Urticaria pigmentosa responsive to nifedipine.

abstract：BACKGROUND:Vascular cell adhesion molecule-1 (VCAM-1) is an endothelial protein with adhesive properties for inflammatory cells including lymphocytes. Its role in skin disease and regulation in vivo are uncertain. OBJECTIVE:Our purpose was to determine expression of VCAM-1 in normal and inflamed skin and the effect on...

journal_title：Journal of the American Academy of Dermatology

authors： Groves RW,Ross EL,Barker JN,MacDonald DM

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Significant unmet need exists for long-term treatment of moderate to severe atopic dermatitis (AD). OBJECTIVE:To assess the long-term safety and efficacy of dupilumab in patients with AD. METHODS:This ongoing, multicenter, open-label extension study (NCT01949311) evaluated long-term dupilumab treatment in ...

journal_title：Journal of the American Academy of Dermatology

authors： Deleuran M,Thaçi D,Beck LA,de Bruin-Weller M,Blauvelt A,Forman S,Bissonnette R,Reich K,Soong W,Hussain I,Foley P,Hide M,Bouaziz JD,Gelfand JM,Sher L,Schuttelaar MLA,Wang C,Chen Z,Akinlade B,Gadkari A,Eckert L,Da

更新日期：2020-02-01 00:00:00

abstract：:The clinical, electron microscopic, and freeze-fracture features of the skin of a harlequin fetus are described. Ultrastructural findings included large, concentric lamellar bodies, focal absence of intercellular stratum corneum lipid, and an increase in the size of desmosomes and the number of tight junctions. Althou...

journal_title：Journal of the American Academy of Dermatology

authors： Fleck RM,Barnadas M,Schulz WW,Roberts LJ,Freeman RG

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:The continuous increase in the US population older than 65 years and the chronic course of psoriasis make management of psoriasis in the elderly an important health care problem. OBJECTIVE:We sought to develop a treatment algorithm for patients with psoriasis who are older than 65 years. METHODS:A systemat...

journal_title：Journal of the American Academy of Dermatology

authors： Grozdev IS,Van Voorhees AS,Gottlieb AB,Hsu S,Lebwohl MG,Bebo BF Jr,Korman NJ,National Psoriasis Foundation.

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Rituximab (RTX) is an effective therapy for patients with pemphigus; however, the therapy does not prevent relapse. OBJECTIVES:To compare early relapsing patients (before 12 months) and late relapsing patients (after 24 months) following RTX therapy. METHOD:In this prospective study, 19 patients were enrol...

journal_title：Journal of the American Academy of Dermatology

authors： Saleh MA

更新日期：2018-07-01 00:00:00

abstract：:Melanocytic nevi are commonly believed to undergo changes during pregnancy. This is probably related to hormonal influences; however, few studies have been able to prove it. We observed a case of a benign melanocytic nevus, which showed significant enlargement during pregnancy and immediate postpartum regression assoc...

journal_title：Journal of the American Academy of Dermatology

authors： Lee HJ,Ha SJ,Lee SJ,Kim JW

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Efficacy of oral antiviral therapies, ie, acyclovir, valacyclovir (VACV), and famciclovir, for suppression of recurrent genital herpes was studied at different doses and regimens. OBJECTIVE:We sought to compare the clinical efficacies of the different oral antiviral drugs prescribed prophylactically to supp...

journal_title：Journal of the American Academy of Dermatology

authors： Lebrun-Vignes B,Bouzamondo A,Dupuy A,Guillaume JC,Lechat P,Chosidow O

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Hereditary polymorphic light eruption (HPLE) occurs unique ly in the American Indian and Inuit and exhibits autosomal dominant transmission. Because the cutaneous expression of HPLE resembles that of polymorphic light eruption (PLE) and because many non-Indians in the United States have American Indian herit...

journal_title：Journal of the American Academy of Dermatology

authors： Fusaro RM,Johnson JA

更新日期：1996-04-01 00:00:00

abstract：:A study comparing direct immunofluorescence assay using a new monoclonal antibody specific for a varicella-zoster virus glycoprotein complex, the Tzanck smear, and virus isolation for detection of varicella-zoster virus in 56 patients with clinically apparent herpes zoster is presented. Of 47 patients with clinical he...

journal_title：Journal of the American Academy of Dermatology

authors： Sadick NS,Swenson PD,Kaufman RL,Kaplan MH

更新日期：1987-07-01 00:00:00

abstract：:One hundred three patients with acne vulgaris were randomly designated to receive either a topical formulation of erythromycin plus zinc or a topical solution of 1% clindamycin phosphate (Cleocin-T). The patients treated themselves twice daily and were examined at 3, 6, 9, and 12 weeks after the start of therapy. By w...

journal_title：Journal of the American Academy of Dermatology

authors： Schachner L,Pestana A,Kittles C

更新日期：1990-03-01 00:00:00

abstract：:The deep penetrating nevus (DPN), also known as the plexiform spindle cell nevus, is a pigmented lesion that commonly arises on the head and neck in the first few decades of life. Histopathologically, the DPN is wedge-shaped and contains melanocytes that exhibit deep infiltration into the dermis. Given these features,...

journal_title：Journal of the American Academy of Dermatology

authors： Strazzula L,Senna MM,Yasuda M,Belazarian L

更新日期：2014-12-01 00:00:00

abstract：:Infantile perineal protrusion, a relatively newly recognized condition, is underreported in both the dermatologic and pediatric literature. The name "infantile perineal protrusion" has evolved based on the typical anatomic location, morphologic features, and prevalence in prepubertal children. It occurs in 3 settings:...

journal_title：Journal of the American Academy of Dermatology

authors： Khachemoune A,Guldbakke KK,Ehrsam E

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:We review our experience with nine patients with partial unilateral lentiginosis (PUL), a rare pigmentary disorder. OBJECTIVE:Our purpose was to define the characteristics of PUL and to discuss the differential diagnosis. METHODS:The records of nine patients with PUL were reviewed. A literature review on d...

journal_title：Journal of the American Academy of Dermatology

authors： Trattner A,Metzker A

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Klippel-Trenaunay syndrome (KTS) is a vascular malformation overgrowth syndrome characterized by capillary malformation, venous malformation, and limb overgrowth, with or without lymphatic malformation. Patients are at an increased risk of hemorrhage and venous thromboembolism (VTE). Consequently, women with...

journal_title：Journal of the American Academy of Dermatology

authors： Marvin EK,Schoch JJ,Nguyen H,Anderson KR,Driscoll DJ,Rose CH,Bendel EC,Tollefson MM

更新日期：2019-12-01 00:00:00

abstract：:Sjögren syndrome (SS) is an autoimmune connective tissue disorder (CTD) that principally affects the lacrimal and salivary glands. Although SS is 1 of the 3 most common autoimmune CTDs alongside systemic lupus erythematosus and progressive systemic sclerosis, it is the least researched CTD overall. SS poses a particul...

journal_title：Journal of the American Academy of Dermatology

authors： Jhorar P,Torre K,Lu J

更新日期：2018-10-01 00:00:00

abstract：:A young woman developed minocycline-related lupus erythematosus with associated autoimmune hepatitis. All clinical and laboratory abnormalities returned to normal when the drug was stopped. The symptoms worsened dramatically upon rechallenge, strongly suggesting the reaction was related to the minocycline. ...

journal_title：Journal of the American Academy of Dermatology

authors： Crosson J,Stillman MT

更新日期：1997-05-01 00:00:00

abstract：:Lupus pernio has been associated with sarcoidosis of the upper respiratory tract. The semantic differences in the use of the designation "lupus pernio" are such that American dermatologists may not consider patients with nasal rim papules of sarcoidosis to have lupus pernio. During a 12-month period, we referred each ...

journal_title：Journal of the American Academy of Dermatology

authors： Jorizzo JL,Koufman JA,Thompson JN,White WL,Shar GG,Schreiner DJ

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND:Established data confirm an increased incidence of skin cancer, mainly squamous cell carcinoma (SCC), in long-term kidney transplant recipients (KTRs). OBJECTIVE:Our purpose was to investigate prospectively the type and frequency of neoplastic and preneoplastic skin lesions in KTRs during the first 3 years ...

journal_title：Journal of the American Academy of Dermatology

authors： Ferrándiz C,Fuente MJ,Ribera M,Bielsa I,Fernández MT,Lauzurica R,Roca J

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:In primary melanomas, data on the degree of intratumoral heterogeneity to date have been lacking. OBJECTIVE:Our purpose was to investigate intratumoral DNA stem-line heterogeneity in superficial spreading melanoma (SSM). METHODS:Multiple measuring fields of 54 SSMs (tumor thickness median 1.60 mm) were stu...

journal_title：Journal of the American Academy of Dermatology

authors： Helmbold P,Altrichter D,Klapperstück T,Marsch WCh

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Bullous pemphigoid is an autoimmune blistering skin disease that predominantly affects the elderly. Conventional therapy using high-dose systemic corticosteroids and immunosuppressive agents can be ineffective in some patients and produce adverse events and relapses. Hence, alternate therapies are required. ...

journal_title：Journal of the American Academy of Dermatology

authors： Ahmed AR,Shetty S,Kaveri S,Spigelman ZS

更新日期：2016-04-01 00:00:00

abstract：:A randomized double-blind trial of topical minoxidil was carried out during a 12-month period in 56 patients with male pattern baldness. Subjects were randomly assigned to treatment with either 2% minoxidil solution, 3% minoxidil solution, or placebo. The placebo group was switched to 3% minoxidil after the first 4 mo...

journal_title：Journal of the American Academy of Dermatology

authors： De Villez RL

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND:Onychomycosis is an increasing problem with limited therapeutic options. OBJECTIVE:We evaluated the safety and efficacy, of oral terbinafine, a new fungicidal antimycotic, in patients with toenail onychomycosis. METHODS:A North American multicenter, double-blind, placebo-controlled study evaluated the myco...

journal_title：Journal of the American Academy of Dermatology

authors： Drake LA,Shear NH,Arlette JP,Cloutier R,Danby FW,Elewski BE,Garnis-Jones S,Giroux JM,Gratton D,Gulliver W,Hull P,Jones HE,Journet M,Krol AL,Leyden JJ,Maddin SC,Ross JB,Savin RC,Scher RK,Sibbald GR,Tawfik NH,Zaia

更新日期：1997-11-01 00:00:00

abstract：:A 49-year-old man presented with an acute onset of folliculitis on his right cheek. The folliculitis was unresponsive to antibiotics. A potassium hydroxide preparation of a scraping from the affected area revealed the presence of numerous Demodex mites. The patient was treated with topical crotamiton (Eurax) cream res...

journal_title：Journal of the American Academy of Dermatology

authors： Purcell SM,Hayes TJ,Dixon SL

更新日期：1986-11-01 00:00:00

abstract：:Multiple studies have shown that dermoscopy increases the sensitivity and specificity for the detection of skin cancers compared with examination by the naked eye. Dermoscopy can also lead to the detection of thinner and smaller cancers. In addition, dermoscopy leads to the more precise selection of lesions requiring ...

journal_title：Journal of the American Academy of Dermatology

authors： Yélamos O,Braun RP,Liopyris K,Wolner ZJ,Kerl K,Gerami P,Marghoob AA

更新日期：2019-02-01 00:00:00

abstract：:Psoriasis is a common, chronic, inflammatory, multisystem disease with predominantly skin and joint manifestations affecting approximately 2% of the population. In this fifth of 6 sections of the guidelines of care for psoriasis, we discuss the use of ultraviolet (UV) light therapy for the treatment of patients with p...

journal_title：Journal of the American Academy of Dermatology

authors： Menter A,Korman NJ,Elmets CA,Feldman SR,Gelfand JM,Gordon KB,Gottlieb A,Koo JYM,Lebwohl M,Lim HW,Van Voorhees AS,Beutner KR,Bhushan R

更新日期：2010-01-01 00:00:00

abstract：:George Cheyne Shattuck's 1808 dissertation on structure and function of the skin is one of the earliest American writings on the topic of skin diseases. Although this essay contributed no important new observations, it does provide insight into the attitudes of American physicians in the post-Revolutionary War period ...

journal_title：Journal of the American Academy of Dermatology

authors： Valentine MC

更新日期：2002-04-01 00:00:00

abstract：:Pyoderma gangrenosum is a rare and often painful skin disease that can be unpredictable in its response to treatment. There is currently no gold standard of treatment or published algorithm for choice of therapy. The majority of data comes from case studies that lack a standard protocol not only for treatment administ...

journal_title：Journal of the American Academy of Dermatology

authors： Miller J,Yentzer BA,Clark A,Jorizzo JL,Feldman SR

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:The Food and Drug Administration (FDA) has received reports of depression and suicide in patients treated with isotretinoin. OBJECTIVE:Our purpose was to provide the number and describe the cases of depression and suicide reported to the FDA in US patients treated with isotretinoin and to consider the natur...

journal_title：Journal of the American Academy of Dermatology

authors： Wysowski DK,Pitts M,Beitz J

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:The appropriate classification of study designs is important for review and assessment of the relevant scientific literature as a basis for decision making; however, little is known about whether study designs have been appropriately reported in the dermatology literature. OBJECTIVE:We aimed to validate the...

journal_title：Journal of the American Academy of Dermatology

authors： Ohn J,Eun SJ,Kim DY,Park HS,Cho S,Yoon HS

更新日期：2018-08-01 00:00:00

abstract：:Novel tretinoin cream and gel formulations have been developed that incorporate polyolprepolymer-2, which is a material designed to help retain drug molecules in and on the skin when applied in topical vehicles. The results of preclinical and clinical investigations have confirmed the beneficial impact of such a vehic...

journal_title：Journal of the American Academy of Dermatology

authors： Quigley JW,Bucks DA

更新日期：1998-04-01 00:00:00