Abstract:
BACKGROUND:Previous studies have shown that ventilation-perfusion matching is improved in the prone as compared with that in the supine position. Regional differences in the regulation of vascular tone may explain this. We have recently demonstrated higher production of nitric oxide in dorsal compared with ventral human lung tissue. The purpose of the present study was to investigate regional differences in actions by another vasoactive mediator, namely prostacyclin. The effects on gas exchange and regional pulmonary perfusion in different body positions were investigated at increased prostacyclin levels by inhalation of a synthetic prostacyclin analogue and decreased prostacyclin levels by unselective cyclooxygenase (COX) inhibition. METHODS:In 19 volunteers, regional pulmonary perfusion in the prone and supine position was assessed by single photon emission computed tomography using (99m)Tc macro-aggregated albumin before and after inhalation of iloprost, a stable prostacyclin analogue, or an intravenous infusion of a non-selective COX inhibitor, diclofenac. In addition, gas distribution was assessed in seven subjects using (99m)Tc-labelled ultra-fine carbon particles before and after iloprost inhalation in the supine position. RESULTS:Iloprost inhalation decreased arterial PaO(2) in both prone (from 14.2+/-0.5 to 11.7+/-1.7 kPa, P<0.01) and supine (from 13.7+/-1.4 to 10.9+/-2.1 kPa, P<0.01) positions. Iloprost inhalation redistributed lung perfusion from non-dependent to dependent lung regions in both prone and supine positions, while ventilation in the supine position was distributed in the opposite direction. No significant effects of non-selective COX inhibition were found in this study. CONCLUSIONS:Iloprost inhalation decreases arterial oxygenation and results in a more gravity-dependent pulmonary perfusion in both supine and prone positions in healthy humans.
journal_name
Acta Anaesthesiol Scandjournal_title
Acta anaesthesiologica Scandinavicaauthors
Rimeika D,Sanchez-Crespo A,Nyren S,Lindahl SG,Wiklund CUdoi
10.1111/j.1399-6576.2009.02018.xsubject
Has Abstractpub_date
2009-10-01 00:00:00pages
1158-66issue
9eissn
0001-5172issn
1399-6576pii
AAS2018journal_volume
53pub_type
杂志文章abstract:BACKGROUND:Epidural fentanyl 100 microg after lidocaine-epinephrine test dose has been shown to provide adequate analgesia in early labor. This investigation determines the effect of three different bolus doses of epidural fentanyl on duration and quality of analgesia during early first stage of labor. METHODS:In this...
journal_title:Acta anaesthesiologica Scandinavica
pub_type: 杂志文章,随机对照试验
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更新日期:2008-10-01 00:00:00
abstract::The effects of surfactant replacement by aerosol inhalation and by bolus instillation were compared in rats with respiratory failure induced by repeated lung lavage. The rats were anesthetized with pentobarbital sodium and mechanically ventilated with 100% oxygen. The PaO2 of control rats not given surfactant (n = 9) ...
journal_title:Acta anaesthesiologica Scandinavica
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journal_title:Acta anaesthesiologica Scandinavica
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journal_title:Acta anaesthesiologica Scandinavica
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更新日期:2004-05-01 00:00:00
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abstract::The haemodynamic effects of morphine (2.5 mg kg-1) and fentanyl (16.7 and 25 micrograms kg-1) were compared in patients undergoing coronary artery bypass surgery. Morphine or fentanyl in combination with pancuronium, nitrous oxide and a small dose of thiopentone produced some deterioration of myocardial performance. B...
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doi:10.1111/j.1399-6576.1983.tb01919.x
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journal_title:Acta anaesthesiologica Scandinavica
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doi:10.1111/j.1399-6576.1986.tb02495.x
更新日期:1986-11-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2010-07-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2010-09-01 00:00:00
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更新日期:2016-09-01 00:00:00
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更新日期:1988-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:Sevoflurane, a potent inhalational anaesthetic agent that is structurally similar to halothane, has some favourable characteristics, but may also be able to trigger malignant hyperthermia (MH) in susceptible patients. The diagnosis of malignant hyperthermia susceptibility relies on the in vitro contracture t...
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doi:10.1034/j.1399-6576.2000.440320.x
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND:Post-operative catheter-related bladder discomfort (CRBD) causes increased emergence agitation. Muscarinic receptor activation is a major mechanism in CRBD development. Experimental studies showed that sevoflurane has anti-muscarinic effects whereas propofol does not. Our hypothesis was that sevoflurane anae...
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更新日期:2017-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00