In vitro effect of etomidate and thiopental on granulocyte migration.

Abstract:

:An increased mortality has been reported during long-term etomidate infusion. Inhibition of adrenal corticosteroid synthesis has been incriminated - but other factors related to host defence cannot be excluded. Using an under-agarose assay, we investigated the effect of etomidate on in vitro granulocyte migration. Unlike thiopental (50 micrograms/ml), etomidate (4-32 micrograms/ml) did not affect either spontaneous or directed migration. Impaired granulocyte migration is an unlikely cause of morbidity during long-term etomidate infusion.

authors

Knudsen F,Klausen NO,Ferguson AH,Pedersen JO

doi

10.1111/j.1399-6576.1987.tb02527.x

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

93-5

issue

1

eissn

0001-5172

issn

1399-6576

journal_volume

31

pub_type

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