Abstract:
:The gastric acid and pepsin-stimulating activities of several C terminal fragments of non-sulphated human gastrin were investigated in the conscious cat prepared with cannulated gastric fistulae with a reproducible, continuous infusion method to construct dose-response curves. The gastric acid-stimulating activities were quantified by reference to the ED50 and were compared with the activity of synthetic non-sulphated human gastrin 17 (SHG17NS) and cat gastrin 17 (SCG17NS). SHG17NS had an ED50 of 0.329 nmol kg-1 h-1. SHG16NS, SHG15NS and SHG13NS all showed similar activities to SHG17NS. SCG17NS tested at low doses had similar activity to SHG17NS. SHG10NS, G5 and G4 and peptavlon showed progressively lower acid-stimulating activities: 26, 12, 9 and 9%, respectively, compared with SHG17NS. The gastric acid-stimulating activities of all the peptides were paralleled by similar pepsin-stimulating activities. The ratios of pepsin secretion:acid secretion were similar for all the peptides (1--2 microgram pepsin/microEq H+). The results are discussed in relation to the biological activity of the circulating gastrin components in the cat compared with other species and it is argued that component IV (corresponding to gastrin tetradecapeptide or minigastrin) is a major, physiologically active, circulating form of the hormone in the cat.
journal_name
Digestionjournal_title
Digestionauthors
Blair EL,Hirst BH,Lund PK,Reed JD,Sanders DJ,Shaw Bdoi
10.1159/000198439subject
Has Abstractpub_date
1980-01-01 00:00:00pages
190-200issue
3eissn
0012-2823issn
1421-9867journal_volume
20pub_type
杂志文章相关文献
DIGESTION文献大全abstract:BACKGROUND/AIMS:In this report, we aimed to investigate the distribution and characterization of biomarker-immunolabeled ductal epithelium in advanced pancreatic ductal adenocarcinoma (PDAC). DESIGN:Eighteen patients with PDAC were medically diagnosed prior to being treated periodically. All clinical records were coll...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000492861
更新日期:2019-01-01 00:00:00
abstract::Zinc nutriture has been studies in 30 patients with Crohn's disease using plasma zinc, hair zinc, and taste acuity as indices. Significant reductions in plasma zinc concentrations and taste acuity were seen in the patient groups as compared with normal controls. Hair zinc content was also generally low with several de...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198059
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND/AIM:Previous studies have reported small intestinal lesions in patients with portal hypertensive disease. However, the etiology of these lesions is not clear, as portal venous pressure was not measured in any of these studies. The aim of this study is to clarify the association between small intestinal lesio...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000338180
更新日期:2012-01-01 00:00:00
abstract:INTRODUCTION:Multiple Lugol-voiding lesions (LVLs) in the esophagus increase the risk of synchronous and metachronous development of esophageal squamous cell carcinoma (ESCC). Chemoradiotherapy (CRT) following endoscopic submucosal dissection (ESD) may reduce the incidence of metachronous ESCC, but few studies have inv...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000510368
更新日期:2020-09-29 00:00:00
abstract:BACKGROUND:Incidence of cholangiocarcinoma (CCA) in western countries is rising. In the palliative setting, chemotherapy is the only established treatment. The evidence for other treatments including locoregional therapy is low. However, such individual treatments are offered in a real-world setting. The aim of this st...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000500894
更新日期:2020-01-01 00:00:00
abstract::The alpha-glucosidase inhibitor voglibose (AO-128) was designed to prevent rapid postprandial blood glucose rises in non-insulin-dependent diabetics. We analyzed its effect on the entero-insular axis in 72 healthy volunteers in a double-blind study design before, after the 1st dose, and on the 7th day of a 7-day treat...
journal_title:Digestion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000201282
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:There are unexpectedly large differences between the incidences of acute pancreatitis (AP) as indicated by different hospitals. Retrospective studies suggest that the reason behind this is the large differences that exist between the local managements of abdominal pain at emergency units. Unfortunately, no e...
journal_title:Digestion
pub_type: 杂志文章,多中心研究
doi:10.1159/000441352
更新日期:2016-01-01 00:00:00
abstract::Whether and to what extent the pancreas is involved in acute viral hepatitis is still unclear. In order to address this issue we evaluated serum and urinary amylase and isoamylase levels in 92 patients with acute viral hepatitis of different etiology and in 60 healthy volunteers. Furthermore, pancreatic structure and ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199831
更新日期:1989-01-01 00:00:00
abstract::The current therapy of choice for all Helicobacter pylori-associated ulcer disease is eradication therapy. Although adequate therapeutic regimens are currently available, often still ineffective therapies are tried. Cure of the infection essentially eliminates the ulcer diathesis. Cure of the infection is especially i...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000007522
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND/AIMS:This study aimed to analyze the endoscopic mucosal resection (EMR) with a novel uniquely shaped, double-loop snare (Dualoop, Medico's Hirata Inc., Tokyo, Japan) for colorectal polyps. METHODS:This was a clinical trial conducted in two referral centers, Kyoto Prefectural University of Medicine and Natio...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000368044
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND AND AIMS:The safety of carbon dioxide (CO(2)) insufflation has not been fully established for esophageal and gastric endoscopic submucosal dissection (ESD) under deep sedation, because CO(2) retention is not only caused by CO(2) insufflation but also by the sedation level and the patient's respiratory status...
journal_title:Digestion
pub_type: 杂志文章,随机对照试验
doi:10.1159/000328694
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Validity of the lactulose breath test (LBT) to diagnose small intestinal bacterial overgrowth (SIBO) has been questioned. Therefore, a study was planned to compare LBT with glucose breath test (GBT) to diagnose SIBO in irritable bowel syndrome (IBS) patients and controls. METHODS:175 diarrhea-predo...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000336174
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:The authors reported that the repair of submucosal tissue is important in ulcer healing. The kinetics of fibroblasts have not been well known in gastric ulcer healing. The effect of subcutaneous administration of indomethacin (1 mg/kg) to submucosal tissue was also examined. METHOD:Immunohistological stainin...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201463
更新日期:1997-01-01 00:00:00
abstract::We studied the functional coupling between antral somatostatin and gastrin cells in pigs using isolated perfused preparations of the antrum with intact supply of the vagus nerves. Luminal acidification significantly inhibited gastrin secretion to 61 +/- 3% of basal secretion and increased somatostatin output 9-fold. I...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200882
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND/AIMS:The changes in gastroesophageal reflux disease (GERD)-related symptoms on treatment are variously described, but currently available questionnaires have shortcomings. We therefore developed a self-assessment reflux questionnaire (ReQuest). This article describes the process of development and testing. ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000101080
更新日期:2007-01-01 00:00:00
abstract::Transforming growth factor-beta 1 (TGF-beta 1) is a multifunctional cytokine which modifies tissue stromal matrix synthesis, cell proliferation and immune function. In the present study, we have used a mouse monoclonal antibody to the latent (intracytoplasmic) form of TGF-beta 1 to compare its expression in 144 cases ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201249
更新日期:1995-01-01 00:00:00
abstract::Familial colorectal cancer (CRC) is heterogeneous. Screening recommendations do exist for individuals with a mild to moderate family history of CRC, with or without early age at onset. However, most attention has properly focused on the identification of individuals in whom a defined susceptibility gene mutation can b...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000108395
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:Impaired intestinal epithelial barrier function is a hallmark of a variety of pathological conditions such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). IBD patients with IBS-like symptoms show higher interleukin-13 (IL-13) serum levels and poor psychological well-being. Supplemen...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000502953
更新日期:2019-09-18 00:00:00
abstract::Prostacyclin, its stable metabolite 6-keto-prostaglandin F1 alpha and prostaglandin E2 were tested on the adenylate cyclase system in human gastric mucosa. All three compounds were able to activate human cyclase. Saturating concentrations of prostacyclin, prostaglandin E2 and 6-keto-prostaglandin F1 alpha (each 0.28 m...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198335
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND/AIMS:To identify the number and potential causes of unnecessary diagnostic procedures in a cohort of patients with autoimmune pancreatitis (AIP). METHODS:All AIP cases at our centre between April 2006 and April 2013 were collected and followed up. Diagnosis was established by the International Consensus Dia...
journal_title:Digestion
pub_type: 临床试验,杂志文章
doi:10.1159/000437259
更新日期:2015-01-01 00:00:00
abstract::An improved GLC method was employed to study individual serum bile acids in 14 control subjects after a 12-hour fast followed by a standard fatty meal. Peripheral venous blood samples were obtained at 15-min intervals for up to 2 h in 7 subjects, and 4 h in 2 subjects. The fasting total bile acids, and cholic:chenodeo...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198094
更新日期:1978-01-01 00:00:00
abstract::The pancreatic exocrine secretory response to increasing doses of exogenous caerulein with and without a background infusion of secretin was studied in 5 healthy volunteers. Caerulein over a full range of doses (2.3-37 pmol/kg/h) produced increasing enzyme secretion up to 18.5 pmol/kg/h, whereas 37 pmol/kg/h was clear...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199357
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND/AIMS:In patients with active ulcerative colitis (UC), pharmacologics, although initially effective in most patients, are associated with refractoriness, loss of response or unfavourable side effects as additional morbidity factors. Depletion of myeloid lineage leucocytes like the CD14(+)CD16(+) monocyte phen...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000479502
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Somatostatin and its analogues have antitumor effects on foregut and midgut neuroendocrine (NE) tumors, but their effect on hindgut NE tumors is unclear. We examined the effect of the somatostatin analogue, octreotide, on human rectal NE carcinoma. MATERIALS AND METHODS:Expression of somatostatin receptor (...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000063822
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND/AIM:The aim of this study was to compare the accuracy of magnifying endoscopy with narrow band imaging for the diagnosis of depth of invasion by Japan Esophageal Society (JES) classification and inter- and intraobserver agreement of JES intrapapillary capillary loop (IPCL) classification. METHODS:It was a r...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000489490
更新日期:2018-01-01 00:00:00
abstract::The effects of rioprostil (a newly developed synthetic prostaglandin E1 analogue) on meal-stimulated gastric acid secretion was evaluated in 8 healthy human volunteers. Gastric acid output was measured by intragastric titration on 4 different occasions. The following procedure was invariably employed: after a basal pe...
journal_title:Digestion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000199413
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND/AIMS:Evaluation of the response of gastroesophageal reflux disease (GERD) symptoms to treatment would be facilitated by a brief, valid, reliable and responsive, self-assessed GERD-sensitive scale. We therefore developed the Reflux Questionnaire (ReQuest). This publication describes the psychometric evaluatio...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000079708
更新日期:2004-01-01 00:00:00
abstract::OctreoTher ((90)Y-DOTA-D-Phe(1)-Tyr(3)-octreotide, a.k.a. (90)Y-SMT 487) consists of a somatostatin peptide analogue (Tyr(3)-octreotide), coupled with a complexing moiety (DOTA), and labeled with a tightly bound beta-emitter (yttrium-90). By targeting somatostatin receptor-positive tumors (as imaged by OctreaScan it m...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000051858
更新日期:2000-01-01 00:00:00
abstract::Mortality data for ulcerative colitis, Crohn's disease, and unspecified inflammatory bowel disease were examined for the countries Venezuela, Italy, and France during the decade 1969-1978. These figures were compared with similar data from England and Wales obtained from 1965 to 1975. In Italy and France deaths from C...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199040
更新日期:1984-01-01 00:00:00
abstract::The effect of maximal doses of cholecystokinin and caerulein on lipase and chymotropsin concentrations were compared in large groups of patients with almost equal capacities of bicarbonate secretion. The responsiveness of the pancreas is, as a whole, higher with caerulein than with cholecystokinin, this feature being ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000197987
更新日期:1977-01-01 00:00:00