Reduced CD4+ subset and Th1 bias of the human iNKT cells in Type 1 diabetes mellitus.

abstract：:Highly active antiretroviral therapy (HAART) against human immunodeficiency virus type 1 (HIV-1) infection dramatically suppresses viral load, leading to marked reductions in HIV-1 associated morbidity and mortality. However, infected cell reservoirs and low-level replication persist in the face of suppressive HAART, ...

journal_title：Journal of leukocyte biology

authors： Kennedy PE,Bera TK,Wang QC,Gallo M,Wagner W,Lewis MG,Berger EA,Pastan I

更新日期：2006-11-01 00:00:00

abstract：:The majority of acute myeloid leukemia (AML) patients will respond to standard chemotherapy, however, resistance is a prevalent problem contributing to incomplete responses, refractory disease, and ultimately patient death. Therefore, choosing more sensitive and effective chemotherapy regimens is of key clinical impor...

journal_title：Journal of leukocyte biology

authors： Lin L,Tong Y,Straube J,Zhao J,Gao Y,Bai P,Li J,Wang J,Wang H,Wang X,Huang S,Xu W,Song X,Li L

更新日期：2020-05-01 00:00:00

abstract：:This study investigated the expression of MUC5B by AMs in the lungs of cigarette smokers and nonsmokers. We analyzed MUC5B expression by measuring the levels of apomucin and mRNA in human BALF cells from 50 subjects (20 nonsmokers, 17 patients with CB, and 13 patients with COPD). apoMUC5B was observed in BALF mononucl...

journal_title：Journal of leukocyte biology

authors： Sepper R,Prikk K,Metsis M,Sergejeva S,Pugatsjova N,Bragina O,Marran S,Fehniger TE

更新日期：2012-08-01 00:00:00

abstract：:It has generally been accepted that most biologically derived agents that are radioprotective in the hemopoietic-syndrome dose range (eg, endotoxin, Bacillus Calmette Guerin, Corynebacterium parvum, etc) exert their beneficial properties by enhancing hemopoietic recovery and hence, by regenerating the host's ability t...

journal_title：Journal of leukocyte biology

authors： Patchen ML,D'Alesandro MM,Brook I,Blakely WF,MacVittie TJ

更新日期：1987-08-01 00:00:00

abstract：:Because myotonic dystrophy (MD) is an autosomal dominant multisystemic disorder affecting plasma membrane, we have studied the oxidative burst of PMNs. The PMA and fMet-Leu-Phe-stimulated superoxide generation is defective in the patient group as compared to controls: the response is both delayed and low. The kinetic ...

journal_title：Journal of leukocyte biology

authors： Mege JL,Pouget J,Capo C,Andre P,Benoliel AM,Serratrice G,Bongrand P

更新日期：1988-09-01 00:00:00

abstract：:Dendritic cells (DC) are key regulators of adaptive immunity with the potential to induce T cell activation/immunity or T cell suppression/tolerance. DC are themselves induced by "maturation" signals such as bacterial lipopolysaccharide (LPS). We demonstrate here that LPS can stimulate DC to display similar maturation...

journal_title：Journal of leukocyte biology

authors： Jiang HR,Muckersie E,Robertson M,Xu H,Liversidge J,Forrester JV

更新日期：2002-11-01 00:00:00

abstract：:Interleukin-10 (IL-10) is a potent anti-inflammatory cytokine with numerous immunomodulatory effects, including the inhibition of proinflammatory cytokine production. The mechanisms by which IL-10 exerts these effects still remain largely unknown. As there is evidence that suggests IL-10-mediated cytokine suppression ...

journal_title：Journal of leukocyte biology

authors： Williams L,Jarai G,Smith A,Finan P

更新日期：2002-10-01 00:00:00

abstract：:TNFR-associated periodic syndrome is an autoinflammatory disorder caused by autosomal-dominant mutations in TNFRSF1A, the gene encoding for TNFR superfamily 1A. The lack of knowledge in the field of TNFR-associated periodic syndrome biology is clear, particularly in the context of control of immune self-tolerance. We ...

journal_title：Journal of leukocyte biology

authors： Pucino V,Lucherini OM,Perna F,Obici L,Merlini G,Cattalini M,La Torre F,Maggio MC,Lepore MT,Magnotti F,Galgani M,Galeazzi M,Marone G,De Rosa V,Talarico R,Cantarini L,Matarese G

更新日期：2016-05-01 00:00:00

abstract：:T helper cell type 1 (Th1)-polarizing cytokines are induced by Legionella pneumophila infection and are suppressed by pretreatment with marijuana cannabinoids (CB). Glucocorticoids and prostaglandin E2(PGE2) are also reported to suppress Th1 polarization and are induced by Delta9-tetrahydrocannabinol (THC), so their r...

journal_title：Journal of leukocyte biology

authors： Newton CA,Lu T,Nazian SJ,Perkins I,Friedman H,Klein TW

更新日期：2004-10-01 00:00:00

abstract：:Interleukin-8 (IL-8), a neutrophil-activating cytokine, also activates certain T cell functions such as chemotaxis. We additionally find (n = 6) that recombinant (rIL-8; 1-100 ng/ml), when added to 24 h culture of human CD4+ T cells, suppressed the spontaneous production of IL-4 (50-85%). Steady state production of Il...

journal_title：Journal of leukocyte biology

authors： Gesser B,Lund M,Lohse N,Vestergaad C,Matsushima K,Sindet-Pedersen S,Jensen SL,Thestrup-Pedersen K,Larsen CG

更新日期：1996-03-01 00:00:00

abstract：:T-cell recognition of foreign antigen and migration to specific anatomic sites in vivo involves transient adhesive contacts between beta1 integrins expressed on T cells and cell surface proteins or extracellular-matrix components. Engagement of the CD3-T-cell receptor (CD3-TCR) complex initiates a complex signaling ca...

journal_title：Journal of leukocyte biology

authors： Woods ML,Shimizu Y

更新日期：2001-06-01 00:00:00

abstract：:Microorganisms interact with the immune system in multiple ways. In an interaction between a microorganism and its host, the defense of the host does not go unchallenged. Microorganisms have for decades been suspected of possessing the capabilities of hiding from and escaping the consequences of immune surveillance. E...

journal_title：Journal of leukocyte biology

authors： Kotwal GJ

更新日期：1997-10-01 00:00:00

abstract：:We report the systematic use of large-scale cDNA microarrays to study the gene expression profiles of primary human peripheral blood monocytes (MONO) in comparison with in vitro-differentiated, M-CSF-induced MONO-derived macrophages (MAC) and primary human alveolar MAC (AM), obtained by bronchoalveolar lavage from the...

journal_title：Journal of leukocyte biology

authors： Li J,Pritchard DK,Wang X,Park DR,Bumgarner RE,Schwartz SM,Liles WC

更新日期：2007-01-01 00:00:00

abstract：:Mice with a naturally occurring Csfm(op)/Csfm(op) (op/op) gene mutation lack functional macrophage-colony stimulating factor (M-CSF) and are deficient of M-CSF-derived macrophages. They are severely monocytopenic, and their remaining M-CSF-independent macrophages were shown to differ in differentiation and distinct fu...

journal_title：Journal of leukocyte biology

authors： Schönlau F,Schlesiger C,Ehrchen J,Grabbe S,Sorg C,Sunderkötter C,Ehrehen J

更新日期：2003-05-01 00:00:00

abstract：:Expression of phosphatidylserine (PS) on the surface of both macrophages and their apoptotic targets is required for efficient phagocytosis. Monocytes, the precursors of macrophages, do not express PS on their surface and do not efficiently phagocytose apoptotic cells. We report here that PS appears on the surface of ...

journal_title：Journal of leukocyte biology

authors： Callahan MK,Halleck MS,Krahling S,Henderson AJ,Williamson P,Schlegel RA

更新日期：2003-11-01 00:00:00

abstract：:Investigators from two different laboratories have compared several variables in the short-term macrophage-mediated cytotoxicity assays used by each group to study the role of MuIFN-gamma in macrophage activation. The findings suggest that the capacity of MuIFN-gamma to activate macrophages without the need for a seco...

journal_title：Journal of leukocyte biology

authors： Pace JL,Varesio L,Russell SW,Blasi E

更新日期：1985-04-01 00:00:00

abstract：:In newborn infants, the innate cellular system plays a crucial role in the first line of defense against pathogens. Neutrophils are the most abundant leukocytes, and their response to the commonly encountered nosocomial bacterial (Gram positive) infection in newborns remains largely unclear. In this study, a genome-wi...

journal_title：Journal of leukocyte biology

authors： Fong ON,Chan KY,Leung KT,Lam HS,Cheung HM,Leung TY,Li K,Ng PC

更新日期：2014-01-01 00:00:00

abstract：:The oxidative metabolic burst of stimulated human polymorphonuclear leukocytes (PMNs) has been evaluated by the measurement of oxygen consumption, chemiluminescence, and oxygen radicals (O2-, H2O2, OH-) derived from activation of the hexose monophosphate shunt (HMPS). PMNs from patients with chronic granulomatous dise...

journal_title：Journal of leukocyte biology

authors： Hassan NF,Campbell DE,Douglas SD

更新日期：1988-04-01 00:00:00

abstract：:Th cells have long been recognized as vital components of the adaptive immune system. Until recently, CD3(+)CD4(+) Th cells were divided into cell-mediated Th1 or humoral Th2 responses. However, the Th1-Th2 hypothesis failed to accommodate the more recently described Th17 cells. Today, the major Th cell subsets includ...

journal_title：Journal of leukocyte biology

authors： Rendon JL,Choudhry MA

更新日期：2012-09-01 00:00:00

abstract：:GCs are widely prescribed to treat inflammatory disorders and autoimmune and allergic diseases. Their anti-inflammatory and immunosuppressive effects may be related, in part, to their ability to control the maturation and functions of DCs. Here, we report that GCs inhibit the maturation of human CD34-DCs induced by th...

journal_title：Journal of leukocyte biology

authors： Larangé A,Antonios D,Pallardy M,Kerdine-Römer S

更新日期：2012-01-01 00:00:00

abstract：:The immune system modulates a number of biological processes to properly defend against pathogens. Here, we review how crosstalk between nuclear hormone receptors and the innate immune system may influence multiple biological functions during an immune response. Although nuclear hormone receptor repression of innate i...

journal_title：Journal of leukocyte biology

authors： Chow EK,Razani B,Cheng G

更新日期：2007-08-01 00:00:00

abstract：:The aim of the study was to elucidate the effect of lipopolysaccharide (LPS) administration in vivo (Escherichia coli endotoxin, 1 mg/kg body weight) on the expression and cellular activity of glucose-6-phosphate dehydrogenase (G6PDH, EC 1.1.1.49), the rate-limiting enzyme of the hexose monophosphate shunt in hepatic ...

journal_title：Journal of leukocyte biology

authors： Spolarics Z,Navarro L

更新日期：1994-10-01 00:00:00

abstract：:Adherence of monocytes to extracellular matrix components is critical for their accumulation at sites of infection. To gain insight into the factors that regulate monocyte recruitment, we have studied monocyte adherence with regard to the regulatory effects of bacterial lipopolysaccharide (LPS) and the mechanisms invo...

journal_title：Journal of leukocyte biology

authors： Owen CA,Campbell EJ,Stockley RA

更新日期：1992-04-01 00:00:00

abstract：:An accessory cell line, designated line A, was generated from bone marrow stem cells which differentiated in vitro in response to colony-stimulating factor (CSF) in substratum cultures. The cells were found to constitutively secrete large amounts of CSF, the activity of which was neutralized by anti-CSF-1 antibodies. ...

journal_title：Journal of leukocyte biology

authors： Apte RN,Huleihel M,Tuvia Y,Buchnik D,Weinstein Y,Segal S

更新日期：1986-08-01 00:00:00

abstract：:Polymorphonuclear leukocytes (PMNs) exert most of their physiological functions while adherent to surfaces rather than in suspension. PMN adhesion is largely dependent on the function of the beta 2 integrins, CD11a,b,c/CD18. We mimicked engagement of beta 2 integrins by antibody cross-linking of CD18 on isolated human...

journal_title：Journal of leukocyte biology

authors： Walzog B,Seifert R,Zakrzewicz A,Gaehtgens P,Ley K

更新日期：1994-11-01 00:00:00

abstract：:Lipopolysaccharide-induced necrosis of grafted tumors was potentiated by several hydrophilic and lipophilic muramyl dipeptide (MDP) derivatives administered a few hours prior to small amounts of lipopolysaccharide (LPS) in spite of low titers of induced circulating tumor necrosis factor (TNF). However, pretreatment wi...

journal_title：Journal of leukocyte biology

authors： Parant M,Parant F,Vinit MA,Jupin C,Noso Y,Chedid L

更新日期：1990-02-01 00:00:00

abstract：:The lymphotoxin signaling pathway plays an important role in the homeostasis and function of peripheral and mucosal dendritic cells, and dendritic cell-intrinsic lymphotoxin β receptor expression is required for optimal responses to opportunistic intestinal bacteria. However, it is unknown whether dendritic cell-intri...

journal_title：Journal of leukocyte biology

authors： Sun T,Rojas OL,Li C,Philpott DJ,Gommerman JL

更新日期：2016-07-01 00:00:00

abstract：:Neutrophil accumulation and plasma leakage induced in rabbit skin by neutrophil-activating peptide-1 (NAP-1, a 72 amino acid peptide produced by monocytes and a variety of tissue cells), E. coli endotoxin, and interleukin-1 (IL-1) were compared. Neutrophil accumulation at sites injected with NAP-1 was intense, rapid, ...

journal_title：Journal of leukocyte biology

authors： Colditz IG,Zwahlen RD,Baggiolini M

更新日期：1990-08-01 00:00:00

abstract：:Stromal cell-derived factor 1alpha (SDF-1alpha) is the exclusive ligand for the chemokine receptor CXCR4. This receptor plays a pivotal role in immune responses, the pathogenesis of infection such as HIV, and cellular trafficking. However, the signaling mechanisms regulating SDF-driven T cell migration are not well de...

journal_title：Journal of leukocyte biology

authors： Shahabi NA,McAllen K,Sharp BM

更新日期：2008-03-01 00:00:00

abstract：:During inflammation the balance between cell activation and cell death is determined by the tight regulation of multiple intracellular enzyme cascades. Key regulatory steps often involve protein kinases. We show that the prototypical pro-inflammatory molecule, bacterial lipopolysaccharide, activates multiple protein k...

journal_title：Journal of leukocyte biology

authors： Lee J,Mira-Arbibe L,Ulevitch RJ

更新日期：2000-12-01 00:00:00