Peripheral venous lactate at admission is associated with in-hospital mortality, a prospective cohort study.


BACKGROUND:The prognostic value of blood lactate as a predictor of adverse outcome in the acutely ill patient is unclear. The aim of this study was to investigate if a peripheral venous lactate measurement, taken at admission, is associated with in-hospital mortality in acutely ill patients with all diagnosis. Furthermore, we wanted to investigate if the test improves a triage model in terms of predicting in-hospital mortality. METHODS:We retrieved a cohort of 2272 adult patients from a prospectively gathered acute admission database. We performed regression analysis to evaluate the association between the relevant covariates and the outcome measure: in-hospital mortality. RESULTS:Lactate as a continuous variable was a risk for in-hospital mortality with an odds ratio (OR) of 1.40 [95% confidence interval (CI) 1.25-1.57, P<0.0001]. OR for in-hospital mortality increased with increasing lactate levels from 2.97 (95% CI 1.55-5.72, P<0.001) for lactate between 2 mmol/l and 4 mmol/l, to 7.77 (95% CI 3.23-18.66, P<0.0001) for lactate>4 mmol/l. If the condition was non-compensated (i.e. pH<7.35), OR for in-hospital mortality increased to 19.99 (7.26-55.06, P<0.0001). Patient with a blood lactate at 4 mmol/l or more had a risk of in-hospital mortality equivalent to the patients in the most urgent triage category. CONCLUSION:We found elevated admission peripheral venous lactate to be independently associated with in-hospital mortality in the acutely ill patient admitted to the emergency department. Patients with a lactate>4 mmol/l at hospital admission should be considered triaged to the most urgent triage category.


Barfod C,Lundstrøm LH,Lauritzen MM,Danker JK,Sölétormos G,Forberg JL,Berlac PA,Lippert FK,Antonsen K,Lange KH




Has Abstract


2015-04-01 00:00:00












  • PCEA compared to continuous epidural infusion in an ultra-low-dose regimen for labor pain relief: a randomized study.

    abstract:BACKGROUND:Patient-controlled epidural analgesia, PCEA, has been introduced in obstetric analgesia during the past decade. Many studies have shown that the consumption of analgesic is reduced when the parturient requests her own doses. This study investigates whether this is also true when using an ultra-low-dose regim...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ledin Eriksson S,Gentele C,Olofsson CH

    更新日期:2003-10-01 00:00:00

  • Impact of gender on treatment and outcome of ICU patients.

    abstract:BACKGROUND:Gender modifies immunologic responses caused by severe trauma or critical illness. The aim of this study was to investigate the impact of gender on hospital mortality, length of intensive care unit (ICU) stay, and intensity of care of patients treated in ICUs. METHODS:Data on 24,341 ICU patients were collec...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Reinikainen M,Niskanen M,Uusaro A,Ruokonen E

    更新日期:2005-08-01 00:00:00

  • Classification of a traumatic brain injury: the Glasgow Coma scale is not enough.

    abstract:BACKGROUND:Classifying the severity of a traumatic brain injury (TBI) solely by means of the Glasgow Coma scale (GCS) is under scrutiny, because it overlooks other important clinical signs. Clinicians treating patients with acute TBI are well placed to suggest which variables, in addition to the GCS, should concur in a...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Chieregato A,Martino C,Pransani V,Nori G,Russo E,Noto A,Simini B

    更新日期:2010-07-01 00:00:00

  • Bupivacaine does not suppress cardiac sympathetic nerve activity during halothane anesthesia in the cat.

    abstract:BACKGROUND:The finding that i.v. lidocaine suppresses cardiac sympathetic nerve activity during 1 MAC halothane, but not during 2 MAC or 3 MAC halothane, suggests that the neurally mediated circulatory effects of i.v. local anesthetics may vary with background autonomic activity. This study aimed to compare the effects...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Nishikawa K,Terai T,Morimoto O,Yukioka H,Asada A

    更新日期:1997-05-01 00:00:00

  • Preoperative predictors of moderate to intense acute postoperative pain in patients undergoing abdominal surgery.

    abstract:BACKGROUND:Pain is a sensory and emotional experience that is influenced by physiologic, sensory, affective, cognitive, socio-cultural, and behavioral factors. Consistent with the perspective to improve the postoperative pain control, the present study has the purpose of assessing the effect of presurgical clinical fac...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Caumo W,Schmidt AP,Schneider CN,Bergmann J,Iwamoto CW,Adamatti LC,Bandeira D,Ferreira MB

    更新日期:2002-11-01 00:00:00

  • The effect of promethazine on postoperative pain: a comparison of preoperative, postoperative, and placebo administration in patients following total abdominal hysterectomy.

    abstract:BACKGROUND:Histamine receptors are involved in the development of inflammatory pain and hyperalgesia, and the use of antihistamines is advocated as an alternative for pain therapy and treatment of postoperative nausea and vomiting. We investigated the influence of timing of promethazine administration on postoperative ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Chia YY,Lo Y,Liu K,Tan PH,Chung NC,Ko NH

    更新日期:2004-05-01 00:00:00

  • Age-dependent decrease in desflurane concentration for maintaining bispectral index below 50.

    abstract:BACKGROUND:We examined the hypothesis that the minimum alveolar concentration of desflurane for maintaining bispectral index (BIS) below 50 (MACBIS 50 ) decreases with advance of age. METHODS:Sixty young (20-30 year), middle-aged (31-65 year) and elderly (66-80 year) patients were included (n = 20, each group). Five m...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Kanazawa S,Oda Y,Maeda C,Okutani R

    更新日期:2016-02-01 00:00:00

  • Regional cerebral glucose metabolism during sevoflurane anaesthesia in healthy subjects studied with positron emission tomography.

    abstract:BACKGROUND:The precise mechanism by which sevoflurane exerts its effects in the human brain remains unknown. In the present study, we quantified the effects of sevoflurane on regional cerebral glucose metabolism (rGMR) in the human brain measured with positron emission tomography. METHODS:Eight volunteers underwent tw...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Schlünzen L,Juul N,Hansen KV,Gjedde A,Cold GE

    更新日期:2010-05-01 00:00:00

  • Repeated episodes of myocardial ischaemia during combined thoracic epidural-isoflurane anaesthesia.

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    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Sigurdsson GH,Brouwer RP,Thomson D

    更新日期:1994-07-01 00:00:00

  • Effects of levosimendan in patients with left ventricular hypertrophy undergoing aortic valve replacement.

    abstract:BACKGROUND:Left ventricular hypertrophy is associated with adverse outcomes, including death, during cardiac surgery. This may be facilitated by an increased oxygen demand and diastolic dysfunction. Levosimendan augments haemodynamics without further oxygen consumption and improves echocardiographic indices of diastoli...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验


    authors: Juhl-Olsen P,Jakobsen CJ,Rasmussen LA,Bhavsar R,Klaaborg KE,Frederiksen CA,Sloth E

    更新日期:2015-01-01 00:00:00

  • The effect of perineural dexamethasone on duration of sciatic nerve blockade: a randomized, double-blind study.

    abstract:BACKGROUND:Major hindfoot and ankle surgery is associated with severe postoperative pain, which is effectively alleviated by combined sciatic and saphenous nerve blockade. Local anaesthetics with added dexamethasone consistently prolongs the duration of pain relief compared to local anaesthetics alone. However, whether...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验


    authors: Hauritz RW,Hannig KE,Henriksen CW,Børglum J,Bjørn S,Bendtsen TF

    更新日期:2018-04-01 00:00:00

  • Clinical effects of carticaine, a new local anesthetic. A survey and a double-blind investigation comparing carticaine with lidocaine in epidural analgesia.

    abstract::Carticaine, a new local anesthetic of the amide type, differs from those previously known in that it contains a thiophene ring. The physico-chemical properties of the compound, its pharmacology and its toxicology are reviewed from the litererture. A controlled, double-blind investigation in which carticaine was compar...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章


    authors: Brinklov MM

    更新日期:1977-01-01 00:00:00

  • Pharmacological evacuation of the stomach with metoclopramide.

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    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章


    authors: Olsson GL,Hallén B

    更新日期:1982-10-01 00:00:00

  • Regional anaesthesia for a Caesarean section in women with cardiac disease: a prospective study.

    abstract:BACKGROUND:We conducted a prospective observational survey of pregnant women with cardiac disease. The aim was to analyse and present the mode of delivery, outcome, and haemodynamic changes during a caesarean section under regional anaesthesia in women with cardiac disease. METHODS:All pregnant women with a cardiovasc...

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    pub_type: 杂志文章


    authors: Langesaeter E,Dragsund M,Rosseland LA

    更新日期:2010-01-01 00:00:00

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    abstract::In order to antagonize immediate postoperative somnolence, 24 surgical patients were given a two-rate infusion of physostigmine, aiming at a constant plasma concentration in the range of 1 to 10 ng/ml. Plasma concentrations of physostigmine were determined during infusion and after infusion and the effects of physosti...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Hartvig P,Lindström B,Pettersson E,Wiklund L

    更新日期:1989-11-01 00:00:00

  • Utilization of Pharma-Plast syringes for gas level determination.

    abstract::A comparative study has been made of Pharma-Plast and Arterial-Blood-Sampler-B-109 syringes. Thirty-two syringes were studied in each group: their properties were compared with regard to blood sampling from intravascular catheters with the object of gas level determination. A comparison of the two groups showed no sig...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Andreasen EE,Bøgh A

    更新日期:1980-10-01 00:00:00

  • Recovery from sevoflurane and isoflurane anaesthesia after outpatient gynaecological laparoscopy.

    abstract::As the low blood solubility (blood gas partition coefficient 0.69) of sevoflurane suggests a rapid emergence from anaesthesia, recovery from sevoflurane anaesthesia was compared to isoflurane in outpatient gynaecological laparoscopy. Fifty ASA I or II, consenting women participated in a randomised, controlled and sing...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Eriksson H,Haasio J,Korttila K

    更新日期:1995-04-01 00:00:00

  • Post-void residual volume in labor: a prospective study comparing parturients with and without epidural analgesia.

    abstract:BACKGROUND:This prospective, non-randomized study compared post-void residual volume in laboring and postpartum women with or without epidural analgesia. METHODS:The study was conducted over 1 year with institutional review board approval. Parturients were recruited in early labor and self-selected to either the study...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Weiniger CF,Wand S,Nadjari M,Elchalal U,Mankuta D,Ginosar Y,Matot I

    更新日期:2006-11-01 00:00:00

  • In vivo spasmolytic effect of ketamine and adrenaline on histamine-induced airway constriction. Direct visualization method with a superfine fibreoptic bronchoscope.

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    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Hirota K,Hashimoto Y,Sakai T,Sato T,Ishihara H,Matsuki A

    更新日期:1998-02-01 00:00:00

  • Recovery characteristics of sevoflurane or halothane for day-case anaesthesia in children aged 1-3 years.

    abstract:BACKGROUND:Our objective was to compare the recovery characteristics of sevoflurane and halothane for short day-case anaesthesia in a specifically limited age group of children 1-3 yr. METHODS:Eighty unpremedicated children undergoing day-case adenoidectomy were randomly assigned to receive inhalational induction with...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Viitanen H,Baer G,Annila P

    更新日期:2000-01-01 00:00:00

  • Computer-aided ventilator resetting is feasible on the basis of a physiological profile.

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    pub_type: 杂志文章


    authors: Uttman L,Jonson B

    更新日期:2002-03-01 00:00:00

  • Comparison of a propofol target-controlled infusion and inhalational sevoflurane for fibreoptic intubation under spontaneous ventilation.

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    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验


    authors: Bonnin M,Therre P,Albuisson E,Beaujard H,Barthelemy I,Mondie JM,Bazin JE

    更新日期:2007-01-01 00:00:00

  • Comparison of the concentration-dependent effect of sevoflurane on the spinal H-reflex and the EEG in humans.

    abstract:BACKGROUND:It has been shown that spinal reflexes such as the H-reflex predict motor responses to painful stimuli better than cortical parameters derived from the EEG. The precise concentration-dependence of H-reflex suppression by anaesthetics, however, is not known. Here we investigated this concentration-response re...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章


    authors: Rehberg B,Bouillon T,Gruenewald M,Schneider J,Baars J,Urban BW,Kox WJ

    更新日期:2004-05-01 00:00:00

  • Regional cerebral oxygenation by NIRS does not correlate with central or jugular venous oxygen saturation during interventional catheterisation in children.

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    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Knirsch W,Stutz K,Kretschmar O,Tomaske M,Balmer C,Schmitz A,Berger F,Bauersfeld U,Weiss M,Working Group on Non-Invasive Haemodynamic Monitoring in Paediatrics.

    更新日期:2008-11-01 00:00:00

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    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Meisler R,Thomsen AB,Abildstrøm H,Guldstad N,Borge P,Rasmussen SW,Rasmussen LS

    更新日期:2010-02-01 00:00:00

  • Plasma vasopressin response to extracorporeal circulation in children.

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    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Yamashita M,Ishihara H,Kudo M,Matsuki A,Oyama T

    更新日期:1984-06-01 00:00:00

  • Effects of anticoagulant treatment on intestinal ischaemia and reperfusion injury in rats.

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    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Olanders K,Börjesson A,Zhao X,Andersson R

    更新日期:2005-04-01 00:00:00

  • Bladder function in spinal anaesthesia.

    abstract::Spinal anaesthesia with bupivacaine (22.5 mg) or with a glucose-containing solution of bupivacaine (20 mg) or tetracaine (15 mg) was given to 21 patients allocated randomly to these three groups. A urodynamic study was performed by CO2 cystometry. It consisted of recording of first sensation of bladder filling, sensat...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Axelsson K,Möllefors K,Olsson JO,Lingårdh G,Widman B

    更新日期:1985-04-01 00:00:00

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    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Høgskilde S,Wagner J,Strøm J,Sjøntoft E,Olesen HP,Bredgaard Sørensen M

    更新日期:1991-10-01 00:00:00

  • The effect of continuous intravenous indomethacin infusion on bleeding time and postoperative pain in patients undergoing emergency surgery of the lower extremities.

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    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Taivainen T,Hiller A,Rosenberg PH,Neuvonen P

    更新日期:1989-01-01 00:00:00