The use of cyclosporine in dermatology: part II.

Abstract:

UNLABELLED:Cyclosporine is highly effective in the treatment of a multitude of dermatoses. Concern over its side effect profile has limited its use in dermatology. Adverse effects are, for the most part, dose dependent and related to duration of therapy. Using the recommended monitoring protocols results in a significant decrease in the incidence of cyclosporine-related toxicities. This article provides a comprehensive review of the pharmacokinetics of cyclosporine, potential drug interactions, adverse effects, and recommendations for monitoring in patients treated with cyclosporine. The use of cyclosporine in pregnancy and in the pediatric population is also addressed. LEARNING OBJECTIVES:After completing this learning activity, participants should be familiar with the monitoring guidelines of cyclosporine, its contraindications, its possible drug interactions, its adverse effect profile, and its use in pregnancy and the childhood and adolescent populations.

journal_name

J Am Acad Dermatol

authors

Ryan C,Amor KT,Menter A

doi

10.1016/j.jaad.2010.02.062

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

949-72; quiz 973-4

issue

6

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(10)00562-1

journal_volume

63

pub_type

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