Abstract:
BACKGROUND:Ropivacaine is the first S-enantiomer aminoamide local anaesthetic in clinical use, and has been found to be less toxic than bupivacaine. Caudal ropivacine has been shown to cause less motor blockade and longer duration of analgesia in the postoperative period than bupivacaine in children. Plasma levels of ropivacaine and bupivacaine have not been previously compared in children. This study was undertaken to compare the total venous plasma concentrations of similar doses of ropivacaine and bupivacaine following caudal administration. METHODS:Blood samples were obtained to determine the total venous plasma levels of the used local anaesthetic in 30 children, aged 2.3-8.7 years, ASA I, given 1 ml x kg of either 0.2% ropivacaine or 0.2% bupivacaine in a prospective, randomised manner. RESULTS:There were no differences in the individual peak plasma concentrations achieved. Time to the measured peak plasma concentration was significantly shorter in the bupivacaine group. The plasma concentrations of bupivacaine were significantly lower than for ropivacaine at 60, 90 and 120 min after the block. CONCLUSION:Absorption and tissue distribution of ropivacaine is slower than for bupivacaine following caudal administration in children.
journal_name
Acta Anaesthesiol Scandjournal_title
Acta anaesthesiologica Scandinavicaauthors
Ala-Kokko TI,Partanen A,Karinen J,Kiviluoma K,Alahuhta Sdoi
10.1034/j.1399-6576.2000.440911.xsubject
Has Abstractpub_date
2000-10-01 00:00:00pages
1099-102issue
9eissn
0001-5172issn
1399-6576journal_volume
44pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND:Induction of mild hypothermia (MH) in patients resuscitated from cardiac arrest improves their outcome. However, benefits and risks of MH in patients who remain in cardiogenic shock after the return of spontaneous circulation (ROSC) are unclear. We analysed all cardiac arrest survivors who were treated with ...
journal_title:Acta anaesthesiologica Scandinavica
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journal_title:Acta anaesthesiologica Scandinavica
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journal_title:Acta anaesthesiologica Scandinavica
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journal_title:Acta anaesthesiologica Scandinavica
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