Generation of kinins during preparation and storage of whole blood-derived platelet concentrates.

abstract：BACKGROUND:Disquieting reports of increased complication and death rates after transfusions of red blood cells (RBCs) stored for more than 14 days prompted us to perform an observational retrospective cohort study of mortality in relation to storage time. STUDY DESIGN AND METHODS:We conducted a cohort study utilizing ...

journal_title：Transfusion

authors： Edgren G,Kamper-Jørgensen M,Eloranta S,Rostgaard K,Custer B,Ullum H,Murphy EL,Busch MP,Reilly M,Melbye M,Hjalgrim H,Nyrén O

更新日期：2010-06-01 00:00:00

abstract：:This study evaluated various algorithms for the generation of a red cell antibody identification panel by computer. The algorithms depended on schemes that optimized Fisher's exact p value for each specificity in the panel rather than using predetermined formulations of desired phenotypic combinations. Panels produced...

journal_title：Transfusion

authors： AuBuchon JP,Roberts GC

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:The disappearance of anti-HCV antibodies over time, after a self-limited infection, also referenced seroreversion, has been observed. The frequency of this phenomenon remains controversial, especially in immunocompetent subjects. However, it has important implications in the context of transfusion inquiries,...

journal_title：Transfusion

authors： Lefrère JJ,Girot R,Lefrère F,Guillaume N,Lerable J,Le Marrec N,Bouchardeau F,Laperche S

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:To reduce donor iron deficiency in whole blood donors, we changed our hemoglobin (Hb) cutoff in males and interdonation interval in females. STUDY DESIGN AND METHODS:A change in messaging to females in fall 2016 was followed by changing the interdonation interval from 56 to 84 days in the appointment bookin...

journal_title：Transfusion

authors： Goldman M,Yi QL,Steed T,O'Brien SF

更新日期：2019-05-01 00:00:00

abstract：:Retrospective studies suggest that the transfusion of older, stored red blood cells (RBCs) may be associated with increases in mortality, serious infections, multiorgan failure, thrombosis, and hospital length of stay. Our research is based on the overarching hypothesis that the adverse effects associated with transfu...

journal_title：Transfusion

authors： Hod EA,Spitalnik SL

更新日期：2011-04-01 00:00:00

abstract：:Four commercial test kits for detecting cytomegalovirus (CMV) antibodies (indirect hemagglutination assay, indirect fluorescent antibody technique, enzyme immunoassay, and passive latex agglutination technique) were compared according to their technical demand, hands-on time, turnaround time, concordance with other te...

journal_title：Transfusion

authors： Feng CS,Williams IB,Gohd RS,Causey AP

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND:Avoiding immunization with clinically important antibodies is a primary objective in transfusion medicine. Therefore, it is central to identify the extent of D antigens that escape routine RhD typing of blood donors and to improve methodology if necessary. STUDY DESIGN AND METHODS:We screened 5058 D- donors...

journal_title：Transfusion

authors： Krog GR,Clausen FB,Berkowicz A,Jørgensen L,Rieneck K,Nielsen LK,Dziegiel MH

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Since screening for antibody to hepatitis C virus (HCV) was introduced in 1990, posttransfusion hepatitis has been reduced to nearly background levels. This has led to reconsideration of the value of testing donated blood for elevated alanine aminotransferase (ALT). The contribution of ALT testing in detecti...

journal_title：Transfusion

authors： Sankary TM,Yang G,Romeo JM,Ulrich PP,Busch MP,Rawal BD,Vyas GN

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:The Mirasol pathogen reduction technology (PRT) system for plasma is based on a riboflavin (vitamin B(2)) and ultraviolet (UV) light treatment process resulting in pathogen inactivation due to irreversible photo-oxidative damage of nucleic acids. The purpose of this study was to evaluate the in vitro protein...

journal_title：Transfusion

authors： Smith J,Rock G

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to estimate the risk of human immunodeficiency virus (HIV) infection via the transfusion of blood tested by inappropriately stored or expired rapid antibody assays in Zambia. STUDY DESIGN AND METHODS:Surgical patients (n = 370) were tested with antibody assays (HIV-spot and HIV...

journal_title：Transfusion

authors： Consten EC,van der Meer JT,de Wolf F,Heij HA,Henny PC,van Lanschot JJ

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:Chronic red blood cell (RBC) transfusion therapy (CTT) is an integral component of the management of severe sickle cell disease (SCD) and can prevent complications, such as stroke. RBC units can be administered via simple transfusion or exchange transfusion, and erythrocytapheresis (automated RBC exchange tr...

journal_title：Transfusion

authors： Kelly S,Quirolo K,Marsh A,Neumayr L,Garcia A,Custer B

更新日期：2016-11-01 00:00:00

abstract：:KEY IDEAS Chimeric antigen receptor (CAR) T-cell therapy has the potential to improve the dismal outcome of patients diagnosed with acute myeloid leukemia (AML). A major challenge for CAR T-cell therapy of AML patients is identifying leukemia-specific target antigens. Immune escape through down-regulation of target an...

journal_title：Transfusion

authors： Sauer T,Rooney CM

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Data on red blood cell (RBC) transfusion in the United States show variation in practice and overprescribing or overdosing is considered to be prevalent. Education or restrictive interventions could modify practice. STUDY DESIGN AND METHODS:RBC transfusion and mortality rates were recorded in a single insti...

journal_title：Transfusion

authors： Tavares MM,Diquattro PJ,Sweeney JD

更新日期：2014-10-01 00:00:00

abstract：:An apparent anti-Jka, reacting only in the presence of methyl esters of hydroxybenzoic acid (HBA), was detected in an individual with Jk (a+) red blood cells. The antibody was first detected when a commercial low-ionic-strength-solution preparation containing the preservative methyl paraben (a methyl ester of hydroxyb...

journal_title：Transfusion

authors： Halima D,Garratty G,Bueno R

更新日期：1982-11-01 00:00:00

abstract：:Cell pheresis was employed in the initial management of a pregnant patient with chronic myelocytic leukemia (CML). Reduction in circulating leukocyte and platelet counts was evident after two weeks of therapy. This technique is an effective mode of management of the pregnant patient with CML and may play an important ...

journal_title：Transfusion

authors： Caplan SN,Coco FV,Berkman EM

更新日期：1978-01-01 00:00:00

abstract：:Blood Centers of California, Inc. (BCC) is a consortium of 19 independent blood centers that collectively draw approximately 800,000 units of whole blood each year. Over the past several years, a committee of BCC, composed primarily of medical and nursing directors at member institutions, developed a Uniform Donor Med...

journal_title：Transfusion

authors： Kolins J,Silvergleid AJ

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:Surgical patients receive platelet concentrates (PCs) for a variety of indications. However, there is limited evidence for efficacy or dosing of PCs. STUDY DESIGN AND METHODS:We performed a retrospective cohort study of surgical patients receiving isolated PC transfusion at a single academic tertiary medica...

journal_title：Transfusion

authors： Anders M,Rock P,Cartron A,Chow J,Henderson R,Martz D,Tanaka K,Mazzeffi M

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:The serological safety of transfusing ≤4 units of low titer group O whole blood (LTOWB) in civilian trauma patients has been demonstrated. This study investigated clinical outcomes of LTOWB recipients compared to patients who received only conventional blood components during their resuscitation. STUDY DESI...

journal_title：Transfusion

authors： Seheult JN,Anto V,Alarcon LH,Sperry JL,Triulzi DJ,Yazer MH

更新日期：2018-08-01 00:00:00

abstract：:Kell blood-group-active protein has been isolated by labeling red cell surface proteins with 125I, sensitizing intact cells with anti-K1, anti-K2, anti-K7, or anti-K22, solubilizing the cell membranes, isolating immune complexes, and separating their components by sodium dodecyl sulfate polyacrylamide gel electrophore...

journal_title：Transfusion

authors： Redman CM,Marsh WL,Mueller KA,Avellino GP,Johnson CL

更新日期：1984-03-01 00:00:00

abstract：:Red blood cells stored in saline solution for two weeks at 12 C lose some of their Fya, Fyb, and Fy3 antigenicity. At the same time substances with specific inhibitory activity against appropriate Duffy antibodies appear in the saline. Similar changes could not be recognized in time-expired commercial reagent red bloo...

journal_title：Transfusion

authors： Williams D,Johnson CL,Marsh WL

更新日期：1981-05-01 00:00:00

abstract：BACKGROUND:Sensitive and accurate counting methods are required to assess the residual white cells (WBCs) in WBC-reduced blood components. The Nageotte hemocytometer, widely used for this purpose, is cumbersome, and its efficacy is dependent upon the skill of the operator. The performance of a simple fluorochromatic as...

journal_title：Transfusion

authors： Borzini P,Dumont LJ

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:To meet European guidelines for plasma for fractionation, plasma fractionators have implemented parvovirus B19 (B19V) and hepatitis A virus (HAV) nucleic acid test (NAT) screening on test pools. In this study we evaluate recently developed in-house NAT assays for B19V DNA and HAV RNA. The B19V NAT was design...

journal_title：Transfusion

authors： Molenaar-de Backer MW,de Waal M,Sjerps MC,Koppelman MH

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Reports of Monosomy 7 in patients receiving granulocyte-colony-stimulating factor (G-CSF) have raised concerns that this cytokine may promote genomic instability. However, there are no studies addressing whether repeated administration of G-CSF produces Monosomy 7 aneuploidy in healthy donors. STUDY DESIGN ...

journal_title：Transfusion

authors： Olnes MJ,Poon A,Miranda SJ,Pfannes L,Tucker Z,Loeliger K,Padilla-Nash H,Yau YY,Ried T,Leitman SF,Young NS,Sloand EM

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:An ongoing issue in transfusion medicine is whether newly identified or emerging pathogens can be transmitted by transfusion. One method to study this question is through the use of a contemporary linked donor-recipient repository. STUDY DESIGN AND METHODS:The Retrovirus Epidemiology Donor Study Allogeneic ...

journal_title：Transfusion

authors： Kleinman SH,Glynn SA,Higgins MJ,Triulzi DJ,Smith JW,Nass CC,Garratty G,Murphy EL,LeParc GF,Schreiber GB,King MR,Chamberland ME,Nemo GJ

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Haploidentical hematopoietic stem cell transplantation (HSCT) has been increasingly applied in high-risk hematologic patients due to the absence of HLA-matched donors. The aim of this study was to investigate the efficacy and safety of unmanipulated haploidentical allogeneic peripheral blood stem cells trans...

journal_title：Transfusion

authors： Huang W,Li H,Gao C,Bo J,Wang Q,Zhao Y,Jing Y,Wang S,Zhu H,Dou L,Wang L,Yu L

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Besides ABO and RH, the KEL blood group system, including the two antithetical antigens KEL1 and KEL2, is the most important owing to the frequent appearance of anti-KEL alloantibodies and their considerable clinical significance. So far, only limited information was available on KEL variant alleles determin...

journal_title：Transfusion

authors： Körmöczi GF,Wagner T,Jungbauer C,Vadon M,Ahrens N,Moll W,Mühlbacher A,Ozgül-Gülce S,Kleinrath T,Kilga-Nogler S,Schönitzer D,Gassner C

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Hematopoietic cell infusion-related adverse events (HCI-AEs) in hematopoietic stem cell transplantations (HSCTs) have been largely attributed to toxicity of dimethyl sulfoxide (DMSO) for cryopreservation, but HSC products also contain various cells and plasma components. Our recent prospective study of 1125 ...

journal_title：Transfusion

authors： Ikeda K,Ohto H,Yamada-Fujiwara M,Okuyama Y,Fujiwara SI,Muroi K,Mori T,Kasama K,Kanamori H,Iseki T,Nagamura-Inoue T,Kameda K,Kanda J,Nagai K,Fujii N,Ashida T,Hirose A,Takahashi T,Minakawa K,Tanosaki R

更新日期：2020-05-01 00:00:00

abstract：:The accumulation of the plasticizer di-2-ethylhexylphthalate (DEHP) in blood and blood components has been of considerable concern for some time. We have followed the accumulation of DEHP and one of its major metabolities, mono-2-ethylhexylphthalate (MEHP) during storage of whole blood, platelet-rich plasma, platelet ...

journal_title：Transfusion

authors： Rock G,Secours VE,Franklin CA,Chu I,Villeneuve DC

更新日期：1978-09-01 00:00:00

abstract：BACKGROUND:Recovery and half-life estimations were carried out to compare a high-purity factor IX concentrate with an established factor IX complex concentrate. STUDY DESIGN AND METHODS:Two high-purity factor IX concentrates, which are identical except for the presence or absence of heparin (Immuninehep-plus and Immun...

journal_title：Transfusion

authors： Poon MC,Aledort LM,Anderle K,Kunschak M,Morfini M

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:High-dose therapy with autologous stem cell support after standard dose induction is a promising approach for therapy of primary central nervous system lymphoma (PCNSL). High-dose methotrexate (HD-MTX) is a standard drug for induction of PCNSL; however, data about the capacity of HD-MTX plus granulocyte-colo...

journal_title：Transfusion

authors： Kiefer T,Krüger WH,Montemurro M,Schüler F,Hirt C,Pasold R,Niederwieser D,Schwenke M,Dölken G

更新日期：2008-12-01 00:00:00