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Identification and characterization of a novel gene encoding an RGD-containing protein in large yellow croaker iridovirus.

Abstract：

:Many virus-encoded RGD-containing proteins have been reported to play important roles in virus attachment and entry. Here we report the identification and functional characterization of a gene encoding an RGD-containing protein (037L) from large yellow croaker iridovirus (LYCIV), a causative agent of epizootics among large yellow croaker, Pseudosciaena crocea. The 037L gene is 1347 bp long and encodes a protein of 449 amino acids containing a biologically active RGD tri-peptide predicted with SURFC and STRIDE software. Temporal analysis of 037L gene transcription showed that this gene was a late gene. Subcellular localization of 037L in insect Hi5 cells using baculovirus vector system indicated that 037L might be a membrane-tropistic protein and functionally associated with the cytoplasma-membrane. The recombinant 037L expressed in E. coli could effectively induce the morphological changes of BF-2 cells and promote cellular aggregation, demonstrating that it can bind with surface molecules of BF-2 cells. The neutralization assay showed that LYCIV infection of BF-2 cells was significantly inhibited by anti-037L IgG, as determined by a real-time PCR of viral concentrations in the culture supernatants of LYCIV-infected cells, suggesting that it might have an important role in virus infectivity. This is the first report of the functional gene involved in virus infection and virus-host interaction in Megalocytivirus.

journal_name

Virology

journal_title

Virology

authors

Ao J,Chen X

doi

10.1016/j.virol.2006.07.004

subject

Has Abstract

pub_date

2006-11-25 00:00:00

pages

213-22

issue

2

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(06)00441-7

journal_volume

355

pub_type

杂志文章

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