Vascular cell adhesion molecule-1: expression in normal and diseased skin and regulation in vivo by interferon gamma.

Abstract:

BACKGROUND:Vascular cell adhesion molecule-1 (VCAM-1) is an endothelial protein with adhesive properties for inflammatory cells including lymphocytes. Its role in skin disease and regulation in vivo are uncertain. OBJECTIVE:Our purpose was to determine expression of VCAM-1 in normal and inflamed skin and the effect on this of the T-cell-derived cytokine interferon gamma (IFN-gamma). METHODS:VCAM-1 was detected immunohistochemically in frozen-section biopsy specimens of inflammatory dermatoses and skin tumors. Volunteers received intradermal IFN-gamma and underwent biopsy 2 hours to 6 days later. RESULTS:In normal skin, VCAM-1 was present on perivascular dendritic cells and some follicular keratinocytes. In allergic contact dermatitis, atopic dermatitis, and psoriasis, VCAM-1 was variably upregulated on dermal endothelium and dendritic cells, but was most pronounced in lichen planus. IFN-gamma led to marked upregulation of endothelial and dermal dendritic cell VCAM-1. CONCLUSION:VCAM-1 may be involved in the pathogenesis of various skin diseases and in vivo, IFN-gamma is a potent modulator of its expression.

journal_name

J Am Acad Dermatol

authors

Groves RW,Ross EL,Barker JN,MacDonald DM

doi

10.1016/0190-9622(93)70154-l

subject

Has Abstract

pub_date

1993-07-01 00:00:00

pages

67-72

issue

1

eissn

0190-9622

issn

1097-6787

pii

0190-9622(93)70154-L

journal_volume

29

pub_type

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