analgesia, but a disadvantage is the limitation of a short duration in spite of the additives co-administered. A few clinica...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2010.02354.x

    authors: Jo YY,Hong JY,Choi EK,Kil HK

    更新日期:2011-01-01 00:00:00

  • Preferences for shared decision making in chronic pain patients compared with patients during a premedication visit.

    abstract:BACKGROUND:There is some evidence that patients' outcomes improve if they are involved in shared decision making (SDM). A chronic pain clinic or premedication visit could be adequate settings for the implementation of SDM. So far, the patients' preference for involvement in decision making and their desire for informat...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2006.01097.x

    authors: Spies CD,Schulz CM,Weiss-Gerlach E,Neuner B,Neumann T,von Dossow V,Schenk M,Wernecke KD,Elwyn G

    更新日期:2006-09-01 00:00:00

  • Increase of interleukin-6 plasma concentrations and HLA-DR positive T-lymphocytes after hypotensive anaesthesia with sodium nitroprusside.

    abstract::Interleukin-6 (IL-6), a cytokine involved in the pathogenesis of sepsis and septic shock, and lymphocyte subpopulations were measured in blood circulation of patients receiving sodium nitroprusside (SNP) for induction of hypotension. The aim of this study was to evaluate whether this procedure influences distribution ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1995.tb04206.x

    authors: Heesen M,Bachmann-Mennenga B,Zeiler D,Mahler M,Hempelmann G

    更新日期:1995-10-01 00:00:00

  • Necrotizing soft tissue infections - a multicentre, prospective observational study (INFECT): protocol and statistical analysis plan.

    abstract:BACKGROUND:The INFECT project aims to advance our understanding of the pathophysiological mechanisms in necrotizing soft tissue infections (NSTIs). The INFECT observational study is part of the INFECT project with the aim of studying the clinical profile of patients with NSTIs and correlating these to patient-important...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,多中心研究

    doi:10.1111/aas.13024

    authors: Madsen MB,Skrede S,Bruun T,Arnell P,Rosén A,Nekludov M,Karlsson Y,Bergey F,Saccenti E,Martins Dos Santos VAP,Perner A,Norrby-Teglund A,Hyldegaard O

    更新日期:2018-02-01 00:00:00