The influence of naloxone infusion on the action of intrathecal diamorphine: low-dose naloxone and neuroendocrine responses.

Abstract:

:The influence of an intravenous infusion of naloxone 1 microgram kg-1 h-1, in combination with intrathecal diamorphine, on analgesia and hormonal stress responses after laminectomy was assessed in a blinded, randomized, placebo-controlled study. Twenty-seven patients undergoing laminectomy with postoperative analgesia provided by intrathecal diamorphine were investigated. Analgesia was reduced by naloxone (P less than 0.05), and the duration of analgesia was shortened by 180 min. The postoperative concentrations of both blood glucose and serum cortisol were reduced in the naloxone group compared to the control group (P less than 0.05). These results may indicate an excitatory role for the hypothalamic mu receptor in hypothalamo-pituitary-adrenocortical axis regulation.

authors

Wright PM,O'Toole DP,Barron DW

doi

10.1111/j.1399-6576.1992.tb03455.x

subject

Has Abstract

pub_date

1992-04-01 00:00:00

pages

230-3

issue

3

eissn

0001-5172

issn

1399-6576

journal_volume

36

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 杂志文章

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    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

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    pub_type: 杂志文章,随机对照试验

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    pub_type: 临床试验,杂志文章,随机对照试验

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    pub_type: 杂志文章,评审

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    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1998.tb05116.x

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    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1997.tb04642.x

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    pub_type: 杂志文章,随机对照试验

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    authors: Ammar A,Mahmoud K,Kasemy Z

    更新日期:2018-07-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1987.tb02566.x

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    pub_type: 杂志文章

    doi:10.1111/aas.12038

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    pub_type: 杂志文章

    doi:10.1111/aas.12739

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    pub_type: 临床试验,杂志文章,随机对照试验

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    pub_type: 杂志文章

    doi:10.1034/j.1399-6576.2003.00190.x

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