Pyrazolopyrimidine metabolism in African trypanosomes: metabolic similarities to Trypanosoma cruzi and Leishmania spp.

Abstract:

:Growth inhibition and radioisotope incorporation studies with allopurinol (4-hydroxypyrazolo(3,4-d)pyrimidine) have shown that the African trypanosomes are biologically and biochemically similar to Leishmania spp. and Trypanosoma cruzi with respect to their response to this compound. These organisms, as a group, share the unique ability to convert allopurinol sequentially to its ribonucleoside monophosphate and 4-aminopyrazolo(3,4-d)pyrimidine ribonucleoside mono-, di- and triphosphates.

journal_name

Mol Biochem Parasitol

authors

Berens RL,Marr JJ,Brun R

doi

10.1016/0166-6851(80)90001-8

subject

Has Abstract

pub_date

1980-04-01 00:00:00

pages

69-73

issue

2

eissn

0166-6851

issn

1872-9428

pii

0166-6851(80)90001-8

journal_volume

1

pub_type

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