Abstract:
BACKGROUND:Basal cell carcinomas (BCCs) with high-risk features are preferably treated by Mohs micrographic surgery. Studies have shown clinicopathologic characteristics that may predict more stages required for clearance. However, few studies have correlated such factors with the number of millimeters removed per stage. OBJECTIVE:To determine margins necessary for BCC clearance according to tumor features, especially for tumors less than 6 mm, and to suggest initial margins for Mohs micrographic surgery and margins for wide local excision. METHODS:Retrospective analysis of 295 consecutive Mohs micrographic surgeries for primary BCCs. Variables analyzed included patient age, sex, immunostatus, lesion size, location, histologic subtype, borders, stage number, and millimeters excised per stage. RESULTS:BCCs less than 6 mm had a clearance rate of 96% with 3-mm margins. In adjusted multivariable analysis, superficial, micronodular, infiltrative, and morpheaform subtypes were associated with larger margins, whereas clinically well-defined tumors were associated with smaller margins. LIMITATIONS:Because of the limited sample of certain subtypes, a 3-mm margin is better suited for nodular tumors. CONCLUSION:These data help guide initial Mohs micrographic surgery and wide local excision margins required for tumor clearance according to tumor features. Nodular BCCs less than 6 mm may be cleared with 3-mm margins instead of the current 4-mm margin recommendation.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Cerci FB,Kubo EM,Werner B,Tolkachjov SNdoi
10.1016/j.jaad.2020.04.008subject
Has Abstractpub_date
2020-08-01 00:00:00pages
493-500issue
2eissn
0190-9622issn
1097-6787pii
S0190-9622(20)30547-8journal_volume
83pub_type
杂志文章abstract::This study compares the histopathologic characteristics of photodistributed and nonphotodistributed lichenoid drug eruptions in 13 patients. Both types have been said to be, in an unknown proportion, different from idiopathic lichen planus in that they can involve the deep as well as the superficial plexus, can contai...
journal_title:Journal of the American Academy of Dermatology
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