Abstract:
BACKGROUND:Paracetamol is commonly used for post-operative pain management in combination with more potent analgesics. The best route of paracetamol administration after major surgery, when oral intake may not be optimal, is not known. Our primary purpose was to study plasma concentrations after the 1st and 4th dose of 1 g of paracetamol given either rectally or intravenously (i.v.) after major surgery. METHODS:In this prospective, randomized study, 48 patients undergoing heart surgery were randomized upon arrival to the intensive care unit (ICU) to receive paracetamol every 6th hour either as suppositories or intravenous injections. In half the patients (n = 24), blood samples for paracetamol concentration were obtained before and 20, 40 and 80 min after the first dose. In the other patients (n = 24), additional samples were taken prior to, and at 20, 40, 80 min and 4 and 6 h after, the 4th dose. RESULTS:Plasma paracetamol concentration peaked (95 +/- 36 micromol/l) within 40 min after initial i.v. administration but did not increase within 80 min after the 1st suppository. Plasma concentration before the 4th dose was 74 +/- 51 and 50 +/- 27 in the rectal and i.v. groups, respectively. Paracetamol concentration peaked 20 min after the 4th dose for the i.v. patients (210 +/- 84 micromol/l) and declined to 99 +/- 27 micromol/l at 80 min as compared with the rectal patients 69 +/- 44 to 77 +/- 48 micromol/l. CONCLUSION:Both time course and peak plasma concentrations of paracetamol given rectally differ from the one seen after intravenous administration. The clinical impact of these differences needs further investigation.
journal_name
Acta Anaesthesiol Scandjournal_title
Acta anaesthesiologica Scandinavicaauthors
Holmér Pettersson P,Jakobsson J,Owall Adoi
10.1111/j.1399-6576.2006.01043.xsubject
Has Abstractpub_date
2006-07-01 00:00:00pages
673-7issue
6eissn
0001-5172issn
1399-6576pii
AAS1043journal_volume
50pub_type
杂志文章,随机对照试验abstract::Infusion of endotoxin elicits granulocytopenia followed by increased numbers of granulocytes in peripheral blood. The purpose of this study was to investigate the redistribution and sequestration of granulocytes in the tissues following E. coli endotoxin induced sepsis. From 16 rabbits granulocytes were isolated, labe...
journal_title:Acta anaesthesiologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1399-6576.1994.tb04017.x
更新日期:1994-11-01 00:00:00
abstract::The onset phase of hypoalgesia, following intrathecal morphine, was assessed by experimental argon laser-induced pain. A dose of 0.4 mg morphine was injected pre-operatively at the L3-L4 level into nine patients. The thresholds to laser-induced pain and pain-evoked brain potentials were monitored for 2 h at the S1, L1...
journal_title:Acta anaesthesiologica Scandinavica
pub_type: 杂志文章
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abstract::A new method of artificial ventilation, intermittent high frequency ventilation (IHFV), is described in which high frequency ventilation (HFV) is intermittently interrupted so that short periods of ventilation and pauses in ventilation occur in sequence several times a minute. During the pauses in ventilation the incr...
journal_title:Acta anaesthesiologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1399-6576.1988.tb02732.x
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journal_title:Acta anaesthesiologica Scandinavica
pub_type: 杂志文章,评审
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abstract::This study evaluated recovery after a fixed dose of midazolam as induction agent and the influence of flumazenil on recovery parameters in patients undergoing day-case surgery (arthroscopy of the knee). In 40 unpremedicated patients, anaesthesia was induced with midazolam 0.2 mg/kg, vecuronium bromide 0.1 mg/kg intrav...
journal_title:Acta anaesthesiologica Scandinavica
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abstract::A 42-year-old male patient, who suffered from insulin-dependent diabetes mellitus (IDDM) and intolerance of lactose, presented with extreme metabolic acidosis (lactic acidosis). On arrival, an arterial blood sample showed: pH 6.79, PO2 18.8 kPa, PCO2 0.9 kPa, base excess-33 mmol l-1, blood glucose 38 mmol l-1 and oeso...
journal_title:Acta anaesthesiologica Scandinavica
pub_type: 杂志文章
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journal_title:Acta anaesthesiologica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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journal_title:Acta anaesthesiologica Scandinavica
pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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journal_title:Acta anaesthesiologica Scandinavica
pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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journal_title:Acta anaesthesiologica Scandinavica
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pub_type: 杂志文章
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journal_title:Acta anaesthesiologica Scandinavica
pub_type: 杂志文章
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journal_title:Acta anaesthesiologica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章,meta分析,评审
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journal_title:Acta anaesthesiologica Scandinavica
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更新日期:1994-10-01 00:00:00
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journal_title:Acta anaesthesiologica Scandinavica
pub_type: 杂志文章
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journal_title:Acta anaesthesiologica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Acta anaesthesiologica Scandinavica
pub_type: 杂志文章,随机对照试验
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更新日期:2019-05-01 00:00:00