Abstract：
:Glycophorin, one of the major glycoproteins of erythrocytes (E), was extracted from human E (glycophorin-Hu) and guinea pig E (glycophorin-GP) and adsorbed to rabbit-E. The adsorption of glycophorin-Hu and glycophorin-GP to rabbit-E made the E resistant to hemolysis by human serum and guinea pig serum, respectively, via the alternative complement pathway (ACP). However, it did not make the rabbit-E resistant to hemolysis by serum heterologous to the glycophorin adsorbed. This species-specific inhibition by glycophorin of ACP activation should play a role in restricting ACP activation on self cell membranes. By recognizing the self-cell surface as the place where the complement reaction must be prevented, ACP will be able to accomplish the discrimination of non-self constituents without diversity of recognition sites for a variety of foreign substances.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Okada H,Tanaka Hdoi
10.1016/0161-5890(83)90148-7subject
Has Abstractpub_date
1983-11-01 00:00:00pages
1233-6issue
11eissn
0161-5890issn
1872-9142journal_volume
20pub_type
杂志文章abstract：:DC-SIGN (dendritic cell-specific ICAM-3-grabbing non-integrin) is a myeloid pathogen-attachment factor C-type lectin which recognizes mannose- and fucose-containing oligosaccharide ligands on clinically relevant pathogens. Intracellular signaling initiated upon ligand engagement of DC-SIGN interferes with TLR-initiate...
journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2010-01-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2012-03-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2011-09-01 00:00:00
abstract：:We recently identified IgE-binding epitopes of bovine serum albumin (BSA), the major beef allergen, and found that the major epitope structure contains an EXXV motif. Here we report hypoallergenic analogue peptides of BSA that preserve T cell reactivity to retain the capacity to induce immunotolerance. Substitution of...
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pub_type： 杂志文章
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journal_title：Molecular immunology
pub_type： 杂志文章,评审
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更新日期：2018-06-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2004.06.034
更新日期：2005-01-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(89)90035-7
更新日期：1989-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0161-5890(93)90009-z
更新日期：1993-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：1994-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2021-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0161-5890(89)90057-6
更新日期：1989-12-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2011.07.007
更新日期：2011-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.molimm.2019.06.001
更新日期：2019-08-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2010.03.005
更新日期：2010-05-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2019-05-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/s0161-5890(01)00060-8
更新日期：2001-08-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2019.04.013
更新日期：2019-07-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2019-10-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2020-12-26 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：1998-06-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：1983-02-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2013-04-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章,评审
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更新日期：2013-06-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2006-03-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：1995-06-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2004.07.028
更新日期：2005-02-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：1996-05-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2012.09.001
更新日期：2013-04-01 00:00:00
abstract：:A two-step purification procedure of Par j I from the whole Parietaria judaica pollen extract is described. The first step consisted of gel filtration HPLC using a TSKG 3000 SW column, and 0.1% trifluoroacetic acid as the eluant. By this method, proteins were separated from the highly colored material present in the e...
journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(90)90110-l
更新日期：1990-02-01 00:00:00
