Effects of organic nitrate vasodilators on platelet function before and after cardiopulmonary bypass.

Abstract:

:Various in vitro, ex vivo and in vivo tests have shown that organic nitrates attenuate platelet function. Because organic nitrates are commonly administered to patients undergoing cardiac surgery, the postoperative bleeding tendency observed in these patients might be strengthened by nitrates. Therefore, we compared the acute effects of nitroglycerin (0.5 micrograms kg-1 min-1) and isosorbide dinitrate (0.5 or 2.5 micrograms kg-1 min-1) with those of placebo on platelet function both before and after cardiopulmonary bypass in 40 patients undergoing coronary artery bypass grafting (CABG). Bleeding time, platelet retention on glass beads, i.e. platelet adhesiveness, and thromboelastograph tracings were used as indicators of platelet function. Although nitroglycerin and isosorbide dinitrate induced significant haemodynamic changes, e.g. decreases in arterial and pulmonary arterial pressure, they had no significant effects on the indices of platelet function. We conclude that, when given in haemodynamically effective doses, neither nitroglycerin nor isosorbide dinitrate have any measurable acute effect on platelet function as evaluated with on-site tests in patients undergoing CABG surgery.

authors

Muikku O,Kuitunen A,Hynynen M

doi

10.1111/j.1399-6576.1995.tb04137.x

subject

Has Abstract

pub_date

1995-07-01 00:00:00

pages

618-23

issue

5

eissn

0001-5172

issn

1399-6576

journal_volume

39

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1979.tb01428.x

    authors: Blichert-Toft M,Christiansen C,Engquist A,Kehlet H,Lindholm J,Hummer L,Dinesen B

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    pub_type: 指南,杂志文章,实务指引,评审

    doi:10.1111/j.1399-6576.2005.00781.x

    authors: Søreide E,Eriksson LI,Hirlekar G,Eriksson H,Henneberg SW,Sandin R,Raeder J,(Task Force on Scandinavian Pre-operative Fasting Guidelines, Clinical Practice Committee Scandinavian Society of Anaesthesiology and Intensive Care Medicine).

    更新日期:2005-09-01 00:00:00

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    authors: Lurf M,Leixnering M

    更新日期:2009-02-01 00:00:00

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    更新日期:2004-07-01 00:00:00

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    pub_type: 杂志文章

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    authors: Sutherland RW,Winter RJ

    更新日期:1997-09-01 00:00:00

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    authors: Hedenstierna G,Santesson J

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    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1990.tb03053.x

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    更新日期:1990-02-01 00:00:00

  • A single-centre, prospective cohort study of COVID-19 patients admitted to ICU for mechanical ventilatory support.

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    pub_type: 杂志文章

    doi:10.1111/aas.13726

    authors: Søvik S,Bådstøløkken PM,Sørensen V,Langeland Myhre P,Prebensen C,Omland T,Berdal JE

    更新日期:2020-10-31 00:00:00

  • Hepatic blood flow and cardiac output during Fluoromar anaesthesia. An animal study.

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    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1976.tb05039.x

    authors: Juhl B,Einer-Jensen N

    更新日期:1976-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1982.tb01731.x

    authors: Sonander H,Stenqvist O

    更新日期:1982-02-01 00:00:00

  • Mucociliary transport with and without the use of a heat and moisture exchanger. An animal study.

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    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1991.tb03293.x

    authors: Eckerbom B,Lindholm CE,Mannting F

    更新日期:1991-05-01 00:00:00

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    pub_type: 杂志文章

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    authors: Frederiksen CA,Knudsen L,Juhl-Olsen P,Sloth E

    更新日期:2011-01-01 00:00:00

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    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.12461

    authors: Unterbuchner C,Ziegleder R,Graf B,Metterlein T

    更新日期:2015-04-01 00:00:00

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    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-6576.2009.02074.x

    authors: Grände PO,Reinstrup P,Romner B

    更新日期:2009-11-01 00:00:00

  • Butyrylcholinesterase gene mutations in patients with prolonged apnea after succinylcholine for electroconvulsive therapy.

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    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2010.02316.x

    authors: Mollerup HM,Gätke MR

    更新日期:2011-01-01 00:00:00

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    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1994.tb03904.x

    authors: Grace D,Milligan KR,Loughran PG,McCaughey W

    更新日期:1994-05-01 00:00:00

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    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1991.tb03359.x

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    更新日期:1991-10-01 00:00:00

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    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

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    authors: Park HP,Jeon Y,Hwang JW,Han SH,Bahk JH,Oh YS

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    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2005.00810.x

    authors: Pleym H,Tjomsland O,Asberg A,Lydersen S,Wahba A,Bjella L,Dale O,Stenseth R

    更新日期:2005-10-01 00:00:00

  • Clinical experience of long-term treatment with epidural and intrathecal opioids--a nationwide survey.

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    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1988.tb02725.x

    authors: Arnér S,Rawal N,Gustafsson LL

    更新日期:1988-04-01 00:00:00

  • Can public health registry data improve Emergency Medical Dispatch?

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    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.12654

    authors: Andersen MS,Christensen EF,Jepsen SB,Nørtved J,Hansen JB,Johnsen SP

    更新日期:2016-03-01 00:00:00

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    abstract:BACKGROUND:We report a documented grade III IgE-mediated hypersensitivity reaction associated with the use of 2.5% patent blue V dye for sentinel lymph node biopsy during breast cancer surgery. METHODS:Immediately after the reaction, when hemodynamic stability was obtained, plasma histamine was measured whereas serum ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2006.00912.x

    authors: Dewachter P,Mouton-Faivre C,Benhaijoub A,Abel-Decollogne F,Mertes PM

    更新日期:2006-02-01 00:00:00

  • Blood circulation in the kidney of the cat under methoxyflurane (penthrane) anaesthesia.

    abstract::In order to establish whether methoxyflurane causes any change in renal vascular resistance, the renal venous flow was measured by means of a drop recording technique in six cats under methoxyflurane anaesthesia. Arterial pressure was recorded simultaneously, and the renal vascular resistance was calculated. Methoxyfl...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1975.tb05184.x

    authors: Irestedt L,Westermark L,Wåhlin A

    更新日期:1975-01-01 00:00:00

  • Perivascular axillary block IV: blockade following 40, 50 or 60 ml of mepivacaine 1% with adrenaline.

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    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1984.tb02020.x

    authors: Vester-Andersen T,Husum B,Lindeburg T,Borrits L,Gøthgen I

    更新日期:1984-02-01 00:00:00

  • Continuous infusion of midazolam during anaesthesia and postoperative sedation after maxillofacial surgery.

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    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1989.tb02872.x

    authors: Driessen JJ,Dirksen MS,Rutten JM,Santman F,van Egmond J,Vree TB

    更新日期:1989-02-01 00:00:00

  • Carbon dioxide and argon gas embolism during laparoscopic hepatic resection.

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    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2007.01361.x

    authors: Min SK,Kim JH,Lee SY

    更新日期:2007-08-01 00:00:00

  • Life-threatening upper airway obstruction in a child caused by retropharyngeal emphysema.

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    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1399-6576.2001.045003393.x

    authors: Skogvoll E,Grammeltvedt AT,Aadahl P,Mostad U,Slørdahl S

    更新日期:2001-03-01 00:00:00

  • Poikilocapnic hypoxic ventilatory response in humans during 0.85 MAC isoflurane anesthesia.

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    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1994.tb03857.x

    authors: Sjögren D,Sollevi A,Ebberyd A,Lindahl SG

    更新日期:1994-02-01 00:00:00

  • The rare Arg181Cys mutation in the μ opioid receptor can abolish opioid responses.

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    pub_type: 杂志文章

    doi:10.1111/aas.12739

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    更新日期:2016-09-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2005.00799.x

    authors: Tallgren M,Klepstad P,Petersson J,Skram U,Hynninen M

    更新日期:2005-09-01 00:00:00