当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY期刊下所有文献 > A prospective study comparing patients with early and late relapsing pemphigus treated with rituximab.

A prospective study comparing patients with early and late relapsing pemphigus treated with rituximab.

Abstract：

BACKGROUND:Rituximab (RTX) is an effective therapy for patients with pemphigus; however, the therapy does not prevent relapse. OBJECTIVES:To compare early relapsing patients (before 12 months) and late relapsing patients (after 24 months) following RTX therapy. METHOD:In this prospective study, 19 patients were enrolled (14 with pemphigus vulgaris and 5 with pemphigus foliaceus). The baseline disease score, autoantibody levels, and percentage of CD20+ cells of patients with pemphigus were measured. Patients received 1 cycle of RTX and were followed for 26 months. RESULTS:Among early relapsing patients (n = 5), the time to relapse was 6 to 11 months. Among late relapsing patients (n = 6), the time to relapse was 24 to 26 months. A significant difference was observed in the mean baseline anti-desmoglein 1 (DSG1) index between early relapsing (705.72) and late relapsing patients (210.4) (P = .0014). A significant negative correlation was found between the baseline anti-DSG1 index and time to relapse (r = -0.777, P = .00009). LIMITATIONS:The small number of patients with pemphigus foliaceus. CONCLUSIONS:Because patients with high baseline anti-DSG1 indices relapsed earlier, it may be important to follow these patients closely for the initial 12 months after RTX therapy. These patients may require a maintenance RTX dose during the first 12 months after RTX therapy.

journal_name

J Am Acad Dermatol

journal_title

Journal of the American Academy of Dermatology

authors

Saleh MA

doi

10.1016/j.jaad.2018.01.029

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

97-103

issue

1

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(18)30148-8

journal_volume

79

pub_type

杂志文章

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