Is current serologic RhD typing of blood donors sufficient for avoiding immunization of recipients?

abstract：:Sterility of blood products is a cardinal contributor to patient safety. Bacteriologic controls of stable products comply with strict regulations, but legislation imposes only limited constraints in the case of perishable products, such as packed red cells (RBCs) or fresh-frozen plasma (FFP). Therefore, it is essentia...

journal_title：Transfusion

authors： Guéguen M,Durand F,Delamaire D,Beauplet A,Tardivel R,Genetet B,Chalumeau H,Balme MC

更新日期：1986-05-01 00:00:00

abstract：BACKGROUND:The Mirasol pathogen reduction technology (PRT) system for plasma is based on a riboflavin (vitamin B(2)) and ultraviolet (UV) light treatment process resulting in pathogen inactivation due to irreversible photo-oxidative damage of nucleic acids. The purpose of this study was to evaluate the in vitro protein...

journal_title：Transfusion

authors： Smith J,Rock G

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to estimate the risk of human immunodeficiency virus (HIV) infection via the transfusion of blood tested by inappropriately stored or expired rapid antibody assays in Zambia. STUDY DESIGN AND METHODS:Surgical patients (n = 370) were tested with antibody assays (HIV-spot and HIV...

journal_title：Transfusion

authors： Consten EC,van der Meer JT,de Wolf F,Heij HA,Henny PC,van Lanschot JJ

更新日期：1997-09-01 00:00:00

abstract：:The studies reported in this monograph were performed between 1972 and 2002 when it was possible to study healthy male and female baboons. A colony of baboons was maintained for 30 years without any adverse events observed in these baboons in the numerous studies that were performed. These protocols were reviewed and ...

journal_title：Transfusion

authors： Valeri CR,Ragno G

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Appropriate management to prevent relapses of acquired, autoimmune thrombotic thrombocytopenic purpura (TTP) is not clear. Rituximab (375 mg/m2 /week × 4) is effective treatment for acute episodes but it is not consistently effective for prevention of relapses. Maintenance rituximab, 375 mg/m2 /3 months for ...

journal_title：Transfusion

authors： Saleem R,Rogers ZR,Neunert C,George JN

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Drug-induced immune pancytopenia is considered an uncommon disorder. CASE REPORT:A 76-year-old woman with metastatic gastric adenocarcinoma received 15 cycles of FOLFOX-6 (oxaliplatin/folinic acid/fluorouracil) with a complete response. Upon disease progression, she was restarted on FOLFOX; during the seven...

journal_title：Transfusion

authors： Fontão-Wendel R,Hoff PM,Lazar A,Freitas D,Novis Y,Patah P,Tsujita M,Balthazar A,Pierroti M,Wendel S

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:The anti-CD20 monoclonal antibody rituximab has immune-modulatory effects similar to intravenous immunoglobulin (IVIG). We performed a systematic review and meta-analysis to determine the efficacy and safety of rituximab in autoimmune diseases that are also treated with IVIG. STUDY DESIGN AND METHODS:The mo...

journal_title：Transfusion

authors： MacIsaac J,Siddiqui R,Jamula E,Li N,Baker S,Webert KE,Evanovitch D,Heddle NM,Arnold DM

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Monitoring blood transfusion for overutilization is standard practice at most institutions. STUDY DESIGN AND METHODS:This study monitored for underutilization of blood transfusion over a 14-month period, by evaluating patients who had Hb levels that were reported to be <5 g per dL or platelet counts <10 x 1...

journal_title：Transfusion

authors： Saxena S,Wehrli G,Makarewicz K,Sartorelli J,Shulman IA

更新日期：2001-05-01 00:00:00

abstract：:The use of citrate-phosphate-dextrose-adenine as an anticoagulant for whole blood increases the storage period permitted for whole blood and red cells from 21 to 35 days. A simulation model was used to analyze the possible consequences for outdates and shortages of the addition of adenine. The model accepts as input (...

journal_title：Transfusion

authors： Cohen MA,Pierskalla WP,Sassetti RJ

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:The pathogenesis of posttransfusion purpura (PTP) and transfusion-associated graft-versus-host disease (TA-GVHD) involves patient exposure to donor platelets (PLTs) and T lymphocytes, respectively, which are removed during blood component leukodepletion (LD). STUDY DESIGN AND METHODS:Reports of PTP and TA-G...

journal_title：Transfusion

authors： Williamson LM,Stainsby D,Jones H,Love E,Chapman CE,Navarrete C,Lucas G,Beatty C,Casbard A,Cohen H

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:WBC reduction of cellular blood components has been introduced in many countries. Owing to concerns of residual WBCs in plasma, a new method to collect WBC-reduced plasma by apheresis was studied. STUDY DESIGN AND METHODS:An apheresis machine (PCS2, Haemonetics) was used, in combination with the "high-separ...

journal_title：Transfusion

authors： Vrielink H,van der Meer PF

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:Storage of blood units (for 35-42 days, depending on the preservative solution) has been reported to induce changes (e.g., reduction of sialic acid level) in red cells that are expected to alter their aggregability. STUDY DESIGN AND METHODS:The aggregability of stored red cells was monitored in their autolo...

journal_title：Transfusion

authors： Hovav T,Yedgar S,Manny N,Barshtein G

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Radiation and filtration have achieved satisfactory results in inactivation or removal of tumor cells mixed in salvage blood, but some drawbacks remain. This study evaluated the inactivation on HCT116 cells mixed in simulative salvage blood by riboflavin photochemical treatment. METHODS:HCT116 cells were ad...

journal_title：Transfusion

authors： Yu Y,Yang L,He C,Tai S,Ma C,Yang T,Wang D

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:When xenotropic murine leukemia virus-related virus (XMRV) was first reported in association with chronic fatigue syndrome, it was suggested that it might offer a risk to blood safety. Thus, the prevalence of the virus among blood donors and, if present, its transmissibility by transfusion need to be defined...

journal_title：Transfusion

authors： Dodd RY,Hackett J Jr,Linnen JM,Dorsey K,Wu Y,Zou S,Qiu X,Swanson P,Schochetman G,Gao K,Carrick JM,Krysztof DE,Stramer SL

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Tranexamic acid (TXA) has been reported to demonstrate efficacy in reducing blood loss during arthroplasty procedures. STUDY DESIGN AND METHODS:This study examines the effectiveness of TXA as a central element of a patient blood management program (PBMP) by evaluating blood loss and transfusion of red blood...

journal_title：Transfusion

authors： Pitta M,Zawadsky M,Verstraete R,Rubinstein A

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Human immunodeficiency virus 1 (HIV-1) subtype B is predominant in Spain. However, the recent arrival of immigrant populations has increased the prevalence of non-B subtypes and circulating recombinant forms. The objective of this study was to determine the prevalence of HIV-1 subtypes and transmitted drug-r...

journal_title：Transfusion

authors： Bes M,Piron M,Casamitjana N,Gregori J,Esteban JI,Ribera E,Quer J,Puig L,Sauleda S

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:The absence of hybrid Rhesus boxes denotes an RHD homozygous status and helps to detect the presence of Dce haplotypes instead of dce. RHCE exon 1 C48, characteristic of RHC alleles, and RHCE exon 5 G733, responsible for VS antigenicity, have been noted in many RHce alleles but it was not clearly established...

journal_title：Transfusion

authors： Cotorruelo CM,Munini GM,García Borrás SE,Racca LL,Biondi CS,Racca AL

更新日期：2007-03-01 00:00:00

abstract：:Iron stores were observed in 57 healthy elderly volunteers, between 63 and 77 years of age, who donated 5 units of blood over approximately 1 year. An equal number of nondonors who contributed approximately 7 mL of blood at each visit for iron status measurements only were seen at the same frequency as the donor popul...

journal_title：Transfusion

authors： Garry PJ,VanderJagt DJ,Wayne SJ,Koehler KH,Rhyne RL,Simon TL

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND:A system has been developed to inactivate a wide spectrum of blood-borne pathogens in red blood cells (RBCs) before transfusion. The system utilizes S-303 to target nucleic acids of pathogens and white blood cells. The safety of pathogen inactivated RBC was assessed using S-303-treated RBCs (S-303 RBCs) and ...

journal_title：Transfusion

authors： North A,Ciaravino V,Mufti N,Corash L

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Cell-free fetal DNA in maternal plasma opens the way for routine risk-free diagnosis of fetal D status of D- mothers. The focus was on accuracy of RHD typing and confirmation of fetal DNA in maternal plasma while RHD was not detected. STUDY DESIGN AND METHODS:Plasma DNA was extracted (by manual and/or autom...

journal_title：Transfusion

authors： Brojer E,Zupanska B,Guz K,Orziñska A,Kaliñska A

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:The performance of the recently launched Procleix Ultrio (Chiron/Gen-Probe) human immunodeficiency virus-1 (HIV-1), hepatitis C virus (HCV), and hepatitis B virus (HBV) blood screening assay was evaluated in a European multicenter study. STUDY DESIGN AND METHODS:Serial dilutions of reference materials were ...

journal_title：Transfusion

authors： Koppelman MH,Assal A,Chudy M,Torres P,de Villaescusa RG,Reesink HW,Lelie PN,Cuypers HT

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:In sub-Saharan Africa (SSA) confirmed viral marker prevalence between family donors (FDs) and first-time volunteer nonremunerated donors (VNRDs) is similar. In a blood service collecting 10 units/1000 inhabitants, a questionnaire examined FD donation conditions and willingness of becoming repeat VNRDs. STUD...

journal_title：Transfusion

authors： Asenso-Mensah K,Achina G,Appiah R,Owusu-Ofori S,Allain JP

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Previously, we evaluated the Mirasol pathogen reduction technology (PRT) system on platelet (PLT) function before resuspension. We now evaluated this system in the presence of PLT additive solution (PAS). STUDY DESIGN AND METHODS:Double-dose PLTs (n = 15) were generated using a commercially available aphere...

journal_title：Transfusion

authors： Picker SM,Tauszig ME,Gathof BS

更新日期：2012-03-01 00:00:00

abstract：:Kell blood-group-active protein has been isolated by labeling red cell surface proteins with 125I, sensitizing intact cells with anti-K1, anti-K2, anti-K7, or anti-K22, solubilizing the cell membranes, isolating immune complexes, and separating their components by sodium dodecyl sulfate polyacrylamide gel electrophore...

journal_title：Transfusion

authors： Redman CM,Marsh WL,Mueller KA,Avellino GP,Johnson CL

更新日期：1984-03-01 00:00:00

abstract：BACKGROUND:If anti-hepatitis B core antibody testing is not mandated blood donors with occult hepatitis B infection (OBI) may transmit hepatitis B virus (HBV) to a recipient in spite of the use of nucleic acid amplification technology (NAT) or pathogen inactivation (PI). STUDY DESIGN AND METHODS:We developed a model t...

journal_title：Transfusion

authors： Weusten J,van Drimmelen H,Vermeulen M,Lelie N

更新日期：2017-03-01 00:00:00

abstract：:Since the first issue of TRANSFUSION in 1961, there has been a tremendous expansion in not only the number of blood group antigens identified but also in our knowledge of their biochemical basis, function, and more recently, associated DNA changes. As certain techniques became available, our ability to discover and el...

journal_title：Transfusion

authors： Daniels G,Reid ME

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Aprotinin has been reapproved for use in Europe and in Canada. We sought to determine if its reintroduction was still pertinent given the widespread administration of tranexamic acid, another antifibrinolytic shown to reduce bleeding and transfusions. STUDY DESIGN AND METHODS:After institutional review boar...

journal_title：Transfusion

authors： Stevens LM,Noiseux N,Prieto I,Hardy JF

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:The severity of hemolytic disease of the newborn (HDN) due to Diego(b) (Di(b)) mismatch ranges from no symptoms to severe jaundice that requires exchange transfusion (ET). The clinical significance of anti-Di(b) is incompletely recognized. CASE REPORT:A male newborn, referred with jaundice, was revealed to ...

journal_title：Transfusion

authors： Mochizuki K,Ohto H,Hirai S,Ujiie N,Amanuma F,Kikuta A,Miura S,Yasuda H,Ishijima A,Suzuki H

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:The writings of the 17th and 19th centuries about experiments and debates about transfusion were often analyzed and discussed in articles and books, but an analysis of illustrations of transfusion during this pioneering epoch can throw new light on the subject. The first transfusion attempts were as sensatio...

journal_title：Transfusion

authors： Lefrère JJ,Danic B

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:This multicenter study was performed to evaluate the efficiency of a multiplex individual-donation nucleic acid amplification technology (ID-NAT) and discriminatory testing algorithm for detecting hepatitis B virus (HBV) infection in Chinese blood donors. STUDY DESIGN AND METHODS:A total of 1,205,796 hepati...

journal_title：Transfusion

authors： Gou H,Pan Y,Ge H,Zheng Y,Wu Y,Zeng J,Yang Z,Pan T,Cun W,Zhou G,Fang G,Zhang J,Zhang K,Zhang R,Sun Y,Xie J,Li J,Wang L

更新日期：2015-09-01 00:00:00