Xenotropic murine leukemia virus-related virus does not pose a risk to blood recipient safety.

Abstract:

BACKGROUND:When xenotropic murine leukemia virus-related virus (XMRV) was first reported in association with chronic fatigue syndrome, it was suggested that it might offer a risk to blood safety. Thus, the prevalence of the virus among blood donors and, if present, its transmissibility by transfusion need to be defined. STUDY DESIGN AND METHODS:Two populations of routine blood donor samples (1435 and 13,399) were obtained for prevalence evaluations; samples from a linked donor-recipient repository were also evaluated. Samples were tested for the presence of antibodies to XMRV-related recombinant antigens and/or for XMRV RNA, using validated, high-throughput systems. RESULTS:The presence of antibodies to XMRV could not be confirmed among a total of 17,249 blood donors or recipients (0%; 95% confidence interval [CI], 0%-0.017%); 1763 tested samples were nonreactive for XMRV RNA (0%; 95% CI, 0%-0.17%). Evidence of infection was absent from 109 recipients and 830 evaluable blood samples tested after transfusion of a total of 3741 blood components. CONCLUSIONS:XMRV and related murine leukemia virus (MLV) markers are not present among a large population of blood donors and evidence of transfusion transmission could not be detected. Thus, these viruses do not currently pose a threat to blood recipient safety and further actions relating to XMRV and MLV are not justified.

journal_name

Transfusion

journal_title

Transfusion

authors

Dodd RY,Hackett J Jr,Linnen JM,Dorsey K,Wu Y,Zou S,Qiu X,Swanson P,Schochetman G,Gao K,Carrick JM,Krysztof DE,Stramer SL

doi

10.1111/j.1537-2995.2011.03450.x

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

298-306

issue

2

eissn

0041-1132

issn

1537-2995

journal_volume

52

pub_type

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